Trained and non-trained research subjects wanted

Published 2016-06-09 17:58. Updated 2016-06-10 08:55Denna sida på svenska

How are muscles affected by long-term exercise? The purpose of this study is to compare individuals with different training history to those without training experience to understand how skeletal muscle and fat tissue change as a result of extended training.

Inclusion criteria

  • Age: 35-50
  • Fit into one of the following groups: Individuals with over 15 years of regular endurance training (elite/sub-elite level) Individuals with over 15 years of strength training experience (elite/sub-elite level)
    ndividuals with limited to no previous exercise experience 
  • Not overweight 
  • Non-smoker
  • Do not currently or have not previously used performance enhancing drugs (e.g. EPO or steroids)
  • Be healthy (do not have an ongoing infection or chronic illness)


If the inclusion criteria describe you, please contact us (see contact information below) -If you participate in the study, you will visit the lab twice.

During the first visit, you will fill in a heath questionnaire and perform two physiological tests. One test will measure your endurance fitness (VO2 max test) and the other will test your strength (maximal knee extension test). This visit will take a total of 2 hours.

According to the results and our established inclusion criteria, you will either be placed into one of the three study groups or excluded from the study.

If you are included, you will come to the lab for a second visit, which will occur about 2 weeks after the first visit.

During visit 2, a whole-body MRI will be performed, 4 muscle biopsies from each leg will be taken and a fat biopsy from the subcutaneous fat on the stomach will be taken.

After the second visit to the lab, participants will receive 2500kr. You will also receive all results from the physiological tests and information about your muscles (such as fiber-type composition)

Interested in participating?

To express interest, contact:

Mark Chapman, PhD, Dept. of Physiology and Pharmacology, Karolinska Institutet

E-mail:, phone: 08-524 868 74. Molecular exercise physiology