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About me

 

Education

M.Sci, Stockholm University 1988

M.Med.Sc, Karolinska Institutet 1989

Ph.D, Karolinska Institutet 1999

Associate Professor, Karolinska Institutet 2007

Research description

Periodontitis is a chronic inflammatory disease in which bacterial products, host response, genetic and environmental factors are involved. It is generally accepted that the bacterial products activate host immunoinflammatory responses and subsequently the production of inflammatory mediators, prostaglandins and proteolytic enzymes which, directly or indirectly, contribute to the destruction of the periodontal tissues. However, neither the precise molecular mechanism(s) nor the regulatory genes underlying periodontitis are fully understood. 
During past decades, reciprocal effects of periodontal disease have been considered as factors potentially affecting the progression of other chronic inflammatory diseases such as cardiovascular diseases, diabetes mellitus, obesity, and rheumatoid arthritis. The underlying pathologic mechanisms of rheumatoid arthritis and periodontitis are strikingly similar although the link, strength and temporality of the association is still unclear.

Objectives of our research are:

- to identify predictive and diagnostic biomarkers for periodontitis
- to develop anti-inflammatory agents targeting the enzyme prostaglandin E synthases for chronic inflammation/periodontal bone destruction  
- to investigate the relationship between periodontitis and other chronic inflammatory diseases such as rheumatoid arthritis

Group members

Tülay Yucel-Lindberg – Associate professor
Anna Kats – Post doc
Linkiat Lee – Post doc
Kaja Eriksson – Post doc
Anna Lundmark – Post doc
Caroline Lindström – Graduate Student 
Martina Ericson – Graduate Student

Research grants 

Vetenskapsrådet (PI)

Stockholm County Council, KI/SLL for odontological research (PI)

Stockholm County Council, ALF (PI)

Patentmedelsfonden (PI)

Seventh Framework Programme, TRIGGER, FP7-HEALTH-2012 (Co-PI)

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