Yan Li

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About me

I studied medicine in Peking University 1996-2003 and defended my thesis entitled "Factors affecting growth, differentiation, and apoptosis of osteoblastic and osteosarcoma cells" in Karolinska Institute in 2008. I continued my research career in bone cell biology and physiology in CLINTEC after disertation. After finishing residency in orthopedic surgery in Karolinska University Hospital 2015. I moved to Gothenburg and received clinical and research training in orthopedic osseointegration for amputation reconstruction under the guidance of Prof. Rickard Brånemark.

Articles

Article: COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE. 2023;234:107502

Positive medial cortical support versus anatomical reduction for trochanteric hip fractures: Finite element analysis and biomechanical testing.

Mao W; Chang S-M; Zhang Y-Q; Li Y; Du S-C; Hu S-J; Yang A; Zhou K-H
Article: MATERIALS TODAY BIO. 2023;19:100592

Recent advances in biomimetic hemostatic materials.

Jiao S; Zhang X; Cai H; Wu S; Ou X; Han G; Zhao J; Li Y; Guo W; Liu T; Qu W
Article: INTERNATIONAL WOUND JOURNAL. 2023;20(2):516-528

The action of topical application of Vitamin B12 ointment on radiodermatitis in a porcine model.

Zhao Y-C; Wang H-Y; Li Y-F; Yang X-Y; Li Y; Wang T-J
Article: ACTA BIOMATERIALIA. 2022;152:255-272

Soft substrates promote direct chemical reprogramming of fibroblasts into neurons.

Xu Z; Li Y; Li P; Sun Y; Lv S; Wang Y; He X; Xu J; Xu Z; Li L; Li Y
Article: BONE. 2022;162:116479

Secular trends in incidence and seasonal variation of distal radius fracture among children: A nationwide study based on the Swedish National Patient Register 2002-2016.

Morohoshi A; Qureshi AR; Iseri K; Morohoshi H; Li Y; Lindholm B; Berg HE; Felländer-Tsai L
Article: ASIA-PACIFIC JOURNAL OF SPORTS MEDICINE, ARTHROSCOPY, REHABILITATION AND TECHNOLOGY. 2022;27:1-8

Timing of postoperative weightbearing in the treatment of traumatic chondral injuries of the knee in athletes - A systematic review of current concepts in clinical practice.

Rolf S; Kwan C-K; Stoddart M; Li Y; Fu S-C
Article: FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY. 2022;10:811128

Extramedullary Osseointegration-A Novel Design of Percutaneous Osseointegration Prosthesis for Amputees.

Sun Y; Xu J; Lv S; Xu Z; Li L; Li Y; Li Y
Article: BIOMATERIALS. 2021;273:120836

The bone anchored prostheses for amputees - Historical development, current status, and future aspects.

Li Y; Felländer-Tsai L
Article: STEM CELL RESEARCH & THERAPY. 2021;12(1):271

MiR-34a suppression targets Nampt to ameliorate bone marrow mesenchymal stem cell senescence by regulating NAD+-Sirt1 pathway.

Pi C; Ma C; Wang H; Sun H; Yu X; Gao X; Yang Y; Sun Y; Zhang H; Shi Y; Li Y; Li Y; He X
Article: AGING-US. 2019;11(11):3505-3522

Nicotinamide phosphoribosyltransferase postpones rat bone marrow mesenchymal stem cell senescence by mediating NAD+-Sirt1 signaling.

Pi C; Yang Y; Sun Y; Wang H; Sun H; Ma M; Lin L; Shi Y; Li Y; Li Y; He X
Article: JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS GLOBAL RESEARCH AND REVIEWS. 2019;3(1):e097

Thumb Amputations Treated With Osseointegrated Percutaneous Prostheses With Up to 25 Years of Follow-up.

Li Y; Kulbacka-Ortiz K; Caine-Winterberger K; Brånemark R
Article: ORTHOPEDICS. 2018;41(2):75-80

Percutaneous Osseointegrated Prostheses for Transfemoral Amputations.

Li Y; Lindeque B
Article: UNFALLCHIRURG. 2017;120(4):285-292

Osseointegrated prostheses for rehabilitation following amputation : The pioneering Swedish model.

Li Y; Brånemark R
Article: EXPERIMENTAL CELL RESEARCH. 2017;352(1):45-52

Nicotinamide phosphoribosyltransferase (Nampt) may serve as the marker for osteoblast differentiation of bone marrow-derived mesenchymal stem cells.

He X; He J; Shi Y; Pi C; Yang Y; Sun Y; Ma C; Lin L; Zhang L; Li Y; Li Y
Article: PLOS ONE. 2017;12(1):e0170930

Nampt Expression Decreases Age-Related Senescence in Rat Bone Marrow Mesenchymal Stem Cells by Targeting Sirt1.

Ma C; Pi C; Yang Y; Lin L; Shi Y; Li Y; Li Y; He X
Article: PLOS ONE. 2016;11(1):e0145838

Insulin-Producing Cells Differentiated from Human Bone Marrow Mesenchymal Stem Cells In Vitro Ameliorate Streptozotocin-Induced Diabetic Hyperglycemia.

Xin Y; Jiang X; Wang Y; Su X; Sun M; Zhang L; Tan Y; Wintergerst KA; Li Y; Li Y
Article: CALCIFIED TISSUE INTERNATIONAL. 2013;93(6):556-564

FGF23 affects the lineage fate determination of mesenchymal stem cells.

Li Y; He X; Olauson H; Larsson TE; Lindgren U
Article: JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH. 2013;8:30

Diclofenac and triamcinolone acetonide impair tenocytic differentiation and promote adipocytic differentiation of mesenchymal stem cells.

Fredriksson M; Li Y; Stålman A; Haldosén L-A; Felländer-Tsai L
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2013;434(1):117-123

Nampt expression increases during osteogenic differentiation of multi- and omnipotent progenitors.

Li Y; He J; He X; Li Y; Lindgren U
Article: JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH. 2012;7:17

The direct anterior approach: initial experience of a minimally invasive technique for total hip arthroplasty.

Hallert O; Li Y; Brismar H; Lindgren U
Article: JOURNAL OF BONE AND MINERAL RESEARCH. 2011;26(11):2656-2664

Nicotinamide phosphoribosyltransferase (Nampt) affects the lineage fate determination of mesenchymal stem cells: a possible cause for reduced osteogenesis and increased adipogenesis in older individuals.

Li Y; He X; Li Y; He J; Anderstam B; Andersson G; Lindgren U
Article: JOURNAL OF BIOMEDICAL SCIENCE. 2011;18(1):59

High efficient isolation and systematic identification of human adipose-derived mesenchymal stem cells.

Yang X-F; He X; He J; Zhang L-H; Su X-J; Dong Z-Y; Xu Y-J; Li Y; Li Y-L
Article: ACTA BIOMATERIALIA. 2011;7(2):751-758

Resveratrol-conjugated poly-ε-caprolactone facilitates in vitro mineralization and in vivo bone regeneration.

Li Y; Dånmark S; Edlund U; Finne-Wistrand A; He X; Norgård M; Blomén E; Hultenby K; Andersson G; Lindgren U
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;401(3):356-362

Resveratrol prevents RANKL-induced osteoclast differentiation of murine osteoclast progenitor RAW 264.7 cells through inhibition of ROS production.

He X; Andersson G; Lindgren U; Li Y
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2009;609(1-3):13-18

Resveratrol inhibits proliferation and promotes apoptosis of osteosarcoma cells.

Li Y; Bäckesjö C-M; Haldosén L-A; Lindgren U
Article: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2008;112(1-3):110-116

Species difference exists in the effects of 1alpha,25(OH)(2)D(3) and its analogue 2-methylene-19-nor-(20S)-1,25-dihydroxyvitamin D(3) (2MD) on osteoblastic cells.

Li Y; Bäckesjö C-M; Haldosén L-A; Lindgren U
Article: CYTOKINE. 2008;43(2):165-173

IL-6 receptor expression and IL-6 effects change during osteoblast differentiation.

Li Y; Bäckesjö C-M; Haldosén L-A; Lindgren U
Article: JOURNAL OF BONE AND MINERAL RESEARCH. 2006;21(7):993-1002

Activation of Sirt1 decreases adipocyte formation during osteoblast differentiation of mesenchymal stem cells.

Bäckesjö C-M; Li Y; Lindgren U; Haldosén L-A
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All other publications

Letter: INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED. 2022;53(12):4165-4168

Growth Differentiation Factor 7 promotes multiple-lineage differentiation in tenogenic cultures of mesenchymal stem cells.

Kumlin M; Lindberg K; Haldosen L-A; Felländer-Tsai L; Li Y
Published paper: CELLS TISSUES ORGANS. 2009;189(1-4):93-97

Activation of Sirt1 decreases adipocyte formation during osteoblast differentiation of mesenchymal stem cells.

Bäckesjö C-M; Li Y; Lindgren U; Haldosén L-A

Employments

Affiliated to Research, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, 2023-2026

Degrees and Education

Docent, Karolinska Institutet, 2021
Degree Of Doctor Of Philosophy, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, 2008

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