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Stephen Strom

Professor/clinical chemist

Visiting address : F56, Karolinska Universitetssjukhuset 14186 Stockholm, Sweden
Postal address : Department of Laboratory Medicine (LABMED), H5, Division of Pathology, F46, Karolinska Universitetssjukhuset, Huddinge 141 86 Stockholm, Sweden
Delivery address : F56 Via Varumottagningen, Karolinska Universitetssjukhuset 14186 Stockholm, Sweden

Publications

Clinical hepatocyte transplantation: practical limits and possible solutions
Gramignoli R, Vosough M, Kannisto K, Srinivasan Rc, Strom Sc
European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes 2015;54(3-4):162-77

Long-term culture of genome-stable bipotent stem cells from adult human liver
Huch M, Gehart H, Van Boxtel R, Hamer K, Blokzijl F, Verstegen Mm, et al
Cell 2015;160(1-2):299-312

Benzothiophene carboxylate derivatives as novel allosteric inhibitors of branched-chain α-ketoacid dehydrogenase kinase
Tso Sc, Gui Wj, Wu Cy, Chuang Jl, Qi X, Skvora Kj, et al
The Journal of biological chemistry 2014;289(30):20583-93

Genetic Variation in Aldo-Keto Reductase 1D1 (AKR1D1) Affects the Expression and Activity of Multiple Cytochrome P450s (vol 41, 1538, 2013)
Chaudhry As, Thirumaran Rk, Yasuda K, Yang X, Fan Y, Strom Sc, et al
DRUG METABOLISM AND DISPOSITION 2014;42(5):917-917

Hypothermic storage of human hepatocytes for transplantation
Gramignoli R, Dorko K, Tahan V, Skvorak Kj, Ellis E, Jorns C, et al
Cell transplantation 2014;23(9):1143-51

Increased reprogramming of human fetal hepatocytes compared with adult hepatocytes in feeder-free conditions
Hansel Mc, Gramignoli R, Blake W, Davila J, Skvorak K, Dorko K, et al
Cell transplantation 2014;23(1):27-38

Potency of individual bile acids to regulate bile acid synthesis and transport genes in primary human hepatocyte cultures
Liu J, Lu H, Lu Yf, Lei X, Cui Jy, Ellis E, et al
Toxicological sciences : an official journal of the Society of Toxicology 2014;141(2):538-46

Potential barriers to human hepatocyte transplantation in MUP-uPAtg(⁺/⁺)Rag2⁻/⁻γC⁻/⁻ mice
Komori J, Deward Ad, Gramignoli R, Strom Sc, Fontes P, Lagasse E
Cell transplantation 2014;23(12):1537-44

Rapid and sensitive assessment of human hepatocyte functions
Gramignoli R, Tahan V, Dorko K, Venkataramanan R, Fox Ij, Ellis Ec, et al
Cell transplantation 2014;23(12):1545-56

Strategies for short-term storage of hepatocytes for repeated clinical infusions
Jorns C, Gramignoli R, Saliem M, Zemack H, Mörk Lm, Isaksson B, et al
Cell transplantation 2014;23(8):1009-18

The history and use of human hepatocytes for the treatment of liver diseases: the first 100 patients
Hansel Mc, Gramignoli R, Skvorak Kj, Dorko K, Marongiu F, Blake W, et al
Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.] 2014;62():14.12.1-23

Why do most human liver cytosol preparations lack xanthine oxidase activity?
Barr Jt, Choughule Kv, Nepal S, Wong T, Chaudhry As, Joswig-jones Ca, et al
Drug metabolism and disposition: the biological fate of chemicals 2014;42(4):695-9

A sensitive and specific CYP cocktail assay for the simultaneous assessment of human cytochrome P450 activities in primary cultures of human hepatocytes using LC-MS/MS
Pillai Vc, Strom Sc, Caritis Sn, Venkataramanan R
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 2013;:126-32

Genetic variation in aldo-keto reductase 1D1 (AKR1D1) affects the expression and activity of multiple cytochrome P450s
Chaudhry As, Thirumaran Rk, Yasuda K, Yang X, Fan Y, Strom Sc, et al
Drug metabolism and disposition: the biological fate of chemicals 2013;41(8):1538-47

Hepatobiliary disposition of 17-OHPC and taurocholate in fetal human hepatocytes: a comparison with adult human hepatocytes
Sharma S, Ellis Ec, Gramignoli R, Dorko K, Tahan V, Hansel M, et al
Drug metabolism and disposition: the biological fate of chemicals 2013;41(2):296-304

Improved amino acid, bioenergetic metabolite and neurotransmitter profiles following human amnion epithelial cell transplant in intermediate maple syrup urine disease mice
Skvorak Kj, Dorko K, Marongiu F, Tahan V, Hansel Mc, Gramignoli R, et al
Molecular genetics and metabolism 2013;109(2):132-8

Mice with chimeric livers are an improved model for human lipoprotein metabolism
Ellis Ec, Naugler We, Parini P, Mörk Lm, Jorns C, Zemack H, et al
PloS one 2013;8(11):e78550-

Mice with human livers
Grompe M, Strom S
Gastroenterology 2013;145(6):1209-14

New potential cell source for hepatocyte transplantation: discarded livers from metabolic disease liver transplants
Gramignoli R, Tahan V, Dorko K, Skvorak Kj, Hansel Mc, Zhao W, et al
Stem cell research 2013;11(1):563-73

Placental stem cell correction of murine intermediate maple syrup urine disease
Skvorak Kj, Dorko K, Marongiu F, Tahan V, Hansel Mc, Gramignoli R, et al
Hepatology (Baltimore, Md.) 2013;57(3):1017-23

Regulation of the human hydroxysteroid sulfotransferase (SULT2A1) by RORα and RORγ and its potential relevance to human liver diseases
Ou Z, Shi X, Gilroy Rk, Kirisci L, Romkes M, Lynch C, et al
Molecular endocrinology (Baltimore, Md.) 2013;27(1):106-15

Ritonavir and efavirenz significantly alter the metabolism of erlotinib--an observation in primary cultures of human hepatocytes that is relevant to HIV patients with cancer
Pillai Vc, Venkataramanan R, Parise Ra, Christner Sm, Gramignoli R, Strom Sc, et al
Drug metabolism and disposition: the biological fate of chemicals 2013;41(10):1843-51

Three-dimensional culture and cAMP signaling promote the maturation of human pluripotent stem cell-derived hepatocytes
Ogawa S, Surapisitchat J, Virtanen C, Ogawa M, Niapour M, Sugamori Ks, et al
Development (Cambridge, England) 2013;140(15):3285-96

Translation of amnion stem cells to the clinic
Strom Sc, Skvorak K, Gramignoli R, Marongiu F, Miki T
Stem cells and development 2013;22 Suppl 1():96-102

Arsenic decreases RXR alpha-dependent transcription of CYP3A and suppresses immune regulators in hepatocytes
Noreault-conti Tl, Fellows A, Jacobs Jm, Trask Hw, Strom Sc, Evans Rm, et al
INTERNATIONAL IMMUNOPHARMACOLOGY 2012;12(4):651-6

ChREBP mediates glucose-stimulated pancreatic β-cell proliferation
Metukuri Mr, Zhang P, Basantani Mk, Chin C, Stamateris Re, Alonso Lc, et al
Diabetes 2012;61(8):2004-15

Development and application of purified tissue dissociation enzyme mixtures for human hepatocyte isolation
Gramignoli R, Green Ml, Tahan V, Dorko K, Skvorak Kj, Marongiu F, et al
Cell transplantation 2012;21(6):1245-60

Effect of voriconazole and other azole antifungal agents on CYP3A activity and metabolism of tacrolimus in human liver microsomes
Zhang Sm, Pillai Vc, Mada Sr, Strom S, Venkataramanan R
XENOBIOTICA 2012;42(5):409-16

Frequent Aneuploidy Among Normal Human Hepatocytes
Duncan Aw, Newell Aeh, Smith L, Wilson Em, Olson Sb, Thayer Mj, et al
GASTROENTEROLOGY 2012;142(1):25-8

Hepatocyte transplantation for inherited metabolic diseases of the liver
Jorns C, Ellis Ec, Nowak G, Fischler B, Nemeth A, Strom Sc, et al
Journal of internal medicine 2012;272(3):201-23

Improving the Techniques for Human Hepatocyte Transplantation: Report From a Consensus Meeting in London
Puppi J, Strom Sc, Hughes Rd, Bansal S, Castell Jv, Dagher I, et al
CELL TRANSPLANTATION 2012;21(1):1-10

The Orphan Nuclear Receptor DAX-1 Functions as a Potent Corepressor of the Constitutive Androstane Receptor (NR1I3)
Laurenzana Em, Chen T, Kannuswamy M, Sell Be, Strom Sc, Li Y, et al
MOLECULAR PHARMACOLOGY 2012;82(5):918-28

A Whole-Organ Regenerative Medicine Approach for Liver Replacement
Soto-gutierrez A, Zhang L, Medberry C, Fukumitsu K, Faulk D, Jiang Hb, et al
TISSUE ENGINEERING PART C-METHODS 2011;17(6):677-86

FoxO6 Integrates Insulin Signaling With Gluconeogenesis in the Liver
Kim Dh, Perdomo G, Zhang T, Slusher S, Lee S, Phillips Be, et al
DIABETES 2011;60(11):2763-74

Hepatic Differentiation of Amniotic Epithelial Cells
Marongiu F, Gramignoli R, Dorko K, Miki T, Ranade Ar, Serra Mp, et al
HEPATOLOGY 2011;53(5):1719-29

Hepatic Organic Anion Transporting Polypeptide Transporter and Thyroid Hormone Receptor Interplay Determines Cholesterol and Glucose Homeostasis
Schwabedissen Hemz, Ware Ja, Finkelstein D, Chaudhry As, Mansell S, Leon-ponte M, et al
HEPATOLOGY 2011;54(2):644-54

MicroRNA hsa-miR-613 Targets the Human LXR alpha Gene and Mediates a Feedback Loop of LXR alpha Autoregulation
Ou Zm, Wada T, Gramignoli R, Li S, Strom Sc, Huang M, et al
MOLECULAR ENDOCRINOLOGY 2011;25(4):584-96

Status of bacterial colonization, Toll-like receptor expression and nuclear factor-kappa B activation in normal and diseased human livers
Singh R, Bullard J, Kalra M, Assefa S, Kaul Ak, Vonfeldt K, et al
CLINICAL IMMUNOLOGY 2011;138(1):41-9

A Novel Bile Acid-Activated Vitamin D Receptor Signaling in Human Hepatocytes
Han Sx, Li Tg, Ellis E, Strom S, Chiang Jyl
MOLECULAR ENDOCRINOLOGY 2010;24(6):1151-64

ATPase Class I Type 8B Member 1 and Protein Kinase C zeta Induce the Expression of the Canalicular Bile Salt Export Pump in Human Hepatocytes
Chen F, Ellis E, Strom Sc, Shneider Bl
PEDIATRIC RESEARCH 2010;67(2):183-7

Barriers to the successful treatment of liver disease by hepatocyte transplantation
Soltys Ka, Soto-gutierrez A, Nagaya M, Baskin Km, Deutsch M, Ito R, et al
JOURNAL OF HEPATOLOGY 2010;53(4):769-74

Chimeric mice with humanized liver: tools for the study of drug metabolism, excretion, and toxicity
Strom Sc, Davila J, Grompe M
Methods in molecular biology (Clifton, N.J.) 2010;640():491-509

CYP2C9(star)1B Promoter Polymorphisms, in Linkage with CYP2C19(star)2, Affect Phenytoin Autoinduction of Clearance and Maintenance Dose
Chaudhry As, Urban Tj, Lamba Jk, Birnbaum Ak, Remmel Rp, Subramanian M, et al
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 2010;332(2):599-611

FoxO1 Links Hepatic Insulin Action to Endoplasmic Reticulum Stress
Kamagate A, Kim Dh, Zhang T, Slusher S, Gramignoli R, Strom Sc, et al
ENDOCRINOLOGY 2010;151(8):3521-35

Genetic Predictors of Interindividual Variability in Hepatic CYP3A4 Expression
Lamba V, Panetta Jc, Strom S, Schuetz Eg
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 2010;332(3):1088-99

Human hepatocyte transplantation
Dhawan A, Strom Sc, Sokal E, Fox Ij
Methods in molecular biology (Clifton, N.J.) 2010;640():525-34

Isolation of amniotic epithelial stem cells
Miki T, Marongiu F, Dorko K, Ellis Ec, Strom Sc
Current protocols in stem cell biology 2010;Chapter 1():1E.3-

Isolation of amniotic mesenchymal stem cells
Marongiu F, Gramignoli R, Sun Q, Tahan V, Miki T, Dorko K, et al
Current protocols in stem cell biology 2010;Chapter 1():1E.5-

Maintenance of Human Hepatocyte Function In Vitro by Liver-Derived Extracellular Matrix Gels
Sellaro Tl, Ranade A, Faulk Dm, Mccabe Gp, Dorko K, Badylak Sf, et al
TISSUE ENGINEERING PART A 2010;16(3):1075-82

Metabolism of 17 alpha-Hydroxyprogesterone Caproate, an Agent for Preventing Preterm Birth, by Fetal Hepatocytes
Sharma S, Ellis Ecs, Dorko K, Zhang Sm, Mattison Dr, Caritis Sn, et al
DRUG METABOLISM AND DISPOSITION 2010;38(5):723-7

Sulforaphane- and Phenethyl Isothiocyanate-Induced Inhibition of Aflatoxin B1-Mediated Genotoxicity in Human Hepatocytes: Role of GSTM1 Genotype and CYP3A4 Gene Expression
Gross-steinmeyer K, Stapleton Pl, Tracy Jh, Bammler Tk, Strom Sc, Eaton Dl
TOXICOLOGICAL SCIENCES 2010;116(2):422-32

Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver
Yang X, Zhang B, Molony C, Chudin E, Hao K, Zhu J, et al
GENOME RESEARCH 2010;20(8):1020-36

The second extracellular loop dictates Occludin-mediated HCV entry
Liu Sf, Kuo W, Yang W, Liu Wq, Gibson Ga, Dorko K, et al
VIROLOGY 2010;407(1):160-70

The Uremic Toxin 3-Indoxyl Sulfate Is a Potent Endogenous Agonist for the Human Aryl Hydrocarbon Receptor
Schroeder Jc, Dinatale Bc, Murray Ia, Flaveny Ca, Liu Q, Laurenzana Em, et al
BIOCHEMISTRY 2010;49(2):393-400

Toward Cell Therapy Using Placenta-Derived Cells: Disease Mechanisms, Cell Biology, Preclinical Studies, and Regulatory Aspects at the Round Table
Parolini O, Alviano F, Bergwerf I, Boraschi D, De Bari C, De Waele P, et al
STEM CELLS AND DEVELOPMENT 2010;19(2):143-54

Bile Acids Activate Fibroblast Growth Factor 19 Signaling in Human Hepatocytes to Inhibit Cholesterol 7 alpha-Hydroxylase Gene Expression
Song Kh, Li Tg, Owsley E, Strom S, Chiang Jyl
HEPATOLOGY 2009;49(1):297-305

Bile acid signaling pathways increase stability of Small Heterodimer Partner (SHP) by inhibiting ubiquitin-proteasomal degradation
Miao J, Xiao Z, Kanamaluru D, Min G, Yau Pm, Veenstra Td, et al
GENES & DEVELOPMENT 2009;23(8):986-96

Differentiation and Transplantation of Human Embryonic Stem Cell-Derived Hepatocytes
Basma H, Soto-gutierrez A, Yannam Gr, Liu Lp, Ito R, Yamamoto T, et al
GASTROENTEROLOGY 2009;136(3):990-9

Effect of Rifampin and Nelfinavir on the Metabolism of Methadone and Buprenorphine in Primary Cultures of Human Hepatocytes
Moody De, Fang Wb, Lin Sn, Weyant Dm, Strom Sc, Omiecinski Cj
DRUG METABOLISM AND DISPOSITION 2009;37(12):2323-9

Embryonic and induced pluripotent stem cells as a model for liver disease
Yagi H, Tafaleng E, Nagaya M, Hansel Mc, Strom Sc, Fox Ij, et al
Critical reviews in biomedical engineering 2009;37(4-5):377-98

Forkhead box transcription factor O1 inhibits cholesterol 7 alpha-hydroxylase in human hepatocytes and in high fat diet-fed mice
Li Tg, Ma Hy, Park Yj, Lee Yk, Strom S, Moore Dd, et al
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 2009;1791(10):991-6

Hepatocyte transplantation (HTx) corrects selected neurometabolic abnormalities in murine intermediate maple syrup urine disease (iMSUD)
Skvorak Kj, Hager Ej, Arning E, Bottiglieri T, Paul Hs, Strom Sc, et al
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2009;1792(10):1004-10

Hepatocyte Transplantation Improves Phenotype and Extends Survival in a Murine Model of Intermediate Maple Syrup Urine Disease
Skvorak Kj, Paul Hs, Dorko K, Marongiu F, Ellis E, Chace D, et al
MOLECULAR THERAPY 2009;17(7):1266-73

Human Pregnane X Receptor Activation and CYP3A4/CYP2B6 Induction by 2,3-Oxidosqualene: Lanosterol Cyclase Inhibition
Duniec-dmuchowski Z, Fang Hl, Strom Sc, Ellis E, Runge-morris M, Kocarek Ta
DRUG METABOLISM AND DISPOSITION 2009;37(4):900-8

Long Term Cultures of Primary Human Hepatocytes as an Alternative to Drug Testing in Animals
Ullrich A, Soltz Db, Ellis Ec, Strom Sc, Michalopoulos Gk, Hengstler Jg, et al
ALTEX-ALTERNATIVEN ZU TIEREXPERIMENTEN 2009;26(4):295-302

Modulation of Aflatoxin B1-Mediated Genotoxicity in Primary Cultures of Human Hepatocytes by Diindolylmethane, Curcumin, and Xanthohumols
Gross-steinmeyer K, Stapleton Pl, Tracy Jh, Bammler Tk, Strom Sc, Buhler Dr, et al
TOXICOLOGICAL SCIENCES 2009;112(2):303-10

Naive Rat Amnion-Derived Cell Transplantation Improved Left Ventricular Function and Reduced Myocardial Scar of Postinfarcted Heart
Fujimoto Kl, Miki T, Liu Lj, Hashizume R, Strom Sc, Wagner Wr, et al
CELL TRANSPLANTATION 2009;18(4):477-86

Production of hepatocyte-like cells from human amnion
Miki T, Marongiu F, Ellis Ec, Dorko K, Mitamura K, Ranade A, et al
Methods in molecular biology (Clifton, N.J.) 2009;481():155-68

A comprehensive in vitro and in silico analysis of antibiotics that activate pregnane X receptor and induce CYP3A4 in liver and intestine
Yasuda K, Ranade A, Venkataramanan R, Strom S, Chupka J, Ekins S, et al
DRUG METABOLISM AND DISPOSITION 2008;36(8):1689-97

Association of breast cancer resistance protein/ABCG2 phenotypes and novel promoter and intron 1 single nucleotide polymorphisms
Poonkuzhali B, Lamba J, Strom S, Sparreboom A, Thummel K, Watkins P, et al
DRUG METABOLISM AND DISPOSITION 2008;36(4):780-95

Concise review: Isolation and characterization of cells from human term placenta: Outcome of the first international workshop on placenta derived stem cells
Parolini O, Alviano F, Bagnara Gp, Bilic G, Buhring Hj, Evangelista M, et al
STEM CELLS 2008;26(2):300-11

Expression profiling of interindividual variability following xenobiotic exposures in primary human hepatocyte cultures
Goyak Kmo, Johnson Mc, Strom Sc, Omiecinski Cj
TOXICOLOGY AND APPLIED PHARMACOLOGY 2008;231(2):216-24

Identification of enzymes involved in the metabolism of 17 alpha-hydroxyprogesterone caproate: An effective agent for prevention of preterm birth
Sharma S, Ou Jh, Strom S, Mattison D, Caritis S, Venkataramanan R
DRUG METABOLISM AND DISPOSITION 2008;36(9):1896-902

Identification of oxysterol 7 alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha ( ROR alpha) (NR1F1) target gene and a functional cross-talk between ROR alpha and liver X receptor (NR1H3)
Wada T, Kang Hs, Angers M, Gong H, Bhatia S, Khadem S, et al
MOLECULAR PHARMACOLOGY 2008;73(3):891-9

Mapping the genetic architecture of gene expression in human liver
Schadt Ee, Molony C, Chudin E, Hao K, Yang X, Lum Py, et al
PLOS BIOLOGY 2008;6(5):e107-

Novel single nucleotide polymorphisms in the promoter and intron 1 of human pregnane X receptor/NR1l2 and their association with CYP3A4 expression
Lamba J, Lamba V, Strom S, Venkataramanan R, Schuetz E
DRUG METABOLISM AND DISPOSITION 2008;36(1):169-81

Preservation of hepatic phenotype in lentiviral-transduced primary human hepatocytes
Zamule Sm, Strom Sc, Omiecinski Cj
CHEMICO-BIOLOGICAL INTERACTIONS 2008;173(3):179-86

To be or not to be: generation of hepatocytes from cells outside the liver
Fox Ij, Strom Sc
GASTROENTEROLOGY 2008;134(3):878-81

Adenoviral-mediated correction of methylmalonyl-CoA mutase deficiency in murine fibroblasts and human hepatocytes
Chandler Rj, Tsai Ms, Dorko K, Sloan J, Korson M, Freeman R, et al
BMC MEDICAL GENETICS 2007;:24-

Effects of green tea compounds on irinotecan metabolism
Mirkov S, Komoroski Bj, Ramirez J, Graber Ay, Ratain Mj, Strom Sc, et al
DRUG METABOLISM AND DISPOSITION 2007;35(2):228-33

Ethanol stimulates bile acid formation in primary human hepatocytes
Nilsson Lm, Sjovall J, Strom S, Bodin K, Nowak G, Einarsson C, et al
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2007;364(4):743-7

Gene expression profiling and differentiation assessment in primary human hepatocyte cultures, established hepatoma cell lines, and human liver tissues
Olsavsky Km, Page Jl, Johnson Mc, Zarbl H, Strom Sc, Omiecinski Cj
TOXICOLOGY AND APPLIED PHARMACOLOGY 2007;222(1):42-56

Gene expression profiling of extracellular matrix as an effector of human hepatocyte phenotype in primary cell culture
Page Jl, Johnson Mc, Olsavsky Km, Strom Sc, Zarbl H, Omiecinski Cj
TOXICOLOGICAL SCIENCES 2007;97(2):384-97

Hepatocyte growth factor signaling pathway inhibits cholesterol 7 alpha-hydroxylase and bile acid synthesis in human hepatocytes
Song Kh, Ellis E, Strom S, Chiang Jyl
HEPATOLOGY 2007;46(6):1993-2002

Identification of stem cell marker-positive cells by immunofluorescence in term human amnion
Miki T, Mitamura K, Ross Ma, Stolz Db, Strom Sc
JOURNAL OF REPRODUCTIVE IMMUNOLOGY 2007;75(2):91-6

Induction of CYP3A in primary cultures of human hepatocytes by ginkgolides A and B
He N, Cai Hb, Xie Hg, Collins X, Edeki Ti, Strom Sc
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 2007;34(7):632-5

Lack of Fas antagonism by Met in human fatty liver disease
Zou Cb, Ma Jh, Wang X, Guo L, Zhu Zq, Stoops J, et al
NATURE MEDICINE 2007;13(9):1078-85

Physiological differences between human and rat primary hepatocytes in response to liver X receptor activation by 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2diphenylethyl)amino]propyloxy] phenylacetic acid hydrochloride (GW3965)
Kotokorpi P, Ellis E, Parini P, Nilsson Lm, Strom S, Steffensen Kr, et al
MOLECULAR PHARMACOLOGY 2007;72(4):947-55

Positive and negative regulation of human hepatic hydroxysteroid sulfotransferase (SULT2A1) gene transcription by rifampicin: Roles of hepatocyte nuclear factor 4 alpha and pregnane X receptor
Fang Hl, Strom Sc, Ellis E, Duanmu Z, Fu J, Duniec-dmuchowski Z, et al
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 2007;323(2):586-98

Regulation of CYP3A4 and CYP2B6 expression by liver X receptor agonists
Duniec-dmuchowski Z, Ellis E, Strom Sc, Kocarek Ta
BIOCHEMICAL PHARMACOLOGY 2007;74(10):1535-40

Regulation of the human cathepsin E gene by the constitutive androstane receptor
Page Jl, Strom Sc, Omiecinski Cj
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 2007;467(1):132-8

Robust expansion of human hepatocytes in Fah(-/-)/Rag2(-/-)/Il2rg(-/-) mice
Azuma H, Paulk N, Ranade A, Dorrell C, Al-dhalimy M, Ellis E, et al
NATURE BIOTECHNOLOGY 2007;25(8):903-10

Transactivation of a DR-1 PPRE by a human constitutive androstane receptor variant expressed from internal protein translation start sites
Stoner Ma, Auerbach Ss, Zamule Sm, Strom Sc, Omiecinski Cj
NUCLEIC ACIDS RESEARCH 2007;35(7):2177-90

Transport, metabolism, and hepatotoxicity of flutamide, drug-drug interaction with acetaminophen involving phase I and phase II metabolites
Kostrubsky Se, Strom Sc, Ellis E, Nelson Sd, Mutlib Ae
CHEMICAL RESEARCH IN TOXICOLOGY 2007;20(10):1503-12

ADME transcriptome in Hispanic versus White donor livers: Evidence of a globally enhanced NR1I3 (CAR, constitutive androstane receptor) gene signature in Hispanics
Finkelstein D, Lamba V, Assem M, Rengelshausen J, Yasuda K, Strom S, et al
XENOBIOTICA 2006;36(10-11):989-1012

Amnion-derived pluripotent/multipotent stem cells
Miki T, Strom Sc
STEM CELL REVIEWS 2006;2(2):133-42

An optimal culture condition maintains human hepatocyte phenotype after long-term culture
Yamamoto N, Wu J, Zhang Yh, Catana Am, Cai Hb, Strom S, et al
HEPATOLOGY RESEARCH 2006;35(3):169-77

Bigger may not be better when it comes to hepatocytes
Strom Sc, Call Hb, Ellis E, Mitamura K, Miki T
LIVER TRANSPLANTATION 2006;12(1):16-8

Hepatocyte transplantation: Clinical experience and potential for future use
Strom Sc, Bruzzone P, Cai Hb, Ellis E, Lehmann T, Mitamura K, et al
CELL TRANSPLANTATION 2006;:S105-10

Historical aspects of hepatocyte transplantation
Bruzzone P, Strom Sc
TRANSPLANTATION PROCEEDINGS 2006;38(4):1179-80

Human hepatocyte transplantation: Worldwide results
Fisher Ra, Strom Sc
TRANSPLANTATION 2006;82(4):441-9

Increased CYP3A4 copy number in TONG/HCC cells but not in DNA from other humans
Lamba Jk, Chen X, Lan Lb, Kim Jw, Wang Xw, Relling Mv, et al
PHARMACOGENETICS AND GENOMICS 2006;16(6):415-27

Induction of leptin resistance through direct interaction of C-reactive protein with leptin
Chen K, Li Fh, Li J, Cai Hb, Strom S, Bisello A, et al
NATURE MEDICINE 2006;12(4):425-32

Inhibition of hepatobiliary transport as a predictive method for clinical hepatotoxicity of nefazodone
Kostrubsky Se, Strom Sc, Kalgutkar As, Kulkarni S, Atherton J, Mireles R, et al
TOXICOLOGICAL SCIENCES 2006;90(2):451-9

Insulin regulation of cholesterol 7 alpha-hydroxylase expression in human hepatocytes - Roles of forkhead box O1 and sterol regulatory element-binding protein 1c
Li Tg, Kong Xy, Owsley E, Ellis E, Strom S, Chiang Jyl
JOURNAL OF BIOLOGICAL CHEMISTRY 2006;281(39):28745-54

In vitro and in vivo assessment of herb drug interactions
Venkataramanan R, Komoroski B, Strom S
LIFE SCIENCES 2006;78(18):2105-15

In vitro methods in human drug biotransformation research: Implications for cancer chemotherapy
Hariparsad N, Sane Rs, Strom Sc, Desai Pb
TOXICOLOGY IN VITRO 2006;20(2):135-53

MDR1 genotype is associated with hepatic cytochrome P450 3A4 basal and induction phenotype
Lamba J, Strom S, Venkataramanan R, Thummel Ke, Lin Ys, Liu W, et al
CLINICAL PHARMACOLOGY & THERAPEUTICS 2006;79(4):325-38

Present status and perspectives of cell-based therapies for liver diseases
Nussler A, Konig S, Ott M, Sokal E, Christ B, Thasler W, et al
JOURNAL OF HEPATOLOGY 2006;45(1):144-59

Study of the genetic determinants of UGT1A1 inducibility by phenobarbital in cultured human hepatocytes
Ramirez J, Komoroski Bj, Mirkov S, Graber Ay, Fackenthal Dl, Schuetz Eg, et al
PHARMACOGENETICS AND GENOMICS 2006;16(2):79-86

Transcriptomic and genomic analysis of human hepatocellular carcinomas and hepatoblastomas
Luo Jh, Ren Bg, Keryanov S, Tseng Gc, Rao Unm, Monga Sp, et al
HEPATOLOGY 2006;44(4):1012-24

Activity and expression of various isoforms of uridine diphosphate glucuronosyltransferase are differentially regulated during hepatic regeneration in rats
Tian H, Ou Jh, Strom Sc, Venkataramanan R
PHARMACEUTICAL RESEARCH 2005;22(12):2007-15

A pregnane X receptor agonist with unique species-dependent stereoselectivity and its implications in drug development
Mu Y, Stephenson Crj, Kendall C, Saini Sps, Toma D, Ren Sr, et al
MOLECULAR PHARMACOLOGY 2005;68(2):403-13

Arsenite decreases CYP3A4 and RXR alpha in primary human hepatocytes
Noreault Tl, Kostrubsky Ve, Wood Sg, Nichols Rc, Strom Sc, Trask Hw, et al
DRUG METABOLISM AND DISPOSITION 2005;33(7):993-1003

Determination of 13-O-demethyl tacrolimus in human liver microsomal incubates using liquid chromatography-mass spectrometric assay (LC-MS)
Feng Y, Zhang Sm, Poloyac S, Strom S, Venkataramanan R
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 2005;821(1):31-7

Effect of the St. John's wort constituent hyperforin on docetaxel metabolism by human hepatocyte cultures
Komoroski Bj, Parise Ra, Egorin Mj, Strom Sc, Venkataramanan R
CLINICAL CANCER RESEARCH 2005;11(19):6972-9

Influence of Matrigel-overlay on constitutive and inducible expression of nine genes encoding drug-metabolizing enzymes in primary human hepatocytes
Gross-steinmeyer K, Stapleton Pl, Tracy Jh, Bammler Tk, Lehman T, Strom Sc, et al
XENOBIOTICA 2005;35(5):419-38

Isolated hepatocyte transplantation for Crigler-Najjar syndrome type 1
Ambrosino G, Varotto S, Strom Sc, Guariso G, Franchin E, Miotto D, et al
CELL TRANSPLANTATION 2005;14(2-3):151-7

Mouse fetal liver cells in artificial capillary beds in three-dimensional four-compartment bioreactors
Monga Sps, Hout Ms, Baun Mj, Micsenyi A, Muller P, Tummalapalli L, et al
AMERICAN JOURNAL OF PATHOLOGY 2005;167(5):1279-92

Pharmacokinetics of tacrolimus and mycophenolic acid are altered, but recover at different times during hepatic regeneration in rats
Tian H, Ou Jh, Strom Sc, Venkataramanan R
DRUG METABOLISM AND DISPOSITION 2005;33(3):329-35

Phenobarbital and phenytoin increased acetaminophen hepatotoxicity due to inhibition of UDP-glucuronosyltransferases in cultured human hepatocytes
Kostrubsky Se, Sinclair Jf, Strom Sc, Wood S, Urda E, Stolz Db, et al
TOXICOLOGICAL SCIENCES 2005;87(1):146-55

Regulation of human hepatic hydroxysteroid sulfotransferase gene expression by the peroxisome proliferator-activated receptor alpha transcription factor
Fang Hl, Strom Sc, Cai Hb, Falany Cn, Kocarek Ta, Runge-morris M
MOLECULAR PHARMACOLOGY 2005;67(4):1257-67

Side population cells derived from adult human liver generate hepatocyte-like cells in vitro
Hussain Sz, Strom Sc, Kirby Mr, Burns S, Langemeijer S, Ueda T, et al
DIGESTIVE DISEASES AND SCIENCES 2005;50(10):1755-63

Stem cell characteristics of amniotic epithelial cells
Miki T, Lehmann T, Cai Hb, Stolz Db, Strom Sc
STEM CELLS 2005;23(10):1549-59

Determination and analysis of single nucleotide polymorphisms and haplotype structure of the human carboxylesterase 2 gene
Wu Mh, Chen Px, Wu Kl, Liu Wq, Strom S, Das S, et al
PHARMACOGENETICS 2004;14(9):595-605

Expanding hepatocytes in vitro before cell transplantation: Donor age-dependent proliferative capacity of cultured human hepatocytes
Walldorf J, Aurich H, Cai H, Runge D, Christ B, Strom Sc, et al
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 2004;39(6):584-93

Expression of constitutive androstane receptor splice variants in human tissues and their functional consequences
Lamba Jk, Lamba V, Yasuda K, Lin Ys, Assem M, Thompson E, et al
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 2004;311(2):811-21

Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures
Komoroski Bj, Zhang Sm, Cai Hb, Hutzler Jm, Frye R, Tracy Ts, et al
DRUG METABOLISM AND DISPOSITION 2004;32(5):512-8

Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice
Assem M, Schuetz Eg, Leggas M, Sun Dx, Yasuda K, Reid G, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2004;279(21):22250-7

PharmGKB update: II. CYP3A5, cytochrome P450, family 3, subfamily A, polypeptide 5
Schuetz Eg, Relling Mv, Kishi S, Yang W, Das S, Chen P, et al
Pharmacological reviews 2004;56(2):159-

Phytochemical-induced changes in gene expression of carcinogen-metabolizing enzymes in cultured human primary hepatocytes
Gross-steinmeyer K, Stapleton Pl, Liu F, Tracy Jh, Bammler Tk, Quigley Sd, et al
XENOBIOTICA 2004;34(7):619-32

PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators
Lamba V, Yasuda K, Lamba Jk, Assem M, Davila J, Strom S, et al
TOXICOLOGY AND APPLIED PHARMACOLOGY 2004;199(3):251-65

Use and application of stem cells in toxicology
Davila Jc, Cezar Gg, Thiede M, Strom S, Miki T, Trosko J
TOXICOLOGICAL SCIENCES 2004;79(2):214-23

A functional polymorphism at the transcriptional initiation site in beta(2)-glycoprotein I (apolipoprotein H) associated with reduced gene expression and lower plasma levels of beta(2)-glycoprotein I
Mehdi H, Manzi S, Desai P, Chen Q, Nestlerode C, Bontempo F, et al
EUROPEAN JOURNAL OF BIOCHEMISTRY 2003;270(2):230-8

Chemical defense in the microplankton I: Feeding and growth rates of heterotrophic protists on the DMS-producing phytoplankter Emiliania huxleyi
Strom S, Wolfe G, Holmes J, Stecher H, Shimeneck C, Lambert S, et al
LIMNOLOGY AND OCEANOGRAPHY 2003;48(1):217-229

Evaluation of hepatotoxic potential of drugs by inhibition of bile-acid transport in cultured primary human hepatocytes and intact rats
Kostrubsky Ve, Strom Sc, Hanson J, Urda E, Rose K, Burliegh J, et al
TOXICOLOGICAL SCIENCES 2003;76(1):220-8

Hepatic CYP2B6 expression: Gender and ethnic differences and relationship to CYP2B6 genotype and CAR (Constitutive Androstane Receptor) expression
Lamba V, Lamba J, Yasuda K, Strom S, Davila J, Hancock Ml, et al
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 2003;307(3):906-22

Hepatocyte transplantation: New possibilities for therapy
Strom S, Fisher R
GASTROENTEROLOGY 2003;124(2):568-71

In vitro expansion of human hepatocytes is restricted by telomere-dependent replicative aging
Wege H, Chui Ms, Le Ht, Strom Sc, Zern Ma
CELL TRANSPLANTATION 2003;12(8):897-906

Isolated hepatocyte transplantation in an infant with a severe urea cycle disorder
Horslen Sp, Mccowan Tc, Goertzen Tc, Warkentin Pi, Cai Hb, Strom Sc, et al
PEDIATRICS 2003;111(6):1262-7

Common allelic variants of cytochrome P4503A4 and their prevalence in different populations
Lamba Jk, Lin Ys, Thummel K, Daly A, Watkins Pb, Strom S, et al
PHARMACOGENETICS 2002;12(2):121-32

Development of a real-time in vivo transcription assay: Application reveals pregnane X receptor-mediated induction of CYP3A4 by cancer chemotherapeutic agents
Schuetz E, Lan Lb, Yasuda K, Kim R, Kocarek Ta, Schuetz J, et al
MOLECULAR PHARMACOLOGY 2002;62(3):439-45

Effects of bergamottin on human and monkey drug-metabolizing enzymes in primary cultured hepatocytes
Wen Yh, Sahi J, Urda E, Kulkarni S, Rose K, Zheng Xx, et al
DRUG METABOLISM AND DISPOSITION 2002;30(9):977-84

Expression and induction of CYP2CP450 enzymes in primary cultures of human Hepatocytes
Raucy Jl, Mueller L, Duan K, Allen Sw, Strom S, Lasker Jm
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 2002;302(2):475-82

Interferon-alpha activates multiple STAT signals and downregulates c-Met in primary human hepatocytes
Radaeva S, Jaruga B, Hong F, Kim Wh, Fan Sj, Cai Hb, et al
GASTROENTEROLOGY 2002;122(4):1020-34

Regulation of CYP2B6 and CYP3A expression by hydroxymethylglutaryl coenzyme a inhibitors in primary cultured human hepatocytes
Kocarek Ta, Dahn Ms, Cai Hb, Strom Sc, Mercer-haines Na
DRUG METABOLISM AND DISPOSITION 2002;30(12):1400-5

Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome p450
Schuetz Eg, Strom S, Yasuda K, Lecureur V, Assem M, Brimer C, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2001;276(42):39411-8

Memorial to Dr. Hugo Osvaldo Jauregui 1934-2000
Strom S
CELL TRANSPLANTATION 2001;10(2):123-123

Promiscuous regulator of xenobiotic removal
Schuetz E, Strom S
NATURE MEDICINE 2001;7(5):536-7

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression
Kuehl P, Zhang J, Lin Y, Lamba J, Assem M, Schuetz J, et al
NATURE GENETICS 2001;27(4):383-91

The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants
Zhang J, Kuehl P, Green Ed, Touchman Jw, Watkins Pb, Daly A, et al
PHARMACOGENETICS 2001;11(7):555-72

Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand
Jo M, Kim Th, Seol Dw, Esplen Je, Dorko K, Billiar Tr, et al
NATURE MEDICINE 2000;6(5):564-7

Cross-talk between epidermal growth factor receptor and c-Met signal pathways in transformed cells
Jo Mj, Stolz Db, Esplen Je, Dorko K, Michalopoulos Gk, Strom Sc
JOURNAL OF BIOLOGICAL CHEMISTRY 2000;275(12):8806-11

Defining hepatocellular chimerism in a liver failure patient bridged with hepatocyte infusion
Fisher Ra, Bu Dw, Thompson M, Tisnado J, Prasad U, Sterling R, et al
TRANSPLANTATION 2000;69(2):303-7

Immunological quantitation and localization of ACAT-1 and ACAT-2 in human liver and small intestine
Chang Ccy, Sakashita N, Ornvold K, Lee O, Chang Et, Dong R, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2000;275(36):28083-92

Induction of cytochrome P450 (CYP)1A1, CYP1A2, and CYP3A4 but not of CYP2C9, CYP2C19, multidrug resistance (MDR-1) and multidrug resistance associated protein (MRP-1) by prototypical inducers in human hepatocytes
Runge D, Kohler C, Kostrubsky Ve, Jager D, Lehmann T, Runge Dm, et al
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2000;273(1):333-41

Milk thistle, a herbal supplement, decreases the activity of CYP3A4 and uridine diphosphoglucuronosyl transferase in human hepatocyte cultures
Venkataramanan R, Ramachandran V, Komoroski Bj, Zhang Sm, Schiff Pl, Strom Sc
DRUG METABOLISM AND DISPOSITION 2000;28(11):1270-3

Recent advances in human hepatocyte culture systems
Runge D, Michalopoulos Gk, Strom Sc, Runge Dm
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2000;274(1):1-3

Serum-free, long-term cultures of human hepatocytes: Maintenance of cell morphology, transcription factors, and liver-specific functions
Runge D, Runge Dm, Jager D, Lubecki Ka, Stolz Db, Karathanasis S, et al
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2000;269(1):46-53

The role of conjugation in hepatotoxicity of troglitazone in human and porcine hepatocyte cultures
Kostrubsky Ve, Sinclair Jf, Ramachandran V, Venkataramanan R, Wen Yh, Kindt E, et al
DRUG METABOLISM AND DISPOSITION 2000;28(10):1192-7

Transplantation of hepatocytes. Possibilities and examples of clinical application
Runge D, Fleig We, Michalopoulos Gk, Strom Sc, Runge Dm
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT 2000;125(13):397-400

Use of indium-111-labeled hepatocytes to determine the biodistribution of transplanted hepatocytes through portal vein infusion
Bohnen Ni, Charron M, Reyes J, Rubinstein W, Strom Sc, Swanson D, et al
CLINICAL NUCLEAR MEDICINE 2000;25(6):447-50

CD14 expression and production by human hepatocytes
Su Gl, Dorko K, Strom Sc, Nussler Ak, Wang Sc
JOURNAL OF HEPATOLOGY 1999;31(3):435-42

Epidermal growth factor- and hepatocyte growth factor-receptor activity in serum-free cultures of human hepatocytes
Runge Dm, Runge D, Dorko K, Pisarov La, Leckel K, Kostrubsky Ve, et al
JOURNAL OF HEPATOLOGY 1999;30(2):265-74

Hepatocyte transplantation for the treatment of human disease
Strom Sc, Chowdhury Jr, Fox Ij
SEMINARS IN LIVER DISEASE 1999;19(1):39-48

Isolation and characterization of a human hepatic epithelial-like cell line (AKN-1) from a normal liver
Nussler Ak, Vergani G, Gollin Sm, Dorko K, Gansauge S, Morris Sm, et al
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL 1999;35(4):190-7

Morphogenetic events in mixed cultures of rat hepatocytes and nonparenchymal cells maintained in biological matrices in the presence of hepatocyte growth factor and epidermal growth factor
Michalopoulos Gk, Bowen Wc, Zajac Vf, Beer-stolz D, Watkins S, Kostrubsky V, et al
HEPATOLOGY 1999;29(1):90-100

Primary human hepatocyte culture for the study of HCV
O' Connell Jf, Cox S, Buontempo P, Skelton A, Pisarov La, Dorko K, et al
Methods in molecular medicine 1999;19():495-500

STAT 1 alpha/1 beta STAT 3 and STAT 5: Expression and association with c-MET and EGF-receptor in long-term cultures of human hepatocytes
Runge Dm, Runge D, Foth H, Strom Sc, Michalopoulos Gk
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 1999;265(2):376-81

The use of human hepatocyte cultures to study the induction of cytochrome P-450
Kostrubsky Ve, Ramachandran V, Venkataramanan R, Dorko K, Esplen Je, Zhang Sm, et al
DRUG METABOLISM AND DISPOSITION 1999;27(8):887-94

Troglitazone increases cytochrome P-450 3A protein and activity in primary cultures of human hepatocytes
Ramachandran V, Kostrubsky Ve, Komoroski Bj, Zhang Sm, Dorko K, Esplen Je, et al
DRUG METABOLISM AND DISPOSITION 1999;27(10):1194-9

Alterations of the catalytic activities of drug-metabolizing enzymes in cultures of human liver slices
Vandenbranden M, Wrighton Sa, Ekins S, Gillespie Js, Binkley Sn, Ring Bj, et al
DRUG METABOLISM AND DISPOSITION 1998;26(11):1063-8

Human cytochrome P450 3A (CYP3A) mediated midazolam metabolism: the effect of assay conditions and regioselective stimulation by alpha-naphthoflavone, terfenadine and testosterone
Maenpaa J, Hall Sd, Ring Bj, Strom Sc, Wrighton Sa
PHARMACOGENETICS 1998;8(2):137-55

Human hepatocyte transplantation: Gene therapy and more?
Chowdhury Jr, Chowdhury Nr, Strom Sc, Kaufman Ss, Horslen S, Fox Ij
PEDIATRICS 1998;102(3):647-8

Induction of cytochrome P4503A by Taxol in primary cultures of human hepatocytes
Kostrubsky Ve, Lewis Ld, Strom Sc, Wood Sg, Schuetz Eg, Schuetz Jd, et al
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 1998;355(2):131-6

Treatment of the Crigler-Najjar syndrome type I with hepatocyte transplantation
Fox Ij, Chowdhury Jr, Kaufman Ss, Goertzen Tc, Chowdhury Nr, Warkentin Pi, et al
NEW ENGLAND JOURNAL OF MEDICINE 1998;338(20):1422-6

A simple method for the isolation and culture of epithelial and stromal cells from benign and neoplastic prostates
Krill D, Shuman M, Thompson Mt, Becich Mj, Strom Sc
UROLOGY 1997;49(6):981-8

Hepatocyte transplantation as a bridge to orthotopic liver transplantation in terminal liver failure
Strom Sc, Fisher Ra, Thompson Mt, Sanyal Aj, Cole Pe, Ham Jm, et al
TRANSPLANTATION 1997;63(4):559-69

Modifications of the hepatocyte growth factor c-met pathway by constitutive expression of transforming growth factor-alpha in rat liver epithelial cells
Presnell Sc, Stolz Db, Mars Wm, Jo M, Michalopoulos Gk, Strom Sc
MOLECULAR CARCINOGENESIS 1997;18(4):244-55

Transplantation of human hepatocytes
Strom Sc, Fisher Ra, Rubinstein Ws, Barranger Ja, Towbin Rb, Charron M, et al
TRANSPLANTATION PROCEEDINGS 1997;29(4):2103-6

Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells
Schuetz Jd, Schuetz Eg, Thottassery Jv, Guzelian Ps, Strom S, Sun D
MOLECULAR PHARMACOLOGY 1996;49(1):63-72

Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF alpha in a chemically defined (HGM) medium
Block Gd, Locker J, Bowen Wc, Petersen Be, Katyal S, Strom Sc, et al
JOURNAL OF CELL BIOLOGY 1996;132(6):1133-49

Use of human hepatocytes to study P450 gene induction
Strom Sc, Pisarov La, Dorko K, Thompson Mt, Schuetz Jd, Schuetz Eg
CYTOCHROME P450, PT B 1996;:388-401

COMPARATIVE-ANALYSIS OF CYTOCHROME P4503A INDUCTION IN PRIMARY CULTURES OF RAT, RABBIT, AND HUMAN HEPATOCYTES
Kocarek Ta, Schuetz Eg, Strom Sc, Fisher Ra, Guzelian Ps
DRUG METABOLISM AND DISPOSITION 1995;23(3):415-21

ETHANOL AND ISOPENTANOL INCREASE CYP3A AND CYP2E IN PRIMARY CULTURES OF HUMAN HEPATOCYTES
Kostrubsky Ve, Strom Sc, Wood Sg, Wrighton Sa, Sinclair Pr, Sinclair Jf
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 1995;322(2):516-20

INDUCTION OF P-GLYCOPROTEIN MESSENGER-RNA BY PROTEIN-SYNTHESIS INHIBITION IS NOT CONTROLLED BY A TRANSCRIPTIONAL REPRESSOR PROTEIN IN RAT AND HUMAN LIVER-CELLS
Schuetz Jd, Strom Sc, Schuetz Eg
JOURNAL OF CELLULAR PHYSIOLOGY 1995;165(2):261-72

INVESTIGATION OF THE COOPERATIVE EFFECTS OF TRANSFORMING GROWTH-FACTOR-ALPHA AND C-MYC OVEREXPRESSION IN RAT-LIVER EPITHELIAL-CELLS
Presnell Sc, Thompson Mt, Strom Sc
MOLECULAR CARCINOGENESIS 1995;13(4):233-44

PHENOTYPIC VARIABILITY IN INDUCTION OF P-GLYCOPROTEIN MESSENGER-RNA BY AROMATIC-HYDROCARBONS IN PRIMARY HUMAN HEPATOCYTES
Schuetz Eg, Schuetz Jd, Thompson Mt, Fisher Ra, Madariage Jr, Strom Sc
MOLECULAR CARCINOGENESIS 1995;12(2):61-5

Short exposure to hepatocyte growth factor stimulates adult human pancreatic beta-cell proliferation
Karatzas T, Strumph P, Ionelle J, Strom S, Michalopoulos G, Fung Jj, et al
TRANSPLANTATION PROCEEDINGS 1995;27(6):3269-

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