Urban Lendahl

About me
Publications
Grants
Public outreach and news

About me

Professor of Genetics.

Research

Notch signalling, cancer biology, vascular biology, developmental biology

Articles

Article: BREAST CANCER RESEARCH. 2024;26(1):4

Identification of a Notch transcriptomic signature for breast cancer.

Braune E-B; Geist F; Tang X; Kalari K; Boughey J; Wang L; Leon-Ferre RA; D'Assoro AB; Ingle JN; Goetz MP; Kreis J; Wang K; Foukakis T; Seshire A; Wienke D; Lendahl U
Article: NEURON. 2023;111(23):3745-3764.e7

Molecular anatomy of adult mouse leptomeninges.

Pietilä R; Del Gaudio F; He L; Vázquez-Liébanas E; Vanlandewijck M; Muhl L; Mocci G; Bjørnholm KD; Lindblad C; Fletcher-Sandersjöö A; Svensson M; Thelin EP; Liu J; van Voorden AJ; Torres M; Antila S; Xin L; Karlström H; Storm-Mathisen J; Bergersen LH; Moggio A; Hansson EM; Ulvmar MH; Nilsson P; Mäkinen T; Andaloussi Mäe M; Alitalo K; Proulx ST; Engelhardt B; McDonald DM; Lendahl U; Andrae J; Betsholtz C
Journal article: MOLECULAR CANCER THERAPEUTICS. 2023;22(12_Supplement):b013

Abstract B013: Identification of a Notch transcriptomic signature for breast cancer

Braune E-B; Geist F; Tang X; Kalari K; Boughey J; Wang L; Leon-Ferre RA; D’Assoro AB; Ingle JN; Goetz MP; Wang K; Foukakis T; Seshire A; Wienke D; Lendahl U
Journal article: SCIENTIFIC REPORTS. 2023;13(1):15022

Left ventricular hypertrophy and metabolic resetting in the Notch3-deficient adult mouse heart.

Del Gaudio F; Liu D; Andaloussi Mäe M; Braune E-B; Hansson EM; Wang Q-D; Betsholtz C; Lendahl U
Article: CELL REPORTS METHODS. 2023;3(3):100431

A robust and efficient microvascular isolation method for multimodal characterization of the mouse brain vasculature.

Bjørnholm KD; Del Gaudio F; Li H; Li W; Vazquez-Liebanas E; Mäe MA; Lendahl U; Betsholtz C; Nilsson P; Karlström H; Vanlandewijck M
Article: EMBO MOLECULAR MEDICINE. 2023;15(2):e16556

Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model.

Oliveira DV; Coupland KG; Shao W; Jin S; Del Gaudio F; Wang S; Fox R; Rutten JW; Sandin J; Zetterberg H; Lundkvist J; Lesnik Oberstein SA; Lendahl U; Karlström H
Article: EMBO MOLECULAR MEDICINE. 2022;14(12):e15809

Sex differences and risk factors for bleeding in Alagille syndrome.

Hankeova S; Van Hul N; Laznovsky J; Verboven E; Mangold K; Hensens N; Adori C; Verhoef E; Zikmund T; Dawit F; Kavkova M; Salplachta J; Sjöqvist M; Johansson BR; Hassan MG; Fredriksson L; Baumgärtel K; Bryja V; Lendahl U; Jheon A; Alten F; Fahnehjelm KT; Fischler B; Kaiser J; Andersson ER
Article: DEVELOPMENTAL CELL. 2022;57(20):2426-2443.e6

A single-cell transcriptomic inventory of murine smooth muscle cells.

Muhl L; Mocci G; Pietilä R; Liu J; He L; Genové G; Leptidis S; Gustafsson S; Buyandelger B; Raschperger E; Hansson EM; Björkegren JLM; Vanlandewijck M; Lendahl U; Betsholtz C
Journal article: NATURE. 2022;610(7930):E1

Author Correction: Specification of CNS macrophage subsets occurs postnatally in defined niches.

Masuda T; Amann L; Monaco G; Sankowski R; Staszewski O; Krueger M; Del Gaudio F; He L; Paterson N; Nent E; Fernández-Klett F; Yamasaki A; Frosch M; Fliegauf M; Bosch LFP; Ulupinar H; Hagemeyer N; Schreiner D; Dorrier C; Tsuda M; Grothe C; Joutel A; Daneman R; Betsholtz C; Lendahl U; Knobeloch K-P; Lämmermann T; Priller J; Kierdorf K; Prinz M
Journal article: CANCER RESEARCH. 2022;82(12_Supplement):3351

Abstract 3351: Identification of a NOTCH transcriptomic signature for basal-like breast cancer

Braune E-B; Geist F; Wienke D; Seshire A; Lendahl U
Journal article: STEM CELL REPORTS. 2022;17(6):1248-1267

100 plus years of stem cell research-20 years of ISSCR.

Lendahl U
Journal article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(11):6241

Roles of Notch Signaling in the Tumor Microenvironment.

D'Assoro AB; Leon-Ferre R; Braune E-B; Lendahl U
Article: STEM CELL REPORTS. 2022;17(5):1089-1104

The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells: Implications for COVID-19 vascular research.

Muhl L; He L; Sun Y; Andaloussi Mäe M; Pietilä R; Liu J; Genové G; Zhang L; Xie Y; Leptidis S; Mocci G; Stritt S; Osman A; Anisimov A; Hemanthakumar KA; Räsänen M; Hansson EM; Björkegren J; Vanlandewijck M; Blomgren K; Mäkinen T; Peng X-R; Hu Y; Ernfors P; Arnold TD; Alitalo K; Lendahl U; Betsholtz C
Journal article: NATURE. 2022;604(7907):740-748

Specification of CNS macrophage subsets occurs postnatally in defined niches.

Masuda T; Amann L; Monaco G; Sankowski R; Staszewski O; Krueger M; Del Gaudio F; He L; Paterson N; Nent E; Fernández-Klett F; Yamasaki A; Frosch M; Fliegauf M; Bosch LFP; Ulupinar H; Hagemeyer N; Schreiner D; Dorrier C; Tsuda M; Grothe C; Joutel A; Daneman R; Betsholtz C; Lendahl U; Knobeloch K-P; Lämmermann T; Priller J; Kierdorf K; Prinz M
Journal article: OPEN BIOLOGY. 2022;12(4):220004

Notch signalling in healthy and diseased vasculature.

Del Gaudio F; Liu D; Lendahl U
Article: EBIOMEDICINE. 2021;74:103689

Biliary Atresia - emerging diagnostic and therapy opportunities.

Lendahl U; Lui VCH; Chung PHY; Tam PKH
Article: BMC BIOLOGY. 2021;19(1):229

MIEF1/2 orchestrate mitochondrial dynamics through direct engagement with both the fission and fusion machineries.

Yu R; Liu T; Jin S-B; Ankarcrona M; Lendahl U; Nistér M; Zhao J
Article: CELL REPORTS METHODS. 2021;1(4):100043

Highly efficient manipulation of nervous system gene expression with NEPTUNE.

Mangold K; Mašek J; He J; Lendahl U; Fuchs E; Andersson ER
Article: NEUROLOGY-GENETICS. 2021;7(3):e584

Novel Cysteine-Sparing Hypomorphic NOTCH3 A1604T Mutation Observed in a Family With Migraine and White Matter Lesions.

Arnardottir S; Del Gaudio F; Klironomos S; Braune E-B; Lombraña AA; Oliveira DV; Jin S; Karlström H; Lendahl U; Sjöstrand C
Article: ELIFE. 2021;10:e60916

DUCT reveals architectural mechanisms contributing to bile duct recovery in a mouse model for Alagille syndrome.

Hankeova S; Salplachta J; Zikmund T; Kavkova M; Van Hul N; Brinek A; Smekalova V; Laznovsky J; Dawit F; Jaros J; Bryja V; Lendahl U; Ellis E; Nemeth A; Fischler B; Hannezo E; Kaiser J; Andersson ER
Article: DISEASE MODELS & MECHANISMS. 2021;14(2):dmm046300

The infantile myofibromatosis NOTCH3 L1519P mutation leads to hyperactivated ligand-independent Notch signaling and increased PDGFRB expression.

Wu D; Wang S; Oliveira DV; Del Gaudio F; Vanlandewijck M; Lebouvier T; Betsholtz C; Zhao J; Jin S; Lendahl U; Karlström H
Journal article: STEM CELL REPORTS. 2021;16(1):1-2

Mentorship in Science: Response to AlShebli et al., Nature Communications 2020.

Mummery C; Little M; Lin H; Clark A; Zaret K; ISSCR Board 2020–2021; Srivastava D; Fuchs E; Watt F; Temple S
Journal article: MOLECULAR THERAPY. 2021;29(1):409

Human ISL1+ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction.

Foo KS; Lehtinen ML; Leung CY; Lian X; Xu J; Keung W; Geng L; Kolstad TRS; Thams S; Wong AO-T; Wong N; Bylund K; Zhou C; He X; Jin S-B; Clarke J; Lendahl U; Li RA; Louch WE; Chien KR
Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2021;9:706687

The Molecular Assembly State of Drp1 Controls its Association With the Mitochondrial Recruitment Receptors Mff and MIEF1/2.

Yu R; Jin S-B; Ankarcrona M; Lendahl U; Nistér M; Zhao J
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2021;296:100593

PIM-induced phosphorylation of Notch3 promotes breast cancer tumorigenicity in a CSL-independent fashion.

Landor SKJ; Santio NM; Eccleshall WB; Paramonov VM; Gagliani EK; Hall D; Jin S-B; Dahlström KM; Salminen TA; Rivero-Müller A; Lendahl U; Kovall RA; Koskinen PJ; Sahlgren C
Article: JOURNAL OF HEPATOLOGY. 2020;73(6):1391-1403

Beta-amyloid deposition around hepatic bile ducts is a novel pathobiological and diagnostic feature of biliary atresia.

Babu RO; Lui VCH; Chen Y; Yiu RSW; Ye Y; Niu B; Wu Z; Zhang R; Yu MON; Chung PHY; Wong KKY; Xia H; Zhang MQ; Wang B; Lendahl U; Tam PKH
Article: EXPERIMENTAL CELL RESEARCH. 2020;395(1):112156

Notch activation in the mouse mammary luminal lineage leads to ductal hyperplasia and altered partitioning of luminal cell subtypes.

Phoon YP; Chivukula IV; Tsoi YL; Kanatani S; Uhlén P; Kuiper R; Lendahl U
Article: NATURE COMMUNICATIONS. 2020;11(1):3953

Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination.

Muhl L; Genové G; Leptidis S; Liu J; He L; Mocci G; Sun Y; Gustafsson S; Buyandelger B; Chivukula IV; Segerstolpe Å; Raschperger E; Hansson EM; Björkegren JLM; Peng X-R; Vanlandewijck M; Lendahl U; Betsholtz C
Journal article: JOURNAL OF HEPATOLOGY. 2020;73:s43

AS058 Double resin casting micro computed tomography (CT) reveals biliary and vascular pathology in tandem in a mouse model for alagille syndrome

Hankeova S; Salplachta J; Zikmund T; Kavkova M; Van Hul NKM; Brinek A; Smekalova V; Laznovsky J; Jaros J; Bryja V; Lendahl U; Ellis E; Hannezo E; Kaiser J; Andersson E
Journal article: JOURNAL OF HEPATOLOGY. 2020;73:s542

FRI286 Cracking the notch code in alagille syndrome: single-cell receptor-ligand interactions and outcomes in vivo, and an emerging role of immune cells

Mašek J; Hankeova S; Jin S-B; Lendahl U; Andersson E
Article: DEVELOPMENT. 2020;147(4):dev183665

Notch signalling regulates epibranchial placode patterning and segregation.

Wang L; Xie J; Zhang H; Tsang LH; Tsang SL; Braune E-B; Lendahl U; Sham MH
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2019;294(46):17262-17277

The phosphorylation status of Ser-637 in dynamin-related protein 1 (Drp1) does not determine Drp1 recruitment to mitochondria.

Yu R; Liu T; Ning C; Tan F; Jin S-B; Lendahl U; Zhao J; Nistér M
Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2019;111(9):983-995

Impact of Epithelial-Stromal Interactions on Peritumoral Fibroblasts in Ductal Carcinoma in Situ.

Strell C; Paulsson J; Jin S-B; Tobin NP; Mezheyeuski A; Roswall P; Mutgan C; Mitsios N; Johansson H; Wickberg SM; Svedlund J; Nilsson M; Hall P; Mulder J; Radisky DC; Pietras K; Bergh J; Lendahl U; Wärnberg F; Östman A
Article: MATRIX BIOLOGY. 2019;81:107-121

Cartilage Oligomeric Matrix Protein initiates cancer stem cells through activation of Jagged1-Notch3 signaling.

Papadakos KS; Bartoschek M; Rodriguez C; Gialeli C; Jin S-B; Lendahl U; Pietras K; Blom AM
Article: EMBO JOURNAL. 2019;38(8):e99748

Human Fis1 regulates mitochondrial dynamics through inhibition of the fusion machinery.

Yu R; Jin S-B; Lendahl U; Nistér M; Zhao J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(14):6985-6994

Triggering of a Dll4-Notch1 loop impairs wound healing in diabetes.

Zheng X; Narayanan S; Sunkari VG; Eliasson S; Botusan IR; Grünler J; Catrina AI; Radtke F; Xu C; Zhao A; Ekberg NR; Lendahl U; Catrina S-B
Article: DEVELOPMENT. 2019;146(2):dev165589

Peri-arterial specification of vascular mural cells from naïve mesenchyme requires Notch signaling.

Ando K; Wang W; Peng D; Chiba A; Lagendijk AK; Barske L; Crump JG; Stainier DYR; Lendahl U; Koltowska K; Hogan BM; Fukuhara S; Mochizuki N; Betsholtz C
Article: METHODS IN MOLECULAR BIOLOGY. 2019;1981:203-236

Mouse Models for Diseases in the Cholangiocyte Lineage.

Van Hul N; Lendahl U; Andersson ER
Article: ONCOGENE. 2018;37(46):6083-6095

Notch signaling promotes a HIF2α-driven hypoxic response in multiple tumor cell types.

Mutvei AP; Landor SK-J; Fox R; Braune E-B; Tsoi YL; Phoon YP; Sahlgren C; Hartman J; Bergh J; Jin S; Lendahl U
Article: SCIENTIFIC DATA. 2018;5:180160

Single-cell RNA sequencing of mouse brain and lung vascular and vessel-associated cell types.

He L; Vanlandewijck M; Mäe MA; Andrae J; Ando K; Del Gaudio F; Nahar K; Lebouvier T; Laviña B; Gouveia L; Sun Y; Raschperger E; Segerstolpe Å; Liu J; Gustafsson S; Räsänen M; Zarb Y; Mochizuki N; Keller A; Lendahl U; Betsholtz C
Article: MOLECULAR THERAPY. 2018;26(7):1644-1659

Human ISL1+ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction.

Foo KS; Lehtinen ML; Leung CY; Lian X; Xu J; Keung W; Geng L; Kolstad TRS; Thams S; Wong AO-T; Wong N; Bylund K; Zhou C; He X; Jin S-B; Clarke J; Lendahl U; Li RA; Louch WE; Chien KR
Article: BLOOD. 2018;131(15):1712-1719

Canonical Notch signaling is dispensable for adult steady-state and stress myelo-erythropoiesis.

Duarte S; Woll PS; Buza-Vidas N; Chin DWL; Boukarabila H; Luís TC; Stenson L; Bouriez-Jones T; Ferry H; Mead AJ; Atkinson D; Jin S; Clark S-A; Wu B; Repapi E; Gray N; Taylor S; Mutvei AP; Tsoi YL; Nerlov C; Lendahl U; Jacobsen SEW
Article: GASTROENTEROLOGY. 2018;154(4):1080-1095

Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations.

Andersson ER; Chivukula IV; Hankeova S; Sjöqvist M; Tsoi YL; Ramsköld D; Masek J; Elmansuri A; Hoogendoorn A; Vazquez E; Storvall H; Netušilová J; Huch M; Fischler B; Ellis E; Contreras A; Nemeth A; Chien KC; Clevers H; Sandberg R; Bryja V; Lendahl U
Article: NATURE. 2018;554(7693):475-480

A molecular atlas of cell types and zonation in the brain vasculature.

Vanlandewijck M; He L; Mäe MA; Andrae J; Ando K; Del Gaudio F; Nahar K; Lebouvier T; Laviña B; Gouveia L; Sun Y; Raschperger E; Räsänen M; Zarb Y; Mochizuki N; Keller A; Lendahl U; Betsholtz C
Article: ELIFE. 2017;6:e30126

An Eya1-Notch axis specifies bipotential epibranchial differentiation in mammalian craniofacial morphogenesis.

Zhang H; Wang L; Wong EYM; Tsang SL; Xu P-X; Lendahl U; Sham MH
Journal article: EXPERIMENTAL CELL RESEARCH. 2017;360(1):1

Introduction.

Lendahl U
Article: EXPERIMENTAL CELL RESEARCH. 2017;356(2):146-151

The interplay between the cellular hypoxic response and Notch signaling.

Landor SK-J; Lendahl U
Article: SCIENTIFIC REPORTS. 2017;7(1):880

MIEF1/2 function as adaptors to recruit Drp1 to mitochondria and regulate the association of Drp1 with Mff.

Yu R; Liu T; Jin S-B; Ning C; Lendahl U; Nistér M; Zhao J
Article: NEUROSCIENCE RESEARCH. 2016;109:9-15

Endogenous APP accumulates in synapses after BACE1 inhibition.

Nigam SM; Xu S; Ackermann F; Gregory JA; Lundkvist J; Lendahl U; Brodin L
Article: ONCOTARGET. 2016;7(28):43220-43238

Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells.

Santio NM; Landor SK-J; Vahtera L; Ylä-Pelto J; Paloniemi E; Imanishi SY; Corthals G; Varjosalo M; Manoharan GB; Uri A; Lendahl U; Sahlgren C; Koskinen PJ
Article: STEM CELL REPORTS. 2016;6(5):643-651

Loss of CSL Unlocks a Hypoxic Response and Enhanced Tumor Growth Potential in Breast Cancer Cells.

Braune E-B; Tsoi YL; Phoon YP; Landor S; Silva Cascales H; Ramsköld D; Deng Q; Lindqvist A; Lian X; Sahlgren C; Jin S-B; Lendahl U
Article: DISCOVERY MEDICINE. 2016;21(115):189-196

Notch -- a goldilocks signaling pathway in disease and cancer therapy.

Braune E-B; Lendahl U
Journal article: LAKARTIDNINGEN. 2015;112:DRCD

[2015 Nobel Prize in Physiology or Medicine. Better health for millions of people thanks to drugs against parasites].

Andersson J; Lendahl U; Forssberg H
Journal article: EXPERIMENTAL CELL RESEARCH. 2015;337(2):v

Cell Biology at High Resolution

Lendahl U
Article: BREAST CANCER RESEARCH. 2015;17(1):109

Decoding breast cancer tissue-stroma interactions using species-specific sequencing.

Chivukula IV; Ramsköld D; Storvall H; Anderberg C; Jin S; Mamaeva V; Sahlgren C; Pietras K; Sandberg R; Lendahl U
Article: BMC CANCER. 2015;15:311

Frequency and distribution of Notch mutations in tumor cell lines.

Mutvei AP; Fredlund E; Lendahl U
Article: JOURNAL OF NEUROCHEMISTRY. 2015;132(4):477-486

Revisiting the peripheral sink hypothesis: inhibiting BACE1 activity in the periphery does not alter β-amyloid levels in the CNS.

Georgievska B; Gustavsson S; Lundkvist J; Neelissen J; Eketjäll S; Ramberg V; Bueters T; Agerman K; Juréus A; Svensson S; Berg S; Fälting J; Lendahl U
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2015;35(2):409-420

Notch3 is necessary for blood vessel integrity in the central nervous system.

Henshall TL; Keller A; He L; Johansson BR; Wallgard E; Raschperger E; Mäe MA; Jin S; Betsholtz C; Lendahl U
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2014;71(19):3841-3857

Cell surface antigen profiling using a novel type of antibody array immobilised to plasma ion-implanted polycarbonate.

Main H; Radenkovic J; Kosobrodova E; McKenzie D; Bilek M; Lendahl U
Article: CELL RESEARCH. 2014;24(4):433-450

PKCζ regulates Notch receptor routing and activity in a Notch signaling-dependent manner.

Sjöqvist M; Antfolk D; Ferraris S; Rraklli V; Haga C; Antila C; Mutvei A; Imanishi SY; Holmberg J; Jin S; Eriksson JE; Lendahl U; Sahlgren C
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2014;289(3):1540-1550

Characterization of intermediate steps in amyloid beta (Aβ) production under near-native conditions.

Olsson F; Schmidt S; Althoff V; Munter LM; Jin S; Rosqvist S; Lendahl U; Multhaup G; Lundkvist J
Article: EXPERIMENTAL CELL RESEARCH. 2013;319(18):2893-2904

The mitochondrial elongation factors MIEF1 and MIEF2 exert partially distinct functions in mitochondrial dynamics.

Liu T; Yu R; Jin S-B; Han L; Lendahl U; Zhao J; Nistér M
Article: ONCOGENE. 2013;32(41):4892-4902

Non-canonical Notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKKα/IKKβ.

Jin S; Mutvei AP; Chivukula IV; Andersson ER; Ramsköld D; Sandberg R; Lee KL; Kronqvist P; Mamaeva V; Ostling P; Mpindi J-P; Kallioniemi O; Screpanti I; Poellinger L; Sahlgren C; Lendahl U
Article: STEM CELLS AND DEVELOPMENT. 2013;22(9):1360-1369

Hypoxia-induced arterial differentiation requires adrenomedullin and notch signaling.

Lanner F; Lee KL; Ortega GC; Sohl M; Li X; Jin S; Hansson EM; Claesson-Welsh L; Poellinger L; Lendahl U; Farnebo F
Article: STEM CELLS. 2013;31(4):741-751

A critical role for Sox9 in notch-induced astrogliogenesis and stem cell maintenance.

Martini S; Bernoth K; Main H; Ortega GDC; Lendahl U; Just U; Schwanbeck R
Article: PLOS ONE. 2013;8(5):e62959

Notch signaling maintains neural rosette polarity.

Main H; Radenkovic J; Jin S-B; Lendahl U; Andersson ER
Article: JOURNAL OF NEUROSCIENCE. 2012;32(48):17297-17305

Alzheimer's disease: presenilin 2-sparing γ-secretase inhibition is a tolerable Aβ peptide-lowering strategy.

Borgegård T; Gustavsson S; Nilsson C; Parpal S; Klintenberg R; Berg A-L; Rosqvist S; Serneels L; Svensson S; Olsson F; Jin S; Yan H; Wanngren J; Jureus A; Ridderstad-Wollberg A; Wollberg P; Stockling K; Karlström H; Malmberg A; Lund J; Arvidsson PI; De Strooper B; Lendahl U; Lundkvist J
Journal article: ALZHEIMERS & DEMENTIA. 2012;8(4S_Part_19):p703-p704

P4‐192: Mechanism of gamma‐secretase‐mediated APP processing and modulation

Lundkvist J; Olsson F; Schmidt S; Althoff V; Jin S; Lendahl U; Multhaup G; Arvidsson P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(46):18814-18819

Hypo- and hyperactivated Notch signaling induce a glycolytic switch through distinct mechanisms.

Landor SK-J; Mutvei AP; Mamaeva V; Jin S; Busk M; Borra R; Grönroos TJ; Kronqvist P; Lendahl U; Sahlgren CM
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2011;413(3):426-431

Numblike and Numb differentially affect p53 and Sonic Hedgehog signaling.

Liu L; Lanner F; Lendahl U; Das D
Article: EMBO JOURNAL. 2011;30(14):2762-2778

Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission.

Zhao J; Liu T; Jin S; Wang X; Qu M; Uhlén P; Tomilin N; Shupliakov O; Lendahl U; Nistér M
Article: JOURNAL OF THEORETICAL BIOLOGY. 2011;268(1):62-76

Modelling cell lineage using a meta-Boolean tree model with a relation to gene regulatory networks.

Larsson J-K; Wadströmer N; Hermanson O; Lendahl U; Forchheimer R
Article: DEVELOPMENTAL BIOLOGY. 2010;348(2):153-166

Notch induces cyclin-D1-dependent proliferation during a specific temporal window of neural differentiation in ES cells.

Das D; Lanner F; Main H; Andersson ER; Bergmann O; Sahlgren C; Heldring N; Hermanson O; Hansson EM; Lendahl U
Article: JOURNAL OF CELL SCIENCE. 2010;123(Pt 17):2931-2942

Control of Notch-ligand endocytosis by ligand-receptor interaction.

Hansson EM; Lanner F; Das D; Mutvei A; Marklund U; Ericson J; Farnebo F; Stumm G; Stenmark H; Andersson ER; Lendahl U
Article: EXPERIMENTAL CELL RESEARCH. 2010;316(9):1610-1624

Interactions between Notch- and hypoxia-induced transcriptomes in embryonic stem cells.

Main H; Lee KL; Yang H; Haapa-Paananen S; Edgren H; Jin S; Sahlgren C; Kallioniemi O; Poellinger L; Lim B; Lendahl U
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;393(1):21-27

Evidence for dimeric BACE-mediated APP processing.

Jin S; Agerman K; Kolmodin K; Gustafsson E; Dahlqvist C; Jureus A; Liu G; Fälting J; Berg S; Lundkvist J; Lendahl U
Article: DEVELOPMENT. 2010;137(3):437-445

Domain-specific control of neurogenesis achieved through patterned regulation of Notch ligand expression.

Marklund U; Hansson EM; Sundström E; de Angelis MH; Przemeck GKH; Lendahl U; Muhr J; Ericson J
Article: JOURNAL OF STEM CELLS AND REGENERATIVE MEDICINE. 2010;6(2):88

Notch1 signaling promotes neuro-ectodermal differentiation of embryonic stem cells via the Notch target gene Sox9.

Martini S; Schwanbeck R; Main H; Lendahl U; Just U
Article: JOURNAL OF INTERNAL MEDICINE. 2009;266(4):303-310

Regenerative medicine: a 2009 overview.

Andersson ER; Lendahl U
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2009;284(39):26928-26940

YB-1 acts as a ligand for Notch-3 receptors and modulates receptor activation.

Rauen T; Raffetseder U; Frye BC; Djudjaj S; Mühlenberg PJT; Eitner F; Lendahl U; Bernhagen J; Dooley S; Mertens PR
Article: JOURNAL OF CELL SCIENCE. 2009;122(Pt 13):2252-2262

The novel conserved mitochondrial inner-membrane protein MTGM regulates mitochondrial morphology and cell proliferation.

Zhao J; Liu T; Jin S-B; Tomilin N; Castro J; Shupliakov O; Lendahl U; Nistér M
Article: ONCOGENE. 2008;27(44):5833-5844

Notch-1 associates with IKKalpha and regulates IKK activity in cervical cancer cells.

Song LL; Peng Y; Yun J; Rizzo P; Chaturvedi V; Weijzen S; Kast WM; Stone PJB; Santos L; Loredo A; Lendahl U; Sonenshein G; Osborne B; Qin J-Z; Pannuti A; Nickoloff BJ; Miele L
Article: CANCER RESEARCH. 2008;68(13):5226-5235

Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches.

Rizzo P; Miao H; D'Souza G; Osipo C; Song LL; Yun J; Zhao H; Mascarenhas J; Wyatt D; Antico G; Hao L; Yao K; Rajan P; Hicks C; Siziopikou K; Selvaggi S; Bashir A; Bhandari D; Marchese A; Lendahl U; Qin J-Z; Tonetti DA; Albain K; Nickoloff BJ; Miele L
Article: CIRCULATION RESEARCH. 2008;102(12):1483-1491

Notch signaling regulates platelet-derived growth factor receptor-beta expression in vascular smooth muscle cells.

Jin S; Hansson EM; Tikka S; Lanner F; Sahlgren C; Farnebo F; Baumann M; Kalimo H; Lendahl U
Article: DEVELOPMENT. 2008;135(10):1843-1851

SoxB1 transcription factors and Notch signaling use distinct mechanisms to regulate proneural gene function and neural progenitor differentiation.

Holmberg J; Hansson E; Malewicz M; Sandberg M; Perlmann T; Lendahl U; Muhr J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(17):6392-6397

Notch signaling mediates hypoxia-induced tumor cell migration and invasion.

Sahlgren C; Gustafsson MV; Jin S; Poellinger L; Lendahl U
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(9):3368-3373

Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways.

Zheng X; Linke S; Dias JM; Zheng X; Gradin K; Wallis TP; Hamilton BR; Gustafsson M; Ruas JL; Wilkins S; Bilton RL; Brismar K; Whitelaw ML; Pereira T; Gorman JJ; Ericson J; Peet DJ; Lendahl U; Poellinger L
Article: EXPERIMENTAL CELL RESEARCH. 2007;313(14):3141-3152

Notch signaling induces SKP2 expression and promotes reduction of p27Kip1 in T-cell acute lymphoblastic leukemia cell lines.

Dohda T; Maljukova A; Liu L; Heyman M; Grandér D; Brodin D; Sangfelt O; Lendahl U
Article: CANCER RESEARCH. 2007;67(12):5611-5616

The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling.

Malyukova A; Dohda T; von der Lehr N; Akhoondi S; Corcoran M; Heyman M; Spruck C; Grandér D; Lendahl U; Sangfelt O
Journal article: EXPERIMENTAL CELL RESEARCH. 2007;313(10):1979-1980

Special issue: Intermediate filaments

Omary MB; Herrmann H; Lendahl U
Article: JOURNAL OF CELL BIOLOGY. 2006;175(4):535-540

High levels of Notch signaling down-regulate Numb and Numblike.

Chapman G; Liu L; Sahlgren C; Dahlqvist C; Lendahl U
Article: DEVELOPMENTAL NEUROSCIENCE. 2006;28(1-2):118-127

Recording Notch signaling in real time.

Hansson EM; Teixeira AI; Gustafsson MV; Dohda T; Chapman G; Meletis K; Muhr J; Lendahl U
Article: JOURNAL OF NEUROCHEMISTRY. 2005;95(3):880-890

gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity.

Strömberg K; Hansson EM; Laudon H; Bergstedt S; Näslund J; Lundkvist J; Lendahl U
Article: DEVELOPMENTAL CELL. 2005;9(5):617-628

Hypoxia requires notch signaling to maintain the undifferentiated cell state.

Gustafsson MV; Zheng X; Pereira T; Gradin K; Jin S; Lundkvist J; Ruas JL; Poellinger L; Lendahl U; Bondesson M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(42):35352-35360

A nine-transmembrane domain topology for presenilin 1.

Laudon H; Hansson EM; Melén K; Bergman A; Farmery MR; Winblad B; Lendahl U; von Heijne G; Näslund J
Article: JOURNAL OF NEUROCHEMISTRY. 2005;92(5):1010-1020

Aph-1 interacts at the cell surface with proteins in the active gamma-secretase complex and membrane-tethered Notch.

Hansson EM; Strömberg K; Bergstedt S; Yu G; Näslund J; Lundkvist J; Lendahl U
Article: GENESIS. 2005;41(1):13-22

Mice carrying a R142C Notch 3 knock-in mutation do not develop a CADASIL-like phenotype.

Lundkvist J; Zhu S; Hansson EM; Schweinhardt P; Miao Q; Beatus P; Dannaeus K; Karlström H; Johansson CB; Viitanen M; Rozell B; Spenger C; Mohammed A; Kalimo H; Lendahl U
Article: NATURE GENETICS. 2004;36(9):925-927

The European dimension for the mouse genome mutagenesis program.

Auwerx J; Avner P; Baldock R; Ballabio A; Balling R; Barbacid M; Berns A; Bradley A; Brown S; Carmeliet P; Chambon P; Cox R; Davidson D; Davies K; Duboule D; Forejt J; Granucci F; Hastie N; de Angelis MH; Jackson I; Kioussis D; Kollias G; Lathrop M; Lendahl U; Malumbres M; von Melchner H; Müller W; Partanen J; Ricciardi-Castagnoli P; Rigby P; Rosen B; Rosenthal N; Skarnes B; Stewart AF; Thornton J; Tocchini-Valentini G; Wagner E; Wahli W; Wurst W
Article: DEVELOPMENTAL BRAIN RESEARCH. 2004;151(1-2):13-23

Nestin expression is lost in a neural stem cell line through a mechanism involving the proteasome and Notch signalling.

Mellodew K; Suhr R; Uwanogho DA; Reuter I; Lendahl U; Hodges H; Price J
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(23):23925-23932

Functional domains in presenilin 1: the Tyr-288 residue controls gamma-secretase activity and endoproteolysis.

Laudon H; Karlström H; Mathews PM; Farmery MR; Gandy SE; Lundkvist J; Lendahl U; Näslund J
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(16):16744-16753

Pen-2 is sequestered in the endoplasmic reticulum and subjected to ubiquitylation and proteasome-mediated degradation in the absence of presenilin.

Bergman A; Hansson EM; Pursglove SE; Farmery MR; Lannfelt L; Lendahl U; Lundkvist J; Näslund J
Article: JOURNAL OF NEUROCHEMISTRY. 2004;89(1):44-53

Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein.

Laudon H; Mathews PM; Karlström H; Bergman A; Farmery MR; Nixon RA; Winblad B; Gandy SE; Lendahl U; Lundkvist J; Näslund J
Article: EXPERIMENTAL CELL RESEARCH. 2004;292(1):21-28

Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors.

Enlund F; Behboudi A; Andrén Y; Oberg C; Lendahl U; Mark J; Stenman G
Article: DEVELOPMENT. 2003;130(24):6089-6099

Functional Notch signaling is required for BMP4-induced inhibition of myogenic differentiation.

Dahlqvist C; Blokzijl A; Chapman G; Falk A; Dannaeus K; Ibâñez CF; Lendahl U
Article: JOURNAL OF CELL BIOLOGY. 2003;163(4):723-728

Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3.

Blokzijl A; Dahlqvist C; Reissmann E; Falk A; Moliner A; Lendahl U; Ibáñez CF
Article: GENESIS. 2003;37(3):139-143

Characterization of Notch3-deficient mice: normal embryonic development and absence of genetic interactions with a Notch1 mutation.

Krebs LT; Xue Y; Norton CR; Sundberg JP; Beatus P; Lendahl U; Joutel A; Gridley T
Article: JOURNAL OF IMMUNOLOGY. 2003;171(9):4504-4511

Expression of activated Notch3 in transgenic mice enhances generation of T regulatory cells and protects against experimental autoimmune diabetes.

Anastasi E; Campese AF; Bellavia D; Bulotta A; Balestri A; Pascucci M; Checquolo S; Gradini R; Lendahl U; Frati L; Gulino A; Di Mario U; Screpanti I
Article: DEVELOPMENT. 2003;130(18):4451-4460

Role of Islet1 in the patterning of murine dentition.

Mitsiadis TA; Angeli I; James C; Lendahl U; Sharpe PT
Article: EXPERIMENTAL CELL RESEARCH. 2003;282(2):101-109

Notch2 protein distribution in human teeth under normal and pathological conditions.

Mitsiadis TA; Roméas A; Lendahl U; Sharpe PT; Farges JC
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2002;99(26):17119-17124

A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling.

Karlström H; Beatus P; Dannaeus K; Chapman G; Lendahl U; Lundkvist J
Article: MOLECULAR AND CELLULAR BIOLOGY. 2002;22(22):7812-7819

p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro.

Wallberg AE; Pedersen K; Lendahl U; Roeder RG
Article: LAKARTIDNINGEN. 2002;99(41):4026-4032

[Sydney Brenner, Robert Horvitz and John Sulston. Winners of the 2002 Nobel Prize in medicine or physiology. Genetic regulation of organ development and programmed cell death].

Lendahl U; Orrenius S
Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2002;69(6):784-794

Nestin enhancer requirements for expression in normal and injured adult CNS.

Johansson CB; Lothian C; Molin M; Okano H; Lendahl U
Journal article: EXPERIMENTAL CELL RESEARCH. 2002;278(2):123-124

Nils Ringertz

Lendahl U
Article: EXPERIMENTAL CELL RESEARCH. 2002;278(1):31-44

Mouse Notch 3 expression in the pre- and postnatal brain: relationship to the stroke and dementia syndrome CADASIL.

Prakash N; Hansson E; Betsholtz C; Mitsiadis T; Lendahl U
Article: APMIS. 2002;110(6):499-507

Patterns of nestin and other intermediate filament expression distinguish between gastrointestinal stromal tumors, leiomyomas and schwannomas.

Sarlomo-Rikala M; Tsujimura T; Lendahl U; Miettinen M
Article: AMERICAN JOURNAL OF PATHOLOGY. 2002;160(6):2123-2133

E- and N-cadherin distribution in developing and functional human teeth under normal and pathological conditions.

Heymann R; About I; Lendahl U; Franquin J-C; Obrink B; Mitsiadis TA
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2002;99(6):3788-3793

Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis.

Bellavia D; Campese AF; Checquolo S; Balestri A; Biondi A; Cazzaniga G; Lendahl U; Fehling HJ; Hayday AC; Frati L; von Boehmer H; Gulino A; Screpanti I
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2002;99(6):4014-4019

Notch receptor cleavage depends on but is not directly executed by presenilins.

Taniguchi Y; Karlström H; Lundkvist J; Mizutani T; Otaka A; Vestling M; Bernstein A; Donoviel D; Lendahl U; Honjo T
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(9):6763-6766

A sensitive and quantitative assay for measuring cleavage of presenilin substrates.

Karlström H; Bergman A; Lendahl U; Näslund J; Lundkvist J
Article: JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY. 2002;50(2):147-158

Immunohistochemical detection of nestin in pediatric brain tumors.

Almqvist PM; Mah R; Lendahl U; Jacobsson B; Hendson G
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2001;98(24):14006-14011

Suppressed kindling epileptogenesis in mice with ectopic overexpression of galanin.

Kokaia M; Holmberg K; Nanobashvili A; Xu ZQ; Kokaia Z; Lendahl U; Hilke S; Theodorsson E; Kahl U; Bartfai T; Lindvall O; Hökfelt T
Article: NEUROSCIENCE LETTERS. 2001;314(3):151-155

Induction of astrocytic nestin expression by depolarization in rats.

Holmin S; von Gertten C; Sandberg-Nordqvist AC; Lendahl U; Mathiesen T
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(38):35847-35853

The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog.

Oberg C; Li J; Pauley A; Wolf E; Gurney M; Lendahl U
Article: MECHANISMS OF DEVELOPMENT. 2001;107(1-2):181-185

A 1.8kb GFAP-promoter fragment is active in specific regions of the embryonic CNS.

Andrae J; Bongcam-Rudloff E; Hansson I; Lendahl U; Westermark B; Nistér M
Journal article: EXPERIMENTAL CELL RESEARCH. 2001;269(1):1

Accelerated Publication in Experimental Cell Research

Lendahl U
Article: MECHANISMS OF DEVELOPMENT. 2001;104(1-2):3-20

The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity.

Beatus P; Lundkvist J; Oberg C; Pedersen K; Lendahl U
Article: JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. 2001;60(6):588-597

The expression of intermediate filament protein nestin as related to vimentin and desmin in regenerating skeletal muscle.

Vaittinen S; Lukka R; Sahlgren C; Hurme T; Rantanen J; Lendahl U; Eriksson JE; Kalimo H
Article: JOURNAL OF IMMUNOLOGY. 2001;166(11):6585-6592

MHC class I-Ly49 interactions shape the Ly49 repertoire on murine NK cells.

Fahlén L; Lendahl U; Sentman CL
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(19):16456-16463

Mitotic reorganization of the intermediate filament protein nestin involves phosphorylation by cdc2 kinase.

Sahlgren CM; Mikhailov A; Hellman J; Chou YH; Lendahl U; Goldman RD; Eriksson JE
Article: AMERICAN JOURNAL OF PATHOLOGY. 2001;158(3):817-823

Expression of the intermediate filament nestin in gastrointestinal stromal tumors and interstitial cells of Cajal.

Tsujimura T; Makiishi-Shimobayashi C; Lundkvist J; Lendahl U; Nakasho K; Sugihara A; Iwasaki T; Mano M; Yamada N; Yamashita K; Toyosaka A; Terada N
Article: NEUROREPORT. 2001;12(2):423-425

Mice over-expressing galanin have elevated heat nociceptive threshold.

Blakeman KH; Holmberg K; Hao JX; Xu XJ; Kahl U; Lendahl U; Bartfai T; Wiesenfeld-Hallin Z; Hökfelt T
Article: BIOESSAYS. 2001;23(1):3-7

Oh no, Notch again!

Frisén J; Lendahl U
Journal article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2001;11:s116-s117

Monoamine—neuropeptide interactions

Hökfelt T; Xu Z-QD; Holmberg K; Kehr J; Schött P; Ögren SO; Wang FH; Yoshitaki T; Bartfai T; Lendahl U; Kokaia M; Nanobashvili A; Kokaia Z; Lindvall O; Kahl U; Yamaguchi M
Article: EMBO JOURNAL. 2000;19(13):3337-3348

Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice.

Bellavia D; Campese AF; Alesse E; Vacca A; Felli MP; Balestri A; Stoppacciaro A; Tiveron C; Tatangelo L; Giovarelli M; Gaetano C; Ruco L; Hoffman ES; Hayday AC; Lendahl U; Frati L; Gulino A; Screpanti I
Article: AMERICAN JOURNAL OF PATHOLOGY. 2000;157(1):287-295

Nestin expression in embryonic and adult human teeth under normal and pathological conditions.

About I; Laurent-Maquin D; Lendahl U; Mitsiadis TA
Article: SCIENCE. 2000;288(5471):1660-1663

Generalized potential of adult neural stem cells.

Clarke DL; Johansson CB; Wilbertz J; Veress B; Nilsson E; Karlström H; Lendahl U; Frisén J
Article: INTERNATIONAL IMMUNOLOGY. 2000;12(2):215-222

Ly49A expression on T cells alters T cell selection.

Fahlén L; Oberg L; Brännström T; Khoo NK; Lendahl U; Sentman CL
Article: DEVELOPMENT. 1999;126(17):3925-3935

The notch 3 intracellular domain represses notch 1-mediated activation through Hairy/Enhancer of split (HES) promoters.

Beatus P; Lundkvist J; Oberg C; Lendahl U
Article: NATURE. 1999;400(6747):877-881

Notch signalling controls pancreatic cell differentiation.

Apelqvist A; Li H; Sommer L; Beatus P; Anderson DJ; Honjo T; Hrabe de Angelis M; Lendahl U; Edlund H
Article: INTERNATIONAL IMMUNOLOGY. 1999;11(7):1017-1025

Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development.

Felli MP; Maroder M; Mitsiadis TA; Campese AF; Bellavia D; Vacca A; Mann RS; Frati L; Lendahl U; Gulino A; Screpanti I
Article: JOURNAL OF CELL BIOLOGY. 1999;145(3):503-514

Abnormal reaction to central nervous system injury in mice lacking glial fibrillary acidic protein and vimentin.

Pekny M; Johansson CB; Eliasson C; Stakeberg J; Wallén A; Perlmann T; Lendahl U; Betsholtz C; Berthold CH; Frisén J
Article: EXPERIMENTAL CELL RESEARCH. 1999;248(2):509-519

Identification of both general and region-specific embryonic CNS enhancer elements in the nestin promoter.

Lothian C; Prakash N; Lendahl U; Wahlström GM
Article: AMERICAN JOURNAL OF PATHOLOGY. 1999;154(2):591-600

Specific and innervation-regulated expression of the intermediate filament protein nestin at neuromuscular and myotendinous junctions in skeletal muscle.

Vaittinen S; Lukka R; Sahlgren C; Rantanen J; Hurme T; Lendahl U; Eriksson JE; Kalimo H
Article: CELL. 1999;96(1):25-34

Identification of a neural stem cell in the adult mammalian central nervous system.

Johansson CB; Momma S; Clarke DL; Risling M; Lendahl U; Frisén J
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(2):1078-1084

Brain-derived neurotrophic factor expression in vivo is under the control of neuron-restrictive silencer element.

Timmusk T; Palm K; Lendahl U; Metsis M
Article: DEVELOPMENTAL BIOLOGY. 1998;204(2):420-431

Delta-notch signaling in odontogenesis: correlation with cytodifferentiation and evidence for feedback regulation.

Mitsiadis TA; Hirsinger E; Lendahl U; Goridis C
Article: JOURNAL OF IMMUNOLOGY. 1998;161(12):6475-6479

MHC class I mosaic mice reveal insights into control of Ly49C inhibitory receptor expression in NK cells.

Andersson M; Freland S; Johansson MH; Wallin R; Sandberg JK; Chambers BJ; Christensson B; Lendahl U; Lemieux S; Salcedo M; Ljunggren HG
Article: NATURE. 1998;395(6700):398-402

Retinoid-X receptor signalling in the developing spinal cord.

Solomin L; Johansson CB; Zetterström RH; Bissonnette RP; Heyman RA; Olson L; Lendahl U; Frisén J; Perlmann T
Article: NEURON. 1998;21(2):305-315

BDNF regulates reelin expression and Cajal-Retzius cell development in the cerebral cortex.

Ringstedt T; Linnarsson S; Wagner J; Lendahl U; Kokaia Z; Arenas E; Ernfors P; Ibáñez CF
Article: JOURNAL OF CELL SCIENCE. 1998;111 ( Pt 14):1951-1961

A rod end deletion in the intermediate filament protein nestin alters its subcellular localization in neuroepithelial cells of transgenic mice.

Marvin MJ; Dahlstrand J; Lendahl U; McKay RD
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1998;95(9):5269-5274

Targeted expression of a multifunctional chimeric neurotrophin in the lesioned sciatic nerve accelerates regeneration of sensory and motor axons.

Funakoshi H; Risling M; Carlstedt T; Lendahl U; Timmusk T; Metsis M; Yamamoto Y; Ibáñez CF
Article: PEDIATRIC RESEARCH. 1998;43(3):386-392

Pediatric rhabdomyosarcomas express the intermediate filament nestin.

Kobayashi M; Sjöberg G; Söderhäll S; Lendahl U; Sandstedt B; Sejersen T
Article: BIOESSAYS. 1998;20(2):103-107

A growing family of Notch ligands.

Lendahl U
Article: DEVELOPMENT. 1997;124(13):2603-2613

Limb proprioceptive deficits without neuronal loss in transgenic mice overexpressing neurotrophin-3 in the developing nervous system.

Ringstedt T; Kucera J; Lendahl U; Ernfors P; Ibáñez CF
Article: DIFFERENTIATION. 1997;61(4):243-249

The intermediate filament protein nestin occurs transiently in differentiating testis of rat and mouse.

Fröjdman K; Pelliniemi LJ; Lendahl U; Virtanen I; Eriksson JE
Journal article: EXPERIMENTAL CELL RESEARCH. 1997;232(2):193

EDITORIAL COMMENT

Ringertz N; Lendahl U; Baserga R
Article: DEVELOPMENT. 1997;124(8):1473-1483

Mouse Serrate-1 (Jagged-1): expression in the developing tooth is regulated by epithelial-mesenchymal interactions and fibroblast growth factor-4.

Mitsiadis TA; Henrique D; Thesleff I; Lendahl U
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 1997;9(3):452-462

An evolutionarily conserved region in the second intron of the human nestin gene directs gene expression to CNS progenitor cells and to early neural crest cells.

Lothian C; Lendahl U
Article: DIFFERENTIATION. 1997;61(3):151-159

Distribution of nestin in the developing mouse limb bud in vivo and in micro-mass cultures of cells isolated from limb buds.

Wroblewski J; Engström M; Edwall-Arvidsson C; Sjöberg G; Sejersen T; Lendahl U
Article: ACTA ANAESTHESIOLOGICA SCANDINAVICA, SUPPLEMENT. 1997;110:116-118

Transgenic analysis of central nervous system development and regeneration.

Lendahl U
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 1997;9(1):65-75

Adult nestin-expressing subependymal cells differentiate to astrocytes in response to brain injury.

Holmin S; Almqvist P; Lendahl U; Mathiesen T
Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 1997;9(4):264-275

Structural and functional characterization of the rat neurotrophin-4 gene.

Salin T; Timmusk T; Lendahl U; Metsis M
Journal article: DIFFERENTIATION. 1997;61(4):243

The intermediate filament protein nestin occurs transiently in differentiating testis of rat and mouse

Fröjdman K; Pelliniemi LJ; Lendahl U; Virtanen I; Eriksson JE
Article: PEDIATRIC RESEARCH. 1996;40(6):809-814

Cerebrospinal fluid of newborn infants contains a deglycosylated form of the intermediate filament nestin.

Grigelioniené G; Blennow M; Török C; Fried G; Dahlin I; Lendahl U; Lagercrantz H
Article: EXPERIMENTAL BRAIN RESEARCH. 1996;112(1):47-57

Fetal ventral mesencephalon of human and rat origin maintained in vitro and transplanted to 6-hydroxydopamine-lesioned rats gives rise to grafts rich in dopaminergic neurons.

Spenger C; Haque NS; Studer L; Evtouchenko L; Wagner B; Bühler B; Lendahl U; Dunnett SB; Seiler RW
Article: MECHANISMS OF DEVELOPMENT. 1996;59(2):177-190

Expression of the Notch 3 intracellular domain in mouse central nervous system progenitor cells is lethal and leads to disturbed neural tube development.

Lardelli M; Williams R; Mitsiadis T; Lendahl U
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1996;26(9):2127-2132

Influence of glycosylphosphatidylinositol-linked H-2Dd molecules on target cell protection and natural killer cell specificity in transgenic mice.

Sentman CL; Olsson-Alheim MY; Lendahl U; Kärre K
Journal article: PEDIATRIC RESEARCH. 1996;40(3):554

The Second Intron of the Human Nestin Gene Directs Gene Expression To Cns Progenitor Cells 236

Török C; Lagercrantz H; Lendahl U
Journal article: PEDIATRIC RESEARCH. 1996;40(3):531

Intermediate Filament Nestin is Present in the Cerebrospinal Fluid of Children. 97

Grigelioniené G; Blennow M; Marchini G; Wahlquist Y; Lendahl U
Article: INTERNATIONAL IMMUNOLOGY. 1996;8(7):1149-1157

Elevated expression levels of an Ig transgene in mice links the IgH 3' enhancer to the regulation of IgH expression.

Arulampalam V; Furebring C; Samuelsson A; Lendahl U; Borrebaeck C; Lundkvist I; Pettersson S
Article: JOURNAL OF IMMUNOLOGY. 1996;156(7):2423-2429

H-2Dp transgene alters natural killer cell specificity at the target and effector cell levels. Comparison with an H-2Dd transgene.

Sentman CL; Olsson-Alheim MY; Lendahl U; Kärre K
Journal article: PEDIATRIC RESEARCH. 1996;39(Suppl 4):373

THE EMBRYONIC INTERMEDIATE FILAMENT PROTEIN NESTIN IS PRESENT IN THE CEREBROSPINAL FLUID OF NICU INFANTS. † 2223

Blennow M; Grigelioniené G; Török C; Lendahl U; Lagercrantz H
Article: INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY. 1996;Suppl 1:113S-114S

Mouse Serrate-1 and Notch genes differ in their response to signaling molecules during odontogenesis.

Mitsiadis TA; Thesleff I; Lendahl U
Article: LABORATORY INVESTIGATION. 1996;74(1):188-198

Coexpression of platelet-derived growth factor alpha and beta receptors on medulloblastomas and other primitive neuroectodermal tumors is consistent with an immature stem cell and neuronal derivation.

Smits A; van Grieken D; Hartman M; Lendahl U; Funa K; Nistér M
Article: INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY. 1995;39(6):947-956

Expression of the intermediate filament nestin during rodent tooth development.

Terling C; Rass A; Mitsiadis TA; Fried K; Lendahl U; Wroblewski J
Article: TRANSGENIC RESEARCH. 1995;4(6):378-387

Altered expression after expansion of a v-erbA transgene in transgenic mice.

Barlow C; Meister B; Lendahl U; Vennström B
Article: MECHANISMS OF DEVELOPMENT. 1995;53(3):357-368

Complementary and combinatorial patterns of Notch gene family expression during early mouse development.

Williams R; Lendahl U; Lardelli M
Article: JOURNAL OF CELL BIOLOGY. 1995;131(2):453-464

Rapid, widespread, and longlasting induction of nestin contributes to the generation of glial scar tissue after CNS injury.

Frisén J; Johansson CB; Török C; Risling M; Lendahl U
Article: JOURNAL OF CELL BIOLOGY. 1995;130(2):407-418

Expression of Notch 1, 2 and 3 is regulated by epithelial-mesenchymal interactions and retinoic acid in the developing mouse tooth and associated with determination of ameloblast cell fate.

Mitsiadis TA; Lardelli M; Lendahl U; Thesleff I
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1995;92(9):4046-4050

Regulatory region in choline acetyltransferase gene directs developmental and tissue-specific expression in transgenic mice.

Lönnerberg P; Lendahl U; Funakoshi H; Arhlund-Richter L; Persson H; Ibáñez CF
Article: DEVELOPMENTAL BRAIN RESEARCH. 1995;84(1):109-129

Nestin mRNA expression correlates with the central nervous system progenitor cell state in many, but not all, regions of developing central nervous system.

Dahlstrand J; Lardelli M; Lendahl U
Article: JOURNAL OF CELL BIOLOGY. 1995;128(1-2):185-199

Identification of brain-derived neurotrophic factor promoter regions mediating tissue-specific, axotomy-, and neuronal activity-induced expression in transgenic mice.

Timmusk T; Lendahl U; Funakoshi H; Arenas E; Persson H; Metsis M
Article: PEDIATRIC RESEARCH. 1995;37(1):15-20

Expression of c-fos, tyrosine hydroxylase, and neuropeptide mRNA in the rat brain around birth: effects of hypoxia and hypothermia.

Ringstedt T; Tang LQ; Persson H; Lendahl U; Lagercrantz H
Journal article: JOURNAL OF IMMUNOLOGY. 1994;153(12):5482-5490

H-2 allele-specific protection from NK cell lysis in vitro for lymphoblasts but not tumor targets. Protection mediated by alpha 1/alpha 2 domains.

Sentman CL; Olsson MY; Salcedo M; Höglund P; Lendahl U; Käre K
Journal article: GENOMICS. 1994;24(2):253-258

The human NOTCH1, 2, and 3 genes are located at chromosome positions 9q34, 1p13-p11, and 19p13.2-p13.1 in regions of neoplasia-associated translocation.

Larsson C; Lardelli M; White I; Lendahl U
Journal article: EXPERIMENTAL CELL RESEARCH. 1994;214(2):447-458

Colocalization of nestin and vimentin/desmin in skeletal muscle cells demonstrated by three-dimensional fluorescence digital imaging microscopy.

Sjöberg G; Jiang WQ; Ringertz NR; Lendahl U; Sejersen T
Journal article: EMBO JOURNAL. 1994;13(18):4241-4250

Thyroid abnormalities and hepatocellular carcinoma in mice transgenic for v-erbA.

Barlow C; Meister B; Lardelli M; Lendahl U; Vennström B
Journal article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1994;24(7):1671-1677

Lipopolysaccharide-dependent transactivation of the temporally regulated immunoglobulin heavy chain 3' enhancer.

Arulampalam V; Grant PA; Samuelsson A; Lendahl U; Pettersson S
Journal article: JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. 1994;53(4):416-423

Myofibers from Duchenne/Becker muscular dystrophy and myositis express the intermediate filament nestin.

Sjöberg G; Edström L; Lendahl U; Sejersen T
Journal article: MECHANISMS OF DEVELOPMENT. 1994;46(2):123-136

The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium.

Lardelli M; Dahlstrand J; Lendahl U
Journal article: LAKARTIDNINGEN. 1994;91(17):1711-1717

[Transgenic animals. Animals with designed genetic changes].

Lendahl U; Törnell J
Journal article: BIOTECHNIQUES. 1994;16(3):420-422

Generating bacteriophage lambda sublibraries enriched for rare clones.

Lardelli M; Lendahl U
Journal article: CANCER RESEARCH. 1994;54(2):354-356

Expression of the neuroectodermal intermediate filament nestin in human melanomas.

Flørenes VA; Holm R; Myklebost O; Lendahl U; Fodstad O
Journal article: NEURON. 1994;12(1):11-24

Independent regulatory elements in the nestin gene direct transgene expression to neural stem cells or muscle precursors.

Zimmerman L; Parr B; Lendahl U; Cunningham M; McKay R; Gavin B; Mann J; Vassileva G; McMahon A
Journal article: CELL. 1990;60(4):585-595

CNS stem cells express a new class of intermediate filament protein.

Lendahl U; Zimmerman LB; McKay RD
Journal article: JOURNAL OF MOLECULAR BIOLOGY. 1990;211(2):331-349

The Balbiani ring 3 gene in Chironomus tentans has a diverged repetitive structure split by many introns.

Paulsson G; Lendahl U; Galli J; Ericsson C; Wieslander L
Journal article: GENETICS. 1987;117(1):43-49

Rapid and concerted evolution of repeat units in a balbiani ring gene.

Lendahl U; Saiga H; Höög C; Edström JE; Wieslander L
Journal article: DEVELOPMENTAL BIOLOGY. 1987;121(1):130-138

BALBIANI RING (BR) GENES EXHIBIT DIFFERENT PATTERNS OF EXPRESSION DURING DEVELOPMENT

LENDAHL U; WIESLANDER L
Journal article: CHEMICA SCRIPTA. 1986;26B:159-163

THE BALBIANI RING GENE FAMILY - AN EXAMPLE OF SATELLITE-LIKE EVOLUTION OF CODING SEQUENCES

WIESLANDER L; HOOG C; LENDAHL U; DANEHOLT B
Journal article: JOURNAL OF MOLECULAR EVOLUTION. 1985;22(1):63-68

ABRUPT EVOLUTIONARY CHANGE IN THE BALBIANI RING GENE FAMILY IN 2 SIBLING SPECIES OF CHIRONOMUS

LENDAHL U; WIESLANDER L
Journal article: CELL. 1984;36(4):1027-1034

Balbiani ring 6 gene in Chironomus tentans: a diverged member of the Balbiani ring gene family.

Lendahl U; Wieslander L
Journal article: JOURNAL OF MOLECULAR EVOLUTION. 1984;20(3-4):304-312

Conserved and nonconserved structures in the secretory proteins encoded in the Balbiani ring genes of Chironomus tentans.

Wieslander L; Höög C; Höög JO; Jörnvall H; Lendahl U; Daneholt B
Journal article: EMBO JOURNAL. 1983;2(7):1169-1175

The Balbiani ring 2 gene in Chironomus tentans is built from two types of tandemly arranged major repeat units with a common evolutionary origin.

Wieslander L; Lendahl U
Show more

All other publications

Book chapter: 2023;p. 125-133

The Notch Signaling Pathway

Braune E-B; Del Gaudio F; Lendahl U
Preprint: 2022;bioRxiv

NOTCH3 active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model

Oliveira DV; Coupland KG; Jin S; Del Gaudio F; Wang S; Fox R; Rutten JW; Sandin J; Lundkvist J; Oberstein SAJL; Lendahl U; Karlström H
Review: NATURE COMMUNICATIONS. 2022;13(1):3409

Identification, discrimination and heterogeneity of fibroblasts.

Lendahl U; Muhl L; Betsholtz C
Corrigendum: NATURE GENETICS. 2022;54(3):358-360

Author Correction: EMPReSS: standardized phenotype screens for functional annotation of the mouse genome.

Eumorphia Consortium
Preprint: 2022;SSRN Electronic Journal

Distinct Fibroblast Subtypes Populate Specific Brain Barriers

Del Gaudio F; He L; Pietilä R; Vanlandewijck M; Muhl L; Mocci G; Bjørnholm KD; Liu J; van Voorden J; Torres M; Moggio A; Antilla S; Storm-Mathisen J; Bergersen LH; Nilsson P; Hansson E; Alitalo K; Lendahl U; Andrae J; Betsholtz C
Preprint: 2022;SSRN Electronic Journal

A Robust and Efficient Microvascular Isolation Method for Multimodal Characterization of the Mouse Brain Vasculature

Bjørnholm KD; Del Gaudio F; Li H; Li W; Vázquez Liébanas E; Mäe MA; Lendahl U; Betsholtz C; Nilsson P; Karlström H; Vanlandewijck M
Conference publication: CANCER RESEARCH. 2022;82(12)

Identification of a NOTCH transcriptomic signature for basal-like breast cancer

Braune E-B; Geist F; Wienke D; Seshire A; Lendahl U
Preprint: 2021;bioRxiv

Multimodal characterization of the murine neurovascular niche using a novel microvascular isolation protocol

Bjørnholm KD; Vanlandewijck M; Del Gaudio F; Lendahl U; Nilsson P; Karlström H; Betsholtz C
Preprint: 2021;bioRxiv

Bleeding in patients and mice with Alagille syndrome: sex differences and risk factors

Hankeova S; Van Hul N; Laznovsky J; Hensen N; Verhoef E; Zikmund T; Dawit F; Kavkova M; Salplachta J; Li L; Sjöqvist M; Johansson BR; Hassan M; Bryja V; Lendahl U; Jheon A; Wang JS; Alten F; Fahnehjelm KT; Fischler B; Kaiser J; Andersson ER
Letter: CIRCULATION. 2021;143(8):865-868

Lack of Evidence of Angiotensin-Converting Enzyme 2 Expression and Replicative Infection by SARS-CoV-2 in Human Endothelial Cells.

McCracken IR; Saginc G; He L; Huseynov A; Daniels A; Fletcher S; Peghaire C; Kalna V; Andaloussi-Mäe M; Muhl L; Craig NM; Griffiths SJ; Haas JG; Tait-Burkard C; Lendahl U; Birdsey GM; Betsholtz C; Noseda M; Baker AH; Randi AM
Preprint: 2020;bioRxiv

Lack of evidence of ACE2 expression and replicative infection by SARS-CoV-2 in human endothelial cells

McCracken I; Saginc G; He L; Huseynov A; Daniels A; Fletcher S; Peghaire C; Kalna V; Andaloussi-Mäe M; Muhl L; Craig NM; Griffiths SJ; Haas JG; Tait-Burkard C; Lendahl U; Birdsey GM; Betsholtz C; Noseda M; Baker A; Randi AM
Corrigendum: NATURE COMMUNICATIONS. 2020;11(1):4493

Publisher Correction: Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination.

Muhl L; Genové G; Leptidis S; Liu J; He L; Mocci G; Sun Y; Gustafsson S; Buyandelger B; Chivukula IV; Segerstolpe Å; Raschperger E; Hansson EM; Björkegren JLM; Peng X-R; Vanlandewijck M; Lendahl U; Betsholtz C
Preprint: 2020;bioRxiv

Neural plate targeting by in utero nanoinjection (NEPTUNE) reveals a role for Sptbn2 in neurulation and abdominal wall closure

Mangold K; Mašek J; He J; Lendahl U; Fuchs E; Andersson E
Preprint: 2020;bioRxiv

Pericyte-specific vascular expression of SARS-CoV-2 receptor ACE2 – implications for microvascular inflammation and hypercoagulopathy in COVID-19

He L; Mäe MA; Muhl L; Sun Y; Pietilä R; Nahar K; Liébanas EV; Fagerlund MJ; Oldner A; Oldner A; Liu J; Genové G; Zhang L; Xie Y; Leptidis S; Mocci G; Stritt S; Osman A; Anisimov A; Hemanthakumar KA; Räsänen M; Mirabeau O; Hansson E; Björkegren J; Vanlandewijck M; Blomgren K; Mäkinen T; Peng X-R; Arnold T; Alitalo K; Eriksson L; Lendahl U; Betsholtz C
Review: FRONTIERS IN ENDOCRINOLOGY. 2020;11:374

Regulation of Mammalian Mitochondrial Dynamics: Opportunities and Challenges.

Yu R; Lendahl U; Nistér M; Zhao J
Conference publication: JOURNAL OF HEPATOLOGY. 2020;73:S542

Cracking the notch code in alagille syndrome: single-cell receptor-ligand interactions and outcomes in vivo, and an emerging role of immune cells

Masek J; Hankeova S; Jin S-B; Lendahl U; Andersson E
Conference publication: JOURNAL OF HEPATOLOGY. 2020;73:S43

Double resin casting micro computed tomography (CT) reveals biliary and vascular pathology in tandem in a mouse model for alagille syndrome

Hankeova S; Salplachta J; Zikmund T; Kavkova M; Van Hul NKM; Brinek A; Smekalova V; Laznovsky J; Jaros J; Bryja V; Lendahl U; Ellis E; Hannezo E; Kaiser J; Andersson E
Preprint: 2019;bioRxiv

DoUble resin casting micro computed tomography (DUCT) reveals biliary and vascular pathology in a mouse model of Alagille syndrome

Hankeova S; Salplachta J; Zikmund T; Kavkova M; Van Hul N; Brinek A; Smekalova V; Laznovsky J; Jaros J; Bryja V; Lendahl U; Ellis E; Hannezo E; Kaiser J; Andersson ER
Review: EMBO REPORTS. 2019;20(11):e48070

Emerging links between cerebrovascular and neurodegenerative diseases-a special role for pericytes.

Lendahl U; Nilsson P; Betsholtz C
Conference publication: JOURNAL OF VASCULAR RESEARCH. 2019;56:87

Characterization of a Novel CADASIL-Like Mutation in the NOTCH3 Receptor

Arnardottir S; Del Gaudio F; Lombrana AA; Oliveira DV; Karlstrom H; Lendahl U; Sjostrand C
Review: BIOMEDICINES. 2018;6(4):E101-101

Notch and Wnt Dysregulation and Its Relevance for Breast Cancer and Tumor Initiation.

Braune E-B; Seshire A; Lendahl U
Review: STROKE. 2018;49(11):2793-2800

Role of NOTCH3 Mutations in the Cerebral Small Vessel Disease Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy.

Coupland K; Lendahl U; Karlström H
Corrigendum: EBIOMEDICINE. 2018;36:564

Corrigendum to "Cholangiopathies - Towards a molecular understanding" [EBioMedicine 35 (2018) 381-393].

Tam PKH; Yiu RS; Lendahl U; Andersson ER
Editorial comment: EXPERIMENTAL CELL RESEARCH. 2018;370(2):189

Changing master regulator without reprogramming.

Lendahl U; Simon A
Review: EBIOMEDICINE. 2018;35:381-393

Cholangiopathies - Towards a molecular understanding.

Tam PKH; Yiu RS; Lendahl U; Andersson ER
Corrigendum: NATURE. 2018;560(7716):E3

Author Correction: A molecular atlas of cell types and zonation in the brain vasculature.

Vanlandewijck M; He L; Mäe MA; Andrae J; Ando K; Del Gaudio F; Nahar K; Lebouvier T; Laviña B; Gouveia L; Sun Y; Raschperger E; Räsänen M; Zarb Y; Mochizuki N; Keller A; Lendahl U; Betsholtz C
Conference publication: JOURNAL OF HEPATOLOGY. 2018;68:S141-S142

Uncovering the liver Notch code using high-throughput reporter imaging on micropatterns

Masek J; Vervuurt C; Hankeova S; Lendahl U; Lindqvist A; Andersson E
Conference publication: JOURNAL OF HEPATOLOGY. 2018;68:S414-S415

Double resin casting micro computed tomography (DUCT) of biliary and vascular system

Hankeova S; Zikmund T; Kavkova M; Brinek A; Lendahl U; Kaiser J; Bryja V; Andersson E
Review: PHYSIOLOGICAL REVIEWS. 2017;97(4):1235-1294

Notch Signaling in Development, Tissue Homeostasis, and Disease.

Siebel C; Lendahl U
Other: CELL DEATH AND DIFFERENTIATION. 2017;24(4):571

Lorenz Poellinger MD, PhD (1957-2016).

Lendahl U
Conference publication: HAEMATOLOGICA. 2017;102:456

BONE MARROW MYELOPOIESIS INDEPENDENTLY OF CANONICAL NOTCH SIGNALING

Duarte S; Woll PS; Natalija B-V; Boukarabila H; Stenson L; Bouriez-Jones T; Ferry H; Mead AJ; Atkinson D; Thongjuea S; Jin S; Clark S-A; Chin D; Lu-S T; Repapi E; Gray N; Taylor S; Mutvei A; Tsoi YL; Nerlov C; Lendahl U; Jacobsen SEW
Editorial comment: TRANSLATIONAL CANCER RESEARCH. 2016;5:S831-S835

A new angle on Notch combination therapies

Lendahl U
Editorial comment: JOURNAL OF INTERNAL MEDICINE. 2016;280(3):232-235

At the interface of stem cell research and new technologies.

Lendahl U
Meeting abstract: CANCER RESEARCH. 2016;76:b41

Cell-contact dependent epithelial-stromal cross talk, including a modulation of stromal PDGFR expression, drives the progression of early-stage breast cancer lesions

Strell C; Paulsson J; Mezheyeuski A; Jin S-B; Roswall P; Andrea J; Frings O; Warnberg F; Johansson H; Jirstrom K; Pietras K; Hall P; Lendahl U; Betsholtz C; Radisky DC; Ostman A
Conference publication: MOLECULAR BIOLOGY OF THE CELL. 2016;27

MIEF1/2 functions in coordination with Mff to regulate the balance of mitochondrial dynamics in mammals.

Yu R; Liu T; Jin S; Ning C; Lendahl U; Nister M; Zhao J
Review: NATURE REVIEWS DRUG DISCOVERY. 2014;13(5):359-380

Therapeutic modulation of Notch signalling--are we there yet?

Andersson ER; Lendahl U
Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 2013;70(6):951-976

Regulation of mitochondrial dynamics: convergences and divergences between yeast and vertebrates.

Zhao J; Lendahl U; Nistér M
Review: JOURNAL OF INTERNAL MEDICINE. 2013;273(3):235-245

Regenerative medicine for the treatment of heart disease.

Hansson EM; Lendahl U
Conference publication: TRANSGENIC RESEARCH. 2013;22(1):224

EMMA: The European Mouse Mutant Archive

Fernandez J; Hong Y; Montoliu L; Tocchini-Valentini G; Herault Y; Brown S; Lendahl U; Demengeot J; Flicek P; Ramirez-Solis R; Kollias G; Sedlacek R; Soininen R; Ruelicke T; Iraqi F; Jonkers J; De Angelis MH
Review: DEVELOPMENT. 2011;138(17):3593-3612

Notch signaling: simplicity in design, versatility in function.

Andersson ER; Sandberg R; Lendahl U
Conference publication: MOLECULAR BIOLOGY OF THE CELL. 2011;22

Human MIEF1 Recruits Drp1 to Mitochondrial Outer Membranes and Promotes Mitochondrial Fusion Rather than Fission

Zhao J; Liu T; Jin S; Wang X; Qu M; Tomilin N; Shupliakov O; Lendahl U; Nister M
Conference publication: TRANSGENIC RESEARCH. 2011;20(5):1179

EMMA: The European mouse mutant archive

Fernandez J; Fessele S; Montoliu L; Tocchini-Valentini G; Herault Y; Brown S; Lendahl U; Demengeot J; Birney E; Ramirez-Solis R; Kollias G; Sedlacek R; Soininen R; Ruelicke T; De Angelis MH
Book chapter: 2010;p. 325-351

γ‐Secretase: An Unusual Enzyme with Many Possible Disease Targets, Including Alzheimer's Disease

Lundkvist J; Lendahl U
Book chapter: 2010;p. 23-36

The molecular basis of central nervous system development

Hermanson O; Lendahl U
Conference publication: TRANSGENIC RESEARCH. 2010;19(2):327-328

EMMA: The European mouse mutant archive

Fernandez J; Hagn M; Fessele S; Marschall S; Jesus del Hierro M; Montoliu L; Matteoni R; Raspa M; Scavizzi F; Tocchini-Valentini G; Larrigaldie V; Paturance S; Herault Y; Fray M; Pickard A; Brown S; Wilbertz J; Lendahl U; Demengeot J; Smedley D; Wilkinson P; Birney E; Bottomley J; Houghton R; Ramirez-Solis R; Ayadi A; Selloum M; Mandel JL; Kontoyiannis D; Kollias G; De Angelis MH
Review: NATURE REVIEWS GENETICS. 2009;10(12):821-832

Generating specificity and diversity in the transcriptional response to hypoxia.

Lendahl U; Lee KL; Yang H; Poellinger L
Review: CURRENT OPINION IN GENETICS & DEVELOPMENT. 2008;18(5):449-454

Modulating Notch signaling by pathway-intrinsic and pathway-extrinsic mechanisms.

Poellinger L; Lendahl U
Review: CURRENT OPINION IN NEUROBIOLOGY. 2008;18(3):232-236

Ion fluxes and neurotransmitters signaling in neural development.

Andäng M; Lendahl U
Review: LAKARTIDNINGEN. 2008;105(20):1492-1494

[Dedifferentiation of specialized cells. New way open for cell therapy and regenerative medicine].

Lendahl U
Review: CURRENT OPINION IN LIPIDOLOGY. 2007;18(5):508-514

Modulation of vascular gene expression by hypoxia.

Ruas JL; Lendahl U; Poellinger L
Review: REGENERATIVE MEDICINE. 2006;1(2):195-205

Notch signaling and its integration with other signaling mechanisms.

Sahlgren C; Lendahl U
Review: NEUROSCIENCE. 2005;133(1):59-77

Generation and phenotypic characterization of a galanin overexpressing mouse.

Holmberg K; Kuteeva E; Brumovsky P; Kahl U; Karlström H; Lucas GA; Rodriguez J; Westerblad H; Hilke S; Theodorsson E; Berge O-G; Lendahl U; Bartfai T; Hökfelt T
Conference publication: EXPERIMENTAL HEMATOLOGY. 2005;33(7):55

Notch activation promotes conversion of B cell to T cell fate at the earliest stages of B cell committed progenitors

Taneera J; Smith E; Sigvarhsson M; Bryder D; Hansson E; Lendahl U; Jacobsen SE
Review: SEMINARS IN CANCER BIOLOGY. 2004;14(5):320-328

Notch signaling in development and disease.

Hansson EM; Lendahl U; Chapman G
Conference publication: NEUROBIOLOGY OF AGING. 2004;25:S559-S560

Functional domains in presenilin 1:: The TYR-288 residue controls gamma-secretas activity and endoproteolysis

Laudon H; Karlstöm H; Mathews PM; Farmery MR; Gandy SE; Lundkvist J; Lendahl U; Näslund J
Conference publication: AMERICAN JOURNAL OF HUMAN GENETICS. 2003;73(5):229

Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas.

Enlund F; Behboudi A; Andren Y; Öberg C; Lendahl U; Mark J; Stenman G
Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2002;12:S169-S170

Peptide receptors:: Anything different from targeting amine systems?

Hökfelt T; Xu ZQD; Holmberg K; Kehr J; Schött PA; Ögren SO; Wang FH; Yoshitaki T; Bartfai T; Lendahl U; Kokaia M; Nanobashvili A; Kokaia Z; Lindvall O; Kahl U; Yamaguchi M
Conference publication: NEUROBIOLOGY OF AGING. 2002;23(1):S206-S207

PS1-controlled γ-secretase activity:: Definition of am minimal structural motif in the N-terminal fragment

Laudon H; Bergman A; Farmery MR; Winblad B; Naslund J; Karlstrom H; Lundkvist J; Lendahl U; Mathews P; Gandy SE
Conference publication: NEUROBIOLOGY OF AGING. 2002;23(1):S174

Measurement of total gamma-cleavage of C99 with mutations in the transmembrane domain by a luciferase assay

Bergman A; Religa D; Laudon H; Lannfelt L; Nüslund J; Karlström H; Lendahl U; Lundqvist J
Conference publication: NEUROBIOLOGY OF AGING. 2002;23(1):S11

A sensitive and quantitative assay for measuring cleavage of presenilin substrates

Karlström H; Bergman A; Lendahl U; Näslund J; Lundkvist J
Review: TRENDS IN NEUROSCIENCES. 2001;24(9):492-494

Notch and the birth of glial cells.

Lundkvist J; Lendahl U
Published paper: JOURNAL OF NEUROSCIENCE METHODS. 2001;109(1):71-80

Microdialysis in freely moving mice: determination of acetylcholine, serotonin and noradrenaline release in galanin transgenic mice.

Kehr J; Yoshitake T; Wang FH; Wynick D; Holmberg K; Lendahl U; Bartfai T; Yamaguchi M; Hökfelt T; Ogren SO
Published paper: ACTA NEUROLOGICA SCANDINAVICA. 2000;102:34

Characterization of neural stem cells in the adult CNS

Johansson CB; Momma S; Clarke DL; Lendahl U; Frisen J
Review: JOURNAL OF NEUROSCIENCE RESEARCH. 1998;54(2):125-136

Notch and neurogenesis.

Beatus P; Lendahl U
Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 1998;54(9):935-945

Central nervous system stem cells in the embryo and adult.

Frisén J; Johansson CB; Lothian C; Lendahl U
Review: LAKARTIDNINGEN. 1997;94(51-52):4908-4913

[Genetic breakthrough within neuroresearch. Notch 3-gene reveals hereditary multiinfarction dementia].

Lendahl U; Wålinder J
Published paper: ACTA PAEDIATRICA, INTERNATIONAL JOURNAL OF PAEDIATRICS, SUPPLEMENT. 1997;422:8-11

Gene regulation in the formation of the central nervous system.

Lendahl U
Published paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 1996;785:353-355

Nestin distribution in the developing limb bud in vivo and in vitro.

Wroblewski J; Engström M; Edwall-Arvidsson C; Sjöberg G; Sejersen T; Lendahl U
Published paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 1996;785:298-300

Expression of Trk receptors during cartilage differentiation.

Mitsiadis TA; Wroblewski J; Urdiales JL; Becker E; Martin-Zanca D; Rudkin BB; Lendahl U
Conference publication: PEDIATRIC RESEARCH. 1996;39(4):2223

The embryonic intermediate filament protein nestin is present in the cerebrospinal fluid of NICU infants.

Blennow M; Grigelioniene G; Torok C; Lendahl U; Lagercrantz F
Review: INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY. 1995;39(5):769-780

Notch-related genes in animal development.

Lardelli M; Williams R; Lendahl U
Conference publication: JOURNAL OF CELLULAR BIOCHEMISTRY. 1995;:98

COEXISTENCE OF TRANSGENE POSITIVE AND NEGATIVE CELLS IN A H-I TRANSGENIC STRAIN WITH A CHIMERIC PHENOTYPE LEADS TO NK TOLERANCE AGAINST MISSING SELF

JOHANSSON M; BIEBERICH C; JAY G; LENDAHL U; KARRE K; HOGLUND P
Conference publication: MOLECULAR BIOLOGY OF THE CELL. 1995;6:2202

MORPHOLOGICAL-CHANGES IN THE INTERMEDIATE FILAMENT (IF) NESTIN NETWORK DURING MITOSIS CORRELATE WITH INCREASED PHOSPHORYLATION OF NESTIN

SAHLGREN C; ERIKSSON JE; LENDAHL U
Conference publication: JOURNAL OF CELLULAR BIOCHEMISTRY. 1994;:511

INTERMEDIATE FILAMENT NESTIN EXPRESSION DURING MYOGENESIS AND IN MUSCLE DISORDERS

SEJERSEN T; LENDAHL U; SJOBERG G; EDSTROM L
Show more

Grants

Establishing how cerebral small vessel disease affects brain vasculature and fluid transport

Swedish Research Council

1 January 2018 - 31 December 2022
How to tame wrongly regulated Notch signaling in cancer

Swedish Cancer Society

1 January 2018
How to tame wrongly regulated Notch signaling in cancer

Swedish Cancer Society

1 January 2017
How to tame wrongly regulated Notch signaling in cancer

Swedish Cancer Society

1 January 2016
Consequences of misregulated Notch signaling in breast cancer

Swedish Cancer Society

1 January 2015
Dysregulation of Notch signaling in vascular disease

Swedish Research Council

1 January 2014 - 31 December 2018
Consequences of misregulated Notch signaling in breast cancer

Swedish Cancer Society

1 January 2014
The Karolinska-China-Hong Kong Regenerative Medicine Initiative.

Swedish Research Council

1 January 2014 - 31 December 2018
Decoding mitochondrial fusion/fission dynamics - elucidating the role of MIEF proteins

Swedish Research Council

1 January 2013 - 31 December 2015
Karolinska CardioVascular Initiative

Knut and Alice Wallenberg Foundation

1 January 2013 - 1 January 2016
Notch signaling in vascular differentiation and disease

Swedish Research Council

1 January 2011 - 31 December 2013
Set-up for high-resolution studies of rapid cellular events

Swedish Research Council

1 July 2009 - 30 June 2014

About me

Research

Articles

All other publications

Grants

News from KI

Events from KI