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About me

A methods oriented docent (Associate professor) of Epidemiology, I'm focused on ways of using epidemiological studies to provide information that will help patients and caregivers better understand chronic disease and disease course, and to make informed choices about therapeutic options.

As a coordinator at the Clinical Epidemiology Unit, I work in many projects in the Chronic Inflammatory Diseases research group, broadly divided in pharmacoepidemiological projects on treatments for rheumatic diseases and multiple sclerosis, and etiological studies with a focus on the familial aggregation of chronic inflammatory joint diseases. My research is funded by research grants from US-based Patient Centered Outcomes Institute (PCORI), a career grant from the Swedish Research Council, and the MS Research Foundation (MS-forskningsfonden). My work is also funded by several pharmaceutical companies through the Anti-Rheumatic Therapies In Sweden (ARTIS) project.


Doctoral thesis

Frisell, T. (2012) Violent crime : addressing causation with family-based methods. Stockholm: Karolinska Institutet. 

University studies

2002-2007. The Master of Science in Molecular Biotechnology Engineering programme, 270 credits, Uppsala University, Uppsala, Sweden.

2003-2006. Extracurricular courses (inter alia Molecular Pharmacology, Quantum Mechanics II & History of Art), in total 147 credits. Uppsala University, Uppsala, Sweden.



Apgar Score Components at 5 Minutes: Risks and Prediction of Neonatal Mortality
Cnattingius S, Norman M, Granath F, Petersson G, Stephansson O, Frisell T
Paediatric and perinatal epidemiology 2017;31(4):328-337

Comparative effectiveness of rituximab relative to IFN-β or glatiramer acetate in relapsing-remitting MS from the Swedish MS registry
Spelman T, Frisell T, Piehl F, Hillert J
Multiple sclerosis (Houndmills, Basingstoke, England) 2017;():1352458517713668-

How well do ACPA discriminate and predict RA in the general population: a study based on 12 590 population-representative Swedish twins
Hensvold Ah, Frisell T, Magnusson Pk, Holmdahl R, Askling J, Catrina Ai
Annals of the rheumatic diseases 2017;76(1):119-125

Malignant Neoplasms in Patients With Rheumatoid Arthritis Treated With Tumor Necrosis Factor Inhibitors, Tocilizumab, Abatacept, or Rituximab in Clinical Practice: A Nationwide Cohort Study From Sweden
Wadström H, Frisell T, Askling J, Anti-rheumatic Therapy In Sweden (artis) Study Group
JAMA internal medicine 2017;177(11):1605-1612

A genetic risk score composed of rheumatoid arthritis risk alleles, HLA-DRB1 haplotypes, and response to TNFi therapy - results from a Swedish cohort study
Jiang X, Askling J, Saevarsdottir S, Padyukov L, Alfredsson L, Viatte S, et al
Arthritis research & therapy 2016;18(1):288-

Can rheumatoid arthritis (RA) registries provide contextual safety data for modern RA clinical trials? The case for mortality and cardiovascular disease
Michaud K, Berglind N, Franzén S, Frisell T, Garwood C, Greenberg Jd, et al
Annals of the rheumatic diseases 2016;75(10):1797-805

Carryover Effects in Sibling Comparison Designs
Sjölander A, Frisell T, Kuja-halkola R, Öberg S, Zetterqvist J
Epidemiology (Cambridge, Mass.) 2016;27(6):852-8

Comparative analysis of first-year fingolimod and natalizumab drug discontinuation among Swedish patients with multiple sclerosis
Frisell T, Forsberg L, Nordin N, Kiesel C, Alfredsson L, Askling J, et al
Multiple sclerosis (Houndmills, Basingstoke, England) 2016;22(1):85-93

Does a family history of RA influence the clinical presentation and treatment response in RA?
Frisell T, Saevarsdottir S, Askling J
Annals of the rheumatic diseases 2016;75(6):1120-5

Do RA or TNF inhibitors increase the risk of cervical neoplasia or of recurrence of previous neoplasia? A nationwide study from Sweden
Wadström H, Frisell T, Sparén P, Askling J, Artis Study Group
Annals of the rheumatic diseases 2016;75(7):1272-8

Familial aggregation of arthritis-related diseases in seropositive and seronegative rheumatoid arthritis: a register-based case-control study in Sweden
Frisell T, Hellgren K, Alfredsson L, Raychaudhuri S, Klareskog L, Askling J
Annals of the rheumatic diseases 2016;75(1):183-9

Family history of rheumatoid arthritis: an old concept with new developments
Frisell T, Saevarsdottir S, Askling J
Nature reviews. Rheumatology 2016;12(6):335-43

How comparable are rates of malignancies in patients with rheumatoid arthritis across the world? A comparison of cancer rates, and means to optimise their comparability, in five RA registries
Askling J, Berglind N, Franzen S, Frisell T, Garwood C, Greenberg Jd, et al
Annals of the rheumatic diseases 2016;75(10):1789-96

Alping P, Frisell T, Svenningsson A, Piehl F
Annals of neurology 2016;80(5):791-792

Rituximab versus fingolimod after natalizumab in multiple sclerosis patients
Alping P, Frisell T, Novakova L, Islam-jakobsson P, Salzer J, Björck A, et al
Annals of neurology 2016;79(6):950-8

Anabolic androgenic steroids and violent offending: confounding by polysubstance abuse among 10 365 general population men
Lundholm L, Frisell T, Lichtenstein P, Langstrom N
ADDICTION 2015;110(1):100-8

Maternal body mass index during early pregnancy, gestational weight gain, and risk of autism spectrum disorders: Results from a Swedish total population and discordant sibling study
Gardner Rm, Lee Bk, Magnusson C, Rai D, Frisell T, Karlsson H, et al
International journal of epidemiology 2015;44(3):870-83

Methodological Challenges When Comparing Demographic and Clinical Characteristics of International Observational Registries
Verstappen Sm, Askling J, Berglind N, Franzen S, Frisell T, Garwood C, et al
Arthritis care & research 2015;67(12):1637-45

New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis
Schizophrenia Working Grp Psychiat, Lee Sh, Byrne Em, Hultman Cm, Kahler A, Vinkhuyzen Aae, et al

Prolonged second stage of labor is associated with low Apgar score
Altman M, Sandström A, Petersson G, Frisell T, Cnattingius S, Stephansson O
European journal of epidemiology 2015;30(11):1209-15

Risk factors for the rapid increase in risk of acute coronary events in patients with new-onset rheumatoid arthritis: a nested case-control study
Mantel Ä, Holmqvist M, Nyberg F, Tornling G, Frisell T, Alfredsson L, et al
Arthritis & rheumatology (Hoboken, N.J.) 2015;67(11):2845-54

Sexual offending runs in families: A 37-year nationwide study
Langstrom N, Babchishin Km, Fazel S, Lichtenstein P, Frisell T

TNF inhibitor therapy and risk of breast cancer recurrence in patients with rheumatoid arthritis: a nationwide cohort study
Raaschou P, Frisell T, Askling J, Artis Study Group
Annals of the rheumatic diseases 2015;74(12):2137-43

To what extent is the familial risk of rheumatoid arthritis explained by established rheumatoid arthritis risk factors?
Jiang X, Frisell T, Askling J, Karlson Ew, Klareskog L, Alfredsson L, et al
Arthritis & rheumatology (Hoboken, N.J.) 2015;67(2):352-62

Association of height and violent criminality: results from a Swedish total population study
Beckley Al, Kuja-halkola R, Lundholm L, Långström N, Frisell T
International journal of epidemiology 2014;43(3):835-42

Genetic contribution to postpartum haemorrhage in Swedish population: cohort study of 466,686 births
Oberg As, Hernandéz-diaź S, Frisell T, Greene Mf, Almqvist C, Bateman Bt
BMJ (Clinical research ed.) 2014;349():g4984-

Hospital admission with infection during childhood and risk for psychotic illness--a population-based cohort study
Blomström Å, Karlsson H, Svensson A, Frisell T, Lee Bk, Dal H, et al
Schizophrenia bulletin 2014;40(6):1518-25

The 1% of the population accountable for 63% of all violent crime convictions
Falk O, Wallinius M, Lundström S, Frisell T, Anckarsäter H, Kerekes N
Social psychiatry and psychiatric epidemiology 2014;49(4):559-71

The association between schizophrenia and rheumatoid arthritis: a nationwide population-based Swedish study on intraindividual and familial risks
Sellgren C, Frisell T, Lichtenstein P, Landèn M, Askling J
Schizophrenia bulletin 2014;40(6):1552-9

Familial risks and heritability of rheumatoid arthritis: role of rheumatoid factor/anti-citrullinated protein antibody status, number and type of affected relatives, sex, and age
Frisell T, Holmqvist M, Källberg H, Klareskog L, Alfredsson L, Askling J
Arthritis and rheumatism 2013;65(11):2773-82

Maternal and fetal genetic contributions to postterm birth: familial clustering in a population-based sample of 475,429 Swedish births
Oberg As, Frisell T, Svensson Ac, Iliadou An
American journal of epidemiology 2013;177(6):531-7

Heritability, Assortative Mating and Gender Differences in Violent Crime: Results from a Total Population Sample Using Twin, Adoption, and Sibling Models
Frisell T, Pawitan Y, Langstrom N, Lichtenstein P
BEHAVIOR GENETICS 2012;42(1):3-18

Is the Association between General Cognitive Ability and Violent Crime Caused by Family-Level Confounders?
Frisell T, Pawitan Y, Langstrom N
PLOS ONE 2012;7(7):e41783-

Sibling Comparison Designs Bias From Non-Shared Confounders and Measurement Error
Frisell T, Oberg S, Kuja-halkola R, Sjolander A
EPIDEMIOLOGY 2012;23(5):713-20

Familial clustering of suicide risk: a total population study of 11.4 million individuals
Tidemalm D, Runeson B, Waern M, Frisell T, Carlstrom E, Lichtenstein P, et al
PSYCHOLOGICAL MEDICINE 2011;41(12):2527-34

Violent crime runs in families: a total population study of 12.5 million individuals
Frisell T, Lichtenstein P, Langstrom N

Bipolar Disorder and Violent Crime: Time at Risk Reanalysis
Fazel S, Lichtenstein P, Frisell T, Grann M, Goodwin G, Langstrom N

Psychiatric morbidity associated with same-sex sexual behaviour: influence of minority stress and familial factors
Frisell T, Lichtenstein P, Rahman Q, Langstrom N

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