Cancer Genetics - Annika Lindblom
Department of Molecular Medicine and Surgery
Within our group we work with two diseases - breast and colon cancer. The overall aim in both projects is to define genes predisposing to these tumours and offer preventive programmes to identified risk groups.
Research group leader
Familial breast cancer and colon cancer where relatives have a very high risk for the disease represent about 10% of all cases. A group of 15-25% of all cases comes from families with an intermediate risk. The remaining cases are caused by genetic variants in combination with environmental factors. In high-risk families preventive programmes with regular surveillance or even prophylactic surgery is offered to subjects at risk. Individuals with a lower increased risk are offered various preventive programmes tailored to the individual risk.
HNPCC diagnostics in 2006: a protocol for testing of Hereditary Non-Polyposis Colorectal Cancer.
JNCI; 99:291-99, 2007
Common Variants on Chromosome 2q35 and 16q12 Confer Susceptibility to Estrogen Receptor Positive Breast Cancer.
Nat Genet. 2007 Jul;39(7):865-9. Epub 2007 May 27.
Prevalence of adenomas and hyperplastic polyps in mismatch repair mutation carriers among CAPP2 participants: report by the colorectal adenoma/carcinoma prevention programme 2.
J Clin Oncol. 2008 Jul 10;26(20):3434-9.
Common Sequence Variants in the MRPS30 Locus on Chromosome 5p12 Confer Susceptibility to Estrogen Receptor Positive Breast Cancer.
Nat Genet. 2008 Jun;40(6):703-6.
The Clinical Phenotype of Lynch Syndrome Because of Germ-Line PMS2 Mutations.
Gastroenterology. 2008 May 2.