High impact publications

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Each year, researchers at Karolinska Institutet publish approx. 4,700 papers with original results in peer-reviewed scientific journals. Here we list the most recent publications with one or several authors from KI in high impact journals (JIF 15 and above). 

Comprehensive Cell Surface Protein Profiling Identifies Specific Markers of Human Naive and Primed Pluripotent States
Collier AJ, Panula SP, Schell JP, Chovanec P,  Plaza Reyes A, Petropoulos S,  Corcoran AE, Walker R, Douagi I, Lanner F, Rugg-Gunn PJ
Cell Stem Cell (2017) Online 23 March. Article.
On KI News: New tools to study the origin of embryonic stem cells

Estimating the Risks of Breast Cancer Radiotherapy: Evidence from Modern Radiation Doses to the Lungs and Heart and From Previous Randomized Trials
Taylor C, Correa C, Duane FK, Aznar MC, Anderson SJ, Bergh J, Dodwell D, Ewertz M, Gray R, Jagsi R, Pierce L, Pritchard KI, Swain S, Wang Z, Wang Y, Whelan T, Peto R, McGale P, for the Early Breast Cancer Trialists Collaborative Group.
JCO (2017) Online 20 March. Original Report.

Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420
Blondiaux N, Moune M, Desroses M, et al.
Science (2017) Online 17 March. Report.

Testosterone Replacement Therapy and Risk of Favorable and Aggressive Prostate Cancer
Loeb S, Folkvaljon Y, Damber J-E. Alukal J, Lambe M, Stattin P
JCO (2017) Online 13 March. Original Report

Herbal Medications in Cardiovascular Medicine
Liperoti R, Vetrano DL, Bernabei R, Onder G
JACC (2017) Online 7 March. The Present and Future.

Association between maternal body mass index in early pregnancy and incidence of cerebral palsy
Villamor E, Tedroff K, Peterson M, Johansson S, Neovius M, Petersson G, Cnattingius S
JAMA (2017) online 7 March. Original Investigation.

Busulfan and melphalan versus carboplatin, etoposide, and melphalan as high-dose chemotherapy treatment for high-risk neuroblastoma (HR-NBL1/SIOPEN): an international, randomised, multi-arm, open-label, phase 3 trial
Ladenstein R, Pötschger U, Pearson ADJ, Brock P, Luksch R, Castel V, Yaniv I, Papadakis V, Laureys G, Malis J, Balwierz W, Ruud E, Kogner P, Schroeder H, Forjaz de Lacerda A, Beck-Popovic M, Bician P, Garami M, Trahair T, Canete A, Ambros PF, Holmes K, Gaze M, Schreier G, Garaventa A, Vassal G, Michon J, Valteau-Couanet D, for the SIOP Europe Neuroblastoma Group (SIOPEN)
The Lancet Oncology (2017) Online 1 March. Article.
On KI News: Increased survival with new treatment for aggressive form of childhood cancer

An atlas of human long non-coding RNAs with accurate 5' ends
Hon C-C, Ramilowski JA, Harshbarger J et al.
Nature (2017) Online 1 March. Article.

Neuraminidase inhibitors during pregnancy and risk of adverse neonatal outcomes and congenital malformations: population based European register study
Graner S, Svensson T, Beau A, Damsel-Michel C, Engeland A, Furu K, Hviid A, Eldevik Håberg S, Molgaard-Nielsen D, Pasternak B, Kieler H.
BMJ (2017) Online 28 February. Research.
On KI News: Safe to take influenza drugs during pregnancy

Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data
Martineau AR, Jolliffe DA, Hooper RL et al.
BMJ (2017) Online 15 February. Research.
On KI News: Vitamin D protects against colds and flu

CD49a expression defines tissue-resident CD8+ T cells poised for cytotoxic function in human skin
Cheuk S, Schlums H, Sérézal IG, Martini E, Chiang SC, Marquardt N, Gibbs A, Detlofsson E, Introini A, Forkel M, Höög C, Tjernlund A, Michaëlsson J, Folkersen L, Mjösberg J, Blomqvist L, Ehrström M, Ståhle M, Bryceson YT, Eidsmo L
Immunity (2017) Online 14 February 2017. Article.
On KI News: Cytotoxic immune cell in sick and healthy skin a key to understanding vitiligo

Targeted sequencing identifies 91 neurodevelopmental disorder risk genes with autism and developmental disability biases
Stessman HAF, Xiong B, Coe BP et al.
Nature Genetics (2017) Online 13 February. Article.

Optimal fractionation of preoperative radiotherapy and timing to surgery for rectal cancer (Stockholm III): a multicentre, randomised, non-blinded, phase 3, non-inferiority trial
Erlandsson J, Holm T, Pettersson D, Berglund Å, Cedermark B, Radu C, Johansson H, Machado M, Hjern F, Hallböök O, Syk I, Glimelius B, Martling A
The Lancet Oncology (2017) Online 9 February. Article.
On KI News: New method reduces adverse effects of rectal cancer treatment

Reducing VEGF-B Signaling Ameliorates Renal Lipotoxicity and Protects against Diabetic Kidney Disease
Falkevall A, Mehlem A, Palmobo I, Heller Sahlgren B, Ebarasi L, He L, Ytterberg J, Olausson H, Axelsson J, Sundelin B, Patrakka J, Scoteny P, Nash A, Eriksson U
Cell Metabolism (2017) Online 9 February. Article.
On KI News: Serious kidney disease can be retarded

Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertension
Kossmann S, Lagrange J, Jäckel S, Jurk K, Moritz Ehlken M, Schönfelder T, Weihert Y, Knorr M, Brandt M, Xia N, Li H, Daiber A,Oelze M, Reinhardt C, Lackner K, Gruber A, Monia B, Karbach SH, Walter U, Ruggeri ZM, Renné T, Ruf W, Münzel T, Wenzel P
Science Translational Medicine (2017) Online 1 February. Research Article.

Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis
Rao DA, Gurish MF, Marshall JL et al.
Nature (2017) Online 1 February. Letter. 

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
Warren HR, Evangelou E, Cabrera CP et al
Nature Genetics (2017) Online 30 January. Article.

Integration of recent evidence into management of patients with atherosclerotic cardiovascular disease and type 2 diabetes
Standl E, Schnell O, McGuire DK, Ceriello A, Rydén L
The Lancet Diabetes & Endorinology (2017) Online 25 January. Review.

Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial
Neoptolemos JP, Pamer DH, Ghaneh P et al.
The Lancet (2017) Online 24 January. Article.

Continuous Glucose Monitoring vs Conventional Therapy for Glycemic Control in Adults With Type 1 Diabetes Treated With Multiple Daily Insulin Injections –The GOLD Randomized Clinical Trial
Lind M, Polonsky W, Hirsch IB, Heise T, Bolinder J, Dahlqvist S, Schwarz E, Ólafsdóttir AF, Frid A, Wedel H, Ahlén E, Nyström T,  Hellman J
JAMA (2017) online 24 January. Original Investigation.

Effectiveness of flexible sigmoidoscopy screening in men and women and different age groups: pooled analysis of randomised trials
Holme Ø , Schoen RE, Senore C, Segnan N, Hoff G, Løberg M, Bretthauer M, Adami H-O, Kalager M
BMJ (2017) Online 13 January. Research.

Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies
Herold N, Rudd SG, Ljungblad L, Sanjiv K, Hed Myrberg I, Paulin CBJ, Heshmati Y, Hagenkort A, Kutzner J, Page BDG, Calderón-Montano JM, Loseva O, Jemth A-S, Bulli L, Axelsson H, Tesi B, Valerie NCK, Höglund A, Bladh J, Wiita E, Sundin M, Uhlin M, Rassidakis G, Heyman M, Pokrovskaja Tamm K, Warpman-Berglund U, Walfridsson J, Lehmann S, Grandér D, Lundbäck T, Kogner P, Henter J-I, Helleday T, Torsten Schaller
Nature Medicine (2017) Online 9 January. Letter.

Laparoscopic Roux-en-Y gastric bypass in adolescents with severe obesity (AMOS): a prospective, 5-year, Swedish nationwide study
Olbers T, Beamish AJ, Gronowitz E et al.
The Lancet Diabetes & Endocrinology (2017). Online 5 January. Article. 

Length of Storage of Red Blood Cells and Patient Survival After Blood Transfusion: A Binational Cohort Study
Halmin M, Rostgaard K, Lee BK, Wikman A, Norda R, Nielsen KR, Pedersen OB, Holmqvist J, Hjalgrim H, Edgren G
Annals of Internal Medicine (2016) Online 20 December. Original Research.

Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes
Romanov RA, Zeisel A, Bakker J, Girach F, Hellysaz A, Tomer R, Alpár A, Mulder J, Clotman F, Keimpema E, Hsueh B, Crow AK, Martens H, Schwindling , Calvigioni D, Bains JS, Máté Z, Szabó G, Yanagawa Y, Zhang M-D, Rendeiro A, Farlik M, Uhlén M, Wulff P, Bock C, Broberger C, Deisseroth K, Hökfelt T, Linnarsson S, Horvath TL, Harkany T
Nature Neuroscience (2016) Online 19 December. Article.

Gotta catch’em all! Pokémon GO and physical activity among young adults: difference in differences study
Howe KB, Suharlim C, Ueda P, Howe D, Kawachi I, Rimm EB
BMJ (2016) Online 13 December. Research, Christmas 2016.

On KI News: Pokemon Go only slightly improves physical activity among adults

The immunopathogenesis of seropositive rheumatoid arthritis: from triggering to targeting
Malmström V, Catrina AI, Klareskog L
Nature Reviews Immunology (2016) Online 5 December. Review.

Human immune system variation
Brodin P, Davis MM
Nature Reviews Immunology (2016) Online 5 December. Review.

Development and validation of risk prediction model for venous thromboembolism in postpartum women: multinational cohort study
Sultan AA, West J, Grainge MJ, Riley RD, Tata LJ, Stephansson O, Fleming KM, Nelson-Pierc C, Ludvigsson JF
BMJ (2016) Online 5 December. Research

Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity
Li J, Casteels T, Frogne T et al.
Cell (2016) Online 1 December. Article.

Sex-Discordant Blood Transfusions and Survival After Cardiac Surgery - A Nationwide Cohort Study
Holzmann MJSartipy U,  Olsson ML,  Dickman PEdgren G
Circulation (2016) Online 21 November. Correspondence.
On KI News: No association between sex-discordant blood transfusions and risk of death

Neural circuitry gets rewired
Adameyko I
Science (2016) Online 18 November. Perspective.

Occurrence of carbapenemase-producing Klebsiella pneumoniae and Escherichia coli in the European survey of carbapenemase-producing Enterobacteriaceae (EuSCAPE): a prospective, multinational study
Grundmann H, Glasner C, Albiger B et al.
The Lancet Infectious Diseases (2016) Online 17 November. Article.

Cardioprotection and lifespan extension by the natural polyamine spermidine
Eisenberg T, Abdellatif M, Schroeder S et al.
Nature Medicine (2016) Online 14 november. Article.

Effect of Tailored Dose-Dense Chemotherapy vs Standard 3-Weekly Adjuvant Chemotherapy on Recurrence-Free Survival AmongWomen With High-Risk Early Breast Cancer A Randomized Clinical Trial
Foukakis T, von Minckwitz G, Bengtsson N-O,  Brandberg Y, Wallberg B, Fornander T, Mlineritsch B, Schmatloch S, Singer CF, Steger G, Egle D, Karlsson E, Carlsson L, Loibl S, Untch M, Hellström M, Johansson H, Anderson H, Malmström P, Gnant M, Greil R, Möbus V, Bergh J
JAMA (2016) Online 8 November. Original Investigation.
On KI News: Tailored, Dense-Dose Chemotherapy for Early Breast Cancer Does Not Result in Significant Improvement in Recurrence-Free Survival

Regulation of autoantibody activity by the IL-23–TH17 axis determines the onset of autoimmune disease
Pfeifle R, Rothe T, Ipseiz N et al.
Nature Immunology (2016) Online 7 November. Article.

Health consequences of shift work and insufficient sleep
Kecklund G, Axelsson J
BMJ (2016) Online 1 November. Clinical Review.

Association Between Prescription of Major Psychotropic Medications and Violent Reoffending After Prison Release
Chang Z, Lichtenstein P, Långström N, Larsson H, Fazel S
JAMA (2016) Online 1 November. Original Investigation.
On KI News: Psychiatric treatment against violent crimes among released prisoners

Genome-wide analysis identifies 12 loci influencing human reproductive behavior
Barban N, Jansen R, de Vlaming R et al
Nature Genetics (2016) Online 31 October. Article.

Lgr6 labels a rare population of mammary gland progenitor cells that are able to originate luminal mammary tumours
Blaas L, Pucci F, Messal HA, Andersson AB, Josue Ruiz EJ, Gerling M, Douagi I, Spencer-Dene B, Musch A, Mitter R, Bhaw L, Stone R, Bornhorst D, Sesay AK, Jonkers J, Stamp G, Malanchi I, Toftgård R, and Behrens A
Nature Cell Biology (2016) Online 31 October 2016. Article.
On KI News: Cells of origin for breast tumours identified

Neutrophils license iNKT cells to regulate self-reactive mouse B cell responses
Hägglöf T, Sedimbi SK, Yates JL, Parsa R, Hauff Salas B, Harris RA, Leadbetter EA,  Karlsson MCI
Nature Immunology (2016) Online 31 October. Article.

On KI News: How autoimmune disease is prevented – mechanism discovered

Single-cell sequencing of the small-RNA transcriptome
Faridani OR, Abdullayev I, Hagemann-Jensen M, Schell JP, Lanner F, Sandberg R
Nature Biotechnology (2016) Online 31 October. Brief Communications.
On KI News: Short RNA molecules mapped in single cell

Single-Cell Analysis Reveals a Close Relationship between Differentiating Dopamine and Subthalamic Nucleus Neuronal Lineages
Kee N, Volakakis N, Kirkeby A, Dahl L, Storvall H, Nolbrant S, Lahti L, Björklund ÅK, Gillberg L, Joodmardi E, Sandberg R, Parmar M, Perlmann T
Cell Stem Cell (2016). Online 27 October. Article.
On KI News: Collaboration leads to new treatment for Parkinson’s disease

Predictive Markers Guide Differentiation to Improve Graft Outcome in Clinical Translation of hESC-Based Therapy for Parkinson’s Disease
Kirkeby A, Nolbrant S, Tiklova K,  Heuer A,  Kee N, Cardoso T,  Rylander Ottosson D,  Lelos MJ, Rifes P,  Dunnett SB, Grealish S,  Perlmann T, Parmar M
Cell Stem Cell (2016) Online 27 October. Clinical Progress.

Mammalian Mitochondria and Aging: An Update
Kauppila TES, Kauppila JHK, Larsson N-G
Cell Metabolism (2016). Online 27 October. Review.

The immunometabolite S-2-hydroxyglutarate regulates fate in CD8+ T-lymphocytes
Petros A. Tyrakis PA, Palazon A, Macias D, Lee KL, Phan AT, Veliça P, You J, Chia GS, Sim J, ADoedens A, Abelanet A, Evans CE, Griffiths JR, Poellinger L, Goldrath AW,  Johnson RS
Nature (2016) Online 26 October. Article.
On KI News: Self-renewable killer cells could be key to making cancer immunotherapy work

Translating genome-wide association findings into new therapeutics for psychiatry
Breen G, Li Q, Roth BL et al.
Nature Neuroscience (2016) Online 26 October. Commentary.

Long-term exposure to ambient air pollution and traffic noise and incident hypertension in seven cohorts of the European study of cohorts for air pollution effects (ESCAPE)
Fuks KB, Weinmyar G, Basagaña X et al.
European Heart Journal (2016) Online 24 October. Meta-Analysis.

Outcomes of Pregnancies for Women Undergoing Endoscopy While They Were Pregnant – a Nationwide Cohort Study 
Ludvigsson JF, Lebwohl BEkbom A, Kiran R, Green PHR , Höijer JStephansson O
Gastroenterology (2016) Online 20 October. Accepted manuscript.
On KI News: New findings on endoscopy during pregnancy

Common variants at PVT1, ATG13–AMBRA1, AHI1 and CLEC16A are associated with selective IgA deficiency
Bronson PG, ChangD, Bhangale T, Seldin MS, Ortmann W, Ferreira RC, Urcelay E, Fernández Pereira L, JMartin J, Plebani A, Lougaris V, Friman V, Freiberger T, Litzman J, Thon V, Pan-Hammarström Q, Hammarström L, Graham RG, Behrens TW
Nature Genetics (2016) Online 10 October. Letter.

Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota
Wang J, Thingholm, LB, Skieceviciene J et al.
Nature Genetics (2016) Online 10 October. Article.

Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells
La Manno G, Gyllborg D, Codeluppi S, Nishimura K, Salto C, Zeisel A, Borm LE, Stott SRW, Toledo EM, Villaescusa JC, Lönnerberg P, Ryge J, Barker RA, Arenas E, Linnarsson S
Cell (2016) Online 6 October. Resource.

Daratumumab, Lenalidomide, and Dexamethasone for Multiple Myeloma
Dimopoulos MA, Oriol A, Nahi H et al.
NEJM (2016) Online 6 October. Original Article. 

Novel genetic loci underlying human intracranial volume identified through genome-wide association
Adams HHH, Hibar DP, Chouraki V et al.
Nature Neuroscience (2016) Online 3 October. Article

Increased burden of ultra-rare protein-altering variants among 4,877 individuals with schizophrenia
Genovese G, Fromer M, Stahl EA, Ruderfer DM, Chambert K, Landén M, Moran JL, Purcell SM, Sklar P, Sullivan PF, Hultman CM, McCarroll SA
Nature Neuroscience (2016) Online 3 October. Article.

Ultra-rare disruptive and damaging mutations influence educational attainment in the general population
Ganna A, Genovese G, Howrigan DP et al
Nature Neuroscience (2016) Online 3 October. Brief Communication.

Pooled Analysis of CNS Response to Alectinib in Two Studies of Pretreated Patients With ALK-Positive Non–Small-Cell Lung Cancer
Gadgeel SM, Shaw AT, Govindan R et al.
JCO (2016) Online 3 October. Original Reports.

Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors
Luis TC, Luc S, Mizukami T, Boukarabila H, Thongjuea S, Woll PS, Azzoni E, Giustacchini A, Lutteropp M, Bouriez-Jones T, Vaidya H, Mead AJ, Atkinson D, Böiers C, Carrelha J, Macaulay IC, Patient R, Geissmann F, Nerlov C, Sandberg R, de Bruijn M, Blackburn CC, Godin I, Jacobsen SEW
Nature Immunology (2016) Online 3 October. Article.

Analysis of allelic expression patterns in clonal somatic cells by single-cell RNA-seq
Reinius B, Mold JE, Ramsköld D, Deng Q, Johnsson P, Michaëlsson J, Frisén J and Sandberg R
Nature Genetics (2016) Online 26 September. Letter.
On KI News: How our cells use mother’s and father’s genes

Gene expression elucidates functional impact of polygenic risk for schizophrenia
Fromer M, Roussos P, Sieberts SK et al.
Nature Neuroscience (2016) online 26 September. Article.

TSHZ3 deletion causes an autism syndrome and defects in cortical projection neurons
Caubit X, Gubellini P, Andrieux J et al.
Nature Genetics (2016) online 26 september. Article.

Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps
Iotchkova V, Huang J, Morris JA et al  
Nature Genetics (2016) online 26 september. Analysis.

Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes
Segerstolpe Å, Palasantza A, Eliasson P, Andersson E, Andréasson A, Sun X, Picelli S, Sabirsh A, Clausen M, Bjursell MK, Smith DM, Kasper M, Ämmälä C, Sandberg R
Cell Metabolism (2016) Online 22 September. Resource.
On KI News: Unique molecular atlas of pancreas produced

Risk for Congenital Malformation With H1N1 Influenza Vaccine: A Cohort Study With Sibling Analysis
Ludvigsson JF, Ström P, Lundholm C, Cnattingius S, Ekbom A, Örtqvist Å, Feltelius N, Granath F, Stephansson O
Annals of Internal Medicine (2016) Online 20 September 2016. Original research.
On KI News: Swine flu jab harmless to unborn babies

Measuring the health-related Sustainable Development Goals in 188 countries: a baseline analysis from the Global Burden of Disease Study 2015
GBD 2015 SDG Collaborators
The Lancet (2016) Online 21 September. Article.

Beyond too little, too late and too much, too soon: a pathway towards evidence-based, respectful maternity care worldwide
Miller S, Abalos E, Chamillard M, Ciapponi A, Colaci D, Comandé D, Diaz V, Geller S,  Hanson C,  Langer A, Manuelli V, Millar K, Morhason-Bello I, Pileggi Castro C, Nogueira Pileggi V, Robinson N, Skaer M,  Souza JP, Vogel JP, Althabe F
The Lancet (2016) Online 16 September. Series.

Drivers of maternity care in high-income countries: can health systems support woman-centred care?
Shaw D, Guise J-M, Shah N, Gemzell-Danielsson K, Joseph KS, Levy B, Wong F, Woodd S, Main EK
The Lancet (2016) Online 16 September. Series.

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals
Ehret GB, Ferreira T,  Chasman DI et al.
Nature Genetics (2016) Online 12 September. Article.

Sunscreen Use and Subsequent Melanoma Risk: A Population-Based Cohort Study
Reza Ghiasvand R, Weiderpass E, Green AC, Lund E,  Veierød MB
JCO (2016) Online 12 September. Original Report.

Blood pressure regulation by CD4+ lymphocytes expressing choline acetyltransferase
Olofsson PS, Steinberg BE, Sobbi R, Cox MA, Ahmed MN, Oswald M, Szekeres F, Hanes WM, Introini A, Fang Liu S, Holodick NE, Rothstein TL, Lövdahl C, Chavan SS, Yang H, Pavlov VA, Broliden K, Andersson U, Diamond B, Miller EJ, Arner A, Gregersen PK, Backx PH, Mak TW, Tracey KJ
Nature Biotechnology (2016) Online 12 September. Letter.
On KI News: Immune cells can regulate blood pressure

Glioma-induced caspase-3 inhibition in microglia promotes a tumor-supportive phenotype
Shen X, Burguillos MA, Osman AM, Frijhoff J, Carrillo-Jiménez A, Kanatani S, Augsten M, Saidi D, Rodhe J, Kavanagh E, Rongvaux A, Rraklli V, Nyman U, Holmberg J, Östman A, Flavell RA, Barragan A, Venero JL, Blomgren K, Joseph B
Nature Immunology (2016) Online 12 September. Article.
On KI News: Study explains mechanisms behind glioblastoma influence on the immune system

Novel glucose-sensing technology and hypoglycaemia in type 1 diabetes: a multicentre, non-masked, randomised controlled trial
Bolinder J, Antuna R, Geelhoed-Duijvestijn P, Kröger J, Weitgasser R
The Lancet (2016) Online 12 September. Article.
On KI News: New technique improves blood sugar control for people with diabetes

Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation
Stellos K, Gatsiou A, Stamatelopoulos K, Perisic Matic L, John D, Francesca Lunella F, Jaé N, Rossbach O, Amrhein C, Sigala F, Boon RA, Fürtig B, Manavski Y, You X, Uchida S, Keller T, Boeckel J-N, Franco-Cereceda A, Maegdefessel L, Chen W, Schwalbe H, Bindereif A, Eriksson P, Hedin U, Zeiher AM, Dimmeler S
Nature Medicine (2016) Online 5 September. Article.

Origin of the U87MG glioma cell line: Good news and bad news
Allen M, Bjerke M, Edlund H, Nelander S, Westermark B
Science Translational Medicine (2016) Online 31 August. Report.

Visceral motor neuron diversity delineates a cellular basis for nipple- and pilo-erection muscle control
Furlan A, La Manno G, Lübke M, Häring M, Abdo H, Hochgerner H, Kupari J, Usoskin D, Airaksinen MS , Oliver G, Linnarsson S,  Ernfors P
Nature Neuroscience (2016) Online 29 August. Article.
On KI News: Special nerve cells cause goose bumps and nipple erection

An AMPK-stabilizing peptide ameliorates adipose tissue wasting in cancer cachexia in mice
Rohm M, Schäfer M, Laurent V, Üstünel BE, Niopek K, Algire C, Hautzinger O, Sijmonsma TP, Zota A, Medrikova D, Pellegata NS, Ryden M, Kulyte A, Dahlman I, Arner P, Petrovic N, Cannon B, Amri E-Z, Kemp BE, Steinberg GR, Janovska P, Kopecky J, Wolfrum C, Blüher M, Berriel Diaz M, Herzig S
Nature Medicine (2016) Online 29 August. Article.

Disentangling neural cell diversity using single-cell transcriptomics
Poulin J-F, Tasic B, Hjerling-Leffler J, Trimarchi JM, Awatramani R
Nature Neuroscience (2016) Online 26 August. Review.

Bariatric Surgery and Preterm Birth
Stephansson O, Johansson K, Näslund  I, Neovius M
NEJM (2016) Online 24 August. Letter to the Editor.
On KI News: Obesity surgery increases the risk of preterm birth

Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice
Vermeij WP, Dollé MET, Reiling E et al.
Nature (2016) Online 24 August. Letter.

Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases
Franzén O, Ermel R, Cohain A, Akers NK, Di Narzo A, Talukdar HA, Foroughi-Asl HGiambartolomei C, Fullard JF, Sukhavasi K, Köks S, Gan L-M, Giannarelli C, Kovacic JC, Betsholtz CLosic B, Michoel T, Hao K,1 Roussos P, Skogsberg JRuusalepp A, Schadt EE, Björkegren JLM
Science (2016) Online 19 August. Report.
On KI News: Genes responsible for risk of heart attack, stroke, and related cardiometabolic diseases identified

Analysis of protein-coding genetic variation in 60,706 humans
Lek M, Karczewski KJ, Minikel EV et al
Nature (2018) Online 18 August. Article.
On KI News: Deep genetic catalog powers studies of disease and dna variation

Pioglitazone use and risk of bladder cancer in patients with type 2 diabetes: retrospective cohort study using datasets from four European countries
Pasi Korhonen P, Heintjes EM, Williams R, Hoti F, Christopher S, Majak M, Kool-Houweling L, Strongman H, Linder M, Dolin P, Bahmanyar S.
BMJ (2016) Online 16 August. Research.

Metabolic Control of Longevity
López-Otín C, Galluzzi L, Freije JMP, Madeo F, Kroemer G
Cell (2016) Online 11 August. Review.

The chaperone co-inducer BGP-15 alleviates ventilation-induced diaphragm dysfunction
Salah H, Li M, Cacciani N, Gastaldello S, Ogilvie H, Akkad H, Namuduri AV, Morbidoni V, Artemenko KA, Balogh G, Martinez-Redondo V, Jannig P, Hedström Y, Dworkin BBergquist J, Ruas J, Vigh L, Salviati L, Larsson L
Science Translational Medicine (2016) Online 3 August. Research Article.

C13orf31 (FAMIN) is a central regulator of immunometabolic function
Cader MZ, Boroviak K, Zhang Q, Assadi G, Kempster SL, Sewell GW, Saveljeva S, Ashcroft JW, Clare S, Mukhopadhyay S, Brown KP, Tschurtschenthaler M, Raine T, Doe B, Chilvers ER, Griffin JL, Kaneider NC, Floto RA, D’Amato M, Bradley A, Wakelam MJO, Dougan G & Kaser A
Nature Immunology (2016) Online 1 August. Article.

A pleiotropic missense variant in SLC39A8 is associated with Crohn’s disease and human gut microbiome composition
Li D, Achkar J-P, Haritunians T et al.
Gastroentereology (2016) Online1  August. Article in press.

Enantioselective Organocatalyzed Transformations of β-Ketoesters
Govender T, Arvidsson PI, Maguire GEM, Kruger HG & Naicker T.
Chemical Reviews (2016) Online 27 July. Review.

Principles for RNA metabolism and alternative transcription initiation within closely spaced promoters
Chen Y, Pai A, Herudek J, Lubas M, Meola N, Järvelin AI, Andersson R, Pelechano V,  Steinmetz L, Heick Jensen T, Jensen H, Sandelin A.
Nature Genetics (2016) Online 25 July. Analysis.

CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis
Kojima Y, Volkmer J-P,  McKenna K, Civelek, Lusis AJ, Miller CL, Direnzo D, Nanda V, Ye J, Connolly AJ, Schadt EE, Quertermous T, Betancur P,  Maegdefessel L, Perisic Matic L , Hedin U, Weissman IL, Leeper NJ.
Nature (2016) Online 20 July. Letter.

Outcomes in patients treated with ticagrelor or clopidogrel after acute myocardial infarction: experiences from SWEDEHEART registry
Sahlén A, Varenhorst C, Lagerqvist B, Renlund H, Omerovic E, Erling D, Wallentin L, James SK, Jernberg T
EHJ (2016) Online 19 July. Editor’s Choice.

Effects of alteplase on survival after ischaemic stroke (IST-3): 3 year follow-up of a randomised, controlled, open-label trial
Berge E, Cohen G, Roaldsen M, Lundström E, Isaksson E, Rudberg A-S, Bruins Slot K, Forbes J, Smith J, Drever J, Wardlaw J, Sandercock P, Whiteley
The Lancet Neurology (2016) Online 19 July. Article.

Cloche is a bHLH-PAS transcription factor that drives endothelial and hematopoietic specification
Reischauer S, Stone OA, Villasenor A et al.
Nature (2016) Online 14 July. Letter. 

The global burden of viral hepatitis from 1990 to 2013: findings from the Global Burden of Disease Study 2013.
Stanaway JD, Flaxman AD, Naghavi M et al.
The Lancet (2016) Online July 6. Article.

Use of evidence based practices to improve survival without severe morbidity for very preterm infants: results from the EPICE population based cohort 
Zeitlin J, Manktelow BN, Piedvache A et al.
BMJ (2016) Online 5 July. Research.
Editorial: Lost in translation – evidence to improve outcomes of very preterm infants

The role of enhancers in cancer
Sur I, Taipale J
Nature Reviews Cancer (2016). Online 1 July. Review.

Patient focused registries can improve health, care, and science
Nelson EC, Dixon-Woods M, Batalden PB, Homa K, Van Citters AD,
Morgan TS, Eftimovska E, Fisher ES, Ovretveit J,  Harrison W,  Lind C, Lindblad S
BMJ (2016) Online 1 July. Analysis.  

Visualization and analysis of gene expression in tissue sections by spatial transcriptomics
Ståhl PL, Salmén F, Vickovic S, Lundmark A, Fernández Navarro J, Magnusson J, Giacomello S, Asp M, Westholm JO, Huss M, Mollbrink A, Linnarsson SCodeluppi S, Borg Å, Pontén F, Costea PI, Sahlén P, Mulder J, Bergmann O, Lundeberg J, Frisén J
Science (2016) Online 1 July. Report.
On KI News: New method provides better information on gene expression