High impact publications

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Each year, researchers at Karolinska Institutet publish approx. 4,700 papers with original results in peer-reviewed scientific journals. Here we list the most recent publications with one or several authors from KI in high impact journals (JIF 15 and above). 

Notch Signaling in Development, Tissue Homeostasis, and Disease
Siebel C, Lendahl U
Physiological Reviews (2017) Online 9 August. Review. 

Distrust in the End-Of-Life Care Provided to a Parent and Long-Term Negative Outcomes Among Bereaved Adolescents: A Population-Based Survey Study
Beernaert K, Kreicbergs U, Furst CJ, Nyberg T, Steineck G, Bylund-Grenklo T
Journal of Clinical Oncology (2017), Original report

IgG Endopeptidase in Highly Sensitized Patients Undergoing Transplantation
Jordan SC, Lorant T, Choi J, et al, NEJM (2017), original article

Cardiovascular mortality and morbidity in patients with type 2 diabetes following initiation of sodium-glucose co-transporter-2 inhibitors versus other glucose-lowering drugs (CVD-REAL Nordic): a multinational observational analysis
Birkeland KI, Jørgensen ME, Carstensen B et al, The Lancet Diabetes & Endocrinology (2017), article.

Increased Total mtDNA Copy Number Cures Male Infertility Despite Unaltered mtDNA Mutation Load
Jiang M, Eino T, Kauppila S et al, Cell Metabolism (2017), short article

Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health
Cervenka I, Agudelo LZ, Ruas JL, Science (2017) 28 July, review.

Sequencing and de novo assembly of 150 genomes from Denmark as a population reference
Maretty L, Jensen JM, Petersen B, Hultman CM och Sullivan P et al. Nature (2017) online 26 July, letter.

Association of genetic variants related to serum calcium levels with coronary artery disease and myocardial infarction
Larsson SC, Burgess S, Michaëlsson K, JAMA (2017) 25 July, original investigation.
KI News: Higher calcium levels and risk of coronary artery disease

Antidepressants during pregnancy and autism in offspring: population based cohort study
Rai D, K Lee B, Dalman C, Newschaffer C, Lewis G, Magnusson C, BMJ, 2017, research article.

Prosthetic valve endocarditis after surgical aortic valve replacement
Natalie Glaser, Veronica Jackson, Martin J. Holzmann, Anders Franco-Cereceda, Ulrik Sartipy, Circulation (2017) online 18 July. Correspondence
KI News: Fewer infections in mechanical heart valves

Cardiomyocyte renewal in the human heart: insights from the fall-out
Lázár E, Sadek HA, Bergmann O
European Heart Journal (2017) Online 7 July. Clinical Review.

Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder
T Lim E, Uddin M, De Rubeis S, Chan Y, S Kamumbu A, Zhang X, M D'Gama A, N Kim S, Sean Hill R, P Goldberg A, Poultney C, J Minshew N, Kushima I, Aleksic B, Ozaki N, Parellada M, Arango C, J Penzol M, Carracedo A, Kolevzon A, M Hultman C, A Weiss L, Fromer M, G Chiocchetti A, M Freitag C, Autism Sequencing Consortium, M Church G, W Scherer S, D Buxbaum J & A Walsh C, Nature Neuroscience (2017) Online 17 July, research article.

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
Rebecca Sims et al. Laura Fratiglioni, Caroline Graff, Lina Keller, Hakan Thonberg, Charlotte Forsell, Lena Lilius, Anne Kinhult-Stählbom, Nature Genetics, (2017) online 17 July. Article.

Association analyses based on false discovery rate implicate new loci for coronary artery disease
Christopher P Nelson et al, Johan L M Björkegren, Nature Genetics (2017), online 17 July. Letter.

Measures of chronic kidney disease and risk of incident peripheral artery disease: a collaborative meta-analysis of individual participant data
Matsushita K, Ballew SH, Coresh J et al.
Lancet Diabetes and Endocrinology (2017). Online 14 July. Article. 

Genotype–covariate interaction effects and the heritability of adult body mass index
Robinson MR, English G, Moser G et al.
Nature Genetics (2017) Online 10 July. Analysis.

Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla
Furlan A, Dyachuk V Kastriti ME Calvo-Enrique L,Abdo H, Hadjab S, Chontorotzea T, Akkuratova N, Usoskin D, Kamenev D, Petersen J, Sunadome K, Memic F, Marklund U, Fried K, Topilko P, Lallemend F, Kharchenko PV, Ernfors P, Adameyko I
Science (2017) Online 7 July. Research Article.

Use of Molecular Tools to Identify Patients With Indolent Breast Cancers With Ultralow Risk Over 2 Decades
Esserman L, Yau C, Thompson C et al.
JAMA Oncology (2017) Online 29 June. Original Investigation.
On KI News: Test identifies breast cancer patients with very low risk of death

Effect of Acupuncture and Clomiphene in Chinese Women With Polycystic Ovary Syndrome – A Randomized Clinical Trial
Wu X-K, Stener-Victorin E, Kuang H-Y et al.
JAMA (2017) Online 27 June. Original Investigation.
On KI News: Acupuncture does not increase fertility in women with PCOS

Oesophageal cancer
Lagergren J, Smyth E, Cunningham D, Lagergren P
The Lancet (2017) Online 22 June. Seminar.

Hotspots of missense mutation identify neurodevelopmental disorder genes and functional domains
Geisheker MR, Heymann G, Wang T et al.
Nature Neuroscience (2017) Online 19 June. Article.

Structural Basis of Egg Coat-Sperm Recognition at Fertilization
Raj I, Al Hosseini HS, Dioguardi E, Nishimura K, Han L, Villa A, de Sanctis D, Jovine L
Cell (2017) Online 15 June. Article.
On KI News: 3D images show how sperm binds to the egg surface

Risk of major congenital malformations in relation to maternal overweight and obesity severity: cohort study of 1.2 million singletons
Persson M, Cnattingius S, Villamor E, Söderling J, Pasternak B, Stephansson O, Neovius M
BMJ (2017) Online 14 June. Research.

Time to Delivery of an Automated External Defibrillator Using a Drone for Simulated Out-of-Hospital Cardiac Arrests vs Emergency Medical Services
Claesson A, Bäckman A, Ringh M, Svensson L, Nordberg P, Djärv T, Hollenberg J
JAMA (2017) Online 13 June. Research Letter.
On KI News: Drones can increase survival from cardiac arrest

Identification of 19 new risk loci and potential regulatory mechanisms influencing susceptibility to testicular germ cell tumor
Litchfield K, Levy M, Orlando G
Nature Genetics (2017) Online 12 June. Letter.

Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor
Wang Z, McGlynn KA, Rajpert-De Meyts E et al
Nature Genetics (2017) Online 12 June. Letter.

Vaccine Priming is Restricted to Draining Lymph Nodes and Controlled by Adjuvant-Mediated Antigen Uptake
Liang F, Lindgren G, Sandgren KJ, Thompson EA, Francica JR, Seubert A, De Gregorio E, Barnett S, O’Hagan DT, Sullivan NJ, Koup RA, Seder RA, Loré K
Science Translational Medicine (2017) Online 7 June. Research Article.

Engineered Cpf1 variants with altered PAM specificities
Gao L, Cox DBT, Yan WX, Manteiga JC, Schneider MW, YamanoT, Nishimasu H, Nureki O, Crosetto N, Zhang F
Nature Biotechnology (2017) Online 5 June. Letter.

Association Between Proton Pump Inhibitor Use and Risk of Progression of Chronic Kidney Disease
Klatte DCF, Gasparini A, Xu H, de Deco P, Trevisan M, Johansson ALV, Wettermark B, Ärnlöv J, Janmaat CJ, Lindholm B, Dekker FW, Coresh J, Grams ME, Carrero JJ
Gastroenterology (2017) Online 2 June. Accepted Manuscript In Press.
On KI News: Heartburn medicine can increase risk of kidney disease

MiR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes
Peng C, Li L, Zhang M-D, Bengtsson Gonzales C, Parisie M, Belfer I, Usoskin D, Abdo H, Furlan A, Häring M, Lallemend F, Harkany T, Diatchenko L, Hökfelt T, Hjerling-Leffler J, Ernfors P
Science (2017) Online 1 June. Report.
On KI News: Unexpected mechanism behind chronic nerve pain

Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women
Klatt NR, Cheu R, Birse K, Zevin AS, Perner M, Noël-Romas L, Grobler A, Westmacott G, Xie IY, Butler J, Mansoor L,
McKinnon LR, Passmore JS, Abdool Karim Q,  Abdool Karim SS, Burgener AD
Science (2017) Online 1 June. Research Article.

Outcomes in Patients With Chest Pain Discharged After Evaluation Using a High-Sensitivity Troponin T Assay
Nejatian A, Omstedt Å, Höijer J, Hansson LO, Djärv T, Eggers KM, Svensson P
JACC (2017) Online 30 May. Article.
On KI News: High-sensitivity assay gives more reassurance to chest pain patients

Seattle Heart Failure and Proportional Risk Models Predict Benefit From Implantable Cardioverter-Defibrillators
Bilchick KC, Wang Y, Cheng A, Curtis JP, Dharmarajan K, Stukenborg GJ, Shadman R, Anand I, Lund LH, Dahlström U, Sartipy U, Maggioni A, Swedberg K, O'Conner C, Levy WC.
JACC (2017) Online 30 May. Article.

Social Fear Learning: from Animal Models to Human Function
Debiec J, Olsson A
Trends in Congnitive Sciences (2017) Online 22 May. Review.

Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues
Sugden WW, Meissner R, Aegerter-Wilmsen T, Tsaryk R, Leonard EV, Bussmann J, Hamm MJ, Herzog W, Jin Y, Jakobsson L, Denz C, Siekmann AF
Nature Cell Biology (2017) Online 22 May. Article.

Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling
Jin Y, Muhl L, Burmakin M, Wang Y, Duchez A-C, Betsholtz C, Arthur HM, Jakobsson L
Nature Cell Biology (2017) Online 22 May. Article.
On KI News: New findings on formation and malformation of blood vessels

Preterm birth and risk of Heart Failure Up to Early Adulthood
Carr H, Cnattingius S, Granath F, Ludvigsson JF, Edstedt Bonamy A-K
JACC (2017) Online 22 May. Article.
On KI News: Preterm birth linked to higher risk of heart failure

Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence
Sniekers S, Stringer S, Watanabe K et al.
Nature Genetics (2017) Online 22 May. Letter.

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles
Galluzzi L, Bravo-San Pedtro JM, Levine B, Green DR, Kroemer G
Nature Reviews Drug Discovery (2017) Online 19 May. Review.

Particulate Array of Well-Ordered HIV Clade C Env Trimers Elicits Neutralizing Antibodies that Display a Unique V2 Cap Approach
Martinez-Murillo P, Tran K, Guenaga J, Lindgren G, Àdori M, Feng Y, Phad GE, Vázquez Bernat N, Bale S, Ingale J, Dubrovskaya V, O’Dell S, Pramanik L, Spångberg M, Corcoran M, Loré K, Mascola JR, Wyatt RT, Karlsson Hedestam GB
Immunity (2017). Online 16 May. Article.

Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders
Weiner DJ, Wigdor EM, Ripke S et al
Nature Genetics (2017) Online 15 May. Analysis.

Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia
Giustacchini A, Thongjuea S, Barkas N et al.
Nature Medicine (2017) Online 15 May. Article.

The changing prevalence and incidence of dementia over time — current evidence
Wu Y-T, Beiser AS, Breteler MB, Fratiglioni L et al.
Nature Reviews Neurology (2017) Online 12 May. Review.

Local amplifiers of IL-4Rα–mediated macrophage activation promote repair in lung and liver
Minutti CM, Jackson-Jones LH, García-Fojeda B, Knipper JA, Sutherland TE, Logan N, Rinqvist E, Guillamat-Prats R, Ferenbach DA, Artigas A, Stamme C, Chroneos ZC, Zaiss DM, Casals C, Allen JE
Science (2017) Online 11 May. Report.

A subcellular map of the human proteome
Thul PJ, Åkesson L, Wiking M
Science (2017) Online 11 May. Research Article.

A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma
Tammela T, Sanchez-Rivera FJ, Cetinbas NM et al.
Nature (2017) Online 10 May. Letter.

Phenome-wide scanning identifies multiple diseases and disease severity phenotypes associated with HLA variants
Karnes JH, Bastarache L, Shaffer CM et al.
Science Translational Medicine (2017) Online 10 May. Research Article.

Impact of cytosine methylation on DNA binding specificities of human transcription factors
Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J
Science (2017) Online 5 May. Research Article.
On KI News: Scientists reveal how epigenetic changes in DNA are interpreted

The limits of exercise physiology: From performance to health
Gabriel BM, Zierath JR
Cell Metabolism (2017) Online 2 May. Perspective.

Sickness Absence and Disability Pension After Breast Cancer Diagnosis: A 5-Year Nationwide Cohort Study
Kvillemo P, Mittendorfer-Rutz E, Bränström R, Nilsson K, Alexanderson K
JCO (2017) Online 1 May. Original Reports.

In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis
Roper J, Tammela T, Malli N et al.
Nature Biotechnology (2017) Online 1 May. Research Letter.

Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy
Levin A, Tonello M, Bonventre J et al.
The Lancet (2017) Online 20 April. Review.

Associations of Maternal Antidepressant Use During the First Trimester of Pregnancy With Preterm Birth, Small for Gestational Age, Autism Spectrum Disorder, and Attention-Deficit/Hyperactivity Disorder in Offspring
Sujan AC,  Rickert ME, Öberg AS,  Quinn PD, Hernández-Díaz S,  Almqvist CLichtenstein P, Larsson H, D’Onofrio BM
JAMA (2017) Online 18 April. Original Investigation.
On KI News: Antidepressant use in pregnancy may be safer than expected


Overall and abdominal obesity and incident aortic valve stenosis: two prospective cohort studies
Larsson SC, Wolk A, Håkansson N, Bäck M
European Heart Journal (2017) Online 11 April. Editor’s Choice.

Cell-Cycle-Targeting MicroRNAs as Therapeutic Tools against Refractory Cancers
Hydbring P, Wang Y, Fassl A et al.
Cancer Cell (2017) Online 10 April. Article.

Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson’s disease model
Rivetti di Val Cervo P, Romanov RA, Spigolon G, Masini D, Martín-Montañez E, Toledo EM, La Manno G, Feyder M, Pifl C, Ng Y-H, Padrell Sánchez S, Linnarsson S, Wernig M, Harkany T, Fisone G, Arenas E
Nature Biotechnology (2017) Online 10 April. Article.
On KI News: Conversion of brain cells offers hope for Parkinson’s patients

The neuron-specific transcription factor Myt1l represses many non-neuronal fates
Mall M, Kareta MS, Chanda S et al
Nature (2017) Online 5 April. Letter.

The Enigma of the Respiratory Chain Supercomplex
Milenkovic D, Blaza JN, Larsson N-G, Hirst J
Cell Metabolism (2017) Online 4 April. Perspective.

Quadrivalent HPV Vaccination and the Risk of Adverse Pregnancy Outcomes
Scheller NM, Pasternak B, Mølgaard-Nielsen D, Svanström H, Hviid H
NEJM (2017) Online 30 March. Original Article.

Can lifestyle changes prevent cognitive impairment? 
Kivipelto M, Mangialasche F, Ngandu T
Lancet Neurology (2017) Online 27 March. Comment. 

Comprehensive Cell Surface Protein Profiling Identifies Specific Markers of Human Naive and Primed Pluripotent States
Collier AJ, Panula SP, Schell JP, Chovanec P,  Plaza Reyes A, Petropoulos S,  Corcoran AE, Walker R, Douagi I, Lanner F, Rugg-Gunn PJ
Cell Stem Cell (2017) Online 23 March. Article.
On KI News: New tools to study the origin of embryonic stem cells

Estimating the Risks of Breast Cancer Radiotherapy: Evidence from Modern Radiation Doses to the Lungs and Heart and From Previous Randomized Trials
Taylor C, Correa C, Duane FK, Aznar MC, Anderson SJ, Bergh J, Dodwell D, Ewertz M, Gray R, Jagsi R, Pierce L, Pritchard KI, Swain S, Wang Z, Wang Y, Whelan T, Peto R, McGale P, for the Early Breast Cancer Trialists Collaborative Group.
JCO (2017) Online 20 March. Original Report.

Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420
Blondiaux N, Moune M, Desroses M, et al.
Science (2017) Online 17 March. Report.

Association Between Rheumatoid Arthritis and Risk of Ischemic and Nonischemic Heart Failure
Mantel Ä, Holmqvist M, Andersson DC, Lund LH, Askling J
JACC (2017) Online 14 March. Article.

Neutrophils as protagonists and targets in chronic inflammation
Soehnlein O, Steffens S, Hidalgo A, Weber C
Nature Reviews Immunology (2017) Online 13 March. Review.

Testosterone Replacement Therapy and Risk of Favorable and Aggressive Prostate Cancer
Loeb S, Folkvaljon Y, Damber J-E. Alukal J, Lambe M, Stattin P
JCO (2017) Online 13 March. Original Report

Herbal Medications in Cardiovascular Medicine
Liperoti R, Vetrano DL, Bernabei R, Onder G
JACC (2017) Online 7 March. The Present and Future.

Association between maternal body mass index in early pregnancy and incidence of cerebral palsy
Villamor E, Tedroff K, Peterson M, Johansson S, Neovius M, Petersson G, Cnattingius S
JAMA (2017) online 7 March. Original Investigation.

Weight Loss and Heart Failure: A Nationwide Study of Gastric Bypass Surgery Versus Intensive Lifestyle Treatment.
Sundström J, Bruze G, Ottosson J, Marcus C, Näslund I, Neovius M
Circulation (2017) Online 3 March. Original Research Article.

Busulfan and melphalan versus carboplatin, etoposide, and melphalan as high-dose chemotherapy treatment for high-risk neuroblastoma (HR-NBL1/SIOPEN): an international, randomised, multi-arm, open-label, phase 3 trial
Ladenstein R, Pötschger U, Pearson ADJ, Brock P, Luksch R, Castel V, Yaniv I, Papadakis V, Laureys G, Malis J, Balwierz W, Ruud E, Kogner P, Schroeder H, Forjaz de Lacerda A, Beck-Popovic M, Bician P, Garami M, Trahair T, Canete A, Ambros PF, Holmes K, Gaze M, Schreier G, Garaventa A, Vassal G, Michon J, Valteau-Couanet D, for the SIOP Europe Neuroblastoma Group (SIOPEN)
The Lancet Oncology (2017) Online 1 March. Article.
On KI News: Increased survival with new treatment for aggressive form of childhood cancer

An atlas of human long non-coding RNAs with accurate 5' ends
Hon C-C, Ramilowski JA, Harshbarger J et al.
Nature (2017) Online 1 March. Article.

Neuraminidase inhibitors during pregnancy and risk of adverse neonatal outcomes and congenital malformations: population based European register study
Graner S, Svensson T, Beau A, Damsel-Michel C, Engeland A, Furu K, Hviid A, Eldevik Håberg S, Molgaard-Nielsen D, Pasternak B, Kieler H.
BMJ (2017) Online 28 February. Research.
On KI News: Safe to take influenza drugs during pregnancy

Long-term incidence of microvascular disease after bariatric surgery or usual care in patients with obesity, stratified by baseline glycaemic status: a post-hoc analysis of participants from the Swedish Obese Subjects study
Carlsson LM, Sjöholm K, Karlsson C, Jacobson P, Andersson-Assarsson JC, Svensson PA, Larsson I, Hjorth S, Neovius M, Taube M, Carlsson B, Peltonen M
Lancet Diabetes Endocrinology (2017) 22 February. Article.

Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data
Martineau AR, Jolliffe DA, Hooper RL et al.
BMJ (2017) Online 15 February. Research.
On KI News: Vitamin D protects against colds and flu

CD49a expression defines tissue-resident CD8+ T cells poised for cytotoxic function in human skin
Cheuk S, Schlums H, Sérézal IG, Martini E, Chiang SC, Marquardt N, Gibbs A, Detlofsson E, Introini A, Forkel M, Höög C, Tjernlund A, Michaëlsson J, Folkersen L, Mjösberg J, Blomqvist L, Ehrström M, Ståhle M, Bryceson YT, Eidsmo L
Immunity (2017) Online 14 February 2017. Article.
On KI News: Cytotoxic immune cell in sick and healthy skin a key to understanding vitiligo

Targeted sequencing identifies 91 neurodevelopmental disorder risk genes with autism and developmental disability biases
Stessman HAF, Xiong B, Coe BP et al.
Nature Genetics (2017) Online 13 February. Article.

Optimal fractionation of preoperative radiotherapy and timing to surgery for rectal cancer (Stockholm III): a multicentre, randomised, non-blinded, phase 3, non-inferiority trial
Erlandsson J, Holm T, Pettersson D, Berglund Å, Cedermark B, Radu C, Johansson H, Machado M, Hjern F, Hallböök O, Syk I, Glimelius B, Martling A
The Lancet Oncology (2017) Online 9 February. Article.
On KI News: New method reduces adverse effects of rectal cancer treatment

Reducing VEGF-B Signaling Ameliorates Renal Lipotoxicity and Protects against Diabetic Kidney Disease
Falkevall A, Mehlem A, Palmobo I, Heller Sahlgren B, Ebarasi L, He L, Ytterberg J, Olausson H, Axelsson J, Sundelin B, Patrakka J, Scoteny P, Nash A, Eriksson U
Cell Metabolism (2017) Online 9 February. Article.
On KI News: Serious kidney disease can be retarded

Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertension
Kossmann S, Lagrange J, Jäckel S, Jurk K, Moritz Ehlken M, Schönfelder T, Weihert Y, Knorr M, Brandt M, Xia N, Li H, Daiber A,Oelze M, Reinhardt C, Lackner K, Gruber A, Monia B, Karbach SH, Walter U, Ruggeri ZM, Renné T, Ruf W, Münzel T, Wenzel P
Science Translational Medicine (2017) Online 1 February. Research Article.

Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis
Rao DA, Gurish MF, Marshall JL et al.
Nature (2017) Online 1 February. Letter. 

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
Warren HR, Evangelou E, Cabrera CP et al
Nature Genetics (2017) Online 30 January. Article.

Integration of recent evidence into management of patients with atherosclerotic cardiovascular disease and type 2 diabetes
Standl E, Schnell O, McGuire DK, Ceriello A, Rydén L
The Lancet Diabetes & Endorinology (2017) Online 25 January. Review.

Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial
Neoptolemos JP, Pamer DH, Ghaneh P et al.
The Lancet (2017) Online 24 January. Article.

Continuous Glucose Monitoring vs Conventional Therapy for Glycemic Control in Adults With Type 1 Diabetes Treated With Multiple Daily Insulin Injections –The GOLD Randomized Clinical Trial
Lind M, Polonsky W, Hirsch IB, Heise T, Bolinder J, Dahlqvist S, Schwarz E, Ólafsdóttir AF, Frid A, Wedel H, Ahlén E, Nyström T,  Hellman J
JAMA (2017) online 24 January. Original Investigation.

Effectiveness of flexible sigmoidoscopy screening in men and women and different age groups: pooled analysis of randomised trials
Holme Ø , Schoen RE, Senore C, Segnan N, Hoff G, Løberg M, Bretthauer M, Adami H-O, Kalager M
BMJ (2017) Online 13 January. Research.

Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies
Herold N, Rudd SG, Ljungblad L, Sanjiv K, Hed Myrberg I, Paulin CBJ, Heshmati Y, Hagenkort A, Kutzner J, Page BDG, Calderón-Montano JM, Loseva O, Jemth A-S, Bulli L, Axelsson H, Tesi B, Valerie NCK, Höglund A, Bladh J, Wiita E, Sundin M, Uhlin M, Rassidakis G, Heyman M, Pokrovskaja Tamm K, Warpman-Berglund U, Walfridsson J, Lehmann S, Grandér D, Lundbäck T, Kogner P, Henter J-I, Helleday T, Torsten Schaller
Nature Medicine (2017) Online 9 January. Letter.

Laparoscopic Roux-en-Y gastric bypass in adolescents with severe obesity (AMOS): a prospective, 5-year, Swedish nationwide study
Olbers T, Beamish AJ, Gronowitz E et al.
The Lancet Diabetes & Endocrinology (2017). Online 5 January. Article.