Thomas Renné
Professor of Clinical Chemistry and Coagulation Research at the Department of Molecular Medicine and Surgery since 2008.
Photo: Bildmakarna
Coagulation factor F XII is normally present in mammals, and it has previously been believed that it is not significant in coagulation. Thomas Renné's group has shown that mice that lack F XII have a lower tendency to form blood clots, without this increasing the risk of haemorrhage. Thus, F XII is now considered to pay a critical role in thrombosis, but not in haemostasis.
The coagulation factor is also involved in conditions such as inflammation and the development of oedema. Mutations in the gene that codes for F XII are associated with oestrogen, and with a particular type of oedema that women experience.
