Professor of Molecular Toxicology at the Department of Physiology and Pharmacology since 1996.
Magnus Ingelman-Sundberg aims to understand the basis of individual differences in drug metabolism and toxicity, with an emphasis on the genetic polymorphism of genes that code for the various forms of cytochrome P450.
Genetic factors account for 20 to 40 per cent of the differences in drug metabolism rates that exist between individuals. A different effect to that intended, an adverse drug reaction, or ADR, occurs in 7 per cent of all treated patients, and ADRs cause more than 100 000 deaths in the USA every year. The group's research is aimed at finding pharmacogenetic markers that can predict the effect of different drugs and the risk of adverse effects in the individual, making it easier to tailor drug treatment.
The research group is also studying the underlying molecular mechanisms, epidemiological associations and epigenetic factors that play an important part in the function of drug metabolism enzymes and transporters.