Enikö Pivarcsi Sonkoly
MiRNAs are a family of small, non-protein coding RNAs (~22 nucleotides) expressed in nearly all multicellular organisms. It is estimated that the majority of protein-encoding mRNAs are regulated by miRNAs. In turn, miRNA-mediated regulation is believed to have a widespread impact on both protein output and gene regulatory networks.
We are interested in the elucidation of the role of miRNAs in skin biology and skin diseases, primarily focusing on skin inflammation. We have shown that microRNAs are deregulated in chronic inflammatory skin diseases such as psoriasis and atopic dermatitis, as compared with normal skin. In particular, we identified a miRNA, miR-203, which is preferentially expressed in the skin in comparison with other organs and is an important regulator of keratinocyte differentiation. Furthermore, we have found that several miRNAs deregulated in psoriasis can modulate immune responses and keratinocyte functions in the skin.
Current work in the group focuses on functional studies of selected skin inflammation-associated miRNAs in in vitro and in vivo settings. Our major goals are to understand the role of miRNAs in skin biology and inflammation as well as to assess the therapeutic potential of miRNA mimics/inhibitors for psoriasis and other skin diseases.
In another line of research, we investigate whether miRNAs in cell-free body fluids (i.e. serum) may serve as biomarkers for response to systemic therapy as well as for the presence of arthritis in patients with psoriasis.
MicroRNA-125b Down-regulates Matrix Metallopeptidase 13 and Inhibits Cutaneous Squamous Cell Carcinoma Cell Proliferation, Migration, and Invasion.
J Biol Chem. 2012 Aug 24;287(35):29899-908. Epub 2012 Jul 10.
MiR-21 is up-regulated in psoriasis and suppresses T cell apoptosis.
Exp Dermatol. 2012 Apr;21(4):312-4. doi: 10.1111/j.1600-0625.2012.01462.x.
MicroRNA-203 functions as a tumor suppressor in basal cell carcinoma.
Oncogenesis (2012) 1, e3; doi:10.1038/oncsis.2012.3; published online 12 March 2012
MiR-125b, a microRNA downregulated in psoriasis, modulates keratinocyte proliferation by targeting FGFR2.
J Invest Derm 2011 (7):1521-9.
The expression of microRNA-203 during human skin morphogenesis.
Exp. Dermatol. 2010 (9):854-6.
MiR-155 is overexpressed in atopic dermatitis and modulates T cell proliferative responses by targeting CTLA-4.
J All Clin Immunol. 2010;126(3):581-9.e1-20.
Protein kinase C-dependent upregulation of miR-203 induces the differentiation of human keratinocytes.
J Invest Dermatol. 2010;130(1):124-34.
MicroRNAs: novel rgulators involved in the pathogenesis of Psoriasis?
PLoS ONE 2007;2: e610
Idenfification and characterization of a novel, psoriasis susceptibility-related noncoding RNA gene, PRINS
J. Biol. Chem. 2005; 280:24159-67
IL-31: a new link between T cells and pruritus in atopic skin inflammation
J. Allergy Clin. Immunol. 2006;117: 411-7
Tumor immune escape by the loss of homeostatic chemokine expression
Proc. Natl. Acad. Sci. U.S.A. 2007; 104:19055-60