Arne Östman: Studies on tumor stroma and protein tyrosine phosphatases
Our research aims at an improved understanding of autocrine and paracrine growth factor signaling in cancer. Within this context we perform studies in cell biology, tumor biology, pathology and experimental cancer therapy.
The studies in cell biology analyze how growth factor signaling is controlled by protein tyrosine phosphatases (PTPs). This class of enzyme has recently been shown to be regulated by reactive oxygen species, suggesting that they act as intermediates in a previously un-recognized crosstalk between redox-signaling and growth factor signaling.
The cancer-related studies deal with the inter-play between malignant and non-malignant cells in solid tumors. In this context, we are particularly interested in the cancer-associated fibroblasts (CAFs) which are major constituents of the tumor micro-environment. Recent studies in our group have identified CAF-derived proteins which impact on cancer growth, metastasis, prognosis and response to treatment.
We have an active interest in combining pre-clinical studies with involvement in drug-development and clinical studies. A number of our projects are performed together with partner groups in different KI-based cancer research networks, e.g, STARGET and BRECT, and involve the participation of experts in oncology and pathology.
Some of our projects also involve collaborations with commercial partners.