Ning Xu Landén
I am an Assistant Professor leading an independent research team at the Department of Medicine Solna, Karolinska Institutet. The goal of my research is to develop novel RNA-based treatments to improve healing of human skin wounds.
The immense economic and social impact of deficient wound healing e.g. chronic ulcers, post-surgical wounds care and skin scarring, calls for attention and allocation of resources to understand biological mechanisms underlying wound complications. Due to the complex nature of wounds, efficient targeted approach to enhance healing are essentially lacking today. The recent discovery of non-coding RNAs (ncRNAs) as powerful gene regulators provides hope to develop novel RNA-based treatments for a wide variety of diseases. Compared to traditional drugs targeting single proteins, modulating ncRNAs may be more effective strategies, since a single ncRNA may modulate an entire functional network.
The objective of my study is to reveal the role(s) of ncRNAs, i.e. microRNAs (miRNAs) and long-non-coding RNAs (lncRNAs) in skin wound healing and to explore the potential of RNA-based therapy for chronic wounds. Our research network is composed of both clinicians and scientists, which allows us to perform ‘Bench-to-Bedside’ research. At present, we are investigating the novel roles of miRNAs and lncRNAs in skin wounds using a unique collection of human wound tissues. In the next step, we aim to translate our basic scientific findings into therapeutic interventions for wound patients.
Li, D., Wang, A., Liu, X., Meisgen, F., Grunler, J., Botusan, I.R., Narayanan, S., Erikci, E., Li, X., Blomqvist, L., Du, L., Pivarcsi, A., Sonkoly, E., Chowdhury, K., Catrina, S., Ståhle, M., Landén, N.X.#. (2015) MicroRNA-132 enhances transition from inflammation to proliferation during wound healing. Journal of Clinical Investigation (IF: 13.8) 3; 125(8):3008-26. PMID: 26121747
Li, D., Wang, A., Meisgen, F., Pivarcsi, A., Sonkoly, E., Ståhle, M., Landén, N.X.#. (2015) MicroRNA-31 promotes skin wound healing by enhancing keratinocyte proliferation and migration. Journal of Investigative Dermatology (IF: 7.2) 135(6): 1676-85. PMID: 25685928
Landén, N.X.#, Li, D., Ståhle, M. (2016) Transition from inflammation to proliferation: a critical step during wound healing. Cellular and Molecular Life Sciences (IF: 5.8) 73(20): 3861-85. PMID: 27180275 (Invited review)