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Cardiology, Department of Medicine

Karolinska Institute, Sweden

2014-2015, Postdoc fellow

Department of Physiology & Pharmacology

West Virginia University, WV


2013, Ph.D.

Experimental Cardiology, Department of Cardiology

Erasmus Medical Center, Erasmus University Rotterdam

The Netherlands


Research description

Research topics:

1. Novel mechanisms underlying type 2 diabetes-induced macro- and microvascular dysfunction

2. Interaction between red blood cells and endothelium in type 2 diabetes

3. Purinergic control of vascular function in type 2 diabetes



Coronary microvascular dysfunction after long-term diabetes and hypercholesterolemia.
Sorop O, van den Heuvel M, van Ditzhuijzen N, de Beer V, Heinonen I, van Duin R, et al
Am. J. Physiol. Heart Circ. Physiol. 2016 Dec;311(6):H1339-H1351

Uridine adenosine tetraphosphate acts as a proangiogenic factor in vitro through purinergic P2Y receptors.
Zhou Z, Chrifi I, Xu Y, Pernow J, Duncker D, Merkus D, et al
Am. J. Physiol. Heart Circ. Physiol. 2016 Jul;311(1):H299-309

Enhanced A2A adenosine receptor-mediated increase in coronary flow in type I diabetic mice.
Labazi H, Teng B, Zhou Z, Mustafa S
J. Mol. Cell. Cardiol. 2016 Jan;90():30-7

Mechanisms underlying uridine adenosine tetraphosphate-induced vascular contraction in mouse aorta: Role of thromboxane and purinergic receptors.
Zhou Z, Sun C, Tilley S, Mustafa S
Vascul. Pharmacol. 2015 Oct;73():78-85

Involvement of NADPH oxidase in A2A adenosine receptor-mediated increase in coronary flow in isolated mouse hearts.
Zhou Z, Rajamani U, Labazi H, Tilley S, Ledent C, Teng B, et al
Purinergic Signal. 2015 Jun;11(2):263-73

Phosphodiesterase-5 activity exerts a coronary vasoconstrictor influence in awake swine that is mediated in part via an increase in endothelin production.
Zhou Z, de Beer V, Bender S, Jan Danser A, Merkus D, Laughlin M, et al
Am. J. Physiol. Heart Circ. Physiol. 2014 Mar;306(6):H918-27

Pulmonary vasoconstrictor influence of endothelin in exercising swine depends critically on phosphodiesterase 5 activity.
Zhou Z, de Beer V, de Wijs-Meijler D, Bender S, Hoekstra M, Laughlin M, et al
Am. J. Physiol. Lung Cell Mol. Physiol. 2014 Mar;306(5):L442-52

Blunted coronary vasodilator response to uridine adenosine tetraphosphate in post-infarct remodeled myocardium is due to reduced P1 receptor activation.
Zhou Z, de Wijs-Meijler D, Lankhuizen I, Jankowski J, Jankowski V, Jan Danser A, et al
Pharmacol. Res. 2013 Nov;77():22-9

Phosphodiesterase 5 inhibition-induced coronary vasodilation is reduced after myocardial infarction.
Merkus D, Visser M, Houweling B, Zhou Z, Nelson J, Duncker D
Am. J. Physiol. Heart Circ. Physiol. 2013 May;304(10):H1370-81

Uridine adenosine tetraphosphate is a novel vasodilator in the coronary microcirculation which acts through purinergic P1 but not P2 receptors.
Zhou Z, Merkus D, Cheng C, Duckers H, Jan Danser A, Duncker D
Pharmacol. Res. 2013 Jan;67(1):10-7


Sunitinib-induced systemic vasoconstriction in swine is endothelin mediated and does not involve nitric oxide or oxidative stress.
Kappers M, de Beer V, Zhou Z, Danser A, Sleijfer S, Duncker D, et al
Hypertension 2012 Jan;59(1):151-7

Low pulmonary vascular resistance breaks the two-hour marathon limit.
Merkus D, Zhou Z
J. Appl. Physiol. 2011 Jan;110(1):289-90; discussion 294

Disruption of CD38 gene enhances cardiac functions by elevating serum testosterone in the male null mice.
Gan L, Jiang W, Xiao Y, Deng L, Gu L, Guo Z, et al
Life Sci. 2011 Sep;89(13-14):491-7

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