Research Group Erik Norberg
Tumor cells display metabolic profiles that are remarkably distinct from their tissue of origin to ensure fulfillment of their higher bioenergetic/biosynthetic needs required to support a rapid proliferation. The mechanisms underlying this metabolic reprogramming are divergent among tumors and are mainly regulated by oncogenes/tumor suppressors.
We are mainly focusing on the following overarching topics:
- Metabolic Adaptations to Oncogenes and Tumor Suppressors.
- Metabolic Signal Transduction.
- Metabolism in Cancer vs. Normal cells.
- Metabolic Control of Epigenetics.
- Metabolic Control of Responsiveness to Clinically relevant Anti-cancer Regimens.
To study these questions we employ a translational approach starting from primary patient material paralleled by studies to elucidate the molecular mechanisms in cancer cells, normal cells and cancer mouse models, with the ultimate goal of identifying novel drug targets and prognostic markers.
We are assessing the above mentioned aims by an integrative approach consisting of metabolomics, proteomics and transcriptomics as well as various genetic, biochemical and molecular biological tools.
About Erik Norberg
- M.Sc. Uppsala University, Uppsala, Sweden.
- M.Sc. Stockholm Research School in Molecular Life Sciences, Karolinska Institutet, Stockholm, Sweden.
- Ph.D. Karolinska Institutet. Erik was awarded with the Dimitris N Chorafas Prize – for the best Ph.D thesis at Karolinska Institute 2011.
- PostDoc at Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Stanley I, Ribeiro S, Gimenez-Cassina A, Norberg E, Danial NN. Changing appetites: The adaptive advantages of fuel choice Trends in Cell Biology . 2014 Feb;24(2):118-27
Caro P#, Kishan AU#, Norberg E#, Stanley IA, Chapuy B, Ficarro SB, Polak K, Tondera D, Gounarides J, Yin H, Zhou F, Green MR, Chen L, Monti S, Marto JA, Shipp MA, Danial NN. Metabolic signatures uncover distinct targets in molecular subsets of diffuse large B cell lymphoma. Cancer Cell. 2012; 16;22(4):547-60. # Equal contribution
Norberg E, Karlsson M, Korenovska O, Uhlén P, Orrenius S, Zhivotovsky B. Critical role for hyperpolarization-activated cyclic nucleotide-gated channel 2 in the AIF-mediated apoptosis. EMBO journal 2010; 29(22):3869-78
Norberg E, Gogvadze V, Vakifahmetoglu H, Orrenius S, Zhivotovsky B. Oxidative modification sensitizes mitochondrial Apoptosis-Inducing Factor to calpain-mediated processing. Free Radic Biol Med. 2010; 15;48(6):791-7.
We are collaborating with colleagues at Harvard Medical School (Boston, MA, USA) and several groups at Karolinska Institute.
We are currently looking for highly motivated and talented:
- MSc.students (Examensarbete/Diploma),
- Ph.D students
Send your application and CV to: Erik Norberg