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Tommy Lundberg


Visiting address : Karolinska Universitetssjukhuset, Huddinge C188 14186 Stockholm, Sweden
Postal address : Department of Laboratory Medicine (LABMED), H5, Division of clinical physiology, Karolinska Universitetssjukhuset, Huddinge C1 88 14186 Stockholm, Sweden
Delivery address : Karolinska Universitetssjukhuset, Huddinge C1 88 14186 Stockholm, Sweden

Research description

An overall theme of my past and intended future long-term research relates to the control and regulation of skeletal muscle mass and function. More specifically, in contexts such as disease, muscle disuseaging or sports performance, I am interested in how human skeletal muscle responds and adapts to increased or decreased use. In this work, the functional, metabolic, morphological, and molecular adaptations to acute and chronic resistance and/or aerobic training are studied.

My ongoing research project relates to non-steroidal anti-inflammatory drugs (NSAID) and muscle adaptations to exercise regimes. NSAIDs are among the most widely used drugs in the world. It has long been thought that chronic intake of NSAIDs impairs exercise-induced skeletal muscle tissue regenereation due to the reported negative effects of COX-inhibiting drugs on muscle satellite cell acitivty and protein synthesis. However, recently, it was shown that daily consumption of maximal over-the-counter doses of NSAID concurrently with performing resistance exercise resulted in significantly greater increases in muscle mass and strength compared with placebo in older adults. As the mechanism(s) behind these effects are currently unknown, we wish to further characterise the effects of NSAID and resistance exercise on the regulation of human skeletal muscle mass and function in both young and old individuals. We will perform both human clinical training studies as well as cell culture work to identify global muscle responses and molecular mechanisms regulating phenotypic outcomes to these interventions. Given the need for effective countermeasures to combat muscle atrophy within the clinical setting (sarcopenia, various muscle disorders etc.), these studies could have a significant impact on exercise and/or medical prescriptions for maintaining muscle health.


Exercise-induced AMPK activation does not interfere with muscle hypertrophy in response to resistance training in men
Lundberg Tr, Fernandez-gonzalo R, Tesch Pa
Journal of applied physiology (Bethesda, Md. : 1985) 2014;116(6):611-20

Muscle damage responses and adaptations to eccentric-overload resistance exercise in men and women
Fernandez-gonzalo R, Lundberg Tr, Alvarez-alvarez L, De Paz Ja
European journal of applied physiology 2014;114(5):1075-84

Truncated splice variant PGC-1α4 is not associated with exercise-induced human muscle hypertrophy
Lundberg Tr, Fernandez-gonzalo R, Norrbom J, Fischer H, Tesch Pa, Gustafsson T
Acta physiologica (Oxford, England) 2014;212(2):142-51

Acute molecular responses in untrained and trained muscle subjected to aerobic and resistance exercise training versus resistance training alone
Fernandez-gonzalo R, Lundberg Tr, Tesch Pa
Acta physiologica (Oxford, England) 2013;209(4):283-94

Aerobic exercise does not compromise muscle hypertrophy response to short-term resistance training
Lundberg Tr, Fernandez-gonzalo R, Gustafsson T, Tesch Pa
Journal of applied physiology (Bethesda, Md. : 1985) 2013;114(1):81-9

Gene Expression After Acute Resistance Exercise is Modified by Aerobic Exercise and Chronic Training
Fernandez-gonzalo R, Lundberg Tr, Tesch Pa

Aerobic exercise alters skeletal muscle molecular responses to resistance exercise
Lundberg Tr, Fernandez-gonzalo R, Gustafsson T, Tesch Pa
Medicine and science in sports and exercise 2012;44(9):1680-8

Increase in Muscle Size Following 5-wk Resistance Training is Exaggerated by Concurrent Aerobic Exercise
Lundberg Tr, Fernandez-gonzalo R, Akerstrom S, Tesch Pa