Marianne Schultzberg
- Address:
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Karolinska Institutet
Department of Neurobiology, Care Sciences and Society
Division of Neurodegeneration
Novum floor 5
S-141 86 Stockholm
Sweden
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Karolinska Institutet
Research Focus
Our group is interested in the role of inflammatory cytokines such as interleukin-1 (IL-1) in the brain in physiological and pathophysiological conditions, particularly analysing the possibility to target glial cells and their products for the treatment of Alzheimer's disease and other neurodegenerative disorders. Specifically, a mouse strain with chronic blocking of IL-1 receptor-mediated acitivity through transgenic overexpression of human soluble IL-1 receptor antagonist (hsIL-1ra) in the central nervous system, has provided new insights into the role of IL-1 signalling in neurogenesis and behaviour, as well as cognitive function. In order to investigate the possibility to stimulate clearance of beta-amyloid, the main constituent of amyloid plaques in Alzheimer's disease brain, the group has developed a model to study phagocytosis of beta-amyloid by human glial cells. Her group also investigates possible role of peripheral inflammation in predisposing for Alzheimer's disease.
