Toppublikationer

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Forskare vid Karolinska Institutet publicerar ungefär 4 700 vetenskapliga artiklar med originalresultat om året. Här listas aktuella publikationer i högt rankade vetenskapliga tidskrifter (impaktfaktor 15 och uppåt) där KI-forskare medverkar.

171011
Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System
Memic F, Knoflach V, Morarach K, Sadler R, Laranjeira C, Hjerling-Leffler J, Sundström E, Pachnis V, Marklund U
Gaestroentology (2017) Online 11 October. Article in Press

171009
Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia
Li Z, Chen J, Yu H et al
Nature Genetics (2017) Online 9 Otctober. Article.

171006
The promise of spatial transcriptomics for neuroscience in the era of molecular cell typing
Lein E, Borm LE, Linnarsson S
Science (2017) Online 6 October. Review.

171005
Rivaroxaban with or without Aspirin in Stable Cardiovascular Disease
Eikelboom JW, Connolly SJ, Bosch J et al.
NEJM (2017) Online 5 October. Original Article.

171002
Risk of Cardiovascular Ischemic Events After Surgical Castration and Gonadotropin-Releasing Hormone Agonist Therapy for Prostate Cancer: A Nationwide Cohort Study
Chen DY,  See LC,  Liu JR,  Chuang CK, Pang ST, Hsieh IC, Wen MS, Chen TH, Lin YC, Liaw CC, Hsu CL, Chang JWC, Kuo CF, Huang  WK
JCO (2017) Online 2 October. Original Report.

170928
Oxygen Therapy in Suspected Acute Myocardial Infarction
Hofmann R, James SK, Jernberg T et al
NEJM (2017) Online 28 September. Original Article.

170926
The Heritability of Autism Spectrum Disorder
Sandin S, Lichtenstein P, Kuja-Halkola R, Hultman C, Larsson H, Reichenberg A
JAMA (2017) Online 26 September. Research Letter.

170921
Bivalirudin versus Heparin Monotherapy in Myocardial Infarction
Erlinge D, Omerovic E, Fröbert O et al.
NEJM (2017) Online 21 September. Original Article.

170920
Childhood onset inflammatory bowel disease and risk of cancer: a Swedish nationwide cohort study 1964-2014
Olén O, Askling J, Frumento P, Neovius M, Smedby KE, Ekbom A, Malmborg P, Ludvigsson JF
BMJ (2017) Online 20 September. Research.
På KI Nyheter: Inflammatorisk tarmsjukdom i barndomen kopplat till ökad cancerrisk

170914
Patent Foramen Ovale Closure or Antiplatelet Therapy for Cryptogenic Stroke
Søndergaard L, Kasner SE, Rhodes JF, Andersen G, Iversen HK, Nielsen-Kudsk JE, Settergren M, Sjöstrand C, Roine RO, Hildick-Smith D, Spence JD,  Thomassen L, for the Gore REDUCE Clinical Study Investigators
NEJM (2017) Online 14 September. Original Article. 

170913
Effects of acarbose on cardiovascular and diabetes outcomes in patients with coronary heart disease and impaired glucose tolerance (ACE): a randomised, double-blind, placebo-controlled trial
Holman RR, Coleman RL, Chan JCN et al
Lancet Diabetes & Endocrinology (2017) Online 13 September. Article.

170912
Autophagy-Dependent Generation of Free Fatty Acids Is Critical for Normal Neutrophil Differentiation
Riffelmacher T, Clarke A, Richter FC, Stranks A, Pandey S, Danielli S, Hublitz P, Yu Z, Johnson E, Schwerd T, McCullagh J, Uhlig H, Jacobsen SEW, Simon AK.
Immunity (2017) Online 12 September. Article.

170912
Association Between Laparoscopic Antireflux Surgery and Recurrence of Gastroesophageal Reflux
Maret-Ouda J, Wahlin K, El-Serag HB, Lagergren J
JAMA (2017) Online 12 September. Original Investigation.
På KI Nyheter: Unga män som opereras mot reflux får sällan återfall

170828
Oxygen Therapy in Suspected Acute Myocardial Infarction
Hofmann R, James SK, Jernberg T et al.
NEJM (2017) Online 28 August. Original Article.
På KI Nyheter: Syrgasbehandling vid hjärtinfarkt saknar effekt

170826
PCI Versus CABG in Patients With Type 1 Diabetes and Multivessel Disease
Nyström T, Sartipy U, Franzén S, Eliasson B, Gudbjörnsdottir S, Miftaraj M, Lagerqvist B, Svensson A-M, och Holzmann MJ.
JACC (2017) Online 26 August. Article.
På KI Nyheter: Kranskärlskirurgi effektivt vid typ 1-diabetes

170809
Notch Signaling in Development, Tissue Homeostasis, and Disease
Siebel C, Lendahl U
Physiological Reviews (2017) Online 9 August. Review.  

170808
Distrust in the End-Of-Life Care Provided to a Parent and Long-Term Negative Outcomes Among Bereaved Adolescents: A Population-Based Survey Study 
Beernaert K, Kreicbergs U, Furst CJ, Nyberg T, Steineck G, Bylund-Grenklo T, Journal of Clinical Oncology (2017), Original Report.

170804
Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis
Alberts R, de Vries EMG, Goode EC et al.
Gut (2017) Online 4 August. Original Article.

170803
IgG Endopeptidase in Highly Sensitized Patients Undergoing Transplantation
Jordan SC, Lorant T, Choi J, et al, NEJM (2017), original article

170803
Cardiovascular mortality and morbidity in patients with type 2 diabetes following initiation of sodium-glucose co-transporter-2 inhibitors versus other glucose-lowering drugs (CVD-REAL Nordic): a multinational observational analysis
Birkeland KI, Jørgensen ME, Carstensen B et al, The Lancet Diabetes & Endocrinology (2017), article

170801
Increased Total mtDNA Copy Number Cures Male Infertility Despite Unaltered mtDNA Mutation Load
Jiang M, Eino T, Kauppila S et al, Cell Metabolism (2017), short article

170728
Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health
Cervenka I, Agudelo LZ, Ruas JL, Science (2017) 28 juli, review.

170726
Sequencing and de novo assembly of 150 genomes from Denmark as a population reference
Maretty L, Jensen JM, Petersen B, Hultman CM och Sullivan P et al, Nature (2017) online 26 juli, letter.

170725
Association of genetic variants related to serum calcium levels with coronary artery disease and myocardial infarction
Larsson SC, Burgess S, Michaëlsson K, JAMA (2017) 25 juli, original investigation.
På KI Nyheter: Förhöjda kalciumnivåer i blodet och risk för kranskärlssjukdom

170719
Antidepressants during pregnancy and autism in offspring: population based cohort study
Rai D, K Lee B, Dalman C, Newschaffer C, Lewis G, Magnusson C, BMJ (2017) 19 juli, research article.

170718
Prosthetic valve endocarditis after surgical aortic valve replacement
Natalie Glaser, Veronica Jackson, Martin J. Holzmann, Anders Franco-Cereceda, Ulrik Sartipy, Circulation (2017) online 18 juli. Correspondence
På Nyheter: Färre infektioner i mekanisk hjärtklaff

170717
Cardiomyocyte renewal in the human heart: insights from the fall-out
Lázár E, Sadek HA, Bergmann O
European Heart Journal (2017) Online 7 July. Clinical Review.

170717
Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder
T Lim E, Uddin M, De Rubeis S, Chan Y, S Kamumbu A, Zhang X, M D'Gama A, N Kim S, Sean Hill R, P Goldberg A, Poultney C, J Minshew N, Kushima I, Aleksic B, Ozaki N, Parellada M, Arango C, J Penzol M, Carracedo A, Kolevzon A, M Hultman C, A Weiss L, Fromer M, G Chiocchetti A, M Freitag C, Autism Sequencing Consortium, M Church G, W Scherer S, D Buxbaum J & A Walsh C, Nature Neuroscience (2017) online 17 juli, research article.
På KI Nyheter: Genmutationer efter befruktning viktiga vid autism

170717
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease, Rebecca Sims et al. Laura Fratiglioni, Caroline Graff, Lina Keller, Hakan Thonberg, Charlotte Forsell, Lena Lilius, Anne Kinhult-Stählbom, Nature Genetics, online 17 juli (2017). Artikel.

170717
Association analyses based on false discovery rate implicate new loci for coronary artery disease
Christopher P Nelson et al, Johan L M Björkegren, Nature Genetics, online 17 juli (2017). Letter.

170714
Measures of chronic kidney disease and risk of incident peripheral artery disease: a collaborative meta-analysis of individual participant data
Matsushita K, Ballew SH, Coresh J et al.
Lancet Diabetes and Endocrinology (2017). Online 14 juli. Article. 

170712
Gonadotropin-releasing Hormone Agonists, Orchiectomy, and Risk of Cardiovascular Disease: Semi-ecologic, Nationwide, Population-based Study
Thomsen FB, Sandin F, Garmo H, Lissbrant IF, Ahlgren G, Van Hemelrijck MAdolfsson J, Robinson D, Stattin P
European Urology (2017) Online 12 July. Article in press.

170710
Genotype–covariate interaction effects and the heritability of adult body mass index
Robinson MR, English G, Moser G et al.
Nature Genetics (2017) Online 10 July. Analysis.

170707 
Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla
Furlan A, Dyachuk V Kastriti ME Calvo-Enrique L,Abdo H, Hadjab S, Chontorotzea T, Akkuratova N, Usoskin D, Kamenev D, Petersen J, Sunadome K, Memic F, Marklund U, Fried K, Topilko P, Lallemend F, Kharchenko PV, Ernfors P, Adameyko I
Science (2017) Online 7 July. Research Article.

170629
Use of Molecular Tools to Identify Patients With Indolent Breast Cancers With Ultralow Risk Over 2 Decades
Esserman L, Yau C, Thompson C et al.
JAMA Oncology (2017) Online 29 June. Original Investigation.
På KI Nyheter: Test identifierar bröstcancerpatienter med mycket låg risk att dö

170627
Effect of Acupuncture and Clomiphene in Chinese Women With Polycystic Ovary Syndrome – A Randomized Clinical Trial
Wu X-K, Stener-Victorin E, Kuang H-Y et al.
JAMA (2017) Online 27 June. Original Investigation.
På KI Nyheter: Akupunktur ökar inte fertiliteten hos kvinnor med PCOS

170622
Oesophageal cancer
Lagergren J, Smyth E, Cunningham D, Lagergren P
The Lancet (2017) Online 22 June. Seminar.

170619
Hotspots of missense mutation identify neurodevelopmental disorder genes and functional domains
Geisheker MR, Heymann G, Wang T et al.
Nature Neuroscience (2017) Online 19 June. Article.

170615
Structural Basis of Egg Coat-Sperm Recognition at Fertilization
Raj I, Al Hosseini HS, Dioguardi E, Nishimura K, Han L, Villa A, de Sanctis D, Jovine L
Cell (2017) Online 15 June. Article.
På KI Nyheter: 3D-bilder visar hur spermien binder till äggets yta

170614
Risk of major congenital malformations in relation to maternal overweight and obesity severity: cohort study of 1.2 million singletons
Persson M, Cnattingius S, Villamor E, Söderling J, Pasternak B, Stephansson O, Neovius M
BMJ (2017) Online 14 June. Research.

170613
Time to Delivery of an Automated External Defibrillator Using a Drone for Simulated Out-of-Hospital Cardiac Arrests vs Emergency Medical Services
Claesson A, Bäckman A, Ringh M, Svensson L, Nordberg P, Djärv T, Hollenberg J
JAMA (2017) Online 13 June. Research Letter.
På KI Nyheter: Drönare kan öka överlevnaden vid hjärtstopp

170612
Variant surface antigens of Plasmodium falciparum and their roles in severe malaria
Wahlgren M, Goel S, Akhouri RR
Nature Reviews Microbiology (2017) Online 12 June. Article Series.

170612
Identification of 19 new risk loci and potential regulatory mechanisms influencing susceptibility to testicular germ cell tumor
Litchfield K, Levy M, Orlando G et al.
Nature Genetics (2017) Online 12 June. Letter.

170612
Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor
Wang Z, McGlynn KA, Rajpert-De Meyts E et al
Nature Genetics (2017) Online 12 June. Letter.

170607
Vaccine Priming is Restricted to Draining Lymph Nodes and Controlled by Adjuvant-Mediated Antigen Uptake
Liang F, Lindgren G, Sandgren KJ, Thompson EA, Francica JR, Seubert A, De Gregorio E, Barnett S, O’Hagan DT, Sullivan NJ, Koup RA, Seder RA, Loré K
Science Translational Medicine (2017) Online 7 June. Research Article.

170605
Engineered Cpf1 variants with altered PAM specificities
Gao L, Cox DBT, Yan WX, Manteiga JC, Schneider MW, YamanoT, Nishimasu H, Nureki O, Crosetto N, Zhang F
Nature Biotechnology (2017) Online 5 June. Letter.

170602
Association Between Proton Pump Inhibitor Use and Risk of Progression of Chronic Kidney Disease
Klatte DCF, Gasparini A, Xu H, de Deco P, Trevisan M, Johansson ALV, Wettermark B, Ärnlöv J, Janmaat CJ, Lindholm B, Dekker FW, Coresh J, Grams ME, Carrero JJ
Gastroenterology (2017) Online 2 June. Accepted Manuscript In Press.
På KI Nyheter: Medicin mot halsbränna kan öka risk för njursvikt

170601
MiR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes
Peng C, Li L, Zhang M-D, Bengtsson Gonzales C, Parisie M, Belfer I, Usoskin D, Abdo H, Furlan A, Häring M, Lallemend F, Harkany T, Diatchenko L, Hökfelt T, Hjerling-Leffler J, Ernfors P
Science (2017) Online 1 June. Report.
På KI Nyheter: Oväntad mekanism bakom kronisk nervsmärta

170601
Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women
Klatt NR, Cheu R, Birse K, Zevin AS, Perner M, Noël-Romas L, Grobler A, Westmacott G, Xie IY, Butler J, Mansoor L,
McKinnon LR, Passmore JS, Abdool Karim Q,  Abdool Karim SS, Burgener AD
Science (2017) Online 1 June. Research Article.

170530
Outcomes in Patients With Chest Pain Discharged After Evaluation Using a High-Sensitivity Troponin T Assay
Nejatian A, Omstedt Å, Höijer J, Hansson LO, Djärv T, Eggers KM, Svensson P
JACC (2017) Online 30 May. Article.
På KI Nyheter: Känslig analysmetod ger ökad trygghet för bröstsmärtepatienter

170530
Seattle Heart Failure and Proportional Risk Models Predict Benefit From Implantable Cardioverter-Defibrillators
Bilchick KC, Wang Y, Cheng A, Curtis JP, Dharmarajan K, Stukenborg GJ, Shadman R, Anand I, Lund LH, Dahlström U, Sartipy U, Maggioni A, Swedberg K, O'Conner C, Levy WC.
JACC (2017) Online 30 May. Article.

170522
Social Fear Learning: from Animal Models to Human Function
Debiec J, Olsson A
Trends in Congnitive Sciences (2017) Online 22 May. Review.

170522
Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues
Sugden WW, Meissner R, Aegerter-Wilmsen T, Tsaryk R, Leonard EV, Bussmann J, Hamm MJ, Herzog W, Jin Y, Jakobsson L, Denz C, Siekmann AF
Nature Cell Biology (2017) Online 22 May. Article.

170522
Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling
Jin Y, Muhl L, Burmakin M, Wang Y, Duchez A-C, Betsholtz C, Arthur HM, Jakobsson L
Nature Cell Biology (2017) Online 22 May. Article.
På KI Nyheter: Nya rön kring hur blodkärl bildas och missbildas

170522
Preterm birth and risk of Heart Failure Up to Early Adulthood
Carr H, Cnattingius S, Granath F, Ludvigsson JF, Edstedt Bonamy A-K
JACC (2017) Online 22 May. Article.
På KI Nyheter: För tidig födsel kopplad till ökad risk för hjärtsvikt

170522
Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence
Sniekers S, Stringer S, Watanabe K et al.
Nature Genetics (2017) Online 22 May. Letter.

170519
Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles
Galluzzi L, Bravo-San Pedtro JM, Levine B, Green DR, Kroemer G
Nature Reviews Drug Discovery (2017) Online 19 May. Review.

170516
Particulate Array of Well-Ordered HIV Clade C Env Trimers Elicits Neutralizing Antibodies that Display a Unique V2 Cap Approach
Martinez-Murillo P, Tran K, Guenaga J, Lindgren G, Àdori M, Feng Y, Phad GE, Vázquez Bernat N, Bale S, Ingale J, Dubrovskaya V, O’Dell S, Pramanik L, Spångberg M, Corcoran M, Loré K, Mascola JR, Wyatt RT, Karlsson Hedestam GB
Immunity (2017). Online 16 May. Article.

170515
Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders
Weiner DJ, Wigdor EM, Ripke S et al
Nature Genetics (2017) Online 15 May. Analysis

170515
Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia
Giustacchini A, Thongjuea S, Barkas N et al.
Nature Medicine (2017) Online 15 May. Article.

170512
The changing prevalence and incidence of dementia over time — current evidence
Wu Y-T, Beiser AS, Breteler MB, Fratiglioni L et al.
Nature Reviews Neurology (2017) Online 12 May. Review.

170511
Local amplifiers of IL-4Rα–mediated macrophage activation promote repair in lung and liver
Minutti CM, Jackson-Jones LH, García-Fojeda B, Knipper JA, Sutherland TE, Logan N, Rinqvist E, Guillamat-Prats R, Ferenbach DA, Artigas A, Stamme C, Chroneos ZC, Zaiss DM, Casals C, Allen JE
Science (2017) Online 11 May. Report.

170511
A subcellular map of the human proteome
Thul PJ, Åkesson L, Wiking M
Science (2017) Online 11 May. Research Article.

170510
A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma
Tammela T, Sanchez-Rivera FJ, Cetinbas NM et al.
Nature (2017) Online 10 May. Letter.

170510
Phenome-wide scanning identifies multiple diseases and disease severity phenotypes associated with HLA variants
Karnes JH, Bastarache L, Shaffer CM et al.
Science Translational Medicine (2017) Online 10 May. Research Article.

170505
Impact of cytosine methylation on DNA binding specificities of human transcription factors
Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J
Science (2017) Online 5 May. Research Article.
På KI Nyheter: Stor kartläggning avslöjar hur epigenetiska förändringar i DNA tolkas

170502
The limits of exercise physiology: From performance to health
Gabriel BM, Zierath JR
Cell Metabolism (2017) Online 2 May. Perspective.

170501
Sickness Absence and Disability Pension After Breast Cancer Diagnosis: A 5-Year Nationwide Cohort Study
Kvillemo P, Mittendorfer-Rutz E, Bränström R, Nilsson K, Alexanderson K
JCO (2017) Online 1 May. Original Reports.

170501
In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis
Roper J, Tammela T, Malli N et al.
Nature Biotechnology (2017) Online 1 May. Research Letter.

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