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Ulla Stenius

Head of department

Visiting address : Scheelelaboratoriet, Nobels Väg 13 Solna, Sweden
Postal address : Institute of Environmental Medicine (IMM), C6, Biochemical toxicology, Box 210 171 77 Stockholm, Sweden
Delivery address : Scheelelaboratoriet, Nobels Väg 13 Solna, Sweden

Research description

Chemical carcinogensis, prevention and risk assessment

Chemical carcinogensis, prevention and risk assessment

The overall goal is to improve the basis of risk assessment of chemical carcinogens.

The CRAB-project investigates a novel approach to cancer risk assessment which could greatly assist risk assessors with the management of large textual data and aid knowledge discovery. We develop TM technology for the needs of cancer research and risk assessment with the aim to integrate this technology in a practical tool which can assist risk assessors and researchers in their work and contribute to effective management of health risks in the future.

In other projects we analyze sex differences in response to carcinogens and the effects of mixtures of polycyclic aromatic hydrocarbons (PAHs) on cellular signaling. The goal of the projects is to improve the scientific base for risk assessment. Statins have been shown to have anticancer effects and to sensitize tumor cells to cytostatic drugs. Our data show that statins regulate nuclear Akt activity via P2X7 receptors. The regulation of Akt/PTEN tumor suppressor pathway is studied.


Using text mining to aid cancer risk assessment
Gender differences in carcinogenesis
Interactions in complex PAH mixtures and cellular effects
Anticancer effect of statins; Akt signaling pathways
Cancer risk of low dose exposure for silica


Medical Research Council, UK
Engineering and Physical Sciences Research Council, UK  
Cancer- och Allergifonden

Five selected publications

Korhonen A, O'Seaghdha D, Silins I, Sun L, Högberg J, Stenius U. (2012)

CRAB- a text mining tool for literature review and knowledge discovery in cancer risk assessment and research.

PLoS ONE, in press.

Guo Y, Korhonen A, Silins I, Stenius U. (2011)

Weakly supervised learning of information structure of scientific abstracts--is it accurate enough to benefit real-world tasks in biomedicine?

Bioinformatics, 27(22):3179-85.

Mistafa O, Ghalali A, Kadekar S, Högberg J, Stenius U. (2010)

Purinergic receptor-mediated rapid depletion of nuclear pAkt depends on PH domain leucine-rich repeat phosphatase (PHLPP), calcineurin, PP2A and PTEN phosphatases.

J Biol Chem, 285, 36, 27900-27910.

Malmlöf M, Roudier E, Högberg J and Stenius U. (2007)

MEK-ERK-mediated phosphorylation of Mdm2 at Ser166 in hepatocytes; Mdm2 is activated in response to inhibited Akt signaling.

J Biol Chem, 282, 2288-2296.

Roudier E, Mistafa O and Stenius U. (2006)

Statins induce mammalian target of rapamycin (mTOR)-mediated inhibition of Akt signaling and sensitize p53-deficient cells to cytostatic drugs.

Molecular Cancer Therapeutics, 5, 2706-2715.