Björn Öbrink, MD, PhD, Professor
Signal regulation by plasma membrane-associated CEA-family cell adhesion receptors
The plasma membrane has a crucial role in integration and regulation of cellular functions, fate and behavior. A large number of different receptors and cell adhesion molecules are operating in these dynamic events. In recent years the carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) have emerged as crucial players in the novel concept of signal regulation by cell surface molecules. The CEACAM family is a subfamily within the Ig-CAM superfamily, that is of particular medical importance since members of the CEACAM family have important roles in a variety of cell-based events including morphogenesis, vasculogenesis, angiogenesis, cell proliferation, cell motility, apoptosis , tumor growth and invasion, infection and inflammation. My present interest is focussed on a plasma membrane systems biology approach to investigate the role of different members of the CEACAM family, particularly CEACAM1, CEACAM5 and CEACAM6, in normal epithelial cell and tumor biology.
Five Selected Publications
The CEACAM1 N-terminal Ig domain mediates cis- and trans-binding and is essential for allosteric rearrangements of CEACAM1 microclusters.
J. Cell Biol. (2009) 187, 553-567.
Homophilic adhesion and CEACAM1-S regulate dimerization of CEACAM1-L and recruitment of SHP-2 and c-Src.
J. Cell Biol. (2009) 187, 569-581.
The cell adhesion receptor carcinoembryonic antigen-related cell adhesion molecule 1 regulates nucleocytoplasmic trafficking of DNA polymerase delta-interacting protein 38.
J. Biol. Chem. (2007) 282, 26629-26640.
Control of density-dependent, cell state-specific signal transduction by the cell adhesion molecule CEACAM1, and its influence on cell cycle regulation.
Exp. Cell Res. (2005) 307, 427-435.
The cytoplasmic domain of CEACAM1-L controls its lateral localization and the organization of desmosomes in polarized epithelial cells.
J. Cell Science (2004) 117, 1091-1104.