Theme Center for Cardiovascular Diseases

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Cardiovascular diseases arising from atherosclerosis constitute the major causes of morbidity and mortality in Sweden and are expected to be the quantitatively largest group of lethal diseases globally within the next two decades. However, the atherosclerotic process and its complications remain enigmatic and the opportunities for prevention and therapy are limited.

The Center for Cardiovascular Disease will integrate clinical, translational and basic research, education and cardiovascular care.

The vision is to operate "from bedside to bench and back", ensuring that clinically relevant problems are addressed and that novel mechanistic insights are rapidly translated into innovative preventive, diagnostic and therapeutic approaches and implemented in clinical care. Focus will be placed on two key questions of particular clinical relevance:

  • How can efficient prevention of plaque rupture/acute coronary syndrome be achieved?
  • How can the function of the ischemic myocardium be preserved and heart failure prevented?

To address these questions, we will develop new concepts for the molecular pathophysiology, prevention, diagnosis and therapy of four central processes in cardiovascular medicine:

  • Atherosclerosis
  • Plaque rupture
  • Myocardial ischemia including endogenous repair processes involving angiogenesis
  • Aneurysm formation

The Center will also provide a unique platform for the training of the next generation of leaders in basic and clinical cardiovascular medicine through implementation of a comprehensive structure for translational research and research training.




Jesper Z. Haeggström

Phone: 08-524 877 58
Organizational unit: Jesper Haeggströms group

Group leaders

Bo AngelinDepartment of Medicine, Huddinge

Ulf de FaireInstitute of Environmental Medicine

Jesper Z HaeggströmDepartment of Medical Biochemistry and Biophysics

Göran K HanssonDepartment of Medicine, Solna

Ulf HedinDepartment of Molecular Medicine and Surgery

Cecilia Söderberg-NauclérDepartment of Medicine, Solna

John PernowDepartment of Medicine, Solna

Lorenz PoellingerDepartment of Cell and Molecular Biology

Mats RudlingDepartment of Medicine, Huddinge

Juleen ZierathDepartment of Molecular Medicine and Surgery


Cardiovascular DiseasesCentre