Publications

SRP Diabetes top publications since 2010

(Journals with IF from PNAS and above)

2014

54. Young capillary vessels rejuvenate aged pancreatic islets.
Almaça J, Molina J, Arrojo E Drigo R, Abdulreda M, Jeon W, Berggren P, et al
Proc. Natl. Acad. Sci. U.S.A. 2014 Dec;111(49):17612-7

53. Ciliary dysfunction impairs beta-cell insulin secretion and promotes development of type 2 diabetes in rodents.
Gerdes J, Christou-Savina S, Xiong Y, Moede T, Moruzzi N, Karlsson-Edlund P, et al
Nat Commun 2014 Nov;5():5308

52. G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy.
White J, Wrann C, Rao R, Nair S, Jedrychowski M, You J, et al
Proc. Natl. Acad. Sci. U.S.A. 2014 Nov;111(44):15756-61

51. Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression.
Agudelo L, Femenía T, Orhan F, Porsmyr-Palmertz M, Goiny M, Martinez-Redondo V, et al
Cell 2014 Sep;159(1):33-45

50. HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials.
Swerdlow D, Preiss D, Kuchenbaecker K, Holmes M, Engmann J, Shah T, et al
Lancet 2015 Jan;385(9965):351-61

49. Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity.
Guo T, Marmol P, Moliner A, Björnholm M, Zhang C, Shokat K, et al
Elife 2014 Aug;3():e03245

48. A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes.
Moltke I, Grarup N, Jørgensen M, Bjerregaard P, Treebak J, Fumagalli M, et al
Nature 2014 Aug;512(7513):190-3

47Adipsin is an adipokine that improves β cell function in diabetes.
Lo J, Ljubicic S, Leibiger B, Kern M, Leibiger I, Moede T, et al
Cell 2014 Jul;158(1):41-53

46. Clonal culturing of human embryonic stem cells on laminin-521/E-cadherin matrix in defined and xeno-free environment.
Rodin S, Antonsson L, Niaudet C, Simonson O, Salmela E, Hansson E, et al
Nat Commun 2014 ;5():3195

45. TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content.
Mahdessian H, Taxiarchis A, Popov S, Silveira A, Franco-Cereceda A, Hamsten A, et al
Proc. Natl. Acad. Sci. U.S.A. 2014 Jun;111(24):8913-8

44.Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis.
Rao R, Long J, White J, Svensson K, Lou J, Lokurkar I, et al
Cell 2014 Jun;157(6):1279-91

43. Early B cell factor 1 regulates adipocyte morphology and lipolysis in white adipose tissue.
Gao H, Mejhert N, Fretz J, Arner E, Lorente-Cebrián S, Ehrlund A, et al
Cell Metab. 2014 Jun;19(6):981-92

42. Effects of long-term exposure to air pollution on natural-cause mortality: an analysis of 22 European cohorts within the multicentre ESCAPE project.
Beelen R, Raaschou-Nielsen O, Stafoggia M, Andersen Z, Weinmayr G, Hoffmann B, et al
Lancet 2014 Mar;383(9919):785-95

41. Warfarin, kidney dysfunction, and outcomes following acute myocardial infarction in patients with atrial fibrillation.
Carrero J, Evans M, Szummer K, Spaak J, Lindhagen L, Edfors R, et al
JAMA 2014 Mar;311(9):919-28

40. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
, , , , , Mahajan A, et al
Nat. Genet. 2014 Mar;46(3):234-44

39. Pdx1 maintains β cell identity and function by repressing an α cell program.
Gao T, McKenna B, Li C, Reichert M, Nguyen J, Singh T, et al
Cell Metab. 2014 Feb;19(2):259-71

38. Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms.
Claussnitzer M, Dankel S, Klocke B, Grallert H, Glunk V, Berulava T, et al
Cell 2014 Jan;156(1-2):343-58

2013

37. Barres, R., Kirchner, H., Rasmussen, M., Yan, J., Kantor, Francisc R., Krook, A., Näslund, E., Zierath, Juleen R. Weight Loss after Gastric Bypass Surgery in Human Obesity Remodels Promoter Methylation. Cell Reports 2013 3, 1020-1027.

36. Egan B, Zierath JR. Exercise metabolism and the molecular regulation of skeletal muscle adaptation. Cell Metab. 2013 Feb 5;17(2):162-84.

35. Spalding KL, Bergmann O, Alkass K, Bernard S, Salehpour M, Huttner HB, Boström E, Westerlund I, Vial C, Buchholz BA, Possnert G, Mash DC, Druid H, Frisén J. Dynamics of hippocampal neurogenesis in adult humans. Cell. 2013 Jun 6;153(6):1219-27.

34. Raaschou-Nielsen O, Andersen ZJ, Beelen R, et al (including Östensson C-G). Air pollution and lung cancer incidence in 17 European cohorts: prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE). Lancet Oncol. 2013Aug;14(9):813-22.

33. Arner E, Arner P. Health and obesity: not just skin deep. Science. 2013 Nov1;342(6158):558-9.

32. Mittag J, Lyons DJ, Sällström J, Vujovic M, Dudazy-Gralla S, Warner A, Wallis K, Alkemade A, Nordström K, Monyer H, Broberger C, Arner A, Vennström B. Thyroid hormone is required for hypothalamic neurons regulating cardiovascular functions. J Clin Invest. 2013 Jan 2;123(1):509-16.

31. Ilegems E, Dicker A, Speier S, Sharma A, Bahow A, Edlund PK, Leibiger IB, Berggren PO. Reporter islets in the eye reveal the plasticity of the endocrine pancreas. Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20581-6.

30. Park S-H, Ryu S-Y, Yu W-J, Han YE, Ji Y-S, Oh K, Sohn J-W, Lim A, Jeon J-P, Lee H, Lee K-H, Lee S-H, Berggren P-O, Jeon J-H, Ho W-K. Leptin promotes KATP channel trafficking by AMPK signaling in pancreatic β-cells. PNAS. 2013; 110: 12673-678

29. Kirchner H, Osler ME, Krook A, Zierath JR. Epigenetic flexibility in metabolic regulation: disease cause and prevention? Trends Cell Biol. 2013 May;23(5):203-9.

28. Global Lipids Genetics Consortium, Willer CJ, et al (including Hamsten A). Discovery and refinement of loci associated with lipid levels. Nat Genet. 2013 Nov;45(11):1274-83.

27. Do R, Willer CJ, Schmidt EM, et al (includingh Hamsten A) Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet. 2013 Nov;45(11):1345-52.

2012

26. Barrès R, Yan J, Egan B, Treebak JT, Rasmussen M, Fritz T, Caidahl K, Krook A, O'Gorman DJ, Zierath JR. Acute exercise remodels promoter methylation in human skeletal muscle. Cell Metab. 2012 Mar 7;15(3):405-11.

25. Manning AK et al. (including Hamsten A). A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet. 2012 May 13;44(6):659-669

24. Yang J et al. (Inlcuding Hamsten A). FTO genotype is associated with phenotypic variability of body mass index. Nature. 2012. 490:267-272.

23. Ruas JL, White JP, Rao RR, Kleiner S, Brannan KT, Harrison BC, Greene NP, Wu J, Estall JL, Irving BA, Lanza IR, Rasbach KA, Okutsu M, Nair KS, Yan Z, Leinwand LA, Spiegelman BM. A PGC-1α Isoform Induced by Resistance Training Regulates Skeletal Muscle Hypertrophy. Cell. 2012. 151: 1319-1331.

22. R Rodriguez-Diaz, S Speier, RD Molano, A Formoso, I Gans, MH Abdulreda, O Cabrera, J Molina, A Fachado, C Ricordi, I Leibiger, A Pileggi, P-O Berggren & A Caicedo. Noninvasive in vivo model demonstrating the effects of autonomic innervations on pancreatic islet function. PNAS. 2012. 109:21456-61

21. B Leibiger, T Moede, TP Muhandiramlage, D Kaiser, P Vaca Sanchez, IB Leibiger & P-O Berggren. Glucagon regulates its own synthesis by autocrine signaling. PNAS. 2012. 109:20925-30

20. S-N Yang, Y Shi, G Yang, Y Li, L Yu, O-H Shin, T Bacaj, TC Südhof, J Yu & P-O Berggren. Inositol hexakis-phosphate suppresses excitatory neuro-transmission via synaptotagmin-1 C2B domain in the hippocampal neuron. PNAS 2012, 109:12183-12188

19. Sten Shi T-J, Zhang M-D, Zeberg H, Nilsson J, Grünler J, Liu S-X, Xiang Q, Persson J, Fried K, Catrina SB, Watanabe M, Århem P, Brismar K, Hökfelt T. Coenzyme Q10 prevents peripheral neuropathy and attenuates neuron loss in the db-/db-mouse, a Type 2 model. PNAS. 2012. E-pub 24 dec

18. Deloukas P et al. (inlcuding Hamsten A). Large-scale association analysis identifies new risk loci for coronary artery disease. Nature Genetics. 2012, Epub ahead of print.

17. Morris AP et al (including Hamsten A). Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nature Genetics. 2012. 44: 981-990.

16. Scott RA, Lagou V, Welch RP, Wheeler E, et al (including Hamsten A). Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet. 2012 Sep;44(9):991-1005.

2011

15. Arner P, Bernard S, Salehpour M, Possnert G, Leibl J, Steier P, Buchholz BA, Eriksson M, Arner E, Hauner H, Skurk T, Ryden M, Frayn KN, Spalding KL Dynamics of human adipose lipid turnover in health and metabolic disease Nature. 2011 478 (7367), 110-113

14. Arner P. Medicine. Lipases in cachexia. Science. 2011 Jul 8;333(6039):163-4.

13. Abdulreda MH, Faleo G, Molano RD, Lopez-Cabezas M, Molina J, Tan Y, Echeverria OA, Zahr-Akrawi E, Rodriguez-Diaz R, Edlund PK, Leibiger I, Bayer AL, Perez V, Ricordi C, Caicedo A, Pileggi A, Berggren PO. High-resolution, noninvasive longitudinal live imaging of immune responses. Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12863-8.

12. Holmberg R, E Refai, A Höög, RM Crooke, M Graham, G Olivecrona, P-O Berggren & L Juntti-Berggren.  Lowering apolipoprotein CIII delays onset of type 1 diabetes. Proc Natl Acad Sci USA 2011: 108, 10685-10689

11. Wu J, Ruas JL, Estall JL, Rasbach KA, Choi JH, Ye L, Boström P, Tyra HM, Crawford RW, Campbell KP, Rutkowski DT, Kaufman RJ, Spiegelman BM. The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex. Cell Metab. 2011: 13, 160-169

10. Rodriguez-Diaz R, Abdulreda MH, Formoso AL, Gans I, Ricordi C, Berggren POCaicedo A. Innervation patterns of autonomic axons in the human endocrine pancreas. Cell Metab. 2011 Jul 6;14(1):45-54.

9. Rodriguez-Diaz R, R Dando, MC Jacques-Silva, A Fachado, J Molina, M Abdulreda, C Ricordi, SD Roper, P-O Berggren & A Caicedo. Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming human beta cell function. Nature Medicine, 2011:17, 888-892

8. Wain LV, Verwoert GC, O'Reilly PF, Shi G et al (including Hamsten A). Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet. 2011 Sep 11;43(10):1005-11.

7. Coronary Artery Disease (C4D) Genetics Consortium (including Hamsten A). A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. Nat Genet. 2011: 43 (4), 339-344

6. International Consortium for Blood Pressure Genome-Wide Association Studies (including Hamsten A). Genetic variants in novel pathways influence blood pressure and cardiovascular risk. Nature. 2011: 478 (7367), 103-109

2010

5. Healy JA, Nilsson KR, Hohmeier HE, Berglund J, Davis J, Hoffman J, Kohler M, Li LS, Berggren PO, Newgard CB, Bennett V. Cholinergic augmentation of insulin release requires ankyrin-B. Sci Signal. 2010 Mar 16;3(113):ra19

4. Wunderlich FT, Ströhle P, Könner AC, Gruber S, Tovar S, Brönneke HS, Juntti-Berggren L, Li LS, van Rooijen N, Libert C, Berggren PO, Brüning JC. Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves systemic insulin action. Cell Metab. 2010 Sep 8;12(3):237-49

3. Arner E, Rydén M, Arner P. Tumor necrosis factor alpha and regulation ofadipose tissue. N Engl J Med. 2010 Mar 25;362(12):1151-3

2. Jacques-Silva MC, Correa-Medina M, Cabrera O, Rodriguez-Diaz R, Makeeva N, Fachado A, Diez J, Berman DM, Kenyon NS, Ricordi C, Pileggi A, Molano RD, Berggren PO, Caicedo A. ATP-gated P2X3 receptors constitute a positive autocrine signal for insulin release in the human pancreatic beta cell. Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6465-70.

1. Cantó C, Jiang LQ, Deshmukh AS, Mataki C, Coste A, Lagouge M, Zierath JRAuwerx J. Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle. Cell Metab. 2010 Mar 3;11(3):213-9.

 

A selection of SRP Diabetes publications during 2011-2013 by subject

2011

Obesity and lipids

Arner P, Bernard S, Salehpour M, Possnert G, Leibl J, Steier P, Buchholz BA, Eriksson M, Arner E, Hauner H, Skurk T, Ryden M, Frayn KN, Spalding KL Dynamics of human adipose lipid turnover in health and metabolic disease Nature. 2011 478 (7367), 110-113

 

Falkén Y, Hellström PM, Holst JJ, Näslund E. Changes in glucose homeostasis after Roux-en-Y gastric bypass surgery for obesity at day three, two months, and one year after surgery: role of gut peptides. J Clin Endocrinol Metab. 2011 Jul;96(7):2227-35

 

Holmberg R, E Refai, A Höög, RM Crooke, M Graham, G Olivecrona, P-O Berggren & L Juntti-Berggren. Lowering apolipoprotein CIII delays onset of type 1 diabetes. Proc Natl Acad Sci USA 2011: 108, 10685-10689

 

Jiao H, Arner P, Dickson SL, Vidal H, Mejhert N, Henegar C, Taube M, Hansson C, Hinney A, Galan P, Simon C, Silveira A, Benrick A, Jansson JO, Bouloumié A, Langin D, Laville M, Debard C, Axelsson T, Rydén M, Kere J, Dahlman-Wright K, Hamsten A, Clement K, Dahlman I.        Genetic association and gene expression analysis identify FGFR1 as a new susceptibility gene for human obesity. J Clin Endocrinol Metab. 2011: 96 (6), E962-6

 

Lamers D, Famulla S, Wronkowitz N, Hartwig S, Lehr S, Ouwens DM, Eckardt K, Kaufman JM, Ryden M, Müller S, Hanisch FG, Ruige J, Arner P, Sell H, Eckel J. Dipeptidyl Peptidase 4 Is a Novel Adipokine Potentially Linking Obesity to the Metabolic Syndrome. Diabetes. 2011 Jul;60(7):1917-25.

 

Laurencikiene J, Skurk T, Kulyté A, Hedén P, Aström G, Sjölin E, Rydén M, Hauner H, Arner P.  Regulation of lipolysis in small and large fat cells of the same subject. J Clin Endocrinol Metab. 2011 Dec;96(12):E2045-9.

 

Skeletal muscle

Kulkarni SS, Karlsson HK, Szekeres F, Chibalin AV, Krook A, Zierath JR.Suppression of 5'-nucleotidase enzymes promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle. J Biol Chem. 2011 Oct 7;286(40):34567-74

 

Wu J, Ruas JL, Estall JL, Rasbach KA, Choi JH, Ye L, Boström P, Tyra HM, Crawford RW, Campbell KP, Rutkowski DT, Kaufman RJ, Spiegelman BM. The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex. Cell Metab. 2011: 13, 160-169

 

Öberg AI, Yassin K, Csikasz RI, Dehvari N, Shabalina IG, Hutchinson DS, Wilcke M, Östenson C-G, Bengtsson T. Shikonin increases glucose uptake in skeletal muscle cells and improves plasma glucose levels in diabetic Goto-Kakizaki rats. PLoS ONE 2011; 6, e22510 

 

Pancreatic islets and beta cells

Perez VL, A Caicedo, DM Berman, E Arrieta, MH Abdulreda, R Rodriguez-Diaz, A Pileggi, E Hernandez, SR Dubovy, JM Parel, C Ricordi, NM Kenyon, NS Kenyon & P-O Berggren. The anterior chamber of the eye as a clinical transplantation site for the treatment of diabetes. Diabetologia. 2011: 54, 1121-1126      

 

Rodriguez-Diaz R, R Dando, MC Jacques-Silva, A Fachado, J Molina, M Abdulreda, C Ricordi, SD Roper, P-O Berggren & A Caicedo. Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming human beta cell function. Nature Medicine, 2011:17, 888-892

                                                                       

Rodriguez-Diaz R, MH Abdulreda, AL Formoso, I Gans, C Ricordi, P-O Berggren & A Caicedo. Innervation patterns of autonomic axons in the human endocrine pancreas. Cell Metab. 2011:14, 45-54     

                                                                       

Jia X, Sharma A, Kumagai-Braesch M, Wernerson A, Sörenby A, Yamamoto S, Wang F, Tibell A. Exendin-4 increases the expression of hypoxia inducible factor 1-alpha in rat islets and preserves the endocrine-cell volume of both free and macroencapsulated rat islet grafts. Cell Transplantation. 2012: in press

 

Friberg A, Lundgren T, Malm H, Felldin M, Nilsson B, Jensson T, Kyllönen L, Tufveson G, Tibell A, Korsgren O. Transplanted functional islet mass – Donor, islet preparation and recipient factors influence early graft function in islet-after-kidney patients. Transplantation. 2012: in press           

 

Fachado A, Molina J, Rodriguez-Diaz R, Jacques-Silva MC, Cabrera O, Abdulreda MH, et al. Measuring dynamic hormone release from pancreatic islets using perifusion assay. Nature Protocol Exchange. 2011.Estrogens and metabolism

 

Faulds MH, Dahlman-Wright K. Metabolic diseases and cancer risk. Curr Opin Oncol. 2012: 24 (1), 58-61

 

Faulds MH, Zhao C, Dahlman-Wright K, Gustafsson JÅ. The diversity of sex steroid action: regulation of metabolism by estrogen signaling. J Endocrinol. 2012: 212 (1),     3-12

 

Gao H, Dahlman-Wright K. The gene regulatory networks controlled by estrogens. Mol Cell Endocrinol. 2011: 334, 83-90 

 

Clinical Diabetology

Spectre G, Arnetz L, Östenson CG, Brismar K, Li N, Hjemdahl P. Twice daily dosing of aspirirn improves placelet inhibition in whole blood in patients with type 2 diabetes mellitus and micro- or macrovascular complications. Thrombosis and Haemostasis. 2011: 106(3),491-499

 

Kidney

Cordiero, Carreo, Barany, Qureshi, Heimburger, Lindholm, Stenvinkel P. Influence of erythropoiesis-stimulating agents on glycated hemoglobin in nondiabetic kidney diseases at the start of dialysis. Am J Nephrol. 2011: 33, 17-24

 

Thomas MC, Groop P-H, Tryggvason K. Towards understanding the inherited susceptibility for nephropathy in diabetes.  Curr Opin Nephrol Hypertens. 2012: in press

 

Zhang D, Gu T, Forsberg E, Efendic S, Brismar K, Gu HF. Genetic and functional effects of membrane metalloendopeptidase (MME) on the diabetic nephropathy development. Am J Nephrol. 2011: 34(5), 483-490

 

Human genetics on diabetes and coronary heart disease

Coronary Artery Disease (C4D) Genetics Consortium (including Hamsten A). A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. Nat Genet. 2011: 43 (4), 339-344

 

de Miguel-Yanez JM, Manning AK, Shrader P, McAteer JB, Goel A, Hamsten A; PROCARDIS, Fox CS, Florez JC, Dupuis J, Meigs JB. Variants at the endocannabinoid receptor CB1 gene (CNR1) and insulin sensitivity, type 2 diabetes, and coronary heart disease. Obesity. 2011: 19 (10), 2031-2037

 

International Consortium for Blood Pressure Genome-Wide Association Studies (including Hamsten A). Genetic variants in novel pathways influence blood pressure and cardiovascular risk. Nature. 2011: 478 (7367), 103-109

 

Långberg EC, Seed Ahmed M, Efendic S, Gu HF, Östenson CG. Genetic associations of aderenergic receptor alpha2A (ADRA2A) with obesity and type 2 diabetes. Obesity. 2011: In press

 

Strawbridge RJ, et al (including Ostensson CG and Hamsten A). Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes. 2011: 60, 2624-2634

 

Vasan SK, Neville MJ, Antonisamy B, Samuel P, Fall CH, Geethanjali FS, Thomas N, Raghupathy P, Brismar K, Karpe F. Absence of birth-weight lowering effect of ADCY5 and near CCNL, but association of impaired glucose-insulin homeostasis with ADCY2 in Asian Indians. PLoS ONE. 2011: 6(6), e21331

 

Vasan SK, Fall T, Neville MJ, Antonisamy B, Fall CH, Geethanjali FS, Gu HF, Raghupathy P, Samuel P, Thomas N, Brismar K, Ingelsson E, Karpe F. Associations of variants in FTO and near MC4R with obesity traits in South Asian Indians. Obesity. 2011: In press

 

Epigenetics

Nikoshkov A, Sunkari VG, Savu O, Forsberg E, Catrina SB, Brismar K. Epigenetic DNA methylation in the promoters of the IGF-I receptor and insulin receptor gene in db/db mice. Epigenetics 2011: 6(4), 405-409

 

Zierath JR, Barrès RE. Nutritional status affects the epigenomic profile of peripheral blood cells. Epigenomics. 2011 Jun;3(3):259-60.

 

Yan J, Zierath JR, Barrès R. Evidence for non-CpG methylation in mammals. Exp Cell Res. 2011 Nov 1;317(18):2555-61.

 

2012

Obesity and lipids

Arner, E., Mejhert, N., Kulyté, A., Balwierz, P.J., Pachov, M., Cormont, M., Lorente-Cebrián, S., Laurencikiene, J., Hedén, P., Dahlman-Wright, K., Tanti, J.-F., Hayashizaki, Y., Rydén, M., Dahlman, I., van Nimwegen, E., Daub, C.O. and Arner, P. Adipose MicroRNAs as Regulators of CCL2 Production in Human Obesity. Diabetes, In press, 2012.

 

Blundell JE, Caudwell P, Gibbons C, Hopkins M, Näslund E, King NA, Finlayson G. Body composition and appetite: fat-free mass (but not fat mass or BMI) is positively associated with self-determined meal size and daily energy intake in humans. Br J Nutr. 2012 Feb;107(3):445-9

 

Dahlman I, Elsen M, Tennagels N, Korn M, Brockmann B, Sell H, Eckel J, Arner P. Functional annotation of the human fat cell secretome. Arch Physiol Biochem. 2012 May 23. [Epub ahead of print]

 

Uebi T et al.  (including Hamsten A). Involvement of SIK3 in Glucose and Lipid Homeostasis in Mice. PLoS One. 2012;7(5):e37803

 

Vasan SK, Fall T, Neville MJ, Antonisamy B, Fall CH, Geethanjali FS, Gu HF, Raghupathy P, Samuel P, Thomas N, Brismar K, Ingelsson E, Karpe F. Associations of Variants in FTO and Near MC4R With Obesity Traits in South Asian Indians. Obesity. 2012 Mar 16.

 

Almgren M, Atkinson R, He J, Hilding A, Hagman E, Wolk A, Thorell A, Marcus C, Näslund E, Östenson C-G, Schalling M, Lavebratt C. Adenovirus-36 is associated with obesity in children and adults in Sweden as determined by rapid ELISA. PLoS ONE. 2012, 7:e41652

 

Bjermo H, Iggman D, Kullberg J, Dahlman I, Johansson L, Persson L, Berglund J, Pulkki K, Basu S, Uusitupa M, Rudling M, Arner P, Cederholm T, Ahlström H, Risérus U. Effects of n-6 PUFAs compared with SFAs on liver fat, lipoproteins, and inflammation in abdominal obesity: a randomized controlled trial. Am J Clin Nutr. 2012 95: 1003-12

 

Frayn K, Bernard, S, Spalding K, Arner P. Adipocyte triglyceride turnovers is independently associated with atherogenic dyslipidemia. JAHA. 2012, in press

 

Långberg E-C, Seed Ahmed M, Efendic S, Gu HF, Östenson CG. Genetic association of adrenergic receptor alpha 2A (ADRA2A) with obesity and type 2 diabetes. Obesity. 2012, in press.

 

Vedin I, Cederholm T, Freund-Levi Y, Basun H, Garlind A, Irving GF, Eriksdotter-Jönhagen M, Wahlund LO, Dahlman I, Palmblad J. Effects of DHA-rich n-3 fatty acid supplementation on gene expression in blood mononuclear leukocytes: the OmegAD study. PLoS ONE. 2012. 7:e35425

 

Yang J et al. (Inlcuding Hamsten A). FTO genotype is associated with phenotypic variability of body mass index. Nature. 2012. 490:267-272.

 

Skeletal muscle

Barrès R, Yan J, Egan B, Treebak JT, Rasmussen M, Fritz T, Caidahl K, Krook A, O'Gorman DJ, Zierath JR. Acute exercise remodels promoter methylation in human skeletal muscle. Cell Metab. 2012 Mar 7;15(3):405-11.

 

Benziane B, Bjornholm M, Pirkmajer S, Austin RL, Kotova O, Violett B, Zierath JR, Chibalin AV. Activation of AMP-activated protein kinase stimulates Na+,K+-ATPase activity in skeletal muscle cells. J Biol Chem. 2012 May 18. [Epub ahead of print].

 

Holmström MH, Iglesias-Gutierrez E, Zierath JR, Garcia-Roves PM. Tissue-specific control of mitochondrial respiration in obesity-related insulin resistance and diabetes. Am J Physiol Endocrinol Metab. 2012 Mar;302(6):E731-9.

 

Kulkarni SS, Salehzadeh F, Fritz T, Zierath JR, Krook A, Osler ME. Mitochondrial regulators of fatty acid metabolism reflect metabolic dysfunction in type 2 diabetes mellitus. Metabolism. 2012 Feb;61(2):175-85.

 

Szekeres F, Chadt A, Tom RZ, Deshmukh AS, Chibalin AV, Bjornholm M, Al-Hasani H, Zierath JR. The Rab-GTPase Activating Protein TBC1D1 Regulates Skeletal Muscle Glucose Metabolism. Am J Physiol Endocrinol Metab. 2012 Jun 12. [Epub ahead of print]

 

Boon H., Kostovski E., Song M., Iversen P.-O.  Hjeltnes N.,  Widegren U.,  and Chibalin A.V. Influence of chronic and acute spinal cord injury on skeletal muscle Na, K-ATPase and phospholemman expression in humans. Am J Physiol Endocrinol Metab. 302, E864-E871, 2012.

 

Chibalin A.V., Heiny J.A., Benziane B., Vasiliev A.V.,  Kravtsova V.V., and  Krivoi I.I. Chronic nicotine exposure modifies Na,K-ATPase activity in skeletal muscle through an interaction of the nAChR with the Na, K-ATPase and phospholemman. PLoS One, 7(3):e33719, 2012.

 

de Castro Barbosa, T., Jiang, L.Q., Zierath, J.R. and Nunes M.T. L-Arginine enhances glucose and lipid metabolism in rat L6 myotubes via the NO/ c-GMP pathway. Metabolism. 2013. 62:79-89.

 

Fritz T, Caidahl K, Krook A, Lundström P, Mashili F, Osler M, Szekeres F, Östenson C- G, Wändell P, Zierath J. Effects of Nordic walking on cardiovascular risk factors in overweight individuals with type 2 diabetes, impaired or normal glucose tolerance. Diabetes Metab Res Rev. 2012, in press.

 

Jiang, L.Q.*, Duque-Guimaraes, D.E.*, Machado, U.F., Zierath, J.R. and Krook, A. Altered Response of Skeletal Muscle to IL-6 in Type 2 Diabetic Patients. Diabetes, 2012, epub ahead of print.

 

Mashili F., Chibalin A.V., Krook A., and Zierath J.R. Constitutive STAT3 phosphorylation contributes to skeletal muscle insulin resistance in type 2 diabetes. Diabetes, in press, 2012 PMID:23043161.

 

Ruas JL, White JP, Rao RR, Kleiner S, Brannan KT, Harrison BC, Greene NP, Wu J, Estall JL, Irving BA, Lanza IR, Rasbach KA, Okutsu M, Nair KS, Yan Z, Leinwand LA, Spiegelman BM. A PGC-1α Isoform Induced by Resistance Training Regulates Skeletal Muscle Hypertrophy. Cell. 2012. 151: 1319-1331.

 

Stepto NK., Benziane B., Wadley G., Chibalin AV., Canny BJ., and McConnell GK. Ten days of intensified cycle training attenuates mitochondrial biogenesis responses to acute exercise in humans. PLoS ONE, in press.

 

Pancreatic islets and beta cells

Caballero-Corbalán J, Brandhorst H, Malm H, Felldin M, Foss A, Salmela K, Tibell A, Tufveson G, Korsgren O, Brandhorst D. Using HTK for prolonged pancreas  preservation prior to human islet isolation. J Surg Res. 2012 Jun 1;175(1):163-8. Epub 2011 Mar 31.

 

Dekki N, Refai E, Holmberg R, Köhler M, Jörnvall H, Berggren PO, Juntti-Berggren L. Transthyretin binds to glucose-regulated proteins and is subjected to endocytosis by the pancreatic β-cell. Cell Mol Life Sci. 2012 May;69(10):1733-43.

 

Friberg A, Lundgren T, Malm H, Felldin M, Nilsson B, Jensson T, Kyllönen L, Tufveson G, Tibell A, Korsgren O. Transplanted functional islet mass – Donor, islet preparation and recipient factors influence early graft function in islet-after-kidney patients. Transplantation. 2012: Mar 27;93(6):632-8.   

 

Henriksnäs J, Lau J, Zang G, Berggren PO, Köhler M, Carlsson PO. Markedly decreased blood perfusion of pancreatic islets transplanted intraportally into the liver: disruption of islet integrity necessary for islet revascularization. Diabetes. 2012 Mar;61(3):665-73.

 

Jeon J, Leibiger I, Moede T, Walter B, Faul C, Maiguel D, Villarreal R, Guzman J, Berggren PO, Mundel P, Ricordi C, Merscher-Gomez S, Fornoni A. Dynamin-mediated Nephrin phosphorylation Regulates Glucose-stimulated Insulin Release in Pancreatic beta Cells. J Biol Chem. 2012 Jun 20

 

Jia X, Sharma A, Kumagai-Braesch M, Wernerson A, Sörenby A, Yamamoto S, Wang F, Tibell A. Exendin-4 increases the expression of hypoxia inducible factor 1-alpha in rat islets and preserves the endocrine-cell volume of both free and macroencapsulated rat islet grafts. Cell Transplant 2012 Mar 8 [Epub ahead of print]

 

Köhler M, e Daré E, Ali MY, Rajasenkaran SS, Moede T, Leibiger B, Leibiger IB, Tibell A, Juntti-berggren L & Berggren P-O. One-step purification of functional human pancreatic alpha cells Integrative Biology 4: 209-219, 2012.

                       

Zheng X, Zheng X, Wang X, Ma Z, Gupta Sunkari V, Botusan I, Takeda T, Björklund A, Inoue M, Catrina SB, Brismar K, Poellinger L, Pereira TS. Acute hypoxia induces apoptosis of pancreatic β-cell by activation of the unfolded protein response and upregulation of CHOP. Cell Death Dis. 2012 Jun 14;3:e322

 

SR Cechin, I Perez-Alvarez, E Fenjves, RD Molano, A Pileggi, P-O Berggren, C Ricordi & RL Pastori. Anti-inflammatory properties of exenatide in human pancreatic islets. Cell Transplant 2012, 21: 633-648.

 

Korsgren S, Molin Y, Salmela K, Lundgren T, Melhus A, Korsgren O. On the etiology of type 1 diabetes: a new animal model signifying a decisive role for bacteria eliciting an adverse innate immunity response. Am Journal of Pathology. 2012. 181:1735-48

 

Kumagai-Braesch, M., Jacobson, S., Mori, S., Jia, X., Takahashi, T., Wernerson, A., Flodström-Tullberg, M., Tibell, A. The TheraCyteTM Device Protects against Islet Allograft Rejection in Immunized Hosts. Cell Transplant, in press

 

Larsson PG, Lakshmikanth T, Svedin E, King C, Flodström-Tullberg M. Previous maternal infection protects offspring from enterovirus infection and prevents experimental diabetes development in mice. Diabetologia, in press

 

R Rodriguez-Diaz, S Speier, RD Molano, A Formoso, I Gans, MH Abdulreda, O Cabrera, J Molina, A Fachado, C Ricordi, I Leibiger, A Pileggi, P-O Berggren & A Caicedo. Noninvasive in vivo model demonstrating the effects of autonomic innervations on pancreatic islet function. PNAS. 2012. 109:21456-61

 

B Leibiger, T Moede, TP Muhandiramlage, D Kaiser, P Vaca Sanchez, IB Leibiger & P-O Berggren. Glucagon regulates its own synthesis by autocrine signaling. PNAS. 2012. 109:20925-30

 

Seed Ahmed M, Kovoor A, Nordman S, Abu Seman N, Gu T, Efendic S, Brismar K, Östenson C-G, Gu HF. Increased expression of adenylyl cyclise 3 in pancreatic islets and central nervous system of diabetic Goto-Kakizaki rats: a possible regulatory role in glucose homeostatis. Islets, E-pub 1/9, 2012

 

S-N Yang, Y Shi, G Yang, Y Li, L Yu, O-H Shin, T Bacaj, TC Südhof, J Yu & P-O Berggren. Inositol hexakis-phosphate suppresses excitatory neuro-transmission via synaptotagmin-1 C2B domain in the hippocampal neuron. PNAS 2012, 109:12183-12188

 

Clinical Diabetology

Arnetz L, Rajamand-Ekberg N, Höybye C, Brismar K, Alvarsson M. Improved insulin sensitivity during pioglitazone treatment is associated with changes in IGF-1 and cortisol secretion in type 2 diabetes and impaired glucose tolerance. Endocrinology, in press

 

Huyen VTT, Phan DV, Thang P, Hoa NK, Östenson CG. Gynostemma Pentaphyllum tea improves insulin sensitivity in type 2 diabetic patients. J Nutr Metab. 2012, in press.

 

Östenson C-G, Hilding A, Grill V, Efendic S. High consumption of smokeless tobacco (“snus”) predicts increased risk of type 2 diabetes in a 10-year prospective study of middle-aged Swedish men.  Scand J Public Health. 2012, in press.

 

Andreasson AN, Undén AL, Elofsson S, Brismar K. Leptin and adiponectin: Distribution and associations with cardiovascular risk factors in men and women of the general population. Am J Hum Biol. 2012 Apr 17

 

Calissendorff J, Gustafsson T, Holst JJ, Brismar K, Röjdmark S. Alcohol Intake and Its Effect on Some Appetite-Regulating Hormones in Man: Influence of Gastroprotection with Sucralfate. Endocr Res. 2012 May 23. [Epub ahead of print

 

Cullmann M, Hilding A, Östenson CG. Alcohol consumption and risk of pre-diabetes and type 2 diabetes development in a Swedish population. Diabet Med. 2012 Apr;29(4):441-52.

 

Deleskog A, Hilding A, Brismar K, Hamsten A, Efendic S, Ostenson CG. Low serum 25-hydroxyvitamin D level predicts progression to type 2 diabetes in individuals with prediabetes but not with normal glucose tolerance. Diabetologia. 2012 Jun;55(6):1668-78.

 

Deleskog A, Piksasova O, Silveira A, Samnegård A, Tornvall P, Eriksson P, Gustafsson S, Ostenson CG, Ohrvik J, Hamsten A. Serum 25-hydroxyvitamin D concentration, established and emerging cardiovascular risk factors and risk of myocardial infarction before the age of 60 years. Atherosclerosis. 2012 May 8. [Epub ahead of print]

 

Rafnsson A, Böhm F, Settergren M, Gonon A, Brismar K, Pernow J. The endothelin receptor antagonist bosentan improves peripheral endothelial function in patients with type 2 diabetes mellitus and microalbuminuria: a randomised trial. Diabetologia. 2012 Mar;55(3):600-7

 

Spectre G, Ostenson CG, Li N, Hjemdahl P. Postprandial Platelet Activation Is Related to Postprandial Plasma Insulin Rather Than Glucose in Patients With Type 2 Diabetes Mellitus. Diabetes. 2012 Jun 11. [Epub ahead of print]

 

Diabetes complications

Anderstam B; Bragfors-Helin; Axelsson; Qureshi; Wibom; Lindholm; Stenvinkel P. Differences in acute metabolism of fructose between hemodialysis patients and healthy subjects. Scandinavian Journal of Clinical and Laboratory Investigation, in press

 

Ansurudeen-Ralf I, Sunkari VG, Grünler J, Peters V, Schmitt CP, Catrina SB, Brismar K, Forsberg EA. Carnosine enhances diabetic wound healing in the db/db mouse model of type 2 diabetes. Amino Acids, 43(1):127-134, 2012

 

Gu T, Horovà E, Möllsten A, Seman NA, Falhammar H, Pràzny M, Brismar K, Gu HF. IGF2BP2 and IGF2 genetic effects in diabetes and diabetic nephropathy. J Diabetes Complications 26(59):393-398, 2012

 

Gu HF, Zheng X, Abu Seman N, Gu T, Botusan IR, Sunkari VG, Lokman EF, Brismar K, Catrina SB. Impact of the hypoxia-inducible factor-1 alfa(HIF-1alfa) Pro582Ser polymorphism on diabetes nephropathy. Diabetes Care, E-pub 18/9, 2012

 

Sten Shi T-J, Zhang M-D, Zeberg H, Nilsson J, Grünler J, Liu S-X, Xiang Q, Persson J, Fried K, Catrina SB, Watanabe M, Århem P, Brismar K, Hökfelt T. Coenzyme Q10 prevents peripheral neuropathy and attenuates neuron loss in the db-/db-mouse, a Type 2 model. PNAS. 2012. E-pub 24 dec

 

Alvarsson A, Sandgren B, Wendel C, Alvarsson M, Brismar K. A retrospective analysis of amputation rates in diabetic patients: can lower extremity amputations be further prevented? Cardiovasc Diabetol. 2012 Mar 2;11:18

 

GEnetics of Nephropathy–an International Effort (GENIE) Consortium (including Tryggvason K). Association Testing of Previously Reported Variants in a Large Case-Control Meta-Analysis of Diabetic Nephropathy. Diabetes. 2012 Jun 20. [Epub ahead of print]

 

Persson MF, Franzén S, Catrina SB, Dallner G, Hansell P, Brismar K, Palm F. Coenzyme Q10 prevents GDP-sensitive mitochondrial uncoupling, glomerular hyperfiltration and proteinuria in kidneys from db/db mice as a model of type 2 diabetes. Diabetologia. 2012 May;55(5):1535-43

 

Human genetics on diabetes and coronary heart disease                       

Dastani Z et al. (including Hamsten A).  Novel loci foradiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet. 2012 Mar;8(3):e1002607.

 

Manning AK et al. (including Hamsten A). A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet. 2012 May 13;44(6):659-669

 

Palmer ND et al. (including Hamsten A). A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One. 2012;7(1):e29202.

 

Saxena R et al. (including Hamsten A). Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet. 2012 Mar 9;90(3):410-25

 

Deloukas P et al. (inlcuding Hamsten A). Large-scale association analysis identifies new risk loci for coronary artery disease. Nature Genetics. 2012, Epub ahead of print.

 

Morris AP et al (including Hamsten A). Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nature Genetics. 2012. 44: 981-990.

 

Sandholm, N et al. (including Brismar K and Tryggvason K) New susceptibility loci associated with kidney disease in type 1 diabetes. PLoS Genet. 2012 Sep;8(9)

 

Central regulation of metabolism

Lyons DJ, Hellysaz A, Broberger C. Prolactin regulates tuberoinfundibular dopamine neuron discharge pattern: novel feedback control mechanisms in the lactotrophic axis. J Neurosci. 2012 Jun 6;32(23):8074-83

 

2013

Obesity and lipids

Andersson DP, Wahrenberg H, Toft E, Qvisth V, Löfgren P, Hertel K, Leijonhufvud BM, Thorell A, Näslund E, Arner P. Waist circumference to assess reversal of insulin resistance following weight reduction after bariatric surgery: cohort and cross sectional studies. Int J Obes. 2013 May 24.

 

Arner P, Andersson DP, Thörne A, Wirén M, Hoffstedt J, Näslund E, Thorell A, Rydén M. Variations in the size of the major omentum are primarily determined by fat cell number. J Clin Endocrinol Metab. 2013 May;98(5):E897-901.

 

Bambace C, Dahlman I, Arner P, Kulyté A. NPC1 in human white adipose tissue and obesity. BMC Endocr Disord. 2013 Jan 30;13:5.

 

Barres, R., Kirchner, H., Rasmussen, M., Yan, J., Kantor, Francisc R., Krook, A., Näslund, E., Zierath, Juleen R. Weight Loss after Gastric Bypass Surgery in Human Obesity Remodels Promoter Methylation. Cell Reports 2013 3, 1020-1027.

 

Caudwell P, Finlayson G, Gibbons C, Hopkins M, King N, Näslund E, Blundell JE. Resting metabolic rate is associated with hunger, self-determined meal size, and daily energy intake and may represent a marker for appetite. Am J Clin Nutr. 2013 Jan;97(1):7-14.

 

Ehrlund A, Mejhert N, Lorente-Cebrián S, Aström G, Dahlman I, Laurencikiene J, Rydén M. Characterization of the Wnt inhibitors secreted frizzled-related proteins (SFRPs) in human adipose tissue. J Clin Endocrinol Metab. 2013 Mar;98(3):E503-8.

 

Girousse A, Tavernier G, Valle C, Moro C, Mejhert N, Dinel AL, Houssier M, Roussel B, Besse-Patin A, Combes M, Mir L, Monbrun L, Bézaire V, Prunet-Marcassus B, Waget A, Vila I, Caspar-Bauguil S, Louche K, Marques MA, Mairal A, Renoud ML, Galitzky J, Holm C, Mouisel E, Thalamas C, Viguerie N, Sulpice T, Burcelin R, Arner P, Langin D. Partial inhibition of adipose tissue lipolysis improves glucose metabolism and insulin sensitivity without alteration of fat mass. PLoS Biol. 2013 Feb;11(2):e1001485.

 

Leibiger IB, Ilegems E, Berggren P-O. You are what you eat – do not blame your mother. Molecular Metabolism. dx.doi.org/10.1016/j.molmet.2013.01.001.

 

Mejhert N, Wilfling F, Esteve D, Galitzky J, Pellegrinelli V, Kolditz CI, Viguerie N, Tordjman J, Näslund E, Trayhurn P, Lacasa D, Dahlman I, Stich V, Lång P, Langin D, Bouloumié A, Clément K, Rydén M. Semaphorin 3C is a novel adipokine linked to extracellular matrix composition. Diabetologia. 2013 May 12. [Epub ahead of print]

 

Strodthoff D, Lundberg AM, Agardh HE, Ketelhuth DF, Paulsson-Berne G, Arner P, Hansson GK, Gerdes N. Lack of invariant natural killer T cells affects lipid metabolism in adipose tissue of diet-induced obese mice. Arterioscler Thromb Vasc Biol. 2013 Jun;33(6):1189-96.

 

Arner E, Arner P. Health and obesity: not just skin deep. Science. 2013 Nov 1;342(6158):558-9.

 

Cheung L, Gertow J, Werngren O, Folkersen L, Petrovic N, Nedergaard J, Franco-Cereceda A,

Eriksson P, and Fisher RM (2013). Human mediastinal adipose tissue displays certain characteristics of brown fat. Nutr Diab. 3: e66

 

Gertow J, Kjellkvist S, Ståhlman M, Cheung L, Gottfries J, Werngren O, Borén J, Franco-Cereceda A, Eriksson P, and Fisher RM (2013). Ceramides are associated with inflammatory processes in human mediastinal adipose tissue. Nutr Metab Cardiovasc Dis. In press

 

Kulyté A, Lorente-Cebrián S, Gao H, Mejhert N, Agustsson T, Arner P, Rydén M, Dahlman I. MicroRNA profiling links miR-378 to enhanced adipocyte lipolysis in human cancer cachexia. Am J Physiol Endocrinol Metab. 2013 Dec 10.

 

Lorente-Cebrián S, Decaunes P, Dungner E, Bouloumié A, Arner P, Dahlman I. Allograft inflammatory factor 1 (AIF-1) is a new human adipokine involved in adipose inflammation in obese women. BMC Endocr Disord. 2013 Nov 25;13(1):54.

 

Mansor F, Gu HF, Ostenson CG, Mannerås-Holm L, Stener-Victorin E, Wan Mohamud WN. Labisia pumila Upregulates Peroxisome Proliferator-Activated Receptor Gamma Expression in Rat Adipose Tissues and 3T3-L1 Adipocytes. Adv Pharmacol Sci. 2013;2013:808914.

 

Marinou K, Hodson L, Vasan SK, Fielding BA, Banerjee R, Brismar K, Koutsilieris M, Clark A, Neville MJ, Karpe F. Structural and functional properties of deep abdominal subcutaneous adipose tissue explain its association  with insulin resistance and cardiovascular risk in men. Diabetes Care. 2013 Nov 1.

 

Mejhert N, Wilfling F, Esteve D, Galitzky J, Pellegrinelli V, Kolditz CI, Viguerie N, Tordjman J, Näslund E, Trayhurn P, Lacasa D, Dahlman I, Stich V, Lång P, Langin D, Bouloumié A, Clément K, Rydén M. Semaphorin 3C is a novel adipokine linked to extracellular matrix composition. Diabetologia. 2013 Aug;56(8):1792-801.

 

Rydén M, Andersson DP, Bernard S, Spalding K, Arner P. Adipocyte triglyceride turnover and lipolysis in lean and overweight subjects. J Lipid Res. 2013 Oct;54(10):2909-13.

 

Pettersson AM, Stenson BM, Lorente-Cebrián S, Andersson DP, Mejhert N, Krätzel J, Aström G, Dahlman I, Chibalin AV, Arner P, Laurencikiene J.LXR is a negative regulator of glucose uptake in human adipocytes. Diabetologia. 2013 Sep;56(9):2044-54.

 

Skeletal muscle

de Castro Barbosa T, Jiang LQ, Zierath JR, Nunes MT. L-Arginine enhances glucose and lipid metabolism in rat L6 myotubes via the NO/ c-GMP pathway. Metabolism. 2013 Jan;62(1):79-89.

 

Fritz T, Caidahl K, Krook A, Lundström P, Mashili F, Osler M, Szekeres FL, Östenson CG, Wändell P, Zierath JR. Effects of Nordic walking on cardiovascular risk factors in overweight individuals with type 2 diabetes, impaired or normal glucose tolerance. Diabetes Metab Res Rev. 2013 Jan;29(1):25-32.

 

Hagmar M, Berglund B, Brismar K, Hirschberg AL. Body composition and endocrine profile of male Olympic athletes striving for leanness. Clinical journal of sport medicine 2013;23(3):197-201.

 

Jiang LQ, Duque-Guimaraes DE, Machado UF, Zierath JR, Krook A. Altered response of skeletal muscle to IL-6 in type 2 diabetic patients. Diabetes. 2013 Feb;62(2):355-61.

 

Koh A, Lee MN, Yang YR, Jeong H, Ghim J, Noh J, Kim J, Ryu D, Park S, Song P,  Koo SH, Leslie NR, Berggren PO, Choi JH, Suh PG, Ryu SH. C1-Ten is a protein tyrosine phosphatase of insulin receptor substrate 1 (IRS-1), regulating IRS-1stability and muscle atrophy. Mol Cell Biol. 2013 Apr;33(8):1608-20.

 

Mashili F, Chibalin AV, Krook A, Zierath JR. Constitutive STAT3 phosphorylation contributes to skeletal muscle insulin resistance in type 2 diabetes. Diabetes. 2013 Feb;62(2):457-65.

 

Song P, Kim JH, Ghim J, Yoon JH, Lee A, Kwon Y, Hyun H, Moon HY, Choi HS, Berggren P-O, Suh PG, Ryu SH. Emodin regulates glucose utilization by activating AMP-activated protein kinase. J Biol Chem. 2013 Feb 22;288(8):5732-42.

 

Brandauer J, Vienberg SG, Andersen MA, Ringholm S, Risis S, Larsen PS, Kristensen JM, Frøsig C, Leick L, Fentz J, Jørgensen S, Kiens B, Wojtaszewski JF, Richter EA, Zierath JR, Goodyear LJ, Pilegaard H, Treebak JT. AMP-activated protein kinase regulates nicotinamide phosphoribosyl transferase expression in skeletal muscle. J Physiol. 2013 Oct 15;591(Pt 20):5207-20.

 

Cansby E, Amrutkar M, Mannerås Holm L, Nerstedt A, Reyahi A, Stenfeldt E, Borén J, Carlsson P, Smith U, Zierath JR, Mahlapuu M. Increased expression of STK25 leads to impaired glucose utilization and insulin sensitivity in mice challenged with a high-fat diet. FASEB J. 2013 Sep;27(9):3660-71.

 

Dokas J, Chadt A, Nolden T, Himmelbauer H, Zierath JR, Joost HG, Al-Hasani H. Conventional knockout of Tbc1d1 in mice impairs insulin- and AICAR-stimulated glucose uptake in skeletal muscle. Endocrinology. 2013 Oct;154(10):3502-14

 

Holmström MH, Tom RZ, Björnholm M, Garcia-Roves PM, Zierath JR. Effect of leptin treatment on mitochondrial function in obese leptin-deficient ob/ob mice. Metabolism. 2013 Sep;62(9):1258-67.

 

Jiang LQ, Franck N, Egan B, Sjögren RJ, Katayama M, Duque-Guimaraes D, Arner P, Zierath JR, Krook A. Autocrine role of interleukin-13 on skeletal muscle glucose metabolism in type 2 diabetic patients involves microRNA let-7. Am J Physiol Endocrinol Metab. 2013 Dec;305(11):E1359-66.

 

Kostovski E, Boon H, Hjeltnes N, Lundell LS, Ahlsén M, Chibalin AV, Krook A, Iversen PO, Widegren U. Altered content of AMP-activated protein kinase isoforms in skeletal muscle from spinal cord injured subjects. Am J Physiol Endocrinol Metab. 2013 Nov;305(9):E1071-80.

 

Nascimento EB, Osler ME, Zierath JR. Sestrin 3 regulation in type 2 diabetic patients and its influence on metabolism and differentiation in skeletal muscle. Am J Physiol Endocrinol Metab. 2013 Dec;305(11):E1408-14.

 

Russell AP, Lamon S, Boon H, Wada S, Güller I, Brown EL, Chibalin AV, Zierath JR, Snow RJ, Stepto N, Wadley GD, Akimoto T. Regulation of miRNAs in human skeletal muscle following acute endurance exercise and short-term endurance training. J Physiol. 2013 Sep 15;591(Pt 18):4637-53.

 

Sczelecki S, Besse-Patin A, Abboud A, Kleiner S, Laznik-Bogoslavski D, Wrann CD, Ruas JL, Haibe-Kains B, Estall JL Loss of Pgc-1α expression in aging mouse muscle potentiates glucose intolerance and systemic inflammation. Am J Physiol Endocrinol Metab. 2013 Nov 26.

 

Pancreatic islets and beta cells

Barker CJ, Leibiger IB, Berggren P-O. The pancreatic islet as a signaling hub. Advances in Biological Regulation 53: 156-163, 2013.

 

Barker CJ, Berggren P-O. New horizons in cellular regulation by inositol polyphosphates: insights from the pancreatic beta cell. Pharmacological Rev 65: 641-669, 2013.

 

Lind K, Richardson SJ, Leete P, Morgan NG, Korsgren O, Flodström-Tullberg M. Induction of an Antiviral State and Attenuated Coxsackievirus Replication in Type III Interferon-Treated Primary Human Pancreatic Islets. J Virol. 2013 Jul;87(13):7646-54.

 

Park S-H, Ryu S-Y, Yu W-J, Han YE, Ji Y-S, Oh K, Sohn J-W, Lim A, Jeon J-P, Lee H, Lee K-H, Lee S-H, Berggren P-O, Jeon J-H, Ho W-K. Leptin promotes KATP channel trafficking by AMPK signaling in pancreatic β-cells. PNAS. In press 2013.

 

MH Abdulreda, A Caicedo, P-O Berggren. A natural body window to study human pancreatic islet cell function and survival. CeeR4. 2013; 1: 111-122

 

MH Abdulreda & P-O Berggren. Islet inflammation in plain sight. Diabetes, Obesity and Metabolism. 2013; 15: 105-116

 

Gao, T., McKenna, B., Li, C., Reichert, M., Nguyen, J., Singh, T., Yang, C., Pannikar, A., Doliba, N., Edlund, H., Matschinsky, F., Stein, R., and Stanger, B.Z. Pdx1 maintains β-cell identity and function by repressing an α-cell program. Cell Metabolism, in press

 

Ghazarian L, Diana J, Beaudoin L, Larsson PG, Puri RK, van Rooijen N, Flodström-Tullberg M, Lehuen A. Protection against type 1 diabetes upon Coxsackievirus B4 infection and iNKT-cell stimulation: role of suppressive macrophages. Diabetes. 2013 Nov;62(11):3785-96.

 

E Ilegems, A Dicker, S Speier, A Sharma, A Bahow, P Karlsson Edlund, IB Leibiger & P-O Berggren. Reporter islets in the eye reveal the plasticity of the endocrine pancreas. PNAS. 2013; Online 18-22 November

 

Lind K, Richardson SJ, Leete P, Morgan NG, Korsgren O, Flodström-Tullberg M. Induction of an antiviral state and attenuated coxsackievirus replication in type III interferon-treated primary human pancreatic islets. J Virol. 2013 Jul;87(13):7646-54.

 

Ma Z, Moruzzi N, Catrina SB, Grill V, Björklund A. Hyperoxia inhibits glucose-induced insulin secretion and mitochondrial metabolism in rat pancreatic islets. Biochem Biophys Res Commun. 2013 Dec 2.

 

Ma Z, Moruzzi N, Catrina SB, Hals I, Oberholzer J, Grill V, Björklund A. Preconditioning with associated blocking of Ca2+ inflow alleviates hypoxia-induced damage to pancreatic β-cells. PLoS ONE. 2013 Jul 25;8(7):e67498.

 

Richardson SJ, Leete P, Dhayal S, Russell MA, Oikarinen M, Laiho JE, Svedin E, Lind K, Rosenling T, Chapman N, Bone AJ; The nPOD-V Consortium, Foulis AK, Frisk G, Flodstrom-Tullberg M, Hober D, Hyoty H, Morgan NG. Evaluation of the fidelity of immunolabelling obtained with clone 5D8/1, a monoclonal antibody directed against the enteroviral capsid protein, VP1, in human pancreas. Diabetologia. 2013 Nov 5

 

A Schmidt-Christensen, L Hansen, E Ilegems, N Fransén-Pettersson, U Dahl, S Gupta, Å Larefalk, TD Hannibal, A Schulz, P-O Berggren & D Holmberg. Imaging dynamics of CD11c+ cells and Foxp3+ cells in progressive autoimmune insulitis in the NOD mouse model of type 1 diabetes. Diabetologia. 2013; 56: 2669-2678

 

Shi Y, Yang G, Yu J, Yu L, Westenbroek R, Catterall WA, Juntti-Berggren L, Berggren PO, Yang SN. Apolipoprotein CIII hyperactivates β cell CaV1 channels through SR-BI/β1 integrin-dependent coactivation of PKA and Src. Cell Mol Life Sci. 2013 Aug 15.

 

Steneberg, P., Bernardo, L., Edfalk, S., Backlund, F., Lundberg, L., Östenson, C.G., and Edlund, H. The type 2 diabetes associated gene Ide is required for insulin secretion and suppression of α-synuclein levels in β-cells. Diabetes. 2013; 62: 2004-2014

 

Haiya Wu & Karima Mezghenna & Patricia Marmol & Tingqing Guo & Annalena Moliner & Shao-Nian Yang & Per-Olof Berggren & Carlos F. Ibáñez. Differential regulation of mouse pancreatic islet insulin secretion and Smad proteins by activin ligands. Diabetologia. 2013; 57(1):148-156

 

Liver

Matic M, Bryzgalova G, Gao H, Antonson P, Humire P, Omoto Y, Portwood N, Pramfalk C, Efendic S, Berggren PO, Gustafsson JÅ, Dahlman-Wright K. Estrogen signalling and the metabolic syndrome: targeting the hepatic estrogen receptor alpha action. PLoS One. 2013;8(2):e57458.

 

Clinical Diabetology

Arnetz L, Dorkhan M, Alvarsson M, Brismar K, Ekberg NR. Gender differences in non-glycemic responses to improved insulin sensitivity by pioglitazone treatment in patients with type 2 diabetes. Acta diabetologica. 2013. Epub 2013/02/08.

 

Arnetz L, Rajamand Ekberg N, Hoybye C, Brismar K, Alvarsson M. Improved Insulin Sensitivity during Pioglitazone Treatment Is Associated with Changes in IGF-I and Cortisol Secretion in Type 2 Diabetes and Impaired Glucose Tolerance. ISRN endocrinology. 2013;2013:148497.

 

Brismar K, Benroubi M, Nicolay C, Schmitt H, Giaconia J, Reaney M. Assessment of Insulin Initiation on Resource Utilisation and Direct Costs of Treatment over 12 Months in Patients with Type 2 Diabetes in Europe: Results from INSTIGATE and TREAT Observational Studies. Journal of medical economics. 2013. Epub 2013/06/07.

 

Hage C, Brismar K, Efendic S, Lundman P, Ryden L, Mellbin L. Sitagliptin improves beta-cell function in patients with acute coronary syndromes and newly diagnosed glucose abnormalities--the BEGAMI study. Journal of internal medicine. 2013;273(4):410-21.

 

Näslund E, Hellström PM. Elucidating the mechanisms behind the restoration of euglycemia after gastric bypass surgery. Diabetes. 2013 Apr;62(4):1012-3.

 

Oguz A, Benroubi M, Brismar K, Melo P, Morar C, Cleall SP, et al. Clinical Outcomes after 24 Months of Insulin Therapy in Patients with Type 2 Diabetes in 5 Countries: Results from the TREAT Study. Current medical research and opinion. 2013. Epub 2013/05/11.

 

Theuri G, Dallner G, Brismar K, Tekle M. Effects of lifestyle on plasma levels of the IGF system and the antioxidants coenzyme Q10 and vitamin E in Kenyan rural and urban populations. Growth hormone & IGF research. 2013;23(3):68-75.

 

Vasan SK, Fall T, Job V, Gu HF, Ingelsson E, Brismar K, et al. A common variant in the FTO locus is associated with waist-hip ratio in Indian adolescents. Pediatric obesity. 2013;8(3):e45-9.

 

Venskutonyte L, Brismar K, Ohrvik J, Ryden L, Kjellstrom B. Self-rated health predicts outcome in patients with type 2 diabetes and myocardial infarction: A DIGAMI 2 quality of life sub-study. Diabetes & vascular disease research. 2013. Epub 2013/05/16.

 

Venskutonyte L, Brismar K, Ryden-Bergsten T, Ryden L, Kjellstrom B. Satisfaction with glucose-lowering treatment and well-being in patients with type 2 diabetes and myocardial infarction: a DIGAMI2 QoL sub-study. Diabetes & vascular disease research . 2013;10(3):263-9.

 

Wirstrom T, Hilding A, Gu HF, Ostenson CG, Bjorklund A. Consumption of whole grain reduces risk of deteriorating glucose tolerance, including progression to prediabetes. The American journal of clinical nutrition. 2013;97(1):179-87.

 

Brismar K, Benroubi M, Nicolay C, Schmitt H, Giaconia J, Reaney M. Evaluation of insulin initiation on resource utilization and direct costs of treatment over 12 months in patients with type 2 diabetes in Europe: results from INSTIGATE and TREAT observational studies. J Med Econ. 2013 Aug;16(8):1022-35.

 

Du Y, Zhang H, Montano S, Hegestam J, Ekberg NR, Holmgren A, Brismar K, Ungerstedt JS. Plasma glutaredoxin activity in healthy subjects and patients with abnormal glucose levels or overt type 2 diabetes. Acta Diabetol. 2013 Jul 9.

 

Geelhoed-Duijvestijn PH, Pedersen-Bjergaard U, Weitgasser R, Lahtela J, Jensen MM, Ostenson CG. Effects of patient-reported non-severe hypoglycemia on healthcare resource use, work-time loss, and wellbeing in insulin-treated patients with diabetes in seven European countries. J Med Econ. 2013 Dec;16(12):1453-61.

 

Gu T, Gu HF, Hilding A, Sjöholm LK, Ostenson CG, Ekström TJ, Brismar K. Increased DNA methylation levels of the insulin-like growth factor binding protein 1 gene are associated with type 2 diabetes in Swedish men. Clin Epigenetics. 2013 Nov 19;5(1):21.

 

Gu HF, Gu T, Hilding A, Zhu Y, Kärvestedt L, Ostenson CG, Lai M, Kutsukake M, Frystyk J, Tamura K, Brismar K. Evaluation of IGFBP-7 DNA methylation changes and serum protein variation in Swedish subjects with and without type 2 diabetes. Clin Epigenetics. 2013 Nov 4;5(1):20.

 

Kiiskinen U, Matthaei S, Reaney M, Mathieu C, Ostenson CG, Krarup T, Theodorakis M, Kiljański J, Salaun-Martin C, Sapin H, Guerci B. Resource use and costs of exenatide bid or insulin in clinical practice: the European CHOICE study. Clinicoecon Outcomes Res. 2013 Jul 11;5:355-67.

 

Lokman FE, Gu HF, Wan Mohamud WN, Yusoff MM, Chia KL, Ostenson CG. Antidiabetic Effect of Oral Borapetol B Compound, Isolated from the Plant Tinospora crispa, by Stimulating Insulin Release. Evid Based Complement Alternat Med. 2013; 2013:727602.  Epub 2013 Nov 10.

 

Mathieu C, Ostenson CG, Matthaei S, Reaney M, Krarup T, Guerci B, Kiljański J,Salaun-Martin C, Sapin H, Theodorakis M. Using Exenatide Twice Daily or Insulin in Clinical Practice: Results from CHOICE. Diabetes Ther. 2013 Sep 10. [Epub ahead of print]

 

Mayega RW, Guwatudde D, Makumbi F, Nakwagala FN, Peterson S, Tomson G, Ostenson CG. Diabetes and pre-diabetes among persons aged 35 to 60 years in eastern Uganda: prevalence and associated factors. PLoS One. 2013 Aug 14;8(8):e72554.

 

Venskutonyte L, Brismar K, Öhrvik J, Rydén L, Kjellström B. Self-rated healthpredicts outcome in patients with type 2 diabetes and myocardial infarction: a DIGAMI 2 quality of life sub-study. Diab Vasc Dis Res. 2013 Jul;10(4):361-7.

 

Diabetes complications

Gu HF, Zheng X, Abu Seman N, Gu T, Botusan IR, Sunkari VG, Lokman EF, Brismar K, Catrina SB Impact of the hypoxia-inducible factor-1 alpha (HIF1A) Pro582Ser polymorphism on diabetes nephropathy. Diabetes care. 2013;36(2):415-21. Epub 2012/09/20.

 

Shi TJ, Zhang MD, Zeberg H, Nilsson J, Grünler J, Liu SX, Xiang Q, Persson J, Fried KJ, Catrina SB, Watanabe M, Arhem P, Brismar K, Hökfelt TG. Coenzyme Q10 prevents peripheral neuropathy and attenuates neuron loss in the db-/db- mouse, a type 2 diabetes model. PNAS. 2013 Jan 8;110(2):690-5.

 

Witasp A, Rydén M, Carrero JJ, Qureshi AR, Nordfors L, Näslund E, Hammarqvist F, Arefin S, Kublickiene K, Stenvinkel P. Elevated circulating levels and tissue expression of pentraxin 3 in uremia: a reflection of endothelial dysfunction. PLoS One. 2013 May 3;8(5):e63493

 

Deleskog A, Piksasova O, Silveira A, Gertow K, Baldassarre D, Veglia F,Sennblad B, Strawbridge RJ, Larsson M, Leander K, Gigante B, Kauhanen J, Rauramaa R, Smit AJ, Mannarino E, Giral P, Gustafsson S, Östenson CG, Humphries SE, Tremoli E, de Faire U, Öhrvik J, Hamsten A. Serum 25-hydroxyvitamin D concentration in subclinical carotid atherosclerosis. Arterioscler Thromb Vasc Biol. 2013 Nov;33(11):2633-8.

 

Gracia-Iguacel C, Qureshi AR, Avesani CM, Heimbürger O, Huang X, Lindholm B, Bárány P, Ortiz A, Stenvinkel P, Carrero JJ. Subclinical versus overt obesity in dialysis patients: more than meets the eye. Nephrol Dial Transplant. 2013 Nov;28 Suppl 4:iv175-iv181.

 

Mao J, Wang D, Mataleena P, He B, Niu D, Katayama K, Xu X, Ojala JR, Wang W, Shu Q, Du L, Liu A, Pikkarainen T, Patrakka J, Tryggvason K. Myo1e impairment results in actin reorganization, podocyte dysfunction, and proteinuria in zebrafish and cultured podocytes. PLoS One. 2013 Aug 19;8(8):e72750.

 

Sandholm N, McKnight AJ, Salem RM, Brennan EP, Forsblom C, Harjutsalo V, Mäkinen VP, McKay GJ, Sadlier DM, Williams WW, Martin F, Panduru NM, Tarnow L, Tuomilehto J, Tryggvason K, Zerbini G, Comeau ME, Langefeld CD; FIND Consortium, Godson C, Hirschhorn JN, Maxwell AP, Florez JC, Groop PH; FinnDiane Study Group and the GENIE Consortium. Chromosome 2q31.1 associates with ESRD in women with type 1 diabetes. J Am Soc Nephrol. 2013 Oct;24(10):1537-43.

 

Stenvinkel P, Zoccali C, Ikizler TA. Obesity in CKD--What Should Nephrologists Know? J Am Soc Nephrol. 2013 Nov;24(11):1727-36

 

Human genetics on diabetes and coronary heart disease

Berndt SI et al. (including Hamsten A). Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet. 2013 May;45(5):501-12.       

 

Deloukas P et al. (including Hamsten A). Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet. 2013 Jan;45(1):25-33.

 

Mannila MN, Mahdessian H, Franco-Cereceda A, Eggertsen G, de Faire U, Syvänen AC, Eriksson P, Hamsten A, van 't Hooft FM. Identification of a functional apolipoprotein E promoter polymorphism regulating plasma apolipoprotein E concentration. Arterioscler Thromb Vasc Biol. 2013 May;33(5):1063-9.

 

Do R, Willer CJ, Schmidt EM, Sengupta S, et al.  (including Hamsten A) Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet. 2013 Nov;45(11):1345-52.

 

Global Lipids Genetics Consortium, Willer CJ, Schmidt EM, et al. (including Hamsten A) Discovery and refinement of loci associated with lipid levels. Nat Genet. 2013 Nov;45(11):1274-83.

 

Vasan SK, Karpe F, Gu HF, Brismar K, Fall CH, Ingelsson E, Fall T. FTO genetic variants and risk of obesity and type 2 diabetes: A meta-analysis of 28,394 Indians. Obesity (Silver Spring). 2013 Aug 20.

 

Metabolic hormones in CNS

Mittag J, Lyons DJ, Sällström J, Vujovic M, Dudazy-Gralla S, Warner A, Wallis K, Alkemade A, Nordström K, Monyer H, Broberger C, Arner A, Vennström B. Thyroid hormone is required for hypothalamic neurons regulating cardiovascular functions. J Clin Invest. 2013 Jan 2;123(1):509-16.

 

Methodology

Abdulreda MH, Caicedo A, Berggren PO. Transplantation into the anterior chamber of the eye for longitudinal, non-invasive in vivo imaging with single-cell resolution in real-time. J Vis Exp. 2013 Mar 10;(73):

 

Katayama S, Töhönen V, Linnarsson S, Kere J. SAMstrt: statistical test fordifferential expression in single-cell transcriptome with spike-in normalization.Bioinformatics. 2013 Nov 15;29(22):2943-5