Ana Teixeira, PhD

We investigate the effects of the physical microenvironment on cancer cells and stem cells.

Electrochemical oxidation of the conducting polymer PEDOT leads to stronger electrostatic interactions between PEDOT and heparin, decreasing the bioavailability of heparin binding GFs and c, d) inducing NSC differentiation.

The conversion of physical microenvironmental signals into biochemical signals regulates cellular response. However, fundaments aspects of this regulation remain unknown due to a lack of appropriate experimental tools. In particular, we study the roles of spatial and mechanical signals on cell-to-cell communication through the ephrin/Eph and Notch signaling pathways and through growth factor signaling. In addition, we explore the applications of microenvironmental control of cell function in cancer and regenerative medicine. The research projects are inherently cross-disciplinary, integrating materials science, cell biology and medicine.

The overarching goals of our research group are to:

  • Investigate the cellular mechanisms of interpretation of the physical microenvironment.
  • Identify opportunities for cancer therapy that target the cancer stem cell/microenvironment interface.
  • Improve the outcomes of stem cell therapy by manipulating the stem cell microenvironment.

Group Members

  • Vanessa Lundin, PhD student
  • Giulia Meneghello, post-doc
  • Richard Mills, post-doc
  • Ekaterina Petrova, student

This group include this project:

Selected publicationas

Herland A, Persson K. M, Lundin V, Fahlman M, Berggren M, Jager W. H. E, Teixeira I. A

Electrochemical Control of Growth Factor Presentation To Steer Neural Stem Cell Differentiation

Angewandte Chemie Int. Ed. 2011, 50 (52) 1252912533 (Impact factor: 12.73)

Lundin V, Herland A, Berggren M, Jager W. H. E, Teixeira I. A

Control of neural stem cell survival by electroactive polymer substrates

PLoS ONE. 2011; 6(4): e18624. 1Shared co-authorship, 2Corresponding author. (IF 4.09)

Teixeira A. I. 1,2, Ilkhanizadeh, S.1, Wigenius, J.A., Duckworth, J. K., Inganäs, O. and Hermanson, O.

The promotion of neuronal maturation on soft substrates.

Biomaterials. 2009; 30: 4567-4572. 1Equal contribution, 2Corresponding author. (IF 7.40)

Teixeira, A. I., Abrams, G. A., Bertics, P. J., Murphy, C. J. and Nealey, P. F.

Epithelial contact guidance on well-defined micro and nanostructured substrates.

Journal of Cell Science. 2003; 116: 1881-1892. (IF 6.11)

Assistant Professor Ana Teixeira, PhD

Work:
+46 (0) 8 524 87979
E-mail:
Address:
  • Dept of Cell and Molecular Biology(CMB)
    Karolinska Institutet
    P.O. Box 285
    SE-171 77 Stockholm, Sweden
Last modified by: Linda Lindell 2013-03-27