Translational Science Centre
The Karolinska Institutet - AstraZeneca Joint Research Program in Translational Science was established in 2012 to establish collaborative research programs aimed at the identification and/or validation of biomarkers of clinical utility.
The Centre hosts eleven research programs, initiated in 2013, in a range of diseases and indications, including oncology, neuroscience, cardiovascular, respiratory, inflammation and toxicology. Many of the research programs are collaborations between clinical research and biobanks, basic science, and technology platforms at the Science for Life Laboratory.
PI and Projects
Project: Circulating tumor DNA as a personalized biomarker for treatment prediction and disease monitoring in prostate and breast cancer.
Project: Search and identification of therapy predictive markers in primary and metastatic breast cancer with focus on TORC1/2 inhibition and AZD8931 with long-term goals of individual prognostication and tailored therapy selections.
Project: Immediate adaptation analysis for prediction of efficient combination therapy with Gefitinib
Project: Discovery of diagnostic and prognostic biomarkers of preclinical Alzheimer´s disease by combining advanced proteomics, metabolomics and lipidomics analyses of blood plasma and cerebrospinal fluid.
Project: The pursuit of immune biomarkers in schizophrenia - tracking down pathophysiological mechanisms.
Project: Biomarkers of early Parkinson´s disease.
Prediction of clinically relevant safety signals of nephrotoxicity through plasma metabolite profiling.
Biomed Res Int 2013 ;2013():202497