DBRM Seminar: Karl Fernandes
Adult neural stem cells: Preserving a "Fountain of Youth" in the aging brain
Karl Fernandes, Université de Montréal
Adult neural stem cells generate fewer and fewer new neurons and glial cells as we age, a phenomenon that adversely impacts brain function and regenerative capacity. In this seminar, I will highlight our recent findings on the intracellular signaling pathways and niche-associated changes involved in neural stem cell regulation during normal and Alzheimer-type aging.
Bouab M, Paliouras GN, Aumont A, Forest-Berard K, Fernandes KJL (2011). Aging of the subventricular zone neural stem cell niche: evidence for quiescence-associated changes between early and mid-adulthood. Neuroscience 173:135-49.
Hamilton LK, Aumont A, Julien C, Vadnais A, Calon F, Fernandes KJL (2010). Widespread deficits in adult neurogenesis precede plaque and tangle formation in the 3xTg mouse model of Alzheimer's disease. Eur J Neurosci 32(6):905-20.
Bednarczyk MR, Hacker LC, Fortin-Nunez S, Aumont A, Bergeron R, Fernandes KJL (2011). Distinct stages of adult hippocampal neurogenesis are regulated by running and the running environment. Hippocampus 21(12):1334-47.