1500s: Swiss physician Paracelsus coins "the dose makes the poison".
1775: Increased incidence of testicular cancer in chimney sweeps is discovered.
1929: Polychlorinated biphenyls, PCBs, are introduced by chemical, pharmaceutical and agricultural companies.
1942: Dichlorodiphenyltrichloroethane, DDT, begins to be used as a pesticide.
1961: The thalidomide disaster - drugs for pregnant women cause birth defects.
1970s: Attention is drawn to the health and safety risks of chemicals in the workplace. DDT and PCBs are banned after the discovery of harmful effects in nature.
1980s: Attention is drawn to chemicals that cause cancer.
1990s: Attention is drawn to endocrine disruptors and fetal sensitivity to chemicals.
1990s/2000s: Attention is drawn to the toxicity of acrylamide - the Hallandsås Tunnel (sealant) in 1997, foods (French fries and crisp bread) in 2002
2001: Attention is drawn to the cocktail effect - can 1 + 1=3?
2007, January: The EU bans endocrine-disrupting phthalates in plastic toys and childcare products.
June: REACH - European chemical legislation is introduced throughout the EU to tighten corporate responsibility
2008: Increasing use of nanoparticles and nanomaterials - potential health risks begin to be discussed.
2011: The EU bans baby bottles made of polycarbonates, which leach bisphenol A.
2013, March: The European Parliament decides that the European Commission shall put forward proposals by June 2015 on the management of endocrine disruptors in consumer products.
July: The Swedish governments ban on substances containing bisphenol A in packaging for foods for children under the age of three enters into force.