Farmakologisk neurokemi

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Forskningen i vår grupp handlar om att utveckla och tillämpa tekniker för att hitta kemiska signaler i hjärnan och andra organ med hjälp av mikrodialys, biosensorer och relaterade bioanalytiska metoder.

Mer information om forskningen finns på engelska

Gruppmedlemmar

Jan KehrForskare
Takashi YoshitakeForskare
Shimako YoshitakeForskare

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Senaste publikationer

The Ginkgo biloba extract EGb 761(R) and its main constituent flavonoids and ginkgolides increase extracellular dopamine levels in the rat prefrontal cortex.
Yoshitake T, Yoshitake S, Kehr J
Br. J. Pharmacol. 2010 Feb;159(3):659-68

Determination of Histamine in Rat Plasma and Tissue Extracts by Intramolecular Excimer-Forming Derivatization and LC with Fluorescence Detection.
Ichinose F, et al. 
Chromatographia 70: 575-580, 2009

Intra- and intermolecular interaction ECL study of novel ruthenium tris-bipyridyl complexes with different amine reductants.
Sun S, Yang Y, Liu F, Fan J, Peng X, Kehr J, et al
Dalton Trans 2009 Oct;(38):7969-74

The role of 5-HT(1A) receptors in learning and memory.
Ogren S, Eriksson T, Elvander-Tottie E, D'Addario C, Ekström J, Svenningsson P, et al
Behav. Brain Res. 2008 Dec;195(1):54-77

From the Golgi-Cajal mapping to the transmitter-based characterization of the neuronal networks leading to two modes of brain communication: wiring and volume transmission.
Fuxe K, Dahlström A, Höistad M, Marcellino D, Jansson A, Rivera A, et al
Brain Res Rev 2007 Aug;55(1):17-54

Effects of the 5-HT1B receptor antagonist NAS-181 on extracellular levels of acetylcholine, glutamate and GABA in the frontal cortex and ventral hippocampus of awake rats: a microdialysis study.
Hu X, Wang F, Stenfors C, Ogren S, Kehr J
Eur Neuropsychopharmacol 2007 Sep;17(9):580-6

Continuous delivery of rotigotine decreases extracellular dopamine suggesting continuous receptor stimulation.
Kehr J, Hu X, Goiny M, Scheller D
J Neural Transm (Vienna) 2007 ;114(8):1027-31

Determination of the dopamine agonist rotigotine in microdialysates from the rat brain by microbore column liquid chromatography with electrochemical detection.
Kehr J, Hu X, Yoshitake T, Scheller D
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2007 Jan;845(1):109-13

The neuropeptide galanin as an in vivo modulator of brain 5-HT1A receptors: possible relevance for affective disorders.
Ogren S, Razani H, Elvander-Tottie E, Kehr J
Physiol. Behav. 2007 Sep;92(1-2):172-9

Reciprocal effects of combined administration of serotonin, noradrenaline and dopamine reuptake inhibitors on serotonin and dopamine levels in the rat prefrontal cortex: the role of 5-HT1A receptors.
Weikop P, Kehr J, Scheel-Krüger J
J. Psychopharmacol. (Oxford) 2007 Nov;21(8):795-804

Differential effects of adjunctive methylphenidate and citalopram on extracellular levels of serotonin, noradrenaline and dopamine in the rat brain.
Weikop P, Yoshitake T, Kehr J
Eur Neuropsychopharmacol 2007 Oct;17(10):658-71

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Jan Kehr

Enhet: Kehr Jan grupp - Farmakologisk neurokemi
E-post: Jan.Kehr@ki.se