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Publications

Feedback from the EBF - Focus Workshop: bringing assay validation and analysis of biomarkers into practice
Timmerman P, Scheel Fjording M, Allinson J, Arfvidsson C, Barroso B, Diczfalusy U, et al
Bioanalysis 2017;9(9):675-681

Comparative performance of oral midazolam clearance and plasma 4β-hydroxycholesterol to explain interindividual variability in tacrolimus clearance
Vanhove T, De Jonge H, De Loor H, Annaert P, Diczfalusy U, Kuypers Dr
British journal of clinical pharmacology 2016;82(6):1539-1549

CYP3A Specifically Catalyzes 1β-Hydroxylation of Deoxycholic Acid: Characterization and Enzymatic Synthesis of a Potential Novel Urinary Biomarker for CYP3A Activity
Hayes Ma, Li Xq, Grönberg G, Diczfalusy U, Andersson Tb
Drug metabolism and disposition: the biological fate of chemicals 2016;44(9):1480-9

Effect of Statin Treatment on Plasma 4β-Hydroxycholesterol Concentrations
Björkhem-bergman L, Nylén H, Eriksson M, Parini P, Diczfalusy U
Basic & clinical pharmacology & toxicology 2016;118(6):499-502

Prevalence and risk factors for efavirenz-based antiretroviral treatment-associated severe vitamin D deficiency: A prospective cohort study
Nylén H, Habtewold A, Makonnen E, Yimer G, Bertilsson L, Burhenne J, et al
Medicine 2016;95(34):e4631-

Recommendations on the Development of a Bioanalytical Assay for 4β-Hydroxycholesterol, an Emerging Endogenous Biomarker of CYP3A Activity
Aubry Af, Dean B, Diczfalusy U, Goodenough A, Iffland A, Mcleod J, et al
The AAPS journal 2016;18(5):1056-66

miRNA-27b levels are associated with CYP3A activity in vitro and in vivo
Ekström L, Skilving I, Ovesjö Ml, Aklillu E, Nylén H, Rane A, et al
Pharmacology research & perspectives 2015;3(6):e00192-

No impact of vitamin D on the CYP3A biomarker 4β-hydroxycholesterol in patients with abnormal glucose regulation
Mannheimer B, Wagner H, Östenson Cg, Diczfalusy U
PloS one 2015;10(4):e0121984-

Immediate effect of passive smoking on microcirculatory flow
Henriksson P, Lu Q, Diczfalusy U, Freyschuss A
Microcirculation (New York, N.Y. : 1994) 2014;21(7):587-92

On the formation of 7-ketocholesterol from 7-dehydrocholesterol in patients with CTX and SLO
Bjorkhem I, Diczfalusy U, Lovgren-sandblom A, Starck L, Jonsson M, Tallman K, et al
JOURNAL OF LIPID RESEARCH 2014;55(6):1165-72

Pharmacokinetic and pharmacogenomic modelling of the CYP3A activity marker 4β-hydroxycholesterol during efavirenz treatment and efavirenz/rifampicin co-treatment
Ngaimisi E, Minzi O, Mugusi S, Sasi P, Riedel Kd, Suda A, et al
The Journal of antimicrobial chemotherapy 2014;69(12):3311-9

Plasma levels of 25-hydroxyvitamin D3 and in vivo markers of cytochrome P450 3A activity in Swedes and Koreans: effects of a genetic polymorphism and oral contraceptives
Nylén H, Björkhem-bergman L, Ekström L, Roh Hk, Bertilsson L, Eliasson E, et al
Basic & clinical pharmacology & toxicology 2014;115(4):366-71

Quinine compared to 4β-hydroxycholesterol and midazolam as markers for CYP3A induction by rifampicin
Björkhem-bergman L, Bäckström T, Nylén H, Rönquist-nii Y, Bredberg E, Andersson Tb, et al
Drug metabolism and pharmacokinetics 2014;29(4):352-5

Reduction of nevirapine-driven HIV mutations by carbamazepine is modulated by CYP3A activity
Baranyai D, Muro E, Gödtel-armbrust U, Schirmer Ma, Kisanga E, Diczfalusy U, et al
The Journal of antimicrobial chemotherapy 2014;69(7):1933-7

A comparison of 4β-hydroxycholesterol : cholesterol and 6β-hydroxycortisol : cortisol as markers of CYP3A4 induction
Mårde Arrhén Y, Nylén H, Lövgren-sandblom A, Kanebratt Kp, Wide K, Diczfalusy U
British journal of clinical pharmacology 2013;75(6):1536-40

Comparison of endogenous 4β-hydroxycholesterol with midazolam as markers for CYP3A4 induction by rifampicin
Björkhem-bergman L, Bäckström T, Nylén H, Rönquist-nii Y, Bredberg E, Andersson Tb, et al
Drug metabolism and disposition: the biological fate of chemicals 2013;41(8):1488-93

On the formation and possible biological role of 25-hydroxycholesterol
Diczfalusy U
Biochimie 2013;95(3):455-60

Pharmacogenetic and pharmacokinetic aspects of CYP3A induction by efavirenz in HIV patients
Habtewold A, Amogne W, Makonnen E, Yimer G, Nylén H, Riedel Kd, et al
The pharmacogenomics journal 2013;13(6):484-9

Serum levels of 25-hydroxyvitamin D and the CYP3A biomarker 4β-hydroxycholesterol in a high-dose vitamin D supplementation study
Björkhem-bergman L, Nylén H, Norlin Ac, Lindh Jd, Ekström L, Eliasson E, et al
Drug metabolism and disposition: the biological fate of chemicals 2013;41(4):704-8

Amidoxime Reductase System Containing Cytochrome b(5) Type B (CYB5B) and MOSC2 Is of Importance for Lipid Synthesis in Adipocyte Mitochondria
Neve Epa, Nordling A, Andersson Tb, Hellman U, Diczfalusy U, Johansson I, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2012;287(9):6307-17

Metabolism of alprazolam (a marker of CYP3A4) in hemodialysis patients with persistent inflammation
Molanaei H, Stenvinkel P, Qureshi Ar, Carrero Jj, Heimburger O, Lindholm B, et al
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 2012;68(5):571-7

Microvascular Reactivity in Response to Smoking and Oral Antioxidants in Humans
Henriksson P, Diczfalusy U, Freyschuss A
MICROCIRCULATION 2012;19(1):86-93

4 beta-hydroxycholesterol, an endogenous marker of CYP3A4/5 activity in humans
Diczfalusy U, Nylen H, Elander P, Bertilsson L
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 2011;71(2):183-9

Cytochrome P450 3A activity in mothers and their neonates as determined by plasma 4 beta-hydroxycholesterol
Nylen H, Sergel S, Forsberg L, Lindemalm S, Bertilsson L, Wide K, et al
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 2011;67(7):715-22

Detecting oxysterols in the human circulation
Bjorkhem I, Diczfalusy U, Olsson T, Russell Dw, Mcdonald Jg, Wang Yq, et al
NATURE IMMUNOLOGY 2011;12(7):577-author

High levels of 15-oxygenated steroids in circulation of patients with multiple sclerosis: fact or fiction?
Bjorkhem I, Lovgren-sandblom A, Piehl F, Khademi M, Pettersson H, Leoni V, et al
JOURNAL OF LIPID RESEARCH 2011;52(1):170-4

Sex and CYP3A5 genotype influence total CYP3A activity: high CYP3A activity and a unique distribution of CYP3A5 variant alleles in Ethiopians
Gebeyehu E, Engidawork E, Bijnsdorp A, Aminy A, Diczfalusy U, Aklillu E
PHARMACOGENOMICS JOURNAL 2011;11(2):130-7

Still another activity by the highly promiscuous enzyme CYP3A4: 25-hydroxylation of cholesterol
Diczfalusy U, Bjorkhem I
JOURNAL OF LIPID RESEARCH 2011;52(8):1447-9

FTY720 Stimulates 27-Hydroxycholesterol Production and Confers Atheroprotective Effects in Human Primary Macrophages
Blom T, Back N, Mutka Al, Bittman R, Li Zg, De Lera A, et al
CIRCULATION RESEARCH 2010;106(4):720-9

4 beta-hydroxycholesterol as a marker of CYP3A4 inhibition in vivo - effects of itraconazole in man
Lutjohann D, Marinova M, Schneider B, Oldenburg J, Von Bergmann K, Bieber T, et al
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS 2009;47(12):709-15

4 beta-Hydroxycholesterol as an endogenous marker for CYP3A4/5 activity. Stability and half-life of elimination after induction with rifampicin
Diczfalusy U, Kanebratt Kp, Bredberg E, Andersson Tb, Bottiger Y, Bertilsson L
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 2009;67(1):38-43

Human Exposure to Triclosan via Toothpaste does not change CYP3A4 Activity or Plasma Concentrations of Thyroid Hormones
Allmyr M, Panagiotidis G, Sparve E, Diczfalusy U, Sandborgh-englund G
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 2009;105(5):339-44

Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide
Diczfalusy U, Olofsson Ke, Carlsson Am, Gong M, Golenbock Dt, Rooyackers O, et al
JOURNAL OF LIPID RESEARCH 2009;50(11):2258-64

Primary Open-Angle Glaucoma: Association with Cholesterol 24S-Hydroxylase (CYP46A1) Gene Polymorphism and Plasma 24-Hydroxycholesterol Levels
Fourgeux C, Martine L, Bjorkhem I, Diczfalusy U, Joffre C, Acar N, et al
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 2009;50(12):5712-7

4 beta-Hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians
Diczfalusy U, Miura J, Roh Hk, Mirghani Ra, Sayi J, Larsson H, et al
PHARMACOGENETICS AND GENOMICS 2008;18(3):201-8

CYP3A induction and inhibition by different antiretroviral regimens reflected by changes in plasma 4 beta-hydroxycholesterol levels
Josephson F, Bertilsson L, Bottiger Y, Flamholc L, Gisslen M, Ormaasen V, et al
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 2008;64(8):775-81

Cytochrome P450 Induction by Rifampicin in Healthy Subjects: Determination Using the Karolinska Cocktail and the Endogenous CYP3A4 Marker 4 beta-Hydroxycholesterol
Kanebratt Kp, Diczfalusy U, Backstrom T, Sparve E, Bredberg E, Bottiger Y, et al
CLINICAL PHARMACOLOGY & THERAPEUTICS 2008;84(5):589-94

Time course of the increase in 4 beta-hydroxycholesterol concentration during carbamazepine treatment of paediatric patients with epilepsy
Wide K, Larsson H, Bertilsson L, Diczfalusy U
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 2008;65(5):708-15

Cholesterol-24S-hydroxylase (CYP46A1) is specifically expressed in neurons of the neural retina
Bretillon L, Diczfalusy U, Bjorkhem I, Maire Ma, Martine L, Joffre C, et al
CURRENT EYE RESEARCH 2007;32(4):361-6

Effects of high-dose itraconazole treatment on lipoproteins in men
Schneider B, Gerdsen R, Plat J, Dullens S, Bjorkhem I, Diczfalusy U, et al
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS 2007;45(7):377-84

Increased plasma levels of oxysterols, in vivo markers of oxidative stress, in patients with familial combined hyperlipidemia: Reduction during atorvastatin and fenofibrate therapy
Arca M, Natoli S, Micheletta F, Riggi S, Di Angelantonio E, Montali A, et al
FREE RADICAL BIOLOGY AND MEDICINE 2007;42(5):698-705

In vivo interconversion of 7 beta-hydroxycholesterol and 7-ketocholesterol, potential surrogate markers for oxidative stress
Larsson H, Bottiger Y, Iuliano L, Diczfalusy U
FREE RADICAL BIOLOGY AND MEDICINE 2007;43(5):695-701

Novel LC-MS/MS method for assay of 7 alpha-hydroxy-4-cholesten-3-one in human plasma evidence for a significant extrahepatic metabolism
Lovgren-sandblom A, Heverin M, Larsson H, Lundstrom E, Wahren J, Diczfalusy U, et al
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 2007;856(1-2):15-9

Novel route for elimination of brain oxysterols across the blood-brain barrier: conversion into 7 alpha-hydroxy-3-oxo-4-cholestenoic acid
Meaney S, Heverin M, Panzenboeck U, Ekstrom L, Axelsson M, Andersson U, et al
JOURNAL OF LIPID RESEARCH 2007;48(4):944-51

Studies on the cholesterol-free mouse - Strong activation of LXR-regulated hepatic genes when replacing cholesterol with desmosterol
Heverin M, Meaney S, Brafman A, Shafir M, Olin M, Shafaati M, et al
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2007;27(10):2191-7

Effect of SLCO1B1 polymorphism on induction of CYP3A4 by rifampicin
Niemi M, Kivisto Kt, Diczfalusy U, Bodin K, Bertilsson L, Fromm Mf, et al
PHARMACOGENETICS AND GENOMICS 2006;16(8):565-8

Effects of high-dosage itraconazole treatment on synthesis, transport and metabolism of cholesterol in men
Schneider B, Plat J, Gerdsen R, Diczfalusy U, Bjorkhem I, Neuvonen Pj, et al
ATHEROSCLEROSIS SUPPLEMENTS 2006;7(3):562-562

Oxysterols and Alzheimer's disease
Bjorkhem I, Heverin M, Leoni V, Meaney S, Diczfalusy U
ACTA NEUROLOGICA SCANDINAVICA 2006;:43-9

Studies on the transcriptional regulation of cholesterol 24-hydroxylase (CYP46A1) - Marked insensitivity toward different regulatory axes
Ohyama Y, Meaney S, Heverin M, Ekstrom L, Brafman A, Shafir M, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2006;281(7):3810-20

Complementary stimulation of hepatobiliary transport and detoxification systems by rifampicin and ursodeoxycholic acid in humans
Marschall Hu, Wagner M, Zollner G, Fickert P, Diczfalusy U, Gumhold J, et al
GASTROENTEROLOGY 2005;129(2):476-85

Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain
Heverin M, Meaney S, Lutjohann D, Diczfalusy U, Wahren J, Bjorkhem I
JOURNAL OF LIPID RESEARCH 2005;46(5):1047-52

Effect of ascorbic acid on microcirculation in patients with Type II diabetes: a randomized placebo-controlled cross-over study
Lu Q, Bjorkhem I, Wretlind B, Diczfalusy U, Henriksson P, Freyschuss A
CLINICAL SCIENCE 2005;108(6):507-13

High preoperative recipient plasma 7 beta-hydroxycholesterol is associated with initial poor graft function after liver transplantation
Corradini Sg, Micheletta F, Natoli S, Iappelli M, Di Angelantonio E, De Marco R, et al
LIVER TRANSPLANTATION 2005;11(12):1494-504

Novel pathways of bile acid metabolism involving CYP3A4
Bodin K, Lindbom U, Diczfalusy U
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 2005;1687(1-3):84-93

Oxidative stress is associated with the insertion/deletion polymorphism in exon 8 of the uncoupling protein 2 gene in ESRD patients
Wang X, Stenvinkel P, Nordfors L, Axelsson J, Qureshi Ar, Barany P, et al
NEPHROLOGY DIALYSIS TRANSPLANTATION 2005;:V130-V130

Patients with atherosclerosis may have increased circulating levels of 27-hydroxycholesterol and cholestenoic acid
Babiker A, Dzeletovic S, Wiklund B, Pettersson N, Salonen J, Nyyssonen K, et al
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION 2005;65(5):365-75

24(S),25-epoxycholesterol - A potential friend
Bjorkhem I, Diczfalusy U
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2004;24(12):2209-10

Analysis of cholesterol oxidation products in biological samples
Diczfalusy U
JOURNAL OF AOAC INTERNATIONAL 2004;87(2):467-73

Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease
Heverin M, Bogdanovic N, Lutjohann D, Bayer T, Pikuleva I, Bretillon L, et al
JOURNAL OF LIPID RESEARCH 2004;45(1):186-93

Comprehensive study of the effects of rifampicin and ursodeoxycholic acid on genes and proteins involved in regulation, transport and detoxification of biliary compounds in gallstone patients
Marschall Hu, Wagner M, Zollner G, Fickert P, Gumholdt J, Silbert D, et al
JOURNAL OF HEPATOLOGY 2004;:93-93

Diagnostic use of cerebral and extracerebral oxysterols
Leoni V, Masterman T, Mousavi Fs, Wretlind B, Wahlund Lo, Diczfalusy U, et al
CLINICAL CHEMISTRY AND LABORATORY MEDICINE 2004;42(2):186-91

Phospholipid plasmalogen, a surrogate marker of oxidative stress, is associated with increased cardiovascular mortality in patients on renal replacement therapy
Stenvinkel P, Diczfalusy U, Lindholm B, Heimburger O
NEPHROLOGY DIALYSIS TRANSPLANTATION 2004;19(4):972-6

Transcriptional regulation of human CYP27 integrates retinoid, peroxisome proliferator-activated receptor, and liver X receptor signaling in macrophages
Szanto A, Benko S, Szatmari I, Balint Bl, Furtos I, Ruhl R, et al
MOLECULAR AND CELLULAR BIOLOGY 2004;24(18):8154-66

Vitamin e supplementation in patients with carotid atherosclerosis - Reversal of altered oxidative stress status in plasma but not in plaque
Micheletta F, Natoli S, Misuraca M, Sbarigia E, Diczfalusy U, Iuliano L
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2004;24(1):136-40

Measurement of oxysterols and alpha-tocopherol in plasma and tissue samples as indices of oxidant stress status
Iuliano L, Micheletta F, Natoli S, Corradini Sg, Iappelli M, Elisei W, et al
ANALYTICAL BIOCHEMISTRY 2003;312(2):217-23

On the origin of the cholestenoic acids in human circulation
Meaney S, Babiker A, Lutjohann D, Diczfalusy U, Axelson M, Bjrokhem I
STEROIDS 2003;68(7-8):595-601

Plasma levels of the brain-specific 24S-hydroxycholesterol may reflect progression of multiple sclerosis (MS).
D'eril Gm, Leoni V, Masterman T, Diczfalusy U, Hillert J, Bjorkhem I
CLINICAL CHEMISTRY 2003;49(6):A163-A164

Quantitation of receptor Ligands by mass Spectrometry
Lund Eg, Diczfalusy U
NUCELAR RECEPTORS 2003;:24-37

Serum ferritin concentration is associated with plasma levels of cholesterol oxidation products in man
Tuomainen Tp, Diczfalusy U, Kaikkonen J, Nyyssonen K, Salonen Jt
FREE RADICAL RESEARCH 2003;:36-36

Serum ferritin concentration is associated with plasma levels of cholesterol oxidation products in man
Tuomainen Tp, Diczfalusy U, Kaikkonen J, Nyyssonen K, Salonen Jt
FREE RADICAL BIOLOGY AND MEDICINE 2003;35(8):922-8

Side chain oxidized oxysterols in cerebrospinal fluid and the integrity of blood-brain and blood-cerebrospinal fluid barriers
Leoni V, Masterman T, Patel P, Meaney S, Diczfalusy U, Bjorkhem I
JOURNAL OF LIPID RESEARCH 2003;44(4):793-9

Simultaneous measurement of oxysterols and alpha-tocopherol in plasma and tissue samples as an index of oxidant stress/antioxidant status
Micheletta F, Natoli S, Corradini S, Diczfalusy U, Iuliano L
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2003;23(5):A23-A23

Analysis of cholesterol oxidation products in plasma, tissues and food
Bodin K, Diczfalusy U
EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY 2002;104(7):435-439

Changes in human plasma levels of the brain specific oxysterol 24S-hydroxycholesterol during progression of multiple sclerosis
Leoni V, Masterman T, Diczfalusy U, De Luca G, Hillert J, Bjorkhem I
NEUROSCIENCE LETTERS 2002;331(3):163-6

CYP46 - An enzyme for "cleaning up" cholesterol in the Alzheimer brain
Heverin M, Bretillon L, Diczfalusy U, Bjorkhem I, Bogdanovic N, Lannfelt L, et al
NEUROBIOLOGY OF AGING 2002;23(1):S182-S182

Excess body iron is associated with elevated levels of cholesterol oxidation products in man: The KIHD study
Tuomainen Tp, Diczfalusy U, Kaikkonen J, Nyyssonen K, Salonen Jt
CIRCULATION 2002;106(19):284-285

Mechanism of accumulation of cholesterol and cholestanol in tendons and the role of sterol 27-hydroxylase (CYP27A1)
Von Bahr S, Movin T, Papadogiannakis N, Pikuleva I, Ronnow P, Diczfalusy U, et al
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2002;22(7):1129-35

Metabolism of 4 beta-hydroxycholesterol in Humans
Bodin K, Andersson U, Rystedt E, Ellis E, Norlin M, Pikuleva I, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2002;277(35):31534-40

On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation: critical importance of the position of the oxygen function
Meaney S, Bodin K, Diczfalusy U, Bjorkhem I
JOURNAL OF LIPID RESEARCH 2002;43(12):2130-5

Oxysterols - Friends, foes, or just fellow passengers?
Bjorkhem I, Diczfalusy U
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2002;22(5):734-42

Oxysterols in human circulation: which role do they have?
Bjorkhem I, Meaney S, Diczfalusy U
CURRENT OPINION IN LIPIDOLOGY 2002;13(3):247-53

Antiepileptic drugs increase plasma levels of 4 beta-hydroxycholesterol in humans - Evidence for involvement of cytochrome P450 3A4
Bodin K, Bretillon L, Aden Y, Bertilsson L, Broome U, Einarsson C, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2001;276(42):38685-9

Bioavailability of vitamin E as function of food intake in healthy subjects - Effects on plasma peroxide-scavenging activity and cholesterol-oxidation products
Iuliano L, Micheletta F, Maranghi M, Frati G, Diczfalusy U, Violi F
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2001;21(10):E34-7

Evidence that the major oxysterols in human circulation originate from distinct pools of cholesterol: a stable isotope study
Meaney S, Hassan M, Sakinis A, Lutjohann D, Von Bergmann K, Wennmalm A, et al
JOURNAL OF LIPID RESEARCH 2001;42(1):70-8

From brain to bile - Evidence that conjugation and omega-hydroxylation are important for elimination of 24S-hydroxycholesterol (cerebrosterol) in humans
Bjorkhem I, Andersson U, Ellis E, Alvelius G, Ellegard L, Diczfalusy U, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2001;276(40):37004-10

Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXR beta-deficient mice
Alberti S, Schuster G, Parini P, Feltkamp D, Diczfalusy U, Rudling M, et al
JOURNAL OF CLINICAL INVESTIGATION 2001;107(5):565-73

On the anti-atherogenic effect of the antioxidant BHT in cholesterol-fed rabbits: inverse relation between serum triglycerides and atheromatous lesions
Freyschuss A, Al-schurbaji A, Bjorkhem B, Babiker A, Diczfalusy U, Berglund L, et al
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 2001;1534(2-3):129-38

On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells
Bogdanovica N, Bretillon L, Lund Eg, Diczfalusy U, Lannfelt L, Winblad B, et al
NEUROSCIENCE LETTERS 2001;314(1-2):45-8

Oxysterols in the circulation of patients with the Smith-Lemli-Opitz syndrome: abnormal levels of 24S-and 27-hydroxycholesterol
Bjorkhem I, Starck L, Andersson U, Lutjohann D, Von Bahr S, Pikuleva I, et al
JOURNAL OF LIPID RESEARCH 2001;42(3):366-71

Acyl-CoA thioesterases belong to a novel gene family of peroxisome proliferator-regulated enzymes involved in lipid metabolism
Hunt Mc, Lindquist Pjg, Nousiainen S, Huttunen M, Orii K, Svensson Tlt, et al
CELL BIOCHEMISTRY AND BIOPHYSICS 2000;:317-24

Formation of oxysterols from different pools of cholesterol as studied by stable isotope technique: cerebral origin of most circulating 24S-hydroxycholesterol in rats, but not in mice
Meaney S, Lutjohann D, Diczfalusy U, Bjorkhem I
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 2000;1486(2-3):293-8

Involvement of the peroxisome proliferator-activated receptor alpha in regulating long-chain acyl-CoA thioesterases
Hunt Mc, Lindquist Pjg, Peters Jm, Gonzalez Fj, Diczfalusy U, Alexson Seh
JOURNAL OF LIPID RESEARCH 2000;41(5):814-23

Long-term effects of vitamin E, vitamin C, and combined supplementation on urinary 7-hydro-8-oxo-2 '-deoxyguanosine, serum cholesterol oxidation products, and oxidation resistance of lipids in nondepleted men
Porkkala-sarataho E, Salonen Jt, Nyyssonen K, Kaikkonen J, Salonen R, Ristonmaa U, et al
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2000;20(9):2087-93

Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases
Bretillon L, Siden A, Wahlund Lo, Lutjohann D, Minthon L, Crisby M, et al
NEUROSCIENCE LETTERS 2000;293(2):87-90

Plasma levels of 24S-hydroxycholesterol reflect the balance between cerebral production and hepatic metabolism and are inversely related to body surface
Bretillon L, Lutjohann D, Stahle L, Widhe T, Bindl L, Eggertsen G, et al
JOURNAL OF LIPID RESEARCH 2000;41(5):840-5

Cloning and regulation of peroxisome proliferator-induced acyl-CoA thioesterases from mouse liver
Hunt M, Lindquist Pjg, Nousiainen S, Svensson Tlt, Diczfalusy U, Alexson Seh
CURRENT VIEWS OF FATTY ACID OXIDATION AND KETOGENESIS 1999;:195-200

Elimination of cholesterol as cholestenoic acid in human lung by sterol 27-hydroxylase: evidence that most of this steroid in the circulation is of pulmonary origin
Babiker A, Andersson O, Lindblom D, Van Der Linden J, Wiklund B, Lutjohann D, et al
JOURNAL OF LIPID RESEARCH 1999;40(8):1417-25

Increased plasma 7 beta-hydroxycholesterol concentrations in a population with a high risk for cardiovascular disease
Zieden B, Kaminskas A, Kristenson M, Kucinskiene Z, Vessby B, Olsson Ag, et al
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 1999;19(4):967-71

Removal of cholesterol from extrahepatic sources by oxidative mechanisms
Bjorkhem I, Diczfalusy U, Lutjohann D
CURRENT OPINION IN LIPIDOLOGY 1999;10(2):161-5

Strong association between malnutrition, inflammation, and atherosclerosis in chronic renal failure
Stenvinkel P, Heimburger O, Paultre F, Diczfalusy U, Wang T, Berglund L, et al
KIDNEY INTERNATIONAL 1999;55(5):1899-911

The lung is the major source of 27-oxygenated cholesterol in the human circulation
Babiker A, Bjorkhem I, Diczfalusy U
ATHEROSCLEROSIS 1999;:121-121

An animal model to study local oxidation of LDL and its biological effects in the arterial wall
Calara F, Dimayuga P, Niemann A, Thyberg J, Diczfalusy U, Witztum Jl, et al
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 1998;18(6):884-93

A study of plasmalogen as an index of oxidative stress in patients with chronic renal failure. Evidence of increased oxidative stress in malnourished patients
Stenvinkel P, Holmberg I, Heimburger O, Diczfalusy U
NEPHROLOGY DIALYSIS TRANSPLANTATION 1998;13(10):2594-600

Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation
Bjorkhem I, Lutjohann D, Diczfalusy U, Stahle L, Ahlborg G, Wahren J
JOURNAL OF LIPID RESEARCH 1998;39(8):1594-600

Effects of vitamin E and vitamin C supplementation on urinary 8-oxodeoxyguanosine, plasma F-2-isoprostanes, cholesterol oxidation products and oxidation resistance of serum lipids and VLDL+LDL in non-depleted men
Salonen Jt, Morrow Jd, Roberts J, Nyyssonen K, Kaikkonen J, Porkkala-sarataho E, et al
CIRCULATION 1998;98(17):601-601

Sterol 27-hydroxylase- and ApoAI/phospholipid-mediated efflux of cholesterol from cholesterol-laden macrophages - Evidence for an inverse relation between the two mechanisms
Westman J, Kallin B, Bjorkhem I, Nilsson J, Diczfalusy U
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 1998;18(4):554-61

Transport of side-chain oxidized oxysterols in the human circulation
Babiker A, Diczfalusy U
BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM 1998;1392(2-3):333-9

Unsaturated fatty acids increase plasminogen activator inhibitor-1 expression in endothelial cells
Nilsson L, Banfi C, Diczfalusy U, Tremoli E, Hamsten A, Eriksson P
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 1998;18(11):1679-85

Ca2+ channel blockers verapamil and nifedipine inhibit apoptosis induced by 25-hydroxycholesterol in human aortic smooth muscle cells
Ares Mps, Pornares Mi, Thyberg J, Junttiberggren L, Berggren Po, Diczfalusy U, et al
JOURNAL OF LIPID RESEARCH 1997;38(10):2049-61

Decreased levels of erythrocyte plasmalogens DMA16/C16 and DMA18/C18 in advanced chronic renal failure.
Stenvinkel P, Heimburger O, Bjorkhem I, Diczfalusy U
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 1997;:A0369-A0369

Effect of the oxidation state of LDL on the modulation of arterial vasomotor response in vitro.
Mougenot N, Lesnik P, Ramirezgil Jf, Nataf P, Diczfalusy U, Chapman Mj, et al
ATHEROSCLEROSIS 1997;133(2):183-92

Elimination of cholesterol in macrophages and endothelial cells by the sterol 27-hydroxylase mechanism - Comparison with high density lipoprotein-mediated reverse cholesterol transport
Babiker A, Andersson O, Lund E, Xiu Rj, Deeb S, Reshef A, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 1997;272(42):26253-61

Higher 7 beta-hydroxycholesterol in high cardiovascular risk population
Zieden B, Diczfalusy U
ATHEROSCLEROSIS 1997;134(1-2):172-172

Lipid peroxidation and progression of carotid atherosclerosis: A prospective 3-year follow-up study
Salonen Jt, Nyyssonen K, Salonen R, Jukka L, Seppo Yh, Diczfalusy U
CIRCULATION 1997;96(8):1879-1879

Lipid peroxidation and progression of carotid atherosclerosis: A prospective 3-year follow-up study
Salonen Jt, Nyyssonen K, Salonen R, Luoma J, Ylaherttuala S, Diczfalusy U, et al
ATHEROSCLEROSIS 1997;134(1-2):217-217

Lipoprotein oxidation and progression of carotid atherosclerosis
Salonen Jt, Nyyssonen K, Salonen R, Porkkalasarataho E, Tuomainen Tp, Diczfalusy U, et al
CIRCULATION 1997;95(4):840-5

Localization of sterol 27-hydroxylase immuno-reactivity in human atherosclerotic plaques
Crisby M, Nilsson J, Kostulas V, Bjorkhem I, Diczfalusy U
BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM 1997;1344(3):278-85

Vitamin A concentration in the liver decreases with age in patients with cystic fibrosis
Lindblad A, Diczfalusy U, Hultcrantz R, Thorell A, Strandvik B
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION 1997;24(3):264-70

Vitamin C reduces cholesterol-induced microcirculatory changes in rabbits
Freyschuss A, Xiu Rj, Zhang J, Ying Xy, Diczfalusy U, Joestrand T, et al
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 1997;17(6):1178-84

Cholesterol homeostasis in human brain: Evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation
Lutjohann D, Breuer O, Ahlborg G, Nennesmo I, Siden A, Diczfalusy U, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 1996;93(18):9799-804

Formation of oxysterols during oxidation of low density lipoprotein by peroxynitrite, myoglobin, and copper
Patel Rp, Diczfalusy U, Dzeletovic S, Wilson Mt, Darleyusmar Vm
JOURNAL OF LIPID RESEARCH 1996;37(11):2361-71

Importance of a novel oxidative mechanism for elimination of intracellular cholesterol in humans
Lund E, Andersson O, Zhang J, Babiker A, Ahlborg G, Diczfalusy U, et al
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 1996;16(2):208-12

Lipoprotein oxidation and progression of carotid atherosclerosis
Salonen Jt, Nyyssonen R, Salonen R, Porkkalasarataho E, Tuomainen Tp, Diczfalusy U, et al
CIRCULATION 1996;94(8):536-536

Novel pathways for elimination of cholesterol by extrahepatic formation of side-chain oxidized oxysterols
Diczfalusy U, Lund E, Lutjohann D, Bjorkhem I
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION 1996;:9-17

Oxysterols present in atherosclerotic tissue decrease the expression of lipoprotein lipase messenger RNA in human monocyte-derived macrophages
Hulten Lm, Lindmark H, Diczfalusy U, Bjorkhem I, Ottosson M, Liu Y, et al
JOURNAL OF CLINICAL INVESTIGATION 1996;97(2):461-8

The oxysterols cholest-5-ene-3 beta,4 alpha-diol, cholest-5-ene-3 beta,4 beta-diol and cholestane-3 beta,5 alpha,6 alpha-triol are formed during in vitro oxidation of low density lipoprotein, and are present in human atherosclerotic plaques
Breuer O, Dzeletovic S, Lund E, Diczfalusy U
BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM 1996;1302(2):145-52

Clofibrate treatment increases stearoyl-CoA desaturase mRNA level and enzyme activity in mouse liver
Diczfalusy U, Eggertsen G, Alexson Seh
BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM 1995;1259(3):313-6

DETERMINATION OF CHOLESTEROL OXIDATION-PRODUCTS IN HUMAN PLASMA BY ISOTOPE-DILUTION MASS-SPECTROMETRY
Dzeletovic S, Breuer O, Lund E, Diczfalusy U
ANALYTICAL BIOCHEMISTRY 1995;225(1):73-80

Time course of oxysterol formation during in vitro oxidation of low density lipoprotein
Dzeletovic S, Babiker A, Lund E, Diczfalusy U
CHEMISTRY AND PHYSICS OF LIPIDS 1995;78(2):119-28

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