One research focus in the group is to understand the molecular mechanisms responsible for immunological tolerance.
. In particular, we study natural killer cells in the mouse using a combination of cellular immunology, biophysical imaging and mathematical modeling. The intracellular signals that control functional responses and development under various conditions are studied. A second more recent interest is to ask how various components of the immune system impact on the outcome of erythrocyte and platelet transfusion in humans. One focus is to understand how antibodies to HLA molecules makes patients refractory to platelet transfusions and another is to study natural killer cells in transfusion reactions. The aim is to develop means to avoid such reactions and to improve transfusion practices.
Skewing of the NK cell repertoire by MHC class I via quantitatively controlled enrichment and contraction of specific Ly49 subsets.
J. Immunol., 188, 2218-2226, 2012.
A modified FCCS procedure applied to Ly49A-MHC class I cis-interaction studies in cell membranes.
Biophys. J., 101, 1257-1269, 2011.
Current perspectives of natural killer cell education by MHC class I molecules.
Nat. Rev. Immunol., 10, 724-734, 2010.
NK cell education: not an on-off switch but a tunable rheostat.
Trends Immunol, 30, 143-149. 2009.
The strength of inhibitory input during education quantitatively tunes the functional responsiveness of individual natural killer cells.
Blood 113, 2434-2441, 2009.