Stemcells and inflammation
The effects of inflammation on neural stem cells
During injuries and inflammation in the central nervous system neural stem/progenitor cells are activated to migrate into the injury. A limited replacement of the injured tissue can be achieved by differentiation of the progenitor cells. The replacement of oligodendrocytes which occurs in the early phases of multiple sclerosis is an example of this mechanism.
Our group works to identify mechanisms important for the regeneration from progenitor cells an how these mechanisms are affected by inflammatory mediators. We have demonstrated that some components in the inflammatory cascade such as nitric oxide can change the fate of the progenitor cells and hampers neurogenesis. We have also demonstrated that progenitor cells carry receptors which on stimulation can cause the release of proinflammatory cytokines from these cells. The aim of our research is to improve the restoration and limit the injury by preservation of restorative mechanisms in the CNS. Our research group consists of neurologists, neurosurgeons and neurobiologists .