Theme Center for Cardiovascular Diseases
Cardiovascular diseases arising from atherosclerosis constitute the major causes of morbidity and mortality in Sweden and are expected to be the quantitatively largest group of lethal diseases globally within the next two decades. However, the atherosclerotic process and its complications remain enigmatic and the opportunities for prevention and therapy are limited.
The Center for Cardiovascular Disease will integrate clinical, translational and basic research, education and cardiovascular care.
The vision is to operate "from bedside to bench and back", ensuring that clinically relevant problems are addressed and that novel mechanistic insights are rapidly translated into innovative preventive, diagnostic and therapeutic approaches and implemented in clinical care. Focus will be placed on two key questions of particular clinical relevance:
- How can efficient prevention of plaque rupture/acute coronary syndrome be achieved?
- How can the function of the ischemic myocardium be preserved and heart failure prevented?
To address these questions, we will develop new concepts for the molecular pathophysiology, prevention, diagnosis and therapy of four central processes in cardiovascular medicine:
- Plaque rupture
- Myocardial ischemia including endogenous repair processes involving angiogenesis
- Aneurysm formation
The Center will also provide a unique platform for the training of the next generation of leaders in basic and clinical cardiovascular medicine through implementation of a comprehensive structure for translational research and research training.
Bo Angelin, Department of Medicine, Huddinge
Ulf de Faire, Institute of Environmental Medicine
Jesper Z Haeggström, Department of Medical Biochemistry and Biophysics
Göran K Hansson, Department of Medicine, Solna
Ulf Hedin, Department of Molecular Medicine and Surgery
Cecilia Söderberg-Nauclér, Department of Medicine, Solna
John Pernow, Department of Medicine, Solna
Lorenz Poellinger, Department of Cell and Molecular Biology
Mats Rudling, Department of Medicine, Huddinge
Juleen Zierath, Department of Molecular Medicine and Surgery