Susanna Kullberg

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Articles

Article: EUROPEAN JOURNAL OF EPIDEMIOLOGY. 2024;39(3):313-322

Menopausal hormone therapy and risk of sarcoidosis: a population-based nested case-control study in Sweden.

Dehara M; Kullberg S; Bixo M; Sachs MC; Grunewald J; Arkema EV
Article: BMJ OPEN RESPIRATORY RESEARCH. 2023;10(1):e001551

Lymphopenia and high Ki-67 expression in peripheral blood CD4+ and CD8+ T cells associate with progressive sarcoidosis.

Kullberg S; Grunewald J; Eklund A
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2023;213(3):357-362

Peripheral blood lymphopenia in sarcoidosis associates with HLA-DRB1 alleles but not with lung immune cells and organ involvement.

Darlington P; Melin J; Rivera N; Grunewald J; Eklund A; Kullberg S
Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2023;12(15):e029481

Clinical Outcomes and Predictors of Long-Term Survival in Patients With and Without Previously Known Extracardiac Sarcoidosis Using Machine Learning: A Swedish Multicenter Study.

Bobbio E; Eldhagen P; Polte CL; Hjalmarsson C; Karason K; Rawshani A; Darlington P; Kullberg S; Sörensson P; Bergh N; Bollano E
Article: FRONTIERS IN MEDICINE. 2023;10:1061654

Functional link between sarcoidosis-associated gene variants and quantitative levels of bronchoalveolar lavage fluid cell types.

Abo Al Hayja M; Kullberg S; Eklund A; Padyukov L; Grunewald J; Rivera NV
Article: FRONTIERS IN MEDICINE. 2023;10:1132799

Sex differences in the genetics of sarcoidosis across European and African ancestry populations.

Xiong Y; Kullberg S; Garman L; Pezant N; Ellinghaus D; Vasila V; Eklund A; Rybicki BA; Iannuzzi MC; Schreiber S; Müller-Quernheim J; Montgomery CG; Grunewald J; Padyukov L; Rivera NV
Journal article: CIRCULATION. 2022;146(Suppl_1):a11874

Abstract 11874: Clinical Outcomes and Predictors of Long-Term Survival in Patients With and Without Extra-Cardiac Sarcoidosis Using Machine Learning: A Swedish Multicenter Study

Bobbio E; Eldhagen P; Polte CL; Hjalmarsson C; Kullberg S; Sorensson P; Bergh N; Bollano E
Article: INTERNATIONAL JOURNAL OF CARDIOLOGY. 2022;359:108-112

Phenotypic and HLA-DRB1 allele characterization of Swedish cardiac sarcoidosis patients.

Eldhagen P; Bobbio E; Darlington P; Grunewald J; Eklund A; Polte CL; Bergh N; Bollano E; Sörensson P; Kullberg S
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2022;111(4):857-866

Pulmonary and blood dendritic cells from sarcoidosis patients more potently induce IFNγ-producing Th1 cells compared with monocytes.

Lepzien R; Nie M; Czarnewski P; Liu S; Yu M; Ravindran A; Kullberg S; Eklund A; Grunewald J; Smed-Sörensen A
Article: HEART. 2022;108(6):467-473

Risk and predictors of heart failure in sarcoidosis in a population-based cohort study from Sweden.

Rossides M; Kullberg S; Grunewald J; Eklund A; Di Giuseppe D; Askling J; Arkema EV
Article: BMC PULMONARY MEDICINE. 2022;22(1):43

Reproductive and hormonal risk factors for sarcoidosis: a nested case-control study.

Dehara M; Sachs MC; Kullberg S; Grunewald J; Blomberg A; Arkema EV
Article: RESPIRATORY MEDICINE. 2022;191:106688

Differences in disease presentation between men and women with sarcoidosis: A cohort study.

Lundkvist A; Kullberg S; Arkema EV; Cedelund K; Eklund A; Grunewald J; Darlington P
Article: RESPIRATORY MEDICINE. 2021;188:106624

Risk of acute myocardial infarction in sarcoidosis: A population-based cohort study from Sweden.

Rossides M; Kullberg S; Grunewald J; Eklund A; Di Giuseppe D; Askling J; Arkema EV
Article: RESPIRATORY MEDICINE. 2021;187:106537

HLA-DRB1 alleles associate with hypercalcemia in sarcoidosis.

Werner J; Rivera N; Grunewald J; Eklund A; Iseda T; Darlington P; Kullberg S
Article: RESPIRATORY MEDICINE. 2021;186:106521

Bronchoalveolar lavage fluid cell subsets associate with the disease course in Löfgren's and non-Löfgren's sarcoidosis patients.

Abo Al Hayja M; Wahlström J; Kullberg S; Darlington P; Eklund A; Grunewald J
Article: EUROPEAN RESPIRATORY JOURNAL. 2021;58(1):2003468

Monocytes in sarcoidosis are potent tumour necrosis factor producers and predict disease outcome.

Lepzien R; Liu S; Czarnewski P; Nie M; Österberg B; Baharom F; Pourazar J; Rankin G; Eklund A; Bottai M; Kullberg S; Blomberg A; Grunewald J; Smed-Sörensen A
Article: BMJ OPEN RESPIRATORY RESEARCH. 2021;8(1):e000933

Effects of infliximab on lung and circulating natural killer cells, CD56+ T cells and B cells in sarcoidosis.

Kullberg S; Rivera NV; Grunewald J; Eklund A
Article: MULTIPLE SCLEROSIS JOURNAL. 2021;27(7):1014-1026

Methylome and transcriptome signature of bronchoalveolar cells from multiple sclerosis patients in relation to smoking.

Ringh MV; Hagemann-Jensen M; Needhamsen M; Kullberg S; Wahlström J; Grunewald J; Brynedal B; Jagodic M; Ekström TJ; Öckinger J; Kular L
Article: EPIDEMIOLOGY. 2021;32(3):444-447

Positive Predictive Value of Sarcoidosis Identified in an Administrative Healthcare Registry: A Validation Study.

Ceder S; Rossides M; Kullberg S; Eklund A; Grunewald J; Arkema EV
Article: RESPIROLOGY. 2021;26(5):452-460

Infection risk in sarcoidosis patients treated with methotrexate compared to azathioprine: A retrospective 'target trial' emulated with Swedish real-world data.

Rossides M; Kullberg S; Di Giuseppe D; Eklund A; Grunewald J; Askling J; Arkema EV
Article: ERJ OPEN RESEARCH. 2021;7(2):28-2021

Type 2 diabetes risk in sarcoidosis patients untreated and treated with corticosteroids.

Entrop JP; Kullberg S; Grunewald J; Eklund A; Brismar K; Arkema EV
Article: EUROPEAN JOURNAL OF EPIDEMIOLOGY. 2020;35(11):1087-1097

Are infectious diseases risk factors for sarcoidosis or a result of reverse causation? Findings from a population-based nested case-control study.

Rossides M; Kullberg S; Askling J; Eklund A; Grunewald J; Di Giuseppe D; Arkema EV
Article: SCIENTIFIC REPORTS. 2020;10(1):15328

Sarcoidosis exosomes stimulate monocytes to produce pro-inflammatory cytokines and CCL2.

Wahlund CJE; Gucluler Akpinar G; Steiner L; Ibrahim A; Bandeira E; Lepzien R; Lukic A; Smed-Sörensen A; Kullberg S; Eklund A; Grunewald J; Gabrielsson S
Article: EUROPEAN RESPIRATORY JOURNAL. 2020;56(3):2000767

Risk of first and recurrent serious infection in sarcoidosis: a Swedish register-based cohort study.

Rossides M; Kullberg S; Eklund A; Di Giuseppe D; Grunewald J; Askling J; Arkema EV
Article: RESPIRATORY RESEARCH. 2020;21(1):225

Maternal and infant outcomes in sarcoidosis pregnancy: a Swedish population-based cohort study of first births.

Köcher L; Rossides M; Remaeus K; Grunewald J; Eklund A; Kullberg S; Arkema EV
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2020;201(1):85-93

Changes in lung immune cells related to clinical outcome during treatment with infliximab for sarcoidosis.

Kullberg S; Rivera NV; Abo Al Hayja M; Grunewald J; Eklund A
Article: RESPIRATORY RESEARCH. 2020;21(1):61

Lung CD4+ Vα2.3+ T-cells in sarcoidosis cohorts with Löfgren's syndrome.

Darlington P; Kullberg S; Eklund A; Grunewald J
Article: EUROPEAN CLINICAL RESPIRATORY JOURNAL. 2020;7(1):1730137

High-intensity resistance training in newly diagnosed sarcoidosis- an exploratory study of effects on lung function, muscle strength, fatigue, dyspnea, health-related quality of life and lung immune cells.

Kullberg S; Rivera NV; Eriksson MJ; Grunewald J; Eklund A
Article: RESPIRATORY MEDICINE. 2020;161:105846

Sarcoidosis diagnosis and treatment in Sweden: A register-based assessment of variations by region and calendar period.

Rossides M; Kullberg S; Eklund A; Grunewald J; Arkema EV
Article: SCIENTIFIC REPORTS. 2019;9(1):18633

A Gene-Environment Interaction Between Smoking and Gene polymorphisms Provides a High Risk of Two Subgroups of Sarcoidosis.

Rivera NV; Patasova K; Kullberg S; Diaz-Gallo LM; Iseda T; Bengtsson C; Alfredsson L; Eklund A; Kockum I; Grunewald J; Padyukov L
Article: EBIOMEDICINE. 2019;46:290-304

Tobacco smoking induces changes in true DNA methylation, hydroxymethylation and gene expression in bronchoalveolar lavage cells.

Ringh MV; Hagemann-Jensen M; Needhamsen M; Kular L; Breeze CE; Sjöholm LK; Slavec L; Kullberg S; Wahlström J; Grunewald J; Brynedal B; Liu Y; Almgren M; Jagodic M; Öckinger J; Ekström TJ
Article: SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES. 2019;36(1):11-17

Diagnostic approach for cardiac involvement in sarcoidosis.

Darlington P; Gabrielsen A; Cederlund K; Kullberg S; Grunewald J; Eklund A; Sörensson P
Article: EUROPEAN RESPIRATORY JOURNAL. 2018;52(2):1800385

Familial aggregation and heritability of sarcoidosis: a Swedish nested case-control study.

Rossides M; Grunewald J; Eklund A; Kullberg S; Di Giuseppe D; Askling J; Arkema EV
Article: RESPIRATORY MEDICINE. 2018;138S:S38-S44

Enhanced CD8+ cytolytic T cell responses in the peripheral circulation of patients with sarcoidosis and non-Löfgren's disease.

Parasa VR; Forsslund H; Enger T; Lorenz D; Kullberg S; Eklund A; Sköld M; Wahlström J; Grunewald J; Brighenti S
Article: EUROPEAN RESPIRATORY JOURNAL. 2018;51(2):1701815

Sarcoidosis mortality in Sweden: a population-based cohort study.

Rossides M; Kullberg S; Askling J; Eklund A; Grunewald J; Arkema EV
Article: SCIENTIFIC REPORTS. 2017;7(1):5623

Common variants of T-cells contribute differently to phenotypic variation in sarcoidosis.

Rivera NV; Hagemann-Jensen M; Ferreira MAR; Kullberg S; Eklund A; Martin NG; Padyukov L; Grunewald J
Article: EUROPEAN RESPIRATORY JOURNAL. 2016;48(6):1690-1699

Sarcoidosis incidence and prevalence: a nationwide register-based assessment in Sweden.

Arkema EV; Grunewald J; Kullberg S; Eklund A; Askling J
Article: MICROBIOME. 2016;4(1):60

The lung microbiota in early rheumatoid arthritis and autoimmunity.

Scher JU; Joshua V; Artacho A; Abdollahi-Roodsaz S; Öckinger J; Kullberg S; Sköld M; Eklund A; Grunewald J; Clemente JC; Ubeda C; Segal LN; Catrina AI
Article: CLINICAL IMMUNOLOGY. 2016;169:114-120

T-cell activation and HLA-regulated response to smoking in the deep airways of patients with multiple sclerosis.

Öckinger J; Hagemann-Jensen M; Kullberg S; Engvall B; Eklund A; Grunewald J; Piehl F; Olsson T; Wahlström J
Article: EUROPEAN RESPIRATORY JOURNAL. 2016;48(2):484-494

Expanded lung T-bet+RORγT+ CD4+ T-cells in sarcoidosis patients with a favourable disease phenotype.

Kaiser Y; Lepzien R; Kullberg S; Eklund A; Smed-Sörensen A; Grunewald J
Article: PLOS ONE. 2016;11(10):e0164751

Distinctive Regulatory T Cells and Altered Cytokine Profile Locally in the Airways of Young Smokers with Normal Lung Function.

Ostadkarampour M; Müller M; Öckinger J; Kullberg S; Lindén A; Eklund A; Grunewald J; Wahlström J
Article: PLOS ONE. 2016;11(8):e0161669

Expression Profile of Six RNA-Binding Proteins in Pulmonary Sarcoidosis.

Navratilova Z; Novosadova E; Hagemann-Jensen M; Kullberg S; Kolek V; Grunewald J; Petrek M
Article: PHYSIOLOGY & BEHAVIOR. 2007;92(1-2):129-135

Factors contributing to neuromuscular impairment and sarcopenia during aging.

Edström E; Altun M; Bergman E; Johnson H; Kullberg S; Ramírez-León V; Ulfhake B
Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2004;78(6):892-900

MHC class I, beta2 microglobulin, and the INF-gamma receptor are upregulated in aged motoneurons.

Edström E; Kullberg S; Ming Y; Zheng H; Ulfhake B
Article: BRAIN RESEARCH. 2001;899(1-2):169-186

Microglial activation, emergence of ED1-expressing cells and clusterin upregulation in the aging rat CNS, with special reference to the spinal cord.

Kullberg S; Aldskogius H; Ulfhake B
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 1999;11(8):2935-2948

Increased glutathione levels in neurochemically identified fibre systems in the aged rat lumbar motor nuclei.

Ramírez-León V; Kullberg S; Hjelle OP; Ottersen OP; Ulfhake B
Article: JOURNAL OF NEUROSCIENCE RESEARCH. 1999;57(2):153-165

Upregulation of GFRalpha-1 and c-ret in primary sensory neurons and spinal motoneurons of aged rats.

Bergman E; Kullberg S; Ming Y; Ulfhake B
Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 1998;53(5):B369-B379

Decreased axosomatic input to motoneurons and astrogliosis in the spinal cord of aged rats.

Kullberg S; Ramírez-León V; Johnson H; Ulfhake B
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All other publications

Corrigendum: FRONTIERS IN MEDICINE. 2024;11:1382584

Corrigendum: Sex differences in the genetics of sarcoidosis across European and African ancestry populations.

Xiong Y; Kullberg S; Garman L; Pezant N; Ellinghaus D; Vasila V; Eklund A; Rybicki BA; Iannuzzi MC; Schreiber S; Müller-Quernheim J; Montgomery CG; Grunewald J; Padyukov L; Rivera NV
Review: JOURNAL OF INTERNAL MEDICINE. 2023;293(6):668-680

Sarcoidosis: Epidemiology and clinical insights.

Rossides M; Darlington P; Kullberg S; Arkema EV
Preprint: RESEARCH SQUARE. 2021

Sex Differences in the Genetics of Sarcoidosis Across European and African Ancestry Populations

Xiong Y; Kullberg S; Garman L; Pezant N; Ellinghaus D; Vasila V; Eklund A; Rybicki B; Iannuzzi M; Schreiber S; Müller-Quernheim J; Montgomery C; Grunewald J; Padyukov L; Rivera N
Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2020;56:4398

Type 2 diabetes mellitus risk associated with sarcoidosis: A Swedish population-based cohort study

Entrop JP; Kullberg S; Grunewald J; Brismar K; Arkema E
Review: EUROPEAN RESPIRATORY REVIEW. 2020;29(155):190146

Delphi consensus recommendations for a treatment algorithm in pulmonary sarcoidosis.

Rahaghi FF; Baughman RP; Saketkoo LA; Sweiss NJ; Barney JB; Birring SS; Costabel U; Crouser ED; Drent M; Gerke AK; Grutters JC; Hamzeh NY; Huizar I; Ennis James W; Kalra S; Kullberg S; Li H; Lower EE; Maier LA; Mirsaeidi M; Müller-Quernheim J; Carmona Porquera EM; Samavati L; Valeyre D; Scholand MB
Letter: EUROPEAN RESPIRATORY JOURNAL. 2020;55(1):1901450

Subpopulations of cells from bronchoalveolar lavage can predict prognosis in sarcoidosis.

Darlington P; Kullberg S; Eklund A; Grunewald J
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2020;26(3_SUPPL):583

Methylome and transcriptome signature of bronchoalveolar cells from multiple sclerosis patients in relation to smoking

Ringh M; Hagemann-Jensen M; Needhamsen M; Kullberg S; Wahlstrom J; Grunewald J; Brynedal B; Jagodic M; Ekstrom T; Ockinger J; Kular L
Letter: RESPIRATORY MEDICINE. 2019;160:105696

Correspondence for "Clinical epidemiology of familial sarcoidosis: A systematic literature review".

Rossides M; Grunewald J; Eklund A; Kullberg S; Askling J; Arkema EV
Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2019;54:oa5160

Serious infections in sarcoidosis and the effect of treatment

Rossides M; Kullberg S; Eklund A; Grunewald J; Arkema E
Meeting abstract: EUROPEAN RESPIRATORY JOURNAL. 2019;54:oa5156

Maternal and fetal outcomes in sarcoidosis pregnancy: a Swedish population-based cohort study

Kocher L; Rossides M; Remaeus K; Grunewald J; Eklund A; Kullberg S; Arkema E
Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2019;199:a2431

Genetic Architecture of Disease Chronicity in Sarcoidosis

Rivera N; Kullberg S; Iseda T; Eklund AG; Padyukov L; Grunewald J
Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2018;52:pa3008

Monocytes and dendritic cells with hyperinflammatory profile in lungs of sarcoidosis patients

Lepzien R; Liu S; Kullberg S; Eklund A; Grunewald J; Smed-Sorensen A
Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2018;197

Familial Aggregation and Heritability of Sarcoidosis: A Swedish Nested Case-Control Study

Rossides M; Grunewald J; Kullberg S; Eklund A; Di Giuseppe D; Askling J; Arkema EV
Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2017;50:pa2595

Sarcoidosis mortality in Sweden: a population-based cohort study

Rossides M; Kullberg S; Askling J; Eklund A; Grunewald J; Arkema E
Conference publication: QUALITY OF LIFE RESEARCH. 2017;26(1):26

Standardised Translation of the King's Sarcoidosis Questionnaire (KSQ) into eleven languages

Birring S; Fletcher H; Tully T; Patel AS; Kullberg S; Mogulkoc N; Dubaniewicz A; Cotta G; Niimi A; Guan W-J; Valeyre D; Castillo Villegas D; Pereira CA; Acquadro C; Baughman R
Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2017;195

Standardised Translation Of The King's Sarcoidosis Questionnaire (ksq) Into Eleven Languages

Birring S; Fletcher H; Tully T; Patel A; Kullberg S; Mogulkoc N; Dubaniewicz A; Cotta Ramusino G; Niimi A; Guan W; Valeyre D; Castillo D; Pereira CA; Acquadro C; Baughman RP
Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2017;195

Multi-Parameter Mass Cytometry Analysis Of Lung Cd4+T Cells In Sarcoidosis Identifies Diverse Immune Pathways In Lofgren's Syndrome And Non-Ls

Kaiser Y; Lakshmikanth T; Chen Y; Mikes J; Kullberg S; Eklund A; Brodin P; Achour A; Grunewald J
Preprint: BIORXIV. 2016

T-cell activation and HLA-regulated response to smoking in the deep airways of patients with multiple sclerosis

Öckinger J; Hagemann-Jensen M; Kullberg S; Engvall B; Eklund A; Grunewald J; Piehl F; Olsson T; Wahlstrom J
Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2016;193

Lung-Specific Clonality And Plasticity Of T Cell Receptor-Restricted Cd4+T Cells In Sarcoidosis - Implications For Pulmonary Antigen Recognition

Kaiser Y; Lepzien R; Ronninger M; Kullberg S; Kaller M; Lundin S; Vezzi F; Olsen R-A; Sandalova T; Wahlstrom J; Sorensen AS; Eklund A; Achour A; Grunewald J
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2016;83(5):369

Investigation of patients with multiple sclerosis using bronchoalveolar lavage indicates T-cell activation in the lung and HLA-regulated response to smoke

Ockinger J; Hagemann-Jenssen M; Kullberg S; Engvall B; Eklund A; Grunewald J; Piehl F; Olsson T; Wahlstrom J
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2014;79(6):458

Characteristics of T Cell Subsets in Smokers and Multiple Sclerosis Patients' Lungs

Hagemann-Jensen M; Ockinger J; Kullberg S; Piehl F; Olsson T; Eklund A; Grunewald J; Wahlstrom J
Conference publication: JOURNAL OF IMMUNOLOGY. 2013;190:43.29

Higher cytotoxic capacity in peripheral blood of sarcoidosis patients

Wahlstrom J; Enger T; Lorenz D; Rao R; Forsslund H; Rahman J; Skold M; Kullberg S; Eklund A; Brighenti S; Grunewald J
Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2013;42

Differential regulation of innate immunity in healthy smokers

Ockinger J; Hagemann-Jensen M; Kullberg S; Eklund A; Grunewald J; Wahlstrom J
Conference publication: IMMUNOLOGY. 2012;137:250

Inflammasome activation in alveolar macrophages from healthy smokers

Ockinger J; Kullberg S; Eklund A; Grunewald J; Wahlstrom J
Review: MOLECULAR NEUROBIOLOGY. 2000;21(3):109-135

Regulation of neurotrophin signaling in aging sensory and motoneurons: dissipation of target support?

Ulfhake B; Bergman E; Edstrom E; Fundin BT; Johnson H; Kullberg S; Ming Y
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Grants

Nya möjligheter till individualiserad prognosbedömning och behandling vid sarkoidos

Swedish Heart-Lung Foundation

1 January 2021 - 31 December 2022
Understanding and targeting human lung dendritic cells in the immunopathology of sarcoidosis

Swedish Heart-Lung Foundation

1 January 2020 - 31 December 2022

Employments

Affiliated to Research, Department of Medicine, Karolinska Institutet, 2022-2024

Degrees and Education

Docent, Karolinska Institutet, 2023
Doctor Of Philosophy, Department of neuroscience, Karolinska Institutet, 2002
University Medical Degree, Karolinska Institutet, 1997

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