Research on alternative methods

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Alternative methods are being developed and tested at several universities in Sweden. The Swedish Research Council also provides funding for projects that aim to develop alternative methods that refine, reduce and/or replace animal experiments. Several research groups at Karolinska Institutet have been awarded this type of funding to use and develop alternative methods in their research.

Cultured epithelial cells in cancer research

Professor Roland Grafström uses human epithelial cells in his research. Epithelial cells coat many of the bodys surfaces, for example the skin, lungs and intestines, and Grafström was the first in Sweden to be able to culture epithelial cells without partially unknown components such as serum. This model system has given him the tools for a better understanding of how cancer develops.

Illuminating model

Researcher Maria Isaguliants uses a method where fluorescent light enables her to monitor the immune response to an inhaled substance, so avoiding injections and other interventions.

Cultured cells to show toxicity

Professor Sandra Ceccatelli uses cultured cells to investigate toxins in the developing nervous system.

Professor Magnus Ingelman-Sundberg has developed a cell culture model to identify liver damage caused by medication.

Animal experiment