Sven-Christian Pawelzik

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About me

I am a team leader in the Translational Cardiology group at the Department of
Medicine, Solna (MedS), driven to learn about new aspects of human health and
apply this knowledge to contribute to innovative therapeutic approaches. My
focus of interest is inflammation as basis of cardiovascular diseases.

2011 - 2016 Postdoctoral Researcher, University of Pennsylvania, Philadelphia, PA, USA
2010 PhD in Medical Science, Karolinska Institutet, Sweden
2006 MSc, Human Biology, University of Marburg, Germany
2001 BSc, Human Biology, University of Marburg, Germany

Teaching

Main supervisor for two PhD students
Co-supervisor for two PhD students
Main supervisor for several BSc and MSc students (Biomedicine, Biochemistry,
Molecular Biology)
PhD course organiser for Lipid Metabolism and Inflammation in Cardiovascular
Disease (https://kiwas.ki.se/katalog/kursplan/show/9584)

Articles

Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023;24(6):5392

Helicobacter Pylori Virulence Factor Cytotoxin-Associated Gene A (CagA) Induces Vascular Calcification in Coronary Artery Smooth Muscle Cells.

Sundqvist MO; Wärme J; Hofmann R; Pawelzik S-C; Bäck M
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2023;194:308-315

Decreased oxidative stress and altered urinary oxylipidome by intravenous omega-3 fatty acid emulsion in a randomized controlled trial of older subjects hospitalized for COVID-19.

Pawelzik S-C; Arnardottir H; Sarajlic P; Mahdi A; Vigor C; Zurita J; Zhou B; Kolmert J; Galano J-M; Religa D; Durand T; Wheelock CE; Bäck M
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2022;179(19):4709-4721

The tyrosine kinase inhibitor nilotinib targets the discoidin domain receptor DDR2 in calcific aortic valve stenosis.

Carracedo M; Pawelzik S-C; Artiach G; Pouwer MG; Plunde O; Saliba-Gustafsson P; Ehrenborg E; Eriksson P; Pieterman E; Stenke L; Princen HMG; Franco-Cereceda A; Bäck M
Article: CLINICAL AND TRANSLATIONAL MEDICINE. 2022;12(9):e895

Immunomodulation by intravenous omega-3 fatty acid treatment in older subjects hospitalized for COVID-19: A single-blind randomized controlled trial.

Arnardottir H; Pawelzik S-C; Sarajlic P; Quaranta A; Kolmert J; Religa D; Wheelock CE; Bäck M
Article: BIOCHEMICAL PHARMACOLOGY. 2022;201:115075

The resolvin D2 - GPR18 axis is expressed in human coronary atherosclerosis and transduces atheroprotection in apolipoprotein E deficient mice.

Bardin M; Pawelzik S-C; Lagrange J; Mahdi A; Arnardottir H; Regnault V; Fève B; Lacolley P; Michel J-B; Mercier N; Bäck M
Journal article: CARDIOLOGY PLUS. 2022;7(1):3-11

Calcific aortic valve stenosis and COVID-19: clinical management, valvular damage, and pathophysiological mechanisms

Bäck M; Hashem M; Giani A; Pawelzik S-C; Franco-Cereceda A
Article: JOURNAL OF CLINICAL INVESTIGATION. 2021;131(24):e142883

The resolvin D1 receptor GPR32 transduces inflammation resolution and atheroprotection.

Arnardottir H; Thul S; Pawelzik S-C; Karadimou G; Artiach G; Gallina AL; Mysdotter V; Carracedo M; Tarnawski L; Caravaca AS; Baumgartner R; Ketelhuth DF; Olofsson PS; Paulsson-Berne G; Hansson GK; Bäck M
Article: CIRCULATION. 2021;144(20):1629-1645

Palmdelphin Regulates Nuclear Resilience to Mechanical Stress in the Endothelium

Franco Cereceda A; Bäck M; Plunde O; Pawelzik S-C
Journal article: CIRCULATION. 2021;144(20):1629-1645

Palmdelphin Regulates Nuclear Resilience to Mechanical Stress in the Endothelium

Sainz-Jaspeado M; Smith RO; Plunde O; Pawelzik S-C; Jin Y; Nordling S; Ding Y; Aspenstrom P; Hedlund M; Bastianello G; Ascione F; Li Q; Demir CS; Fernando D; Daniel G; Franco-Cereceda A; Kroon J; Foiani M; Petrova TV; Kilimann MW; Back M; Claesson-Welsh L
Article: AMERICAN HEART JOURNAL. 2021;231:105-109

Helicobacter pylori screening in clinical routine during hospitalization for acute myocardial infarction.

Wärme J; Sundqvist M; Mars K; Aladellie L; Pawelzik S-C; Erlinge D; Jernberg T; James S; Hofmann R; Bäck M
Article: CELLS. 2020;9(7):E1710-1710

TLR7 Expression Is Associated with M2 Macrophage Subset in Calcific Aortic Valve Stenosis.

Karadimou G; Plunde O; Pawelzik S-C; Carracedo M; Eriksson P; Franco-Cereceda A; Paulsson-Berne G; Bäck M
Article: OXIDATIVE MEDICINE AND CELLULAR LONGEVITY. 2020;2020:5197376-9

Semicarbazide-Sensitive Amine Oxidase Increases in Calcific Aortic Valve Stenosis and Contributes to Valvular Interstitial Cell Calcification.

Mercier N; Pawelzik S-C; Pirault J; Carracedo M; Persson O; Wollensack B; Franco-Cereceda A; Bäck M
Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2019;145:106361

Urinary prostaglandin D2 and E2 metabolites associate with abdominal obesity, glucose metabolism, and triglycerides in obese subjects.

Pawelzik S-C; Avignon A; Idborg H; Boegner C; Stanke-Labesque F; Jakobsson P-J; Sultan A; Bäck M
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2019;176(24):4625-4638

Biological characterization of new inhibitors of microsomal PGE synthase-1 in preclinical models of inflammation and vascular tone.

Larsson K; Steinmetz J; Bergqvist F; Arefin S; Spahiu L; Wannberg J; Pawelzik S-C; Morgenstern R; Stenberg P; Kublickiene K; Korotkova M; Jakobsson P-J
Article: JOURNAL OF IMMUNOLOGY. 2018;200(12):4004-4011

Platelet-Activating Factor-Induced Reduction in Contact Hypersensitivity Responses Is Mediated by Mast Cells via Cyclooxygenase-2-Dependent Mechanisms.

Ocana JA; Romer E; Sahu R; Pawelzik S-C; FitzGerald GA; Kaplan MH; Travers JB
Article: CIRCULATION. 2016;134(4):328-338

Cardiovascular Consequences of Prostanoid I Receptor Deletion in Microsomal Prostaglandin E Synthase-1-Deficient Hyperlipidemic Mice.

Tang SY; Monslow J; R Grant G; Todd L; Pawelzik S-C; Chen L; Lawson J; Puré E; FitzGerald GA
Article: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS. 2014;91(6):269-275

Evaluation of urinary prostaglandin E2 metabolite as a biomarker in infants with fever due to viral infection.

Idborg H; Pawelzik S-C; Perez-Manso M; Björk L; Hamrin J; Herlenius E; Jakobsson P-J
Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2013;102-103:1-12

Characterization of a new mPGES-1 inhibitor in rat models of inflammation.

Leclerc P; Pawelzik S-C; Idborg H; Spahiu L; Larsson C; Stenberg P; Korotkova M; Jakobsson P-J
Article: BIOCHEMISTRY. 2011;50(35):7684-7693

Location of inhibitor binding sites in the human inducible prostaglandin E synthase, MPGES1.

Prage EB; Pawelzik S-C; Busenlehner LS; Kim K; Morgenstern R; Jakobsson P-J; Armstrong RN
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(38):29254-29261

Identification of key residues determining species differences in inhibitor binding of microsomal prostaglandin E synthase-1.

Pawelzik S-C; Uda NR; Spahiu L; Jegerschöld C; Stenberg P; Hebert H; Morgenstern R; Jakobsson P-J
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2010;1801(4):462-472

Hyperforin induces Ca(2+)-independent arachidonic acid release in human platelets by facilitating cytosolic phospholipase A(2) activation through select phospholipid interactions.

Hoffmann M; Lopez JJ; Pergola C; Feisst C; Pawelczik S; Jakobsson P-J; Sorg BL; Glaubitz C; Steinhilber D; Werz O
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(44):18757-18762

Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells.

Hanaka H; Pawelzik S-C; Johnsen JI; Rakonjac M; Terawaki K; Rasmuson A; Sveinbjörnsson B; Schumacher MC; Hamberg M; Samuelsson B; Jakobsson P-J; Kogner P; Rådmark O
Article: LEUKEMIA & LYMPHOMA. 2009;50(7):1198-1203

Lymphoblastic T-cell lymphoma in mice is unaffected by Celecoxib as single agent or in combination with cyclophosphamide.

Johansson A-S; Pawelzik S-C; Larefalk A; Jakobsson P-J; Holmberg D; Lindskog M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(32):11110-11115

Structural basis for induced formation of the inflammatory mediator prostaglandin E2.

Jegerschöld C; Pawelzik S-C; Purhonen P; Bhakat P; Gheorghe KR; Gyobu N; Mitsuoka K; Morgenstern R; Jakobsson P-J; Hebert H
Article: CIRCULATION. 2008;117(13):1701-1710

Microsomal prostaglandin E2 synthase-1 deletion leads to adverse left ventricular remodeling after myocardial infarction.

Degousee N; Fazel S; Angoulvant D; Stefanski E; Pawelzik S-C; Korotkova M; Arab S; Liu P; Lindsay TF; Zhuo S; Butany J; Li R-K; Audoly L; Schmidt R; Angioni C; Geisslinger G; Jakobsson P-J; Rubin BB
Journal article: GBM ANNUAL SPRING MEETING MOSBACH 2006. 2006;2006(Spring)

Mutational Analysis of human glutathione-dependent microsomal Prostaglandin E synthase-1 (mPGES-1)

Pawelzik S-C; Jegerschöld C; Pettersson PL; Morgenstern R; Hebert H; Jakobsson P-J
Journal article: VALUE IN HEALTH. 2004;7(2):144-152

Resource utilization and costs of stroke unit care in Germany.

Dodel RC; Haacke C; Zamzow K; Paweilik S; Spottke A; Rethfeldt M; Siebert U; Oertel WH; Schöffski O; Back T
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All other publications

Review: METABOLITES. 2022;12(8):721

Prostanoid Metabolites as Biomarkers in Human Disease.

Idborg H; Pawelzik S-C
Editorial comment: CARDIOVASCULAR RESEARCH. 2022;118(2):353-354

von Willebrand factor's vascular crossroad.

Pawelzik S-C; Bäck M
Preprint: MEDRXIV. 2021

Immunomodulation by intravenous omega-3 fatty acid treatment in older subjects hospitalized for COVID-19: a single-blind randomized controlled trial

Arnardottir H; Pawelzik S-C; Sarajlic P; Quaranta A; Kolmert J; Religa D; Wheelock C; Bäck M
Conference publication: ATHEROSCLEROSIS. 2021;331:E9

THE RESOLVIN D1 RECEPTOR GPR32 TRANSDUCES INFLAMMATION-RESOLUTION AND ATHEROPROTECTION

Arnardottir H; Thul S; Karadimou G; Pawelzik S-C; Artiach G; Mysdotter V; Carracedo M; Tarnawski L; Caravaca AS; Baumgartner R; Ketelhuth DF; Olofsson PS; Paulsson-Berne G; Hansson GK; Back M
Review: TOXINS. 2020;12(4):E227-227

Inflammation and Premature Ageing in Chronic Kidney Disease.

Ebert T; Pawelzik S-C; Witasp A; Arefin S; Hobson S; Kublickiene K; Shiels PG; Bäck M; Stenvinkel P
Editorial comment: ANNALS OF TRANSLATIONAL MEDICINE. 2020;8(6):258

Eastern Remedies for Western-type diet induced atherosclerosis.

Pawelzik S-C; Bäck M
Review: FRONTIERS IN PHYSIOLOGY. 2020;11:624657

Stimulating the Resolution of Inflammation Through Omega-3 Polyunsaturated Fatty Acids in COVID-19: Rationale for the COVID-Omega-F Trial.

Arnardottir H; Pawelzik S-C; Öhlund Wistbacka U; Artiach G; Hofmann R; Reinholdsson I; Braunschweig F; Tornvall P; Religa D; Bäck M
KI thesis / dissertation: 2010

Structure and function of microsomal prostaglandin E synthase-1

Pawelzik, Sven-Christian
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2010;71(6):508

Characterization of mPGES-1 Inhibition in Rat Models of Inflammation

Leclerc P; Larsson C; Spahiu L; Pawelzik S-C; Idborg H; Stenberg P; Korotkova M; Jakobsson P-J
Conference publication: ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES. 2009;65:S77

Structure of Microsomal Prostaglandin E Synthase 1 as Determined by Electron Crystallography

Hebert H; Jegerschoeld C; Purhonen P; Bhakat P; Gheorghe K; Gyobu N; Mitsuoka K; Pawelzik S; Jakobsson P-J; Morgenstern R

Grants

Optimizing omega-3 supplementation to resolve inflammation in a personalized medicine CVD prevention

VINNOVA

21 November 2022 - 31 December 2025
Personalised blueprint of chronic inflammation in health-to-disease transition

European Commission

1 November 2022
Mast cell derived lipid mediators in atherogenesis

Swedish Research Council

1 January 2013 - 31 December 2015

Employments

Adjunct Lecturer, Department of Medicine, Karolinska Institutet, 2023-2025
Affiliated to Research, Department of Medicine, Karolinska Institutet, 2022-2025

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Medicine, Solna, Karolinska Institutet, 2010

About me

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