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Yihai Cao

Professor

Visiting address : Nobels Väg 16 171 77 Stockholm, Sweden
Postal address : Department of Microbiology, Tumor and Cell Biology (MTC), C1, Yihai Cao group, Box 280 171 77 Stockholm, Sweden
Delivery address : Nobels Väg 16 171 77 Stockholm, Sweden

About me

Professor of Vascular Biology.

Research description

My research group is presented here.

Publications

Co-option of pre-existing vascular beds in adipose tissue controls tumor growth rates and angiogenesis
Lim S, Hosaka K, Nakamura M, Cao Yh
ONCOTARGET 2016;7(25):38282-38291

Discontinuation of anti-VEGF cancer therapy promotes metastasis through a liver revascularization mechanism
Yang Y, Zhang Y, Iwamoto H, Hosaka K, Seki T, Andersson P, et al
Nature communications 2016;7():12680-

Endocrine vasculatures are preferable targets of an antitumor ineffective low dose of anti-VEGF therapy
Zhang Y, Yang Y, Hosaka K, Huang G, Zang J, Chen F, et al
Proceedings of the National Academy of Sciences of the United States of America 2016;113(15):4158-63

Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat
Seki T, Hosaka K, Lim S, Fischer C, Honek J, Yang Y, et al
Nature communications 2016;7():12152-

Estrogen Receptor α Promotes Breast Cancer by Reprogramming Choline Metabolism
Jia M, Andreassen T, Jensen L, Bathen Tf, Sinha I, Gao H, et al
Cancer research 2016;76(19):5634-5646

Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE
Carmona G, Perera U, Gillett C, Naba A, Law Al, Sharma Vp, et al
Oncogene 2016;35(39):5155-69

MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis
Wong Hl, Jin G, Cao R, Zhang S, Cao Y, Zhou Z
Nature communications 2016;7():10824-

Pericyte-fibroblast transition promotes tumor growth and metastasis
Hosaka K, Yang Y, Seki T, Fischer C, Dubey O, Fredlund E, et al
Proceedings of the National Academy of Sciences of the United States of America 2016;113(38):E5618-27

Resveratrol analogue 4,4'-dihydroxy-trans-stilbene potently inhibits cancer invasion and metastasis
Savio M, Ferraro D, Maccario C, Vaccarone R, Jensen Ld, Corana F, et al
Scientific reports 2016;6():19973-

The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages
Yang Y, Andersson P, Hosaka K, Zhang Y, Cao R, Iwamoto H, et al
Nature communications 2016;7():11385-

CCL2 and CCL5 Are Novel Therapeutic Targets for Estrogen-Dependent Breast Cancer
Svensson S, Abrahamsson A, Rodriguez Gv, Olsson Ak, Jensen L, Cao Y, et al
Clinical cancer research : an official journal of the American Association for Cancer Research 2015;21(16):3794-805

Environmental changes in oxygen tension reveal ROS-dependent neurogenesis and regeneration in the adult newt brain
Hameed Ls, Berg Da, Belnoue L, Jensen Ld, Cao Y, Simon A
eLife 2015;4():-

Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis
Singleton Dc, Rouhi P, Zois Ce, Haider S, Li Jl, Kessler Bm, et al
Oncogene 2015;34(36):4713-22

Invasiveness and metastasis of retinoblastoma in an orthotopic zebrafish tumor model
Chen X, Wang J, Cao Z, Hosaka K, Jensen L, Yang H, et al
Scientific reports 2015;5():10351-

MicroRNA-206 functions as a pleiotropic modulator of cell proliferation, invasion and lymphangiogenesis in pancreatic adenocarcinoma by targeting ANXA2 and KRAS genes
Keklikoglou I, Hosaka K, Bender C, Bott A, Koerner C, Mitra D, et al
Oncogene 2015;34(37):4867-78

Novel mechanism of macrophage-mediated metastasis revealed in a zebrafish model of tumor development
Wang J, Cao Z, Zhang Xm, Nakamura M, Sun M, Hartman J, et al
Cancer research 2015;75(2):306-15

PlGF-induced VEGFR1-dependent vascular remodeling determines opposing antitumor effects and drug resistance to Dll4-Notch inhibitors
Iwamoto H, Zhang Y, Seki T, Yang Y, Nakamura M, Wang J, et al
Science advances 2015;1(3):e1400244-

VEGF-B-Neuropilin-1 signaling is spatiotemporally indispensable for vascular and neuronal development in zebrafish
Jensen Ld, Nakamura M, Bräutigam L, Li X, Liu Y, Samani Nj, et al
Proceedings of the National Academy of Sciences of the United States of America 2015;112(44):E5944-53

VEGF-B promotes cancer metastasis through a VEGF-A-independent mechanism and serves as a marker of poor prognosis for cancer patients
Yang X, Zhang Y, Hosaka K, Andersson P, Wang J, Tholander F, et al
Proceedings of the National Academy of Sciences of the United States of America 2015;112(22):E2900-9

Genome-wide profiling of AP-1-regulated transcription provides insights into the invasiveness of triple-negative breast cancer
Zhao C, Qiao Y, Jonsson P, Wang J, Xu L, Rouhi P, et al
Cancer research 2014;74(14):3983-94

Hypoxia-induced and calpain-dependent cleavage of filamin A regulates the hypoxic response
Zheng X, Zhou Ax, Rouhi P, Uramoto H, Borén J, Cao Y, et al
Proceedings of the National Academy of Sciences of the United States of America 2014;111(7):2560-5

Modulation of age-related insulin sensitivity by VEGF-dependent vascular plasticity in adipose tissues
Honek J, Seki T, Iwamoto H, Fischer C, Li J, Lim S, et al
Proceedings of the National Academy of Sciences of the United States of America 2014;111(41):14906-11

Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis
Arjonen A, Kaukonen R, Mattila E, Rouhi P, Hognas G, Sihto H, et al
JOURNAL OF CLINICAL INVESTIGATION 2014;124(3):1069-82

Targeting filamin B induces tumor growth and metastasis via enhanced activity of matrix metalloproteinase-9 and secretion of VEGF-A
Bandaru S, Zhou Ax, Rouhi P, Zhang Y, Bergo Mo, Cao Y, et al
Oncogenesis 2014;3():e119-

TNFR1 mediates TNF-α-induced tumour lymphangiogenesis and metastasis by modulating VEGF-C-VEGFR3 signalling
Ji H, Cao R, Yang Y, Zhang Y, Iwamoto H, Lim S, et al
Nature communications 2014;5():4944-

Vasoprotective effect of PDGF-CC mediated by HMOX1 rescues retinal degeneration
He C, Zhao C, Kumar A, Lee C, Chen M, Huang L, et al
Proceedings of the National Academy of Sciences of the United States of America 2014;111(41):14806-11

VEGFR2-mediated vascular dilation as a mechanism of VEGF-induced anemia and bone marrow cell mobilization
Lim S, Zhang Y, Zhang D, Chen F, Hosaka K, Feng N, et al
Cell reports 2014;9(2):569-80

Anti-VEGF- and anti-VEGF receptor-induced vascular alteration in mouse healthy tissues
Yang Y, Zhang Y, Cao Z, Ji H, Yang X, Iwamoto H, et al
Proceedings of the National Academy of Sciences of the United States of America 2013;110(29):12018-23

Clock controls angiogenesis
Jensen Ld, Cao Y
Cell cycle (Georgetown, Tex.) 2013;12(3):405-8

Cold exposure promotes atherosclerotic plaque growth and instability via UCP1-dependent lipolysis
Dong M, Yang X, Lim S, Cao Z, Honek J, Lu H, et al
Cell metabolism 2013;18(1):118-29

Glutaredoxin regulates vascular development by reversible glutathionylation of sirtuin 1
Bräutigam L, Jensen Ld, Poschmann G, Nyström S, Bannenberg S, Dreij K, et al
Proceedings of the National Academy of Sciences of the United States of America 2013;110(50):20057-62

Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay
Martinez Molina D, Jafari R, Ignatushchenko M, Seki T, Larsson Ea, Dan C, et al
Science (New York, N.Y.) 2013;341(6141):84-7

Tumor cell-derived placental growth factor sensitizes antiangiogenic and antitumor effects of anti-VEGF drugs
Hedlund Em, Yang X, Zhang Y, Yang Y, Shibuya M, Zhong W, et al
Proceedings of the National Academy of Sciences of the United States of America 2013;110(2):654-9

Tumour PDGF-BB expression levels determine dual effects of anti-PDGF drugs on vascular remodelling and metastasis
Hosaka K, Yang Y, Seki T, Nakamura M, Andersson P, Rouhi P, et al
Nature communications 2013;4():2129-

Vascular endothelial growth factor-dependent spatiotemporal dual roles of placental growth factor in modulation of angiogenesis and tumor growth
Yang X, Zhang Y, Yang Y, Lim S, Cao Z, Rak J, et al
Proceedings of the National Academy of Sciences of the United States of America 2013;110(34):13932-7

VEGF significantly restores impaired memory behavior in Alzheimer's mice by improvement of vascular survival
Religa P, Cao R, Religa D, Xue Y, Bogdanovic N, Westaway D, et al
Scientific reports 2013;3():2053-

Cold-induced activation of brown adipose tissue and adipose angiogenesis in mice
Lim S, Honek J, Xue Y, Seki T, Cao Zq, Andersson P, et al
NATURE PROTOCOLS 2012;7(3):606-15

Collaborative interplay between FGF-2 and VEGF-C promotes lymphangiogenesis and metastasis
Cao Rh, Ji H, Feng Nh, Zhang Y, Yang Xj, Andersson P, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2012;109(39):15894-9

MT1-MMP Inactivates ADAM9 to Regulate FGFR2 Signaling and Calvarial Osteogenesis
Chan Km, Wong Hlx, Jin Gx, Liu Bh, Cao Rh, Cao Yh, et al
DEVELOPMENTAL CELL 2012;22(6):1176-90

Opposing Effects of Circadian Clock Genes Bmal1 and Period2 in Regulation of VEGF-Dependent Angiogenesis in Developing Zebrafish
Jensen Ld, Cao Zq, Nakamura M, Yang Yl, Brautigam L, Andersson P, et al
CELL REPORTS 2012;2(2):231-41

PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cells
Xue Y, Lim S, Yang Yl, Wang Zw, Jensen Lde, Hedlund Em, et al
NATURE MEDICINE 2012;18(1):100-10

Proliferative and Survival Effects of PUMA Promote Angiogenesis
Zhang F, Li Y, Tang Zs, Kumar A, Lee C, Zhang Lp, et al
CELL REPORTS 2012;2(5):1272-85

Targeting filamin A reduces K-RAS-induced lung adenocarcinomas and endothelial response to tumor growth in mice
Nallapalli Rk, Ibrahim Mx, Zhou Ax, Bandaru S, Sunkara Sn, Redfors B, et al
MOLECULAR CANCER 2012;:50-

When MT1-MMP meets ADAMs
Wong Hlx, Cao Rh, Jin Gx, Chan Km, Cao Yh, Zhou Zj
CELL CYCLE 2012;11(15):2793-8

Antiangiogenic agents significantly improve survival in tumor-bearing mice by increasing tolerance to chemotherapy-induced toxicity
Zhang Df, Hedlund Eme, Lim S, Chen F, Zhang Y, Sun Bc, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2011;108(10):4117-22

Antiangiogenic cancer therapy: why do mouse and human patients respond in a different way to the same drug?
Cao Yh
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY 2011;55(4-5):557-62

Arteriogenic Therapy by Intramyocardial Sustained Delivery of a Novel Growth Factor Combination Prevents Chronic Heart Failure
Banquet S, Gomez E, Nicol L, Edwards-levy F, Henry Jp, Cao Rh, et al
CIRCULATION 2011;124(9):1059-69

Mouse corneal lymphangiogenesis model
Cao Rh, Lim S, Ji H, Zhang Y, Yang Yl, Honek J, et al
NATURE PROTOCOLS 2011;6(6):817-26

Adipose angiogenesis: quantitative methods to study microvessel growth, regression and remodeling in vivo
Xue Y, Lim S, Brakenhielm E, Cao Yh
NATURE PROTOCOLS 2010;5(5):912-20

Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases
Cao Yh
NATURE REVIEWS DRUG DISCOVERY 2010;9(2):107-15

Angiotensin-converting enzyme 2 attenuates atherosclerotic lesions by targeting vascular cells
Zhang C, Zhao Yx, Zhang Yh, Zhu L, Deng Bp, Zhou Zl, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2010;107(36):15886-91

Cancer-associated retinopathy A new mechanistic insight on vascular remodeling
Cao Rh, Cao Yh
CELL CYCLE 2010;9(10):1882-5

Collective cell motion in endothelial monolayers
Szabo A, Unnep R, Mehes E, Twal Wo, Argraves Ws, Cao Y, et al
PHYSICAL BIOLOGY 2010;7(4):46007-

Hypoxia-induced metastasis model in embryonic zebrafish
Rouhi P, Jensen Ld, Cao Zq, Hosaka K, Lanne T, Wahlberg E, et al
NATURE PROTOCOLS 2010;5(12):1911-8

Hypoxia-induced retinopathy model in adult zebrafish
Cao Zq, Jensen Ld, Rouhi P, Hosaka K, Lanne T, Steffensen Jf, et al
NATURE PROTOCOLS 2010;5(12):1903-10

Off-tumor target-beneficial site for antiangiogenic cancer therapy?
Cao Yh
NATURE REVIEWS CLINICAL ONCOLOGY 2010;7(10):604-8

Optimizing the Delivery of Cancer Drugs that Block Angiogenesis
Cao Yh, Langer R
SCIENCE TRANSLATIONAL MEDICINE 2010;2(15):15ps3-

Pathological angiogenesis facilitates tumor cell dissemination and metastasis
Rouhi P, Lee Slc, Cao Zq, Hedlund Em, Jensen Ld, Cao Yh
CELL CYCLE 2010;9(5):913-7

PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets
Hou X, Kumar A, Lee C, Wang B, Arjunan P, Dong Lj, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2010;107(27):12216-21

Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3 beta phosphorylation
Tang Zs, Arjunan P, Lee C, Li Y, Kumar A, Hou X, et al
JOURNAL OF EXPERIMENTAL MEDICINE 2010;207(4):867-80

Therapeutic angiogenesis for ischemic disorders: what is missing for clinical benefits?
Cao Y
Discovery medicine 2010;9(46):179-84

VEGFR1-mediated pericyte ablation links VEGF and PlGF to cancer-associated retinopathy
Cao Rh, Xue Y, Hedlund Em, Zhong Zd, Tritsaris K, Tondelli B, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2010;107(2):856-61

Differential roles of PDGFR-alpha and PDGFR-beta in angiogenesis and vessel stability
Zhang Jh, Cao Rh, Zhang Y, Jia Th, Cao Yh, Wahlberg E
FASEB JOURNAL 2009;23(1):153-63

Hypoxia-Independent Angiogenesis in Adipose Tissues during Cold Acclimation
Xue Y, Petrovic N, Cao Rh, Larsson O, Lim S, Chen S, et al
CELL METABOLISM 2009;9(1):99-109

Hypoxia-induced pathological angiogenesis mediates tumor cell dissemination, invasion, and metastasis in a zebrafish tumor model
Lee Slc, Rouhi P, Jensen Ld, Zhang Df, Ji H, Hauptmann G, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2009;106(46):19485-90

Malignant cell-derived PlGF promotes normalization and remodeling of the tumor vasculature
Hedlund Em, Hosaka K, Zhong Zd, Cao Rh, Cao Yh
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2009;106(41):17505-10

Nitric oxide permits hypoxia-induced lymphatic perfusion by controlling arterial-lymphatic conduits in zebrafish and glass catfish
Jensen Lde, Cao R, Hedlund Em, Soll I, Lundberg Jo, Hauptmann G, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2009;106(43):18408-13

Tumor angiogenesis and molecular targets for therapy
Cao Yh
FRONTIERS IN BIOSCIENCE-LANDMARK 2009;:3962-73

Tumor-derived VEGF modulates hematopoiesis
Xue Y, Chen F, Zhang D, Lim S, Cao Y
Journal of angiogenesis research 2009;1():9-

VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis
Zhang F, Tang Zs, Hou X, Lennartsson J, Li Y, Koch Aw, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2009;106(15):6152-7

A novel gene expression profile in lymphatics associated with tumor growth and nodal metastasis
Clasper S, Royston D, Baban D, Cao Yh, Ewers S, Butz S, et al
CANCER RESEARCH 2008;68(18):7293-303

Anti-VEGF agents confer survival advantages to tumor-bearing mice by improving cancer-associated systemic syndrome
Xue Y, Religa P, Cao Rh, Hansen Aj, Lucchini F, Jones B, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2008;105(47):18513-8

Characterization of neuroprogenitor cells expressing the PDGF beta-receptor within the subventricular zone of postnatal mice
Ishii Y, Matsumoto Y, Watanabe R, Elmi M, Fujimori T, Nissen J, et al
MOLECULAR AND CELLULAR NEUROSCIENCE 2008;37(3):507-18

FOXC2 controls Ang-2 expression and modulates angiogenesis, vascular patterning, remodeling, and functions in adipose tissue
Xue Y, Cao Rh, Nilsson D, Chen Sh, Westergren R, Hedlund Em, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2008;105(29):10167-72

Hypoxia-Induced Retinal Angiogenesis in Zebrafish as a Model to Study Retinopathy
Cao Rh, Jensen Lde, Soll I, Hauptmann G, Cao Yh
PLOS ONE 2008;3(7):e2748-

Vascular Endothelial Growth Factor-A and Platelet-Derived Growth Factor-B Combination Gene Therapy Prolongs Angiogenic Effects via Recruitment of Interstitial Mononuclear Cells and Paracrine Effects Rather Than Improved Pericyte Coverage of Angiogenic Vessels
Korpisalo P, Karvinen H, Rissanen Tt, Kilpijoki J, Marjomaki V, Baluk P, et al
CIRCULATION RESEARCH 2008;103(10):1092-9

VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats
Li Y, Zhang F, Nagai Nb, Tang Zs, Zhang Sh, Scotney P, et al
JOURNAL OF CLINICAL INVESTIGATION 2008;118(3):913-23

Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis
Nissen Lj, Cao R, Hedlund Em, Wang Zw, Zhao X, Wetterskog D, et al
JOURNAL OF CLINICAL INVESTIGATION 2007;117(10):2766-77

Combinatorial protein therapy of angiogenic and arteriogenic factors remarkably improves collaterogenesis and cardiac function in pigs
Lu Hx, Xu Xs, Zhang M, Cao Rh, Brakenhielm E, Li Cj, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2007;104(29):12140-5

Filamin B deficiency in mice results in skeletal malformations and impaired microvascular development
Zhou X, Tian F, Sandzen J, Cao Rh, Flaberg E, Szekely L, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2007;104(10):3919-24

IL-20 is an arteriogenic cytokine that remodels collateral networks and improves functions of ischemic hind limbs
Tritsaris K, Myren M, Ditlev Sb, Hubschmann Mv, Van Der Blom I, Hansen Aj, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2007;104(39):15364-9

Intra- and extracellular signaling by endothelial neuregulin-1
Iivanainen E, Paatero I, Heikkinen Sm, Junttila Tt, Cao R, Klint P, et al
EXPERIMENTAL CELL RESEARCH 2007;313(13):2896-909

Tumor-derived lymphangiogenic factors and lymphatic metastasis
Cao Y, Zhong W
BIOMEDICINE & PHARMACOTHERAPY 2007;61(9):534-9

Cell-type-specific regulation of degradation of hypoxia-inducible factor 1 alpha: Role of subcellular compartmentalization
Zheng Xw, Ruas Jl, Cao Rh, Salomons Fa, Cao Yh, Poellinger L, et al
MOLECULAR AND CELLULAR BIOLOGY 2006;26(12):4628-41

Gene transfer of kringle 1-5 suppresses tumor development and improves prognosis of mice with hepatocellular carcinoma
Torimura T, Ueno T, Kin M, Taniguchi E, Nakamura T, Inoue K, et al
GASTROENTEROLOGY 2006;130(4):1301-10

Hepatocyte growth factor is a lymphanoiogenic factor with an indirect mechanism of action
Cao Rh, Bjorndahl Ma, Gallego Mi, Chen Sh, Religa P, Hansen Aj, et al
BLOOD 2006;107(9):3531-6

Direct role of PDGF-BB in lymphangiogenesis and lymphatic metastasis
Cao Yh
CELL CYCLE 2005;4(2):228-30

Genomic instability in laminopathy-based premature aging
Liu Bh, Wang Jm, Chan Km, Tjia Wm, Deng W, Guan Xy, et al
NATURE MEDICINE 2005;11(7):780-5

Insulin-like growth factors 1 and 2 induce lymphangiogenesis in vivo
Bjorndahl M, Cao Rh, Nissen Lj, Clasper S, Johnson La, Xue Y, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2005;102(43):15593-8

Presence of bone marrow-derived circulating progenitor endothelial cells in the newly formed lymphatic vessels
Religa P, Cao Rh, Bjorndahl M, Zhou Zj, Zhu Zp, Cao Yh
BLOOD 2005;106(13):4184-90

Tumor angiogenesis and therapy
Cao Y
BIOMEDICINE & PHARMACOTHERAPY 2005;:S340-3

Vascular endothelial growth factor-a promotes peritumoral lymphangiogenesis and lymphatic metastasis
Bjorndahl Ma, Cao R, Burton Jb, Brakenhielm E, Religa P, Galter D, et al
CANCER RESEARCH 2005;65(20):9261-8

Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis
Brakenhielm E, Veitonmaki N, Cao Rh, Kihara S, Matsuzawa Yj, Zhivotovsky B, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2004;101(8):2476-81

Angiogenesis inhibitor, TNP-470, prevents diet-induced and genetic obesity in mice
Brakenhielm E, Cao Rh, Gao Bh, Angelin B, Cannon B, Parini P, et al
CIRCULATION RESEARCH 2004;94(12):1579-88

Angiostatin
Cao Yh, Xue Lx
SEMINARS IN THROMBOSIS AND HEMOSTASIS 2004;30(1):83-93

Antiangiogenic cancer therapy
Cao Yh
SEMINARS IN CANCER BIOLOGY 2004;14(2):139-45

Blockage of VEGF-induced angiogenesis by preventing VEGF secretion
Bjorndahl M, Cao Rh, Eriksson A, Cao Yh
CIRCULATION RESEARCH 2004;94(11):1443-50

Comparative evaluation of FGF-2-, VEGF-A-, and VEGF-C-induced angiogenesis, lymphangiogenesis, vascular fenestrations, and permeability
Cao Rh, Eriksson A, Kubo H, Alitalo K, Cao Yh, Thyberg J
CIRCULATION RESEARCH 2004;94(5):664-70

Deletion of laminin-8 results in increased tumor neovascularization and metastasis in mice
Zhou Zj, Doi M, Wang Jm, Cao Rh, Liu Bh, Chan Km, et al
CANCER RESEARCH 2004;64(12):4059-63

Endothelial cell surface ATP synthase-triggered caspase-apoptotic pathway is essential for K1-5-Induced antiangiogenesis
Veitonmaki N, Cao R, Wu Lh, Moser Tl, Li B, Pizzo Sv, et al
CANCER RESEARCH 2004;64(10):3679-86

Impaired angiogenesis, delayed wound healing and retarded tumor growth in perlecan heparan sulfate-deficient mice
Zhou Zj, Wang Jm, Cao Rh, Morita H, Soininen R, Chan Km, et al
CANCER RESEARCH 2004;64(14):4699-702

PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis
Cao Rh, Bjorndahl Ma, Religa P, Clasper S, Garvin S, Galter D, et al
CANCER CELL 2004;6(4):333-45

Angiogenesis inhibitors and their therapeutic potentials
Cao Yh
NEW TRENDS IN CANCER FOR THE 21ST CENTURY 2003;:109-20

Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2
Cao Rh, Brakenhielm E, Pawliuk R, Wariaro D, Post Mj, Wahlberg E, et al
NATURE MEDICINE 2003;9(5):604-13

Deletion of neuropeptide Y (NPY) 2 receptor in mice results in blockage of NPY-induced angiogenesis and delayed wound healing
Ekstrand Aj, Cao Rh, Bjorndahl M, Nystrom S, Jonsson-rylander Ac, Hassani H, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2003;100(10):6033-8

Immortalization of bovine capillary endothelial cells by hTERT alone involves inactivation of endogenous p16(INK4A)/pRb
Veitonmaki N, Fuxe J, Hultdin M, Roos G, Pattersson Rf, Cao Y
FASEB JOURNAL 2003;17(2):764-6

Small GTP-binding protein Rac is an essential mediator of vascular endothelial growth factor-induced endothelial fenestrations and vascular permeability
Eriksson A, Cao Rh, Roy J, Tritsaris K, Wahlestedt C, Dissing S, et al
CIRCULATION 2003;107(11):1532-8

The angiogenesis inhibitor protease-activated kringles 1-5 reduces the severity of murine collagen-induced arthritis
Sumariwalla Pf, Cao Yh, Wu Hl, Feldmann M, Paleolog Em
ARTHRITIS RESEARCH & THERAPY 2003;5(1):R32-9

Vascular endothelial growth factor improves functional outcome and decreases secondary degeneration in experimental spinal cord contusion injury
Widenfalk J, Lipson A, Jubran M, Hofstetter C, Ebendal T, Cao Y, et al
NEUROSCIENCE 2003;120(4):951-60

Angiogenesis stimulated by PDGF-CC, a novel member in the PDGF family, involves activation of PDGFR-alpha alpha and -alpha beta receptors
Cao Rh, Brakenhielm E, Li Xr, Pietras K, Widenfalk J, Ostman A, et al
FASEB JOURNAL 2002;16(12):1575-83

Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea
Kubo H, Cao Rh, Brakenhielm E, Makinen T, Cao Yh, Alitalo K
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2002;99(13):8868-73

Continuous intravascular secretion of endostatin in mice from transduced hematopoietic stem cells
Pawliuk R, Bachelot T, Zurkiya O, Eriksson A, Cao Yh, Leboulch P
MOLECULAR THERAPY 2002;5(4):345-51

Deletion of the laminin alpha 4 chain leads to impaired microvessel maturation
Thyboll J, Kortesmaa J, Cao Rh, Soininen R, Wang L, Iivanainen A, et al
MOLECULAR AND CELLULAR BIOLOGY 2002;22(4):1194-202

Placenta growth factor-1 antagonizes VEGF-induced angiogenesis and tumor growth by the formation of functionally inactive PlGF-1/VEGF heterodimers
Eriksson A, Cao Rh, Pawliuk R, Berg Sm, Tsang M, Zhou D, et al
CANCER CELL 2002;1(1):99-108

Combination angiostatin and endostatin gene transfer induces synergistic antiangiogenic activity in vitro and antitumor efficacy in leukemia and solid tumors in mice
Scappaticci Fa, Smith R, Pathak A, Schloss D, Lum B, Cao Yh, et al
MOLECULAR THERAPY 2001;3(2):186-96

Effects of angiostatin gene transfer on functional properties and in vivo growth of Kaposi's sarcoma cells
Indraccolo S, Morini M, Gola E, Carrozzino F, Habeler W, Minghelli S, et al
CANCER RESEARCH 2001;61(14):5441-6

Embryonic stem cell-derived embryoid bodies development in collagen gels recapitulates sprouting angiogenesis
Feraud O, Cao Yh, Vittet D
LABORATORY INVESTIGATION 2001;81(12):1669-81

Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression
Makino Y, Cao Rh, Svensson K, Bertilsson Gr, Asman M, Tanaka H, et al
NATURE 2001;414(6863):550-4

Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF
Cao Rh, Brakenhielm E, Wahlestedt C, Thyberg J, Cao Yh
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2001;98(11):6390-5

Suppression of angiogenesis, tumor growth, and wound healing by resveratrol, a natural compound in red wine and grapes
Brakenhielm E, Cao Rh, Cao Yh
FASEB JOURNAL 2001;15(8):1798-800

The metastasis-associated Mts1(S100A4) protein could act as an angiogenic factor
Ambartsumian N, Klingelhofer J, Grigorian M, Christensen C, Kriajevska M, Tulchinsky E, et al
ONCOGENE 2001;20(34):4685-95

Vascular endothelial growth factor-B-deficient mice display an atrial conduction defect
Aase K, Von Euler G, Li X, Ponten A, Thoren P, Cao R, et al
CIRCULATION 2001;104(3):358-64

Elevated levels of urine angiostatin and plasminogen/plasmin in cancer patients
Cao Yh, Veitonmaki N, Keough K, Cheng H, Lee Ls, Cao Ym, et al
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 2000;5(5):547-51

Human plasmin enzymatic activity is inhibited by chemically modified dextrans
Ledoux D, Papy-garcia D, Escartin Q, Sagot Ma, Cao Yh, Barritault D, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2000;275(38):29383-90

Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I
Zhou Zj, Apte Ss, Soininen R, Cao Rh, Baaklini Gy, Rauser Rw, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2000;97(8):4052-7

IAS position paper on prevention of HIV1 mother-to-child transmission
Hirsch Ms, Wilfert C, Ammann A, Coovadia Hm, Cu-uvin S, Dabis F, et al
AIDS 1999;13(11):A5-A9

Interleukin-18 acts as an angiogenesis and tumor suppressor
Cao Rh, Farnebo J, Kurimoto M, Cao Yh
FASEB JOURNAL 1999;13(15):2195-202

Suppression of angiogenesis and tumor growth by the inhibitor K1-5 generated by plasmin-mediated proteolysis
Cao Rh, Wu Hl, Veitonmaki N, Linden P, Farnebo J, Shi Gy, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 1999;96(10):5728-33

Systemic gene delivery expands the repertoire of effective antiangiogenic agents
Liu Y, Thor A, Shtivelman E, Cao Yh, Tu Gh, Heath Td, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 1999;274(19):13338-44

Therapeutic potentials of angiostatin in the treatment of cancer
Cao Yh
HAEMATOLOGICA 1999;84(7):643-50

Expression of angiostatin cDNA in a murine fibrosarcoma suppresses primary tumor growth and produces long-term dormancy of metastases
Cao Yh, O'reilly Ms, Marshall B, Flynn E, Ji Rw, Folkman J
JOURNAL OF CLINICAL INVESTIGATION 1998;101(5):1055-63

Microbead assay: A novel assay that detects endothelial cell proliferation and inhibition
Cao Yh, Ji Rwd, Folkman J
LABORATORY INVESTIGATION 1998;78(8):1029-30

Placenta growth factor stimulates MAP kinase and mitogenicity but not phospholipase C-gamma and migration of endothelial cells expressing Flt 1
Landgren E, Schiller P, Cao Yh, Claesson-welsh L
ONCOGENE 1998;16(3):359-67

Vascular endothelial growth factor C induces angiogenesis in vivo
Cao Yh, Linden P, Farnebo J, Cao Rh, Eriksson A, Kumar V, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 1998;95(24):14389-94

Viral vector-targeted antiangiogenic gene therapy utilizing an angiostatin complementary DNA
Tanaka T, Cao Yh, Folkman J, Fine Ha
CANCER RESEARCH 1998;58(15):3362-9

Kringle 5 of plasminogen is a novel inhibitor of endothelial cell growth
Cao Yh, Chen A, An Ssa, Ji Rwd, Davidson D, Cao Ym, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 1997;272(36):22924-8

Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways
Arbiser Jl, Moses Ma, Fernandez Ca, Ghiso N, Cao Yh, Klauber N, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 1997;94(3):861-6

Placenta growth factor: Identification and characterization of a novel isoform generated by RNA alternative splicing
Cao Yh, Ji Wdr, Qi P, Rosin A, Cao Ym
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 1997;235(3):493-8

Proteolytic processing regulates receptor specificity and activity of VEGF-C
Joukov V, Sorsa T, Kumar V, Jeltsch M, Claessonwelsh L, Cao Yh, et al
EMBO JOURNAL 1997;16(13):3898-911

Distribution of acidic fibroblast growth factor-like immunoreactivity in rat skeletal muscle fibers
Junttila T, Rechardt L, Cao Yh, Hokfelt T, Peltohuikko M
BRAIN RESEARCH 1996;707(1):81-7

Heterodimers of placenta growth factor vascular endothelial growth factor - Endothelial activity, tumor cell expression, and high affinity binding to Flk-1/KDR
Cao Yh, Chen H, Zhou L, Chiang Mk, Anandapte B, Weatherbee Ja, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 1996;271(6):3154-62

In vivo angiogenic activity and hypoxia induction of heterodimers of placenta growth factor vascular endothelial growth factor
Cao Yh, Linden P, Shima D, Browne F, Folkman J
JOURNAL OF CLINICAL INVESTIGATION 1996;98(11):2507-11

Kringle domains of human angiostatin - Characterization of the anti-proliferative activity on endothelial cells
Cao Yh, Ji Rw, Davidson D, Schaller J, Marti D, Sohndel S, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 1996;271(46):29461-7

Spinal cord repair in adult paraplegic rats: Partial restoration of hind limb function
Cheng H, Cao Yh, Olson L
SCIENCE 1996;273(5274):510-3

GRO-BETA, GRO-ALPHA -C-X-C- CHEMOKINE, IS AN ANGIOGENESIS INHIBITOR THAT SUPPRESSES THE GROWTH OF LEWIS-LUNG-CARCINOMA IN MICE
Cao Yh, Chen C, Weatherbee Ja, Tsang M, Folkman J
JOURNAL OF EXPERIMENTAL MEDICINE 1995;182(6):2069-77

THE SITE OF ACTION OF NEURONAL ACIDIC FIBROBLAST GROWTH-FACTOR IS THE ORGAN OF CORTI OF THE RAT COCHLEA
Pirvola U, Cao Yh, Oellig C, Zhai Sq, Pettersson Rf, Ylikoski J
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 1995;92(20):9269-73

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