Marie Carlén, Ph.D.
Cognition encompasses sensory processing, perception, attention, working memory and more. Proper cognitive functions are thus essential for most aspects in our everyday life. Extensive evidence exists that cognitive functions depend on synchronization of neuronal activity within and between brain areas. Synchronization of neuronal activity depends on interplay between excitation and inhibition, and the inhibitory interneurons expressing parvalbumin (PV) are key players in this interplay. Data support that the excitation-inhibition balance and synchrony are deficient in psychiatric disorders with cognitive dysfunctions, such as schizophrenia.
Normal network functions in cognition
With electrophysiology recordings and optogenetic manipulations in behaving animals we are probing the contribution of specific neuronal subtypes to cognitive functions, with a strong focus on PV interneurons. Our projects include attentional and working memory tasks, investigating local and global synchronies and their roles in behaviors.
Mechanisms underlying psychiatric disorders
Ongoing research in the lab aims to understand how brain activity and neuronal networks are affected or altered in psychiatric disorders such as schizophrenia. We are using transgenic animals modelling aspects of mental disorders as well as optogenetics to change brain activity and probe network activities with tetrode recordings and behavior.
- Hoseok Kim, postdoc
- Calvin Young, postdoc
- Daniel Kaping, postdoc
- Ĺsa Konradsson-Geuken, researcher
- Xinming Wang, PhD student
- Yang Xuan, PhD student
- Cleiton Aguiar, visiting PhD student
A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior.
Molecular Psychiatry. (2011)
Chronically implanted hyperdrive for cortical recording and optogenetic control in behaving mice.
Conf. Proc. IEEE Eng. Med. Biol. Soc. (2011) 7529-32
Neocortical interneurons: from diversity, strength.
Cell. (2010) 142:189-193
Targeted optogenetic stimulation and recording of neurons in vivo using cell-type-specific expression of Channelrhodopsin-2.
Nature Protocols. (2010) 5:247-254
Driving fast-spiking cells induces gamma rhythm and controls sensory responses.