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Ulf Hedin

Professor/senior physician

About me

Research group leader of the group Vascular Surgery

Education

Högskoleexamen                     Karolinska Institutet, Läkarutbildningen, 1985

Doktorsexamen                        Karolinska Institutet, Medicinsk Cellbiologi, 1989

Postdoktorvistelser                Post-doc: Senior Vascular Fellow Dept Surgery, Div Vascular Surgery, Univ Washington, Seattle, USA, 1995-1996

Docentkompetens                  Docent, Karolinska Institutet, 1994

Specialistexamen                    Kirurgi, 1997; Kärlkirurgi, 1997 (efter tillkomst av grenspecialitet)

Nuvarande anställning          Professor/överläkare, Kärlkirurgiska sektionen, Institutionen för molekylär medicin och kirurgi, Karolinska Institutet samt Kärlkirurgiska kliniken, Karolinska Universitetssjukhuset, Solna.

Gruppledare , Vascular Surgery Research Group , Institutionen för molekylär medicin och kirurgi Solna , Karolinska Institutet.

Tidigare befattningar             Utbildningsbidrag KI 1985-09-01 till 1988-06-30; Doktorand-tjänst, KI 1988-07-01 till 1989-11-01; Stipendium vid MFR för övergång till klinisk forskning 1991-1993; Forskarassistenttjänst i Molekylär Medicin, Karolinska Sjukhuset/Institutet 93-97 (50%); Särskild forskartjänst (lektor 50%) kardiovaskulär forskning Hjärt- Lungfonden 1998-2004; Universitetslektor/Överläkare Kärl-kirurgiska kliniken, Karolinska Sjukhuset 2001-03-01; Biträdande prefekt, MMK, Karolinska Institutet 2005-2009; Förslag professor vaskulärbiologi , Linköpings universitet , 2001; Förslag professor i kirurgi , Kings College , London , Storbritannien, 2009; Verksamhetschef Kärlkirurgiska kliniken, Karolinska Universitetssjukhuset 2010-2016

Research description

Background

Apart from cardiac embolism, most ischemic strokes occur as a consequence to end-stage atherosclerotic disease. Atherosclerosis leads to formation of plaques in the intima of major arteries with accumulation of lipids, inflammation, fibrosis, cell death and calcification. Stable lesions are generally asymptomatic but when plaques become unstable from enhanced inflammation and proteolysis, destabilization of the fibrous cap may lead to plaque rupture, thrombosis (atherothrombosis), embolism and cerebral ischemia. More than 50% of ischemic strokes are caused by thromboembolism from extracranial vessels, as unstable plaques in the carotid bifurcation. The condition can cause transient ischemic attack (TIA), retinal symptoms (amaurosis fugax) or complete stroke. The significance of this process has been confirmed in studies demonstrating that surgery for carotid stenosis, carotid endarterectomy (CEA), in patients with symptomatic (unstable) lesions prevents stroke. Today, there are no diagnostic methods available to predict or identify plaque rupture and thus to prevent stroke from unstable atherosclerosis. Selection of patients for intervention instead rests on surrogate variables for stroke risk, such as the degree of luminal narrowing by the stenosis. In our unit, approximately 60-70 symptomatic patients undergo CEA annually, >85% within two weeks after index event (national guideline), and with an estimated efficacy of 10 prevented strokes whereas 10-15 asymptomatic patients undergo CEA with less than one prevented stroke estimated.

Work plan

This project is based on current studies utilizing an established biobank (BiKE) of plaque and plasma samples from n>800 patients treated at our clinic, which have been prospectively processed for RNA, DNA, proteomic, in situ and in vitro analyses. The biobank is combined with data of phenotypic information, transcriptomic array profiles and genome wide SNP data. The resource has progressively developed and over the years been extensively utilised to identify gene signatures in atherosclerotic plaque instability. The project is currently being expanded to include large-scale characterization of plasma- and tissue proteins as well as non-coding RNAs (miRs) of human atherosclerosis in correlation to transcriptomic profiles, ultimately aiming at detection of plausible biomarkers for unstable end-stage atherosclerosis. Through established collaborations with international and national resources (SciLife; SCAPIS; Göteborgs Universitet; Stanford; King’s College, London), we are implementing state-of-the-art proteomics (mass spectroscopy and affinity-based) of plasma- and tissue samples from patients with stable- and unstable carotid stenosis, next generation methodology for RNA expression analyses in situ, and pre-operative imaging of patients with new MRI- and ultrasound based technology with the ultimate goal of developing targeted bioimaging for the localization of unstable atherosclerotic lesions. 

Aims

Through the identification of circulating signature molecules (biomarkers) for the unstable atheroma and the development of diagnostic tools for morphological characterization of unstable carotid plaques this project will improve stroke-prevention by:

optimizing risk intervention
improving selection of patients for stroke preventive surgery and
supporting development of plaque-stabilizing drugs

Teaching portfolio

Huvudhandledning                 Joy Roy, MD PhD                                                                010831

                            Piotr Religa, MD PhD                                                      030214

                            Monsur Kazi, MD PhD                                                     030328

                            Kiet Tran, MD PhD                                                            050218

                            Karin Tran Lundmark, MD PhD                                 080307

                            Anton Razuvaev, MD PhD                                            090603

                           

                            Jing Wang, post-doc                                                        2008-2010

                            Cecilia Österholm-Corbascio post-doc              2010-2014

                            Ljubica Perisic, post-doc                                             2012-

                            Silvia Aldi, post-doc                                                         2014-

                            Linnea Eriksson, post-doc                                           2014-

 

Bihandledning                           Chi-Nan Tseng, MD PhD                                                150410

                            Ya Ting Chang, MD PhD                                                  150612

                            Carl Montán, MD PhD                                                    150529

                            Alireza Daraypeyma, MD PhD                                  150424

                           

Undervisning                Kursarrangör Forskarutbildningskurser 6st

                                              Kursarrangör ST utbildningskurser Kärlkirurgi 16st

Studierektor Biomedicinarprogrammet Molekylär Medicin, KI 1996-1998; bitr Studierektor Biomedicinarprogrammet Molekylär Medicin, KI 1999; Utbildningsansvarig Läkarprogrammet Kärlkirurgi 1997-2003

                                              Handledning projektarbeten Läkarprogrammet, KI 13 studenter

Academic honours, awards and prizes

Förtroendeuppdrag               Styrelseledamot: Scandinavian Society for Atherosclerosis Research 1994-1999; Inst Kir, KI/KS 2001-; Beredningrupp VR 2000-2006; SPESAK Stockholms län (SLL) 2006-2011; Nationell representant European Society for Vascular Surgery 2008-2011; Forskningsrådet Hjärt-Lungfonden 2011-2015; International Surgical Group 2011-; Forskningsrådet Lundbeck Foundation 2012 -; Elektor VR 2015; Valberedning VR 2015; Nominerad Prefekt Inst Mol Med Kir, KI 2016; Socialstyrelsens Prioriteringsgrupp Strokeriktlinjer 2016.

Sakkunniguppdrag                   Extern sakkunnig: Docentur: Lunds Universitet 6 st; Sahlgrenska Akademin 2 st; KI 8 st. Uppsala Universitet 1 st. Lektorat: Lunds Universitet 2 st. Professur Kärlkirurgi: Köpenhamns Universitet 2013; Syddansk Universitet 2012; Helsingfors Universitet 2014; Lunds Universitet 2015; Harvard Medical School 2015. Söderbergska Priset, Svensk Kirurgisk Förening 2013. Syddansk Center of Excellence 2015.

1.          Fakultetsopponent: 15 st (Yenfeng Wang, Wihuri Res Inst, Helsinki, Finland, 1999; Lars Lohikangas, Uppsala Universitet, Uppsala, 2000; Audrey Niemann-Jönsson, Lunds Universitet, Malmö, 2000; Sara Moses, Lunds Universitet, 2002; Marie-Louise Moes Grönholdt, Rigshospitalet, Köpenhamn, Danmark, 2003; Helena Peilot, Sahlgrenska Akademin, Göteborg, 2003; Per Fogelstrand, Sahlgrenska Akademin, Göteborg, 2004; Andreas Bergdahl, Lunds Universitet, 2004; Nikolaj Eldrup, Köpenhamns Universitet, 2008; Per Wastesson, Sahlgrenska Akademin, 2008; Niklas Bergh, Sahlgrenska Akademin, 2009; Tomas Block, Uppsala Universitet, 2010; Martin Graebe, Köpenhamns Universitet, 2010; Louise Rosenörn de la Motte, Köpenhamns Universitet, 2013; Charlotte Eklund, Göteborgs Universitet, 2014); Halvtidskontroller 24 st; Betygsnämnd 22st

2.                                 Referee 17 Tidskrifter

Utmärkelser                                Forskargrupp graderad ’excellent’ efter internationell utvärdering av alla forskargrupper vid Karolinska Institutet

2013 Harry Broström Memorial Lecture, Svenska föreningen för invärtesmedicin

Publications

Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques
Langley Sr, Willeit K, Didangelos A, Matic Lp, Skroblin P, Barallobre-barreiro J, et al
JOURNAL OF CLINICAL INVESTIGATION 2017;127(4):1546-1560

MicroRNA-210 Enhances Fibrous Cap Stability in Advanced Atherosclerotic Lesions
Eken Sm, Jin H, Chernogubova E, Li Y, Simon N, Sun C, et al
Circulation research 2017;120(4):633-644

TCF21 and the environmental sensor aryl-hydrocarbon receptor cooperate to activate a pro-inflammatory gene expression program in coronary artery smooth muscle cells
Kim Jb, Pjanic M, Nguyen T, Miller Cl, Iyer D, Liu B, et al
PLoS genetics 2017;13(5):e1006750-

Upper-arm hemodialysis access in Sweden
Hedin U, Welander G
The journal of vascular access 2017;18(Suppl. 1):110-113

Vaccination against T-cell epitopes of native ApoB100 reduces vascular inflammation and disease in a humanized mouse model of atherosclerosis
Gisterå A, Hermansson A, Strodthoff D, Klement Ml, Hedin U, Fredrikson Gn, et al
Journal of internal medicine 2017;281(4):383-397

Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation
Stellos K, Gatsiou A, Stamatelopoulos K, Perisic Matic L, John D, Lunella Ff, et al
Nature medicine 2016;22(10):1140-1150

CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis
Kojima Y, Volkmer Jp, Mckenna K, Civelek M, Lusis Aj, Miller Cl, et al
NATURE 2016;536(7614):86-90

CDKN2B Regulates TGFβ Signaling and Smooth Muscle Cell Investment of Hypoxic Neovessels
Nanda V, Downing Kp, Ye J, Xiao S, Kojima Y, Spin Jm, et al
Circulation research 2016;118(2):230-40

Commentary on 'Plaque Echolucency and the Risk of Ischaemic Stroke in Patients with Asymptomatic Carotid Stenosis Within the First Asymptomatic Carotid Surgery Trial (ACST-1)'
Roy J, Hedin U
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 2016;51(5):622-

Functional Analysis of a Novel Genome-Wide Association Study Signal in SMAD3 That Confers Protection From Coronary Artery Disease
Turner Aw, Martinuk A, Silva A, Lau P, Nikpay M, Eriksson P, et al
Arteriosclerosis, thrombosis, and vascular biology 2016;36(5):972-83

Gene expression signatures, pathways and networks in carotid atherosclerosis
Perisic L, Aldi S, Sun Y, Folkersen L, Razuvaev A, Roy J, et al
Journal of internal medicine 2016;279(3):293-308

Heparanase expression upregulates platelet adhesion activity and thrombogenicity
Cui H, Tan Yx, Österholm C, Zhang X, Hedin U, Vlodavsky I, et al
Oncotarget 2016;7(26):39486-39496

Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci
Miller Cl, Pjanic M, Wang T, Nguyen T, Cohain A, Lee Jd, et al
Nature communications 2016;7():12092-

miRNA Targeting of Oxysterol-Binding Protein-Like 6 Regulates Cholesterol Trafficking and Efflux
Ouimet M, Hennessy Ej, Van Solingen C, Koelwyn Gj, Hussein Ma, Ramkhelawon B, et al
Arteriosclerosis, thrombosis, and vascular biology 2016;36(5):942-951

Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice
Skarpengland T, Holm S, Scheffler K, Gregersen I, Dahl Tb, Suganthan R, et al
Scientific reports 2016;6():28337-

NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis
Paramel Varghese G, Folkersen L, Strawbridge Rj, Halvorsen B, Yndestad A, Ranheim T, et al
Journal of the American Heart Association 2016;5(5):-

Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM
Perisic Matic L, Rykaczewska U, Razuvaev A, Sabater-lleal M, Lengquist M, Miller Cl, et al
Arteriosclerosis, thrombosis, and vascular biology 2016;36(9):1947-61

Targeting macrophage necroptosis for therapeutic and diagnostic interventions in atherosclerosis
Karunakaran D, Geoffrion M, Wei L, Gan W, Richards L, Shangari P, et al
Science advances 2016;2(7):e1600224-

Versican accumulates in vascular lesions in pulmonary arterial hypertension
Chang Yt, Chan Ck, Eriksson I, Johnson Py, Cao X, Westöö C, et al
Pulmonary circulation 2016;6(3):347-59

VORTEC technique in central venous recanalization for haemodialysis access salvage
Törnqvist P, Hedin U, Asciutto G, Engström J, Bountouris I, Kristmundsson T, et al
The journal of vascular access 2016;17(1):e3-4

Aspirin-triggered 15-epi-lipoxin A₄ signals through FPR2/ALX in vascular smooth muscle cells and protects against intimal hyperplasia after carotid ligation
Petri Mh, Laguna-fernandez A, Tseng Cn, Hedin U, Perretti M, Bäck M
International journal of cardiology 2015;179():370-2

Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells that Contribute to the Fibrous Cap
Nurnberg St, Cheng K, Raiesdana A, Kundu R, Miller Cl, Kim Jb, et al
Genomics data 2015;5():36-37

Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap
Nurnberg St, Cheng K, Raiesdana A, Kundu R, Miller Cl, Kim Jb, et al
PLoS genetics 2015;11(5):e1005155-

Glucagon-Like Peptide-1 Receptor Activation Does not Affect Re-Endothelialization but Reduces Intimal Hyperplasia via Direct Effects on Smooth Muscle Cells in a Nondiabetic Model of Arterial Injury
Eriksson L, Saxelin R, Röhl S, Roy J, Caidahl K, Nyström T, et al
Journal of vascular research 2015;52(1):41-52

Glycolaldehyde and maleyl conjugated human serum albumin as potential macrophage-targeting carriers for molecular imaging purposes
Gustafsson B, Hedin U, Caidahl K
Contrast media & molecular imaging 2015;10(1):37-42

Long-term results of PTFE grafts
Hedin U
The journal of vascular access 2015;16 Suppl 9():S87-92

Macrophage Mitochondrial Energy Status Regulates Cholesterol Efflux and Is Enhanced by Anti-miR33 in Atherosclerosis
Karunakaran D, Thrush Ab, Nguyen Ma, Richards L, Geoffrion M, Singaravelu R, et al
Circulation research 2015;117(3):266-78

Perlecan heparan sulfate deficiency impairs pulmonary vascular development and attenuates hypoxic pulmonary hypertension
Chang Yt, Tseng Cn, Tannenberg P, Eriksson L, Yuan K, De Jesus Perez Va, et al
Cardiovascular research 2015;107(1):20-31

Perlecan Heparan Sulfate Is Required for the Inhibition of Smooth Muscle Cell Proliferation by All-trans-Retinoic Acid
Tran-lundmark K, Tannenberg P, Rauch Bh, Ekstrand J, Tran Pk, Hedin U, et al
JOURNAL OF CELLULAR PHYSIOLOGY 2015;230(2):482-7

Platelet adhesion on endothelium early after vein grafting mediates leukocyte recruitment and intimal hyperplasia in a murine model
Tseng Cn, Chang Yt, Lengquist M, Kronqvist M, Hedin U, Eriksson Ee
Thrombosis and haemostasis 2015;113(4):813-25

Preoperative hypofibrinogenemia is associated with increased intraoperative bleeding in ruptured abdominal aortic aneurysms
Montán C, Johansson F, Hedin U, Wahlgren Cm
Thrombosis research 2015;135(3):443-8

Schip1 is a novel podocyte foot process protein that mediates actin cytoskeleton rearrangements and forms a complex with Nherf2 and ezrin
Perisic L, Rodriguez Pq, Hultenby K, Sun Y, Lal M, Betsholtz C, et al
PloS one 2015;10(3):e0122067-

Schip1 Is a Novel Podocyte Foot Process Protein that Mediates Actin Cytoskeleton Rearrangements and Forms a Complex with Nherf2 and Ezrin (vol 10, e0122067, 2015)
Perisic L, Rodriguez Pq, Hultenby K, Sun Y, Lal M, Betsholtz C, et al
PLOS ONE 2015;10(5):e0126079-

Contribution of endothelial injury and inflammation in early phase to vein graft failure: the causal factors impact on the development of intimal hyperplasia in murine models
Tseng Cn, Karlöf E, Chang Yt, Lengquist M, Rotzius P, Berggren Po, et al
PloS one 2014;9(6):e98904-

Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation
Miller Cl, Haas U, Diaz R, Leeper Nj, Kundu Rk, Patlolla B, et al
PLoS genetics 2014;10(3):e1004263-

Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis
Kojima Y, Downing K, Kundu R, Miller C, Dewey F, Lancero H, et al
JOURNAL OF CLINICAL INVESTIGATION 2014;124(3):1083-97

Early changes of gene expression profiles in the rat model of arterial injury
Fedorov A, Kostareva A, Raud J, Roy J, Hedin U, Razuvaev A
Journal of vascular and interventional radiology : JVIR 2014;25(5):789-796.e7

Heparan sulfate side chains have a critical role in the inhibitory effects of perlecan on vascular smooth muscle cell response to arterial injury
Gotha L, Lim Sy, Osherov Ab, Wolff R, Qiang B, Erlich I, et al
American journal of physiology. Heart and circulatory physiology 2014;307(3):H337-45

Innate immune receptor NOD2 promotes vascular inflammation and formation of lipid-rich necrotic cores in hypercholesterolemic mice
Johansson Me, Zhang Xy, Edfeldt K, Lundberg Am, Levin Mc, Borén J, et al
European journal of immunology 2014;44(10):3081-92

Perlecan heparan sulfate proteoglycan is a critical determinant of angiogenesis in response to mouse hind-limb ischemia
Qiang B, Lim Sy, Lekas M, Kuliszewski Ma, Wolff R, Osherov Ab, et al
The Canadian journal of cardiology 2014;30(11):1444-51

Synergy between shear-induced migration and secondary flows on red blood cells transport in arteries: considerations on oxygen transport
Biasetti J, Spazzini Pg, Hedin U, Gasser Tc
Journal of the Royal Society, Interface 2014;11(97):20140403-

The collagen cross-linking enzyme lysyl oxidase is associated with the healing of human atherosclerotic lesions
Ovchinnikova Oa, Folkersen L, Persson J, Lindeman Jh, Ueland T, Aukrust P, et al
Journal of internal medicine 2014;276(5):525-36

Vascular access: a never-ending story
Hedin U
The Journal of cardiovascular surgery 2014;55(6):793-801

Identification of carotid plaque tissue properties using an experimental-numerical approach
Heiland Vm, Forsell C, Roy J, Hedin U, Gasser Tc
Journal of the mechanical behavior of biomedical materials 2013;27():226-38

Increased expression of heparanase in symptomatic carotid atherosclerosis
Osterholm C, Folkersen L, Lengquist M, Pontén F, Renné T, Li J, et al
Atherosclerosis 2013;226(1):67-73

NOD2-mediated innate immune signaling regulates the eicosanoids in atherosclerosis
Liu Hq, Zhang Xy, Edfeldt K, Nijhuis Mo, Idborg H, Bäck M, et al
Arteriosclerosis, thrombosis, and vascular biology 2013;33(9):2193-201

Profiling of atherosclerotic lesions by gene and tissue microarrays reveals PCSK6 as a novel protease in unstable carotid atherosclerosis
Perisic L, Hedin E, Razuvaev A, Lengquist M, Osterholm C, Folkersen L, et al
Arteriosclerosis, thrombosis, and vascular biology 2013;33(10):2432-43

[Tools for control of bleeding during vascular trauma]
Wahlgren Cm, Montán C, Hedin U
Lakartidningen 2013;110(7):354-7

Antenatal imatinib treatment reduces pulmonary vascular remodeling in a rat model of congenital diaphragmatic hernia
Chang Yt, Uggla Ar, Osterholm C, Tran Pk, Eklof Ac, Lengquist M, et al
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 2012;302(11):L1159-66

High plasma adiponectin concentration is associated with all-cause mortality in patients with carotid atherosclerosis
Persson J, Folkersen L, Ekstrand J, Helleberg J, Gabrielsen A, Lundman P, et al
Atherosclerosis 2012;225(2):491-6

Identification of the BCAR1-CFDP1-TMEM170A locus as a determinant of carotid intima-media thickness and coronary artery disease risk
Gertow K, Sennblad B, Strawbridge Rj, Ohrvik J, Zabaneh D, Shah S, et al
Circulation. Cardiovascular genetics 2012;5(6):656-65

Increased levels of the homeostatic chemokine CXCL13 in human atherosclerosis - Potential role in plaque stabilization
Smedbakken Lm, Halvorsen B, Daissormont I, Ranheim T, Michelsen Ae, Skjelland M, et al
ATHEROSCLEROSIS 2012;224(1):266-73

Prediction of Ischemic Events on the Basis of Transcriptomic and Genomic Profiling in Patients Undergoing Carotid Endarterectomy
Folkersen L, Persson J, Ekstrand J, Agardh He, Hansson Gk, Gabrielsen A, et al
MOLECULAR MEDICINE 2012;18(4):669-75

The expression of IGFs and IGF binding proteins in human carotid atherosclerosis, and the possible role of IGF binding protein-1 in the regulation of smooth muscle cell proliferation
Wang J, Razuvaev A, Folkersen L, Hedin E, Roy J, Brismar K, et al
ATHEROSCLEROSIS 2012;220(1):102-9

Toll-Like Receptor 7 Protects From Atherosclerosis by Constraining "Inflammatory" Macrophage Activation
Salagianni M, Galani Ie, Lundberg Am, Davos Ch, Varela A, Gavriil A, et al
CIRCULATION 2012;126(8):952-62

12-and 15-lipoxygenases in human carotid atherosclerotic lesions: Associations with cerebroyascular symptoms
Gertow K, Nobili E, Folkersen L, Newman Jw, Pedersen Tl, Ekstrand J, et al
ATHEROSCLEROSIS 2011;215(2):411-6

Correlations Between Clinical Variables and Gene-expression Profiles in Carotid Plaque Instability
Razuvaev A, Ekstrand J, Folkersen L, Agardh H, Markus D, Swedenborg J, et al
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY 2011;42(6):722-30

Expression of fatty acid-binding protein 4/aP2 is correlated with plaque instability in carotid atherosclerosis
Agardh He, Folkersen L, Ekstrand J, Marcus D, Swedenborg J, Hedin U, et al
JOURNAL OF INTERNAL MEDICINE 2011;269(2):200-10

[Hemodialysis access--a vascular surgical problem]
Hedin U
Lakartidningen 2011;108(8):406-10

Identification of a Danger-Associated Peptide From Apolipoprotein B100 (ApoBDS-1) That Triggers Innate Proatherogenic Responses
Ketelhuth Dfj, Rios Fjo, Wang Yj, Liu Hq, Johansson Me, Fredrikson Gn, et al
CIRCULATION 2011;124(22):2433-43

A Mouse Model of Vascular Grafting
Tseng Cn, Eriksson E, Hedin U
JOURNAL OF VASCULAR SURGERY 2010;:79S-79S

A Specific Inhibitor of IGF-1 Receptor - Picropodophyllin Can Suppress Atheroma Progression and Has a Stabilizing Effect on Atherosclerotic Lesions in ApoE Deficient Mice
Razuvaev A, Larsson O, Axelson M, Hedin U, Roy J
JOURNAL OF VASCULAR SURGERY 2010;:72S-73S

Association of Genetic Risk Variants With Expression of Proximal Genes Identifies Novel Susceptibility Genes for Cardiovascular Disease
Bike Study Grp, Asap Study Grp, Folkersen L, Van't Hooft F, Chernogubova E, Agardh He, et al
CIRCULATION-CARDIOVASCULAR GENETICS 2010;3(4):365-73

[Ethics Review Boards discriminate the most severely ill--Swedish researchers are prevented to participate in an international study]
Björck M, Berg B, Hedin U, Wingren U
Lakartidningen 2010;107(21):1356-7

Hemodynamics of the Normal Aorta Compared to Fusiform and Saccular Abdominal Aortic Aneurysms with Emphasis on a Potential Thrombus Formation Mechanism
Biasetti J, Gasser Tc, Auer M, Hedin U, Labruto F
ANNALS OF BIOMEDICAL ENGINEERING 2010;38(2):380-90

Regulation of Endothelin-1 and Endothelin Receptors by Shear Stress in Vascular Smooth Muscle Cells
Ekstrand J, Razuvaev A, Roy J, Hedin U
JOURNAL OF VASCULAR SURGERY 2010;:80S-80S

The use of network analyses for elucidating mechanisms in cardiovascular disease
Diez D, Wheelock Am, Goto S, Haeggstrom Jz, Paulsson-berne G, Hansson Gk, et al
MOLECULAR BIOSYSTEMS 2010;6(2):289-304

Thromboxane synthase expression and thromboxane A(2) production in the atherosclerotic lesion
Gabrielsen A, Qiu H, Back M, Hamberg M, Hemdahl Al, Agardh H, et al
JOURNAL OF MOLECULAR MEDICINE-JMM 2010;88(8):795-806

Tissue factor pathway inhibitor-2 is induced by fluid shear stress in vascular smooth muscle cells and affects cell proliferation and survival
Ekstrand J, Razuvaev A, Folkersen L, Roy J, Hedin U
JOURNAL OF VASCULAR SURGERY 2010;52(1):167-75

Genetic variants of TNFSF4 and risk for carotid artery disease and stroke
Olofsson Ps, Soderstrom La, Jern C, Sirsjo A, Ria M, Sundler E, et al
JOURNAL OF MOLECULAR MEDICINE-JMM 2009;87(4):337-46

Mast cells associate with neovessels in the media and adventitia of abdominal aortic aneurysms
Mayranpaa Mi, Trosien Ja, Fontaine V, Folkesson M, Kazi M, Eriksson P, et al
JOURNAL OF VASCULAR SURGERY 2009;50(2):388-95

Role of Chymase in the Regulation of the Insulin-like Growth Factor System in Human Carotid Atherosclerosis
Wang J, Brismar K, Roy J, Razuvaev A, Hedin U
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2009;29(7):E43-E43

Use of Gene Expression Profiling to Study the Healing Process in Carotid Plaques
Razuvaev A, Ekstrand J, Agardh H, Paulsson-berne G, Hansson G, Swedenborg J, et al
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2009;29(7):E73-E73

A potential role of the CXC chemokine GRO alpha in atherosclerosis and plaque destabilization - Downregulatory effects of statins
Breland Um, Halvorsen B, Hol J, Oie E, Paulsson-berne G, Yndestad A, et al
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2008;28(5):1005-11

CD137 is expressed in human atherosclerosis and promotes development of plaque inflammation in hypercholesterolemic mice
Olofsson Ps, Soderstrom La, Wagsater D, Sheikine Y, Ocaya P, Lang F, et al
CIRCULATION 2008;117(10):1292-301

ENHANCED EXPRESSION OF THE CHEMOKINE CXCL1 IN ATHEROSCLEROTIC DISORDERS, DOWN-REGULATORY EFFECTS OF STATIN
Breland Um, Halvorsen B, Hol J, Oie E, Yndestad A, Smith C, et al
ATHEROSCLEROSIS SUPPLEMENTS 2008;9(1):198-198

Heparan sulfate in perlecan promotes mouse atherosclerosis - Roles in lipid permeability, lipid retention, and smooth muscle cell proliferation
Tran-lundmark K, Tran Pk, Paulsson-berne G, Friden V, Soininen R, Tryggvason K, et al
CIRCULATION RESEARCH 2008;103(1):43-52

High F-18-FDG Uptake in Synthetic Aortic Vascular Grafts on PET/CT in Symptomatic and Asymptomatic Patients
Wasselius J, Malmstedt J, Kalin B, Larsson S, Sundin A, Hedin U, et al
JOURNAL OF NUCLEAR MEDICINE 2008;49(10):1601-5

Noninvasive real-time imaging of intima thickness after rat carotid artery balloon injury using ultrasound biomicroscopy
Razuvaev A, Lund K, Roy J, Hedin U, Caidahl K
ATHEROSCLEROSIS 2008;199(2):310-6

Variants of the interferon regulatory factor 5 gene regulate expression of IRF5 mRNA in atherosclerotic tissue but are not associated with myocardial infarction
Malarstig A, Sigurdsson S, Eriksson P, Paulsson-berne G, Hedin U, Wallentin L, et al
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2008;28(5):975-82

Cardioprotective effect of rosuvastatin in vivo is dependent on inhibition of geranylgeranyl pyrophosphate and altered RhoA membrane translocation
Bulhak A, Roy J, Hedin U, Sjoquist Po, Pernow J
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 2007;292(6):H3158-63

Presence of NGAL/MMP-9 complexes in human abdominal aortic aneurysms
Folkesson M, Kazi M, Zh C, Silveira A, Hemclahl Al, Harristen A, et al
THROMBOSIS AND HAEMOSTASIS 2007;98(2):427-33

Reduced perlecan expression and accumulation in human carotid atherosclerotic lesions
Tran Pk, Agardh He, Tran-lundmark K, Ekstrand J, Roy J, Henderson B, et al
ATHEROSCLEROSIS 2007;190(2):264-70

[Symptomatic carotid stenosis should be treated surgically, not with stenting. Great risks with stents, according to studies]
Swedenborg J, Hedin U, Bergqvist D
Lakartidningen 2007;104(6):412-4

The cyclolignan picropodophyllin attenuates intimal hyperplasia after rat carotid balloon injury by blocking insulin-like growth factor-1 receptor signaling
Razuvaev A, Henderson B, Girnita L, Larsson O, Axelson M, Hedin U, et al
JOURNAL OF VASCULAR SURGERY 2007;46(1):108-15

Ultrasound biomicroscopy of rat carotid intima and wall thicknesses
Razuvaev A, Lund K, Roy J, Hedin U, Caidahl K
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 2007;49(9):406A-406A

Expression of 5-lipoxygenase and leukotriene A(4) hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability
Qiu H, Gabrielsen A, Agardh He, Wan M, Wetterholm A, Wong Ch, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2006;103(21):8161-6

Expression of neutrophil gelatinase-associated lipocalin in atherosclerosis and myocardial infarction
Hemdahl Al, Gabrielsen A, Zhu Cy, Eriksson P, Hedin U, Kastrup J, et al
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2006;26(1):136-42

Geranylgeranyl pyrophosphate blocks cardioprotective effect of rosuvastatin in vivo
Bulhak A, Roy J, Hedin U, Sjoquist Po, Pernow J
EUROPEAN HEART JOURNAL 2006;:67-67

Inflammatory response inhuman atherosclerosis : bike - Biobank of karolinska endartherectomy
Paulsson-berne G, Gabrielsen A, Agardh He, Ekstrand J, Marcus D, Bodin I, et al
ATHEROSCLEROSIS SUPPLEMENTS 2006;7(3):248-248

Invariant NKT cells present in human atherosclerotic lesions
Agardh He, Eriksson P, Tupin E, Kazi M, Hedin U, Olsson A, et al
ATHEROSCLEROSIS SUPPLEMENTS 2006;7(3):406-406

Reduced atherosclerosis in APO E-/- mice with heparan sulfate-deficient perlecan
Lundmark Kt, Tran Pk, Berne Gp, Soininen R, Tryggvason K, Wight Tn, et al
ATHEROSCLEROSIS SUPPLEMENTS 2006;7(3):489-489

Allogenic immune response promotes the accumulation of host-derived smooth muscle cells in transplant arteriosclerosis
Religa P, Bojakowski K, Bojakowska M, Gaciong Z, Thyberg J, Hedin U
CARDIOVASCULAR RESEARCH 2005;65(2):535-45

Difference in matrix-degrading protease expression and activity between thrombus-free and thrombus-covered wall of abdominal aortic aneurysm
Kazi M, Zhu Cy, Roy J, Paulsson-berne G, Hamsten A, Swedenborg J, et al
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2005;25(7):1341-6

Powerful inflammatory properties of large vein endothelium in vivo
Eriksson Ee, Karlof E, Lundmark K, Rotzius P, Hedin U, Xie X
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2005;25(4):723-8

The antiviral cytomegalovirus inducible gene 5/viperin is expressed in atherosclerosis and regulated by proinflammatory agents
Olofsson Ps, Jatta K, Wågsäter D, Gredmark S, Hedin U, Paulsson-berne G, et al
Arteriosclerosis, thrombosis, and vascular biology 2005;25(7):e113-6

The antiviral cytomegalovirus inducible gene 5/viperin is expressed in atherosclerosis and regulated by proinflammatory agents
Olofsson Ps, Jatta K, Wagsater D, Gredmark S, Hedin U, Paulsson-berne G, et al
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2005;25(7):E113-E116

Allogenic immune response promotes accumulation of host-derived smooth muscle cells in transplant arteriosclerosis
Bojakowski K, Religa P, Bojakowska M, Gaciong Z, Thyberg J, Hedin U
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2004;24(5):E76-E76

Control of smooth muscle cell proliferation in vascular disease
Hedin U, Roy J, Tran Pk
CURRENT OPINION IN LIPIDOLOGY 2004;15(5):559-65

CXCL16/SR-PSOX is an interferon-gamma-regulated chemokine and scavenger receptor expressed in atherosclerotic lesions
Wuttge Dm, Zhou Xh, Sheikine Y, Wagsater D, Stemme V, Hedin U, et al
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2004;24(4):750-5

Identification of Endothelial Proteins by MALDI-MS Using a Compact Disc Microfluidic System
Hirschberg D, Tryggvason S, Gustafsson M, Bergman T, Swedenborg J, Hedin U, et al
PROTEIN JOURNAL 2004;23(4):263-71

Increased intimal hyperplasia and smooth muscle cell proliferation in transgenic mice with heparan sulfate-deficient perlecan
Tran Pk, Tran-lundmark K, Soininen R, Tryggvason K, Thyberg J, Hedin U
CIRCULATION RESEARCH 2004;94(4):550-8

Influence of the intraluminal thrombus in abdominal aortic aneurysms
Swedenborg J, Kazi M, Eriksson R, Hedin U
ACTA CHIRURGICA BELGICA 2004;104(6):606-8

Allogenic response determines accumulation of host-derived smooth muscle cells in transplant arteriosclerosis
Religa P, Bojakowski K, Gaciong Z, Thyberg J, Hedin U
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2003;23(5):A81-A81

Arteriosclerosis in rat aortic allografts: Dynamics of cell growth, apoptosis and expression of extracellular matrix proteins
Religa P, Bojakowski K, Gaciong Z, Thyberg J, Hedin U
MOLECULAR AND CELLULAR BIOCHEMISTRY 2003;249(1-2):75-83

Influence of intraluminal thrombus on structural and cellular composition of abdominal aortic aneurysm wall
Kazi M, Thyberg J, Religa P, Roy J, Eriksson P, Hedin U, et al
JOURNAL OF VASCULAR SURGERY 2003;38(6):1283-92

Enhanced vasoconstrictor effect of big endothelin-1 in patients with atherosclerosis: relation to conversion to endothelin-1
Bohm F, Johansson Bl, Hedin U, Alving K, Pernow J
ATHEROSCLEROSIS 2002;160(1):215-22

Extracellular matrix composition and cellular mechanisms of transplant vasculopathy in rat aortic allografts
Religa P, Bojakowski K, Bojakowska M, Gaciong Z, Thyberg J, Hedin U
TRANSPLANTATION PROCEEDINGS 2002;34(2):687-8

Fibronectin promotes cell cycle entry in smooth muscle cells in primary culture
Roy J, Tran Pk, Religa P, Kazi M, Henderson B, Lundmark K, et al
EXPERIMENTAL CELL RESEARCH 2002;273(2):169-77

Inhibition of rat smooth muscle cell adhesion and proliferation by non-anticoagulant heparins
Kazi M, Lundmark K, Religa P, Gouda I, Larm O, Ray A, et al
JOURNAL OF CELLULAR PHYSIOLOGY 2002;193(3):365-72

Perlecan side chains suppress PDGF-BB-induced proliferation in vascular smooth muscle cells: Potential role of basic FGF
Schmidt O, Tran Pk, Kalmes A, Daum G, Thyberg J, Hedin U, et al
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2002;22(5):A65-A65

Recombinant human laminin-10 (alpha 5,beta 1,gamma 1) - Production, purification, and migration-promoting activity on vascular endothelial cells
Doi M, Thyboll J, Kortesmaa J, Jansson K, Iivanainen A, Parvardeh M, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2002;277(15):12741-8

Rho regulates extracellular matrix-mediated activation of arterial smooth muscle cells
Roy J, Henderson B, Thyberg J, Hedin U
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2002;22(5):A45-A45

Smooth-muscle progenitor cells of bone marrow origin contribute to the development of neointimal thickenings in rat aortic allografts and injured rat carotid arteries
Religa P, Bojakowski K, Maksymowicz M, Bojakowska M, Sirsjo A, Gaciong Z, et al
TRANSPLANTATION 2002;74(9):1310-5

Arteriosclerosis in rat aortic allografts: Dependence of cell phenotype, growth and apoptosis on extracellular matrix composition
Religa P, Bojakowski K, Gaciong Z, Hedin U, Thyberg J
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 2001;33(6):A100-A100

Perlecan inhibits smooth muscle cell adhesion to fibronectin: Role of heparan sulfate
Lundmark K, Tran Pk, Kinsella Mg, Clowes Aw, Wight Tn, Hedin U
JOURNAL OF CELLULAR PHYSIOLOGY 2001;188(1):67-74

Phenotypic modulation of arterial smooth muscle coils is associated with prolonged activation of Erk1/2
Roy J, Kazi M, Hedin U, Thyberg J
DIFFERENTIATION 2001;67(1-2):50-8

Targeted deletion of the attachment sites for heparansulfate chains in domain-I of perlecan leads to an increased growth response in vascular smooth muscle cells.
Tran Pk, Soininen R, Lundmark K, Tryggvason K, Hedin U, Thyberg J
CIRCULATION 2001;104(17):275-275

Arteriosclerosis in rat aortic allografts: Early changes in endothelial integrity and smooth muscle phenotype
Bojakowski K, Religa P, Bojakowska M, Hedin U, Gaciong Z, Thyberg J
TRANSPLANTATION 2000;70(1):65-72

Enhanced vasoconstriction and conversion to endothelin-1 in response to big endothelin-1 administration in patients with atherosclerosis
Bohm Fm, Johansson Bl, Hedin U, Alving K, Pernow J
CIRCULATION 2000;102(18):170-170

Enhanced vasoconstrictor response to endothelin-B-receptor stimulation in patients with atherosclerosis
Pernow J, Bohm F, Johansson Bl, Hedin U, Ryden L
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 2000;:S418-20

Control of smooth muscle cell proliferation--the role of the basement membrane
Hedin U, Roy J, Tran Pk, Lundmark K, Rahman A
Thrombosis and haemostasis 1999;82 Suppl 1():23-6

Cytokine expression in advanced human atherosclerotic plaques: dominance of pro-inflammatory (Th1) and macrophage-stimulating cytokines
Frostegard J, Ulfgren Ak, Nyberg P, Hedin U, Swedenborg J, Andersson U, et al
ATHEROSCLEROSIS 1999;145(1):33-43

[Intermittent claudication--a major cardiovascular risk factor. Proposed guidelines for investigation and treatment]
Svensson P, Wahlberg E, Hedin U, Ostergren J
Lakartidningen 1999;96(13):1585-90

Heparan sulfate proteoglycans mediate a potent inhibitory signal for migration of vascular smooth muscle cells
Koyama N, Kinsella Mg, Wight Tn, Hedin U, Clowes Aw
CIRCULATION RESEARCH 1998;83(3):305-13

Heparin inhibits thrombin-induced mitogen-activated protein kinase signaling in arterial smooth muscle cells
Hedin U, Daum G, Clowes Aw
JOURNAL OF VASCULAR SURGERY 1998;27(3):512-20

Disruption of integrin alpha(5)beta(1) signaling does not impair PDGF-BB-Mediated stimulation of the extracellular signal-regulated kinase pathway in smooth muscle cells
Hedin U, Daum G, Clowes Aw
JOURNAL OF CELLULAR PHYSIOLOGY 1997;172(1):109-16

Diverse effects of heparin on mitogen-activated protein kinase-dependent signal transduction in vascular smooth muscle cells
Daum G, Hedin U, Wang Yx, Wang T, Clowes Aw
CIRCULATION RESEARCH 1997;81(1):17-23

Expression of caveolae on the surface of rat arterial smooth muscle cells is dependent on the phenotypic state of the cells
Thyberg J, Roy J, Tran Pk, Blomgren K, Dumitrescu A, Hedin U
LABORATORY INVESTIGATION 1997;77(1):93-101

Expression of phospholipase A(2) isoforms in human normal and atherosclerotic arterial wall
Elinder Ls, Dumitrescu A, Larsson P, Hedin U, Frostegard J, Claesson He
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 1997;17(10):2257-63

Gene therapy and vascular disease: Potential applications in vascular surgery
Hedin U, Wahlberg E
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY 1997;13(2):101-11

[Gene therapy in peripheral vascular disease. A future therapeutic method?]
Wahlberg E, Hedin U
Lakartidningen 1997;94(14):1276-8

Phenotypic modulation of smooth muscle cells after arterial injury is associated with changes in the distribution of laminin and fibronectin
Thyberg J, Blomgren K, Roy J, Tran Pk, Hedin U
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 1997;45(6):837-46

[Restenosis--elusive shadow of vascular biology. New discoveries set hopes about future therapy]
Hedin U
Lakartidningen 1997;94(26-27):2481-4

Role of tyrosine kinases in extracellular matrix-mediated modulation of arterial smooth muscle cell phenotype
Hedin U, Thyberg J, Roy J, Dumitrescu A, Tran Pk
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 1997;17(10):1977-84

Autocrine induction of DNA synthesis by mechanical injury of cultured smooth muscle cells - Potential role of FGF and PDGF
Calara F, Ameli S, Hultgardhnilsson A, Cercek B, Kupfer J, Hedin U, et al
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 1996;16(2):187-93

ANTITHROMBIN-III MEDIATED INHIBITION OF THROMBIN-INDUCED PROLIFERATION IN ARTERIAL SMOOTH-MUSCLE CELLS - FUNCTIONAL DIFFERENCES BETWEEN ANTITHROMBIN-III ISOFORMS
Frebelius S, Isaksson S, Hedin U, Dryjski M, Swedenborg J
THROMBOSIS AND HAEMOSTASIS 1995;73(6):926-926

PHENOTYPIC MODULATION OF SMOOTH-MUSCLE CELLS DURING THE FORMATION OF NEOINTIMAL THICKENINGS IN THE RAT CAROTID-ARTERY AFTER BALLOON INJURY - AN ELECTRON-MICROSCOPIC AND STEREOLOGICAL STUDY
Thyberg J, Blomgren K, Hedin U, Dryjski M
CELL AND TISSUE RESEARCH 1995;281(3):421-33

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