Jan Albert group
The research in our group focuses on HIV genetic variation, evolution and resistance. We take part in several EU projects, such as Eurocoord and CHAIN, as well as other international projects and collaborations.
One main area of research concerns molecular epidemiology, spread and incidence of HIV, including resistant HIV variants. We also study the emergence and spread HIV variants that are resistant to antiretroviral drugs. To guide prevention it is essential to have correct and detailed information about the local and global HIV epidemic. Phylodynamics is a rapidly developing interdisciplinary research field in which modern maximum likelihood and Bayesian methods are used for phylogenetic inference. We use these methods to gain detailed information of HIV spread in local communities, in Sweden, in Scandinavia and internationally. The methods are also combined with other biomarkers (such as the BED serological incidence test) to estimate time-of-infection for individual HIV patients.
A second area of research is the application of next-generation sequencing to dissect HIV evolution with a previously unattainable resolution. We study how HIV evolves over time within single infected patients. This is used to study the significance of minority variants with populations for instance such variants that are resistant to antiretroviral drugs.