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Ylva Trolle Lagerros


Visiting address : Eugeniahemmet, T2, Karolinska Universitetssjukhuset, Solna 171 76 Stockholm, Sweden
Delivery address : Eugeniahemmet, T2, Karolinska Universitetssjukhuset, Solna 171 76 Stockholm, Sweden


1998 Medical Degree, Uppsala University

1999 Master of Public Health, Harvard School of Public Health

2006 PhD, Karolinska Institutet

2011 Associate Professor, Karolinska Institutet

Research description

Combining population-based epidemiological research with clinical intervention studies for improved understanding in the area of obesity and lifestyle related diseases

The main purpose of my research is to disentangle how health and future disease is associated with lifestyle. There are lots of opinions and advice about obesity, physical activity, sleep, and diet, but some are not based on facts. My aim is that the research that my doctoral students and I conduct, render in knowledge which can be transferred into practical use.

Obesity – from mitochondria to large epidemiological studies

Globally obesity is a more important public health issue than hunger. I have conducted epidemiological studies in the field of obesity, clinical trials and intervention studies to study the effect of weight loss, but also more preclinical work about mitochondrial capacity before and after weight loss.

Thousands of Swedes undergo bariatric surgery every year. Several of my studies are about bariatric surgery. However, surgery is not always the best solution, many patients don’t want to go through surgery, and many patients should not go through surgery either. Research about other ways to lose weight are important, and done in my research group.

Physical activity and sleep – important parts of lifestyle

I have conducted a number of studies on the role of physical (in)activity and its association with different types of cancer and other diseases. But to be able to study physical activity in large populations, valid and reliable methods to measure physical activity are key, and thus, I have conducted a number of studies to develop and test different methods to assess physical activity. Sleep is also an important lifestyle issue. We are currently conducting several studies on the association between sleep and future disease.

Diabetes and osteoporosis – common diseases affecting many

Common diseases such as diabetes and osteoporosis are influenced by our lifestyle. To understand the interplay between lifestyle and medications is of high relevance for the success of future treatment methods. In my pharmacoepidemiological studies I am able to combine my experience of lifestyle related research with my daily clinical work, meeting patients with diabetes and obesity.

Apps and webb – newcomers in healthcare, in need of evaluation

Modern technology such as webb, sms and apps are for many natural parts of everyday life. However, health care is lagging behind. During the last couple of years I have been working with new technology in a number of studies. For example, webb-based lifestyle intervention among train drivers and Weight Club on internet for weight loss. We are currently setting up a study to evaluate a digital health care plan and app-support to improve lifestyle in patients with diabetes. This type of technology is a necessity in the modern society and is a powerful tool in research, but it is still a newcomer in daily health care. With well conducted studies I envision that it can be adjusted and improved to reach the health needs of society.


A Mobile Phone Based Method to Assess Energy and Food Intake in Young Children: A Validation Study against the Doubly Labelled Water Method and 24 h Dietary Recalls
Delisle Nyström C, Forsum E, Henriksson H, Trolle-lagerros Y, Larsson C, Maddison R, et al
Nutrients 2016;8(1):-

A prospective cohort study of the combined effects of physical activity and anthropometric measures on the risk of post-menopausal breast cancer
Bellocco R, Marrone G, Ye W, Nyrén O, Adami Ho, Mariosa D, et al
European journal of epidemiology 2016;31(4):395-404

Eating for one, exercising for two: a long journey from old knowledge to new perspectives
Lagerros Yt
European journal of epidemiology 2016;31(10):953-955

Improved Muscle Mitochondrial Capacity Following Gastric Bypass Surgery in Obese Subjects
Fernström M, Bakkman L, Loogna P, Rooyackers O, Svensson M, Jakobsson T, et al
Obesity surgery 2016;26(7):1391-7

Prospective study of dietary Non Enzymatic Antioxidant Capacity on the risk of hip fracture in the elderly
Hantikainen E, Grotta A, Ye W, Adami Ho, Surkan Pj, Serafini M, et al
Bone 2016;90():31-6

Relationships Between Questionnaire Ratings of Sleep Quality and Polysomnography in Healthy Adults
Westerlund A, Lagerros Yt, Kecklund G, Axelsson J, Åkerstedt T
Behavioral sleep medicine 2016;14(2):185-99

The Effect of Tailored Web-Based Feedback and Optional Telephone Coaching on Health Improvements: A Randomized Intervention Among Employees in the Transport Service Industry
Solenhill M, Grotta A, Pasquali E, Bakkman L, Bellocco R, Trolle Lagerros Y
Journal of medical Internet research 2016;18(8):e158-

[Aerobic physical activity and dietary advice advocated in obesity and overweight]
Trolle Lagerros Y
Lakartidningen 2015;112():-

A Validation Study of the Web-Based Physical Activity Questionnaire Active-Q Against the GENEA Accelerometer
Bonn Se, Bergman P, Trolle Lagerros Y, Sjölander A, Bälter K
JMIR research protocols 2015;4(3):e86-

A web- and mobile phone-based intervention to prevent obesity in 4-year-olds (MINISTOP): a population-based randomized controlled trial
Delisle C, Sandin S, Forsum E, Henriksson H, Trolle-lagerros Y, Larsson C, et al
BMC public health 2015;15():95-

Insufficient Sleep and Risk of Prostate Cancer in a Large Swedish Cohort
Markt Sc, Grotta A, Nyren O, Adami Ho, Mucci La, Valdimarsdottir Ua, et al
Sleep 2015;38(9):1405-10

Outcomes of pregnancy after bariatric surgery
Johansson K, Cnattingius S, Näslund I, Roos N, Trolle Lagerros Y, Granath F, et al
The New England journal of medicine 2015;372(9):814-24

Outcomes of Pregnancy After Bariatric Surgery
Johansson K, Cnattingius S, Naslund I, Roos N, Lagerros Yt, Granath F, et al

Physical activity and body mass index as predictors of prostate cancer risk
Grotta A, Bottai M, Adami Ho, Adams Sa, Akre O, Blair Sn, et al
World journal of urology 2015;33(10):1495-502

Physical activity and risk of Parkinson's disease in the Swedish National March Cohort
Yang F, Trolle Lagerros Y, Bellocco R, Adami Ho, Fang F, Pedersen Nl, et al
Brain : a journal of neurology 2015;138(Pt 2):269-75

Physical activity and survival among men diagnosed with prostate cancer
Bonn Se, Sjölander A, Lagerros Yt, Wiklund F, Stattin P, Holmberg E, et al
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2015;24(1):57-64

Dose-response relationship of total and leisure time physical activity to risk of heart failure: a prospective cohort study
Andersen K, Mariosa D, Adami Ho, Held C, Ingelsson E, Lagerros Yt, et al
Circulation. Heart failure 2014;7(5):701-8

Habitual sleep patterns and the distribution of body mass index: cross-sectional findings among Swedish men and women
Westerlund A, Bottai M, Adami Ho, Bellocco R, Nyrén O, Åkerstedt T, et al
Sleep medicine 2014;15(10):1196-203

Perceived Reasons, Incentives, and Barriers to Physical Activity in Swedish Elderly Men
Sjors C, Bonn Se, Lagerros Yt, Sjolander A, Balter K

Snus (Swedish smokeless tobacco) use and risk of stroke: pooled analyses of incidence and survival
Hansson J, Galanti Mr, Hergens Mp, Fredlund P, Ahlbom A, Alfredsson L, et al
Journal of internal medicine 2014;276(1):87-95

The change in eating behaviors in a Web-based weight loss program: a longitudinal analysis of study completers
Svensson M, Hult M, Van Der Mark M, Grotta A, Jonasson J, Von Hausswolff-juhlin Y, et al
Journal of medical Internet research 2014;16(11):e234-

Use of Scandinavian moist smokeless tobacco (snus) and the risk of atrial fibrillation
Hergens Mp, Galanti R, Hansson J, Fredlund P, Ahlbom A, Alfredsson L, et al
Epidemiology (Cambridge, Mass.) 2014;25(6):872-6

Using the Karolinska Sleep Questionnaire to identify obstructive sleep apnea syndrome in a sleep clinic population
Westerlund A, Brandt L, Harlid R, Akerstedt T, Lagerros Yt

An interactive internet-based plate for assessing lunchtime food intake: a validation study on male employees
Svensson M, Bellocco R, Bakkman L, Trolle Lagerros Y
Journal of medical Internet research 2013;15(1):e13-

Evaluation of an algorithm ascertaining cases of osteonecrosis of the jaw in the Swedish National Patient Register
Bergdahl J, Jarnbring F, Ehrenstein V, Gammelager H, Granath F, Kieler H, et al
Clinical epidemiology 2013;5():1-7

How valid are Web-based self-reports of weight?
Bonn Se, Trolle Lagerros Y, Bälter K
Journal of medical Internet research 2013;15(4):e52-

Obesity management: what brings success?
Lagerros Yt, Rössner S
Therapeutic advances in gastroenterology 2013;6(1):77-88

Perinatal outcomes after bariatric surgery: nationwide population based matched cohort study
Roos N, Neovius M, Cnattingius S, Trolle Lagerros Y, Sääf M, Granath F, et al
BMJ (Clinical research ed.) 2013;347():f6460-

Sleep characteristics and cardiovascular events in a large Swedish cohort
Westerlund A, Bellocco R, Sundström J, Adami Ho, Åkerstedt T, Trolle Lagerros Y
European journal of epidemiology 2013;28(6):463-73

[The Hedenhös Children are eating dangerously]
Ludvigsson Jf, Lagerros Yt, Bälter K
Lakartidningen 2013;110(51-52):2317-8

["Tools for clinical research"--a new series of articles in Läkartidningen]
Smedby Ke, Lagerros Yt
Lakartidningen 2013;110(3):81-

Active-Q: Validation of the Web-Based Physical Activity Questionnaire Using Doubly Labeled Water
Bonn Se, Lagerros Yt, Christensen Se, Moller E, Wright A, Sjolander A, et al

Estimating physical activity using a cell phone questionnaire sent by means of short message service (SMS): a randomized population-based study
Lagerros Yt, Sandin S, Bexelius C, Litton Je, Löf M
European journal of epidemiology 2012;27(7):561-6

Feasibility of a novel web-based physical activity questionnaire for young children
Bonn Se, Surkan Pj, Lagerros Yt, Bälter K
Pediatric reports 2012;4(4):e37-

From infancy to pregnancy: birth weight, body mass index, and the risk of gestational diabetes
Lagerros Yt, Cnattingius S, Granath F, Hanson U, Wikström Ak
European journal of epidemiology 2012;27(10):799-805

High birth weight and obesity--a vicious circle across generations
Cnattingius S, Villamor E, Lagerros Yt, Wikström Ak, Granath F
International journal of obesity (2005) 2012;36(10):1320-4

The effect of reminders in a web-based intervention study
Svensson M, Svensson T, Hansen Aw, Lagerros Yt

Use of snus and acute myocardial infarction: pooled analysis of eight prospective observational studies
Hansson J, Galanti Mr, Hergens Mp, Fredlund P, Ahlbom A, Alfredsson L, et al
European journal of epidemiology 2012;27(10):771-9

Estimation of Physical Activity Levels Using Cell Phone Questionnaires: A Comparison With Accelerometry for Evaluation of Between-Subject and Within-Subject Variations
Bexelius C, Sandin S, Lagerros Yt, Litton Je, Lof M

Longer term effects of very low energy diet on obstructive sleep apnoea in cohort derived from randomised controlled trial: prospective observational follow-up study
Johansson K, Hemmingsson E, Harlid R, Trolle Y, Granath F, Rossner S, et al

Managing obesity - from childhood and onwards
Lagerros Yt, Rossner S

Physical Activity, Stress, and Self-Reported Upper Respiratory Tract Infection
Fondell E, Lagerros Yt, Sundberg Cj, Lekander M, Balter O, Rothman Kj, et al

Predictors of Erroneous Perception of Being Overweight among Adolescents
Galanti Mr, Caria Mp, Bellocco R, Lagerros Yt
OBESITY FACTS 2011;4(4):319-23

Effects of physical activity, body mass index, waist-to-hip ratio and waist circumference on total mortality risk in the Swedish National March Cohort
Bellocco R, Jia Cq, Ye Wm, Lagerros Yt

Measures of Physical Activity Using Cell Phones: Validation Using Criterion Methods
Bexelius C, Lof M, Sandin S, Lagerros Yt, Forsum E, Litton Je

Motivational technologies to promote weight loss-From Internet to gadgets
Svensson M, Lagerros Yt

Reduced Respiratory Capacity in Muscle Mitochondria of Obese Subjects
Bakkman L, Fernstrom M, Loogna P, Rooyackers O, Brandt L, Lagerros Yt
OBESITY FACTS 2010;3(6):371-5

Effect of a very low energy diet on moderate and severe obstructive sleep apnoea in obese men: a randomised controlled trial
Johansson K, Neovius M, Lagerros Yt, Harlid R, Rossner S, Granath F, et al

Measures of physical activity and their correlates: The Swedish National March Cohort
Lagerros Yt, Bellocco R, Adami Ho, Nyren O

Older Members Perform Better in an Internet-Based Behavioral Weight Loss Program Compared to Younger Members
Van Der Mark M, Jonasson J, Svensson M, Linne Y, Rossner S, Lagerros Yt
OBESITY FACTS 2009;2(2):74-9

Physical activity-the more we measure, the more we know how to measure
Lagerros Y

Lifetime total physical activity and prostate cancer risk: a population-based case-control study in Sweden
Wiklund F, Lageros Yt, Chang E, Balter K, Johansson Je, Adami Ho, et al

Assessment of physical activity and energy expenditure in epidemiological research of chronic diseases
Lagerros Yt, Lagiou P

Validity and reliability of self-reported total energy expenditure using a novel instrument
Lagerros Yt, Mucci La, Bellocco R, Nyren O, Balter O, Balter Ka

Physical activity as a determinant of mortality in women
Trolle-lagerros Y, Mucci La, Kumle M, Braaten T, Weiderpass E, Hsieh Cc, et al
EPIDEMIOLOGY 2005;16(6):780-5

Physical activity in different periods of life and the risk of breast cancer: The Norwegian-Swedish women's lifestyle and health cohort study
Margolis Kl, Mucci L, Braaten T, Kumle M, Lagerros Yt, Adami Ho, et al

Web-based and mailed questionnaires: A comparison of response rates and compliance
Balter Ka, Balter O, Fondell E, Lagerros Yt
EPIDEMIOLOGY 2005;16(4):577-9

Physical activity in adolescence and young adulthood and breast cancer risk: a quantitative review
Lagerros Yt, Hsieh Sf, Hsieh Cc

Body mass index in relation to energy intake and expenditure among adults in Greece
Lagerros Yt
EPIDEMIOLOGY 2001;12(1):136-7

Opportunities for young scientists
Rossner S, Trolle Y
LANCET 1996;347(9001):592-593

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