Agneta Richter-Dahlfors Ph. D.
Situated in the Swedish Medical Nanoscience Center, Richter-Dahlfors' research group embraces scientists with expertise in microbiology/infection, neuroscience, and medicine as well as chemistry, organic- and microelectronics. Via extensive engagement in national and international multidisciplinary collaborations, we focus on defining the integrated pathophysiology of bacterial infections, and on generating novel technologies for neuromodulation.
Tissue microbiology reveals the integrated pathophysiology of infection: By applying a panel of intravital techniques (e.g. intravital 2-photon microscopy, amperometric biosensors), we study the real-time dynamics of the infection process within the organ at high resolution using uropathogenic E. coli-induced pyelonephritis as model.
Our work a) aids in establishing the emerging field "tissue microbiology", b) advances the development of biomimetic tools for complementary in vitro studies, and c) focuses on developing biosensors for hospital-acquired infections.
Organic bioelectronics in nanomedicine: We recently demonstrated the use of conducting polymers for precise, non-convective, electrophoretic delivery of signal substances, such as ions and neurotransmitters. Analogously to the function of neurons, the device mimics the action potential causing release of chemical substances into the synaptic cleft. We currently focus on integrating this technology as a novel machine-to-brain interface and as an implantable neuromodulation technology.
- Charalampos Antypas, PhD student
- Ferdinand Xiankeng Choong, PhD student
- Salvador Gomez Carrerero, PhD student
- Mohammad Mirazul Islam, PhD student
- Svava Steiner, student
- Susanne Löffler, postdoc
- Yasuhiro Maeda, visiting assistant professor
- Tatsuro Goda, visiting assistant professor
- Peter Kjäll, project coordinator
- Gunilla Jacobsson, researcher
- Margret Wahlström, project administrator
Tissue microbiology provides a coherent picture of infection.
Curr. Opin. Microbiol. (2012) 15:15-22
Multiphoton microscopy applied for real time intravital imaging of bacterial infections in vivo.
Methods Enzymol. (2012) 506:35-61
Uropathogenic Escherichia coli P and Type 1 fimbriae act in synergy in a living host to facilitate renal colonization leading to nephron obstruction.
PLoS Pathog. (2011) (2):e1001298
Ion bipolar junction transistors.
Proc. Natl. Acad. Sci. USA. (2010) 107, 9929-32
Organic electronics for precise delivery of neurotransmitters to modulate mammalian sensory function.
Nature Materials (2009) 8:742-6