Cardell, Lars Olaf
Allergy, rhinitis and asthma:
Our interest is presently focused on toll and nod-like receptors (TLR/NLRs) and their role in allergy and rhinitis. 16 integrated projects are ongoing. The two first focus on the screening of more than 44 000 genes. TLR/NLRs and their associated mediators with a potential role in allergy and airway inflammation are mapped. mRNA and its corresponding protein expression will be compared. The next two deal with TLR/NLR expression in the upper airways, separating TLR/NLR related events associated with seasonal allergy from unspecific hyperreactivity. The following two projects are centered on compartments other than the airways (blood, lymphoid tissue and bone marrow) of importance for the development of airway inflammation. In two projects the effect of different types of anti-inflammatory treatment (steroids and specific immunotherapy) on the expression of TLR/NLRs and its associated mediators, are investigated. The effects of specific TLR ligand stimulation (LPS, poly I:C and CpG) in the human upper airways are explored in a separate project. Three projects explore the mechanistic role of TLR/NLRs in the lower airways. Finally, there are three projects working with in vivo and vitro based technology dealing with isolated inflammatory cells.
Head and neck cancer:
Chronic inflammation constitutes a risk factor for epithelial cancers. Pathogen-recognition receptors (PRRs), comprising the Toll-, Nod- and Rig-like receptors (TLR, NLR and RLR), recognize microbial structures and initiate an immune response. Despite their protective role against infections, they are increasingly implicated in the pathogenesis of e.g. chronic inflammation and cancer The overall aim is to investigate the role of innate immunity and chronic inflammation in head and neck squamous cell carcinomas (HNSCC) by focusing on how PRR stimulation affects normal and tumorigenic epithelial cells. Cultured tumorigenic and normal epithelial cells are used as a model of HNsCC.
|Camilla Rydberg Millrud||Huvudhandledare|