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Sten Eirik Jacobsen

Professor/senior physician

About me

Professor of Stem Cell Biology and Regenerative Medicine.

Research description

My research group is presented here.

Publications

A dynamic niche provides Kit ligand in a stage-specific manner to the earliest thymocyte progenitors
Buono M, Facchini R, Matsuoka S, Thongjuea S, Waithe D, Luis Tc, et al
Nature cell biology 2016;18(2):157-67

Distinct myeloid progenitor-differentiation pathways identified through single-cell RNA sequencing
Drissen R, Buza-vidas N, Woll P, Thongjuea S, Gambardella A, Giustacchini A, et al
NATURE IMMUNOLOGY 2016;17(6):666-76

Macrophage colony-stimulating factor receptor marks and regulates a fetal myeloid-primed B-cell progenitor in mice
Zriwil A, Böiers C, Wittmann L, Green Jc, Woll Ps, Jacobsen Se, et al
Blood 2016;128(2):217-26

Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development
Barrett Na, Malouf C, Kapeni C, Bacon Wa, Giotopoulos G, Jacobsen Se, et al
Cell reports 2016;16(4):1039-54

Primitive Embryonic Macrophages are Required for Coronary Development and Maturation
Leid J, Carrelha J, Boukarabila H, Epelman S, Jacobsen Se, Lavine Kj
Circulation research 2016;118(10):1498-511

Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells
Grover A, Sanjuan-pla A, Thongjuea S, Carrelha J, Giustacchini A, Gambardella A, et al
Nature communications 2016;7():11075-

Absence of Fms-like tyrosine kinase 3 ligand (Flt3L) signalling protects against collagen-induced arthritis
Ramos Mip, Karpus On, Broekstra P, Aarrass S, Jacobsen Se, Tak Pp, et al
ANNALS OF THE RHEUMATIC DISEASES 2015;74(1):211-9

Clonal variegation and dynamic competition of leukemia-initiating cells in infant acute lymphoblastic leukemia with MLL rearrangement
Bardini M, Woll Ps, Corral L, Luc S, Wittmann L, Ma Z, et al
LEUKEMIA 2015;29(1):38-50

Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo (vol 25, pg 794, 2014)
Woll Ps, Kjallquist U, Chowdhury O, Doolittle H, Wedge Dc, Thongjuea S, et al
CANCER CELL 2015;27(4):603-605

A pilot phase I dose finding safety study of the thrombopoietin-receptor agonist, eltrombopag, in patients with myelodysplastic syndrome treated with azacitidine
Svensson T, Chowdhury O, Garelius H, Lorenz F, Saft L, Jacobsen Se, et al
European journal of haematology 2014;93(5):439-45

Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate
Grover A, Mancini E, Moore S, Mead Aj, Atkinson D, Rasmussen Kd, et al
JOURNAL OF EXPERIMENTAL MEDICINE 2014;211(2):181-8

Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo
Woll Ps, Kjällquist U, Chowdhury O, Doolittle H, Wedge Dc, Thongjuea S, et al
Cancer cell 2014;25(6):794-808

Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo (vol 25, pg 794, 2014)
Woll Ps, Kjallquist U, Chowdhury O, Doolittle H, Wedge Dc, Thongjuea S, et al
CANCER CELL 2014;25(6):861-861

Characterization of transcriptional networks in blood stem and progenitor cells using high-throughput single-cell gene expression analysis
Moignard V, Macaulay Ic, Swiers G, Buettner F, Schütte J, Calero-nieto Fj, et al
Nature cell biology 2013;15(4):363-72

Characterization of transcriptional networks in blood stem and progenitor cells using high-throughput single-cell gene expression analysis (vol 15, pg 363, 2013)
Moignard V, Macaulay Ic, Swiers G, Buettner F, Schutte J, Calero-nieto Fj, et al
NATURE CELL BIOLOGY 2013;15(5):544-544

FLT3-ITDs Instruct a Myeloid Differentiation and Transformation Bias in Lymphomyeloid Multipotent Progenitors
Mead Aj, Kharazi S, Atkinson D, Macaulay I, Pecquet C, Loughran S, et al
CELL REPORTS 2013;3(6):1766-76

Germline Counterparts of Oncogenic Mutations: Who Gives a JAK?
Mead Aj, Constantinescu Sn, Jacobsen Sew
ONCOTARGET 2013;4(6):814-5

Impact of isolated germline JAK2V617I mutation on human hematopoiesis
Mead Aj, Chowdhury O, Pecquet C, Dusa A, Woll P, Atkinson D, et al
BLOOD 2013;121(20):4156-65

Lymphomyeloid contribution of an immune-restricted progenitor emerging prior to definitive hematopoietic stem cells
Böiers C, Carrelha J, Lutteropp M, Luc S, Green Jc, Azzoni E, et al
Cell stem cell 2013;13(5):535-48

Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy
Sanjuan-pla A, Macaulay Ic, Jensen Ct, Woll Ps, Luis Tc, Mead A, et al
NATURE 2013;502(7470):232-6

Quiescent leukaemic cells account for minimal residual disease in childhood lymphoblastic leukaemia
Lutz C, Woll Ps, Hall G, Castor A, Dreau H, Cazzaniga G, et al
LEUKEMIA 2013;27(5):1204-7

Silencing of ASXL1 impairs the granulomonocytic lineage potential of human CD34(+) progenitor cells
Davies C, Yip Bh, Fernandez-mercado M, Woll Ps, Agirre X, Prosper F, et al
BRITISH JOURNAL OF HAEMATOLOGY 2013;160(6):842-50

Transcriptional Repression of Gata3 Is Essential for Early B Cell Commitment
Banerjee A, Northrup D, Boukarabila H, Jacobsen Sew, Allman D
IMMUNITY 2013;38(5):930-42

Adaptor Protein LNK Is a Negative Regulator of Brain Neural Stem Cell Proliferation after Stroke
Ahlenius H, Devaraju K, Monni E, Oki K, Wattananit S, Darsalia V, et al
JOURNAL OF NEUROSCIENCE 2012;32(15):5151-64

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
Schulz C, Perdiguero Eg, Chorro L, Szabo-rogers H, Cagnard N, Kierdorf K, et al
SCIENCE 2012;336(6077):86-90

Dicer is selectively important for the earliest stages of erythroid development
Buza-vidas N, Cismasiu Vb, Moore S, Mead Aj, Woll Ps, Lutteropp M, et al
BLOOD 2012;120(12):2412-6

Emergence of NK-cell progenitors and functionally competent NK-cell lineage subsets in the early mouse embryo
Tang Yj, Peitzsch C, Charoudeh Hn, Cheng M, Chaves P, Jacobsen Sew, et al
BLOOD 2012;120(1):63-75

FOG-1 and GATA-1 act sequentially to specify definitive megakaryocytic and erythroid progenitors
Mancini E, Sanjuan-pla A, Luciani L, Moore S, Grover A, Zay A, et al
EMBO JOURNAL 2012;31(2):351-65

Germline JAK2 Mutation in a Family with Hereditary Thrombocytosis
Mead Aj, Rugless Mj, Jacobsen Sew, Schuh A
NEW ENGLAND JOURNAL OF MEDICINE 2012;366(10):967-9

Molecular and cellular effects of oncogene cooperation in a genetically accurate AML mouse model
Reckzeh K, Bereshchenko O, Mead A, Rehn M, Kharazi S, Jacobsen Se, et al
LEUKEMIA 2012;26(7):1527-36

Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow
Mansour A, Abou-ezzi G, Sitnicka E, Jacobsen Sew, Wakkach A, Blin-wakkach C
JOURNAL OF EXPERIMENTAL MEDICINE 2012;209(3):537-49

Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21
Roy A, Cowan G, Mead Aj, Filippi S, Bohn G, Chaidos A, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2012;109(43):17579-84

The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential
Luc S, Luis Tc, Boukarabila H, Macaulay Ic, Buza-vidas N, Bouriez-jones T, et al
NATURE IMMUNOLOGY 2012;13(4):412-9

Acute Multiple Organ Failure in Adult Mice Deleted for the Developmental Regulator Wt1
Chau Yy, Brownstein D, Mjoseng H, Lee Wc, Buza-vidas N, Nerlov C, et al
PLOS GENETICS 2011;7(12):e1002404-

Clever Leukemic Stem Cells Branch Out
Vyas P, Jacobsen Sew
CELL STEM CELL 2011;8(3):242-4

Coexistence of LMPP-like and GMP-like Leukemia Stem Cells in Acute Myeloid Leukemia
Goardon N, Marchi E, Atzberger A, Quek L, Schuh A, Soneji S, et al
CANCER CELL 2011;19(1):138-52

FLT3 expression initiates in fully multipotent mouse hematopoietic progenitor cells
Buza-vidas N, Woll P, Hultquist A, Duarte S, Lutteropp M, Bouriez-jones T, et al
BLOOD 2011;118(6):1544-8

GATA3 is redundant for maintenance and self-renewal of hematopoietic stem cells
Buza-vidas N, Duarte S, Luc S, Bouriez-jones T, Woll Ps, Jacobsen Sew
BLOOD 2011;118(5):1291-3

Hoxb4-YFP reporter mouse model: a novel tool for tracking HSC development and studying the role of Hoxb4 in hematopoiesis
Hills D, Gribi R, Ure J, Buza-vidas N, Luc S, Jacobsen Sew, et al
BLOOD 2011;117(13):3521-8

Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation
Kharazi S, Mead Aj, Mansour A, Hultquist A, Boiers C, Luc S, et al
BLOOD 2011;118(13):3613-21

The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance
Mortensen M, Soilleux Ej, Djordjevic G, Tripp R, Lutteropp M, Sadighi-akha E, et al
JOURNAL OF EXPERIMENTAL MEDICINE 2011;208(3):455-67

Tumor necrosis factor restricts hematopoietic stem cell activity in mice: involvement of two distinct receptors
Pronk Cjh, Veiby Op, Bryder D, Jacobsen Sew
JOURNAL OF EXPERIMENTAL MEDICINE 2011;208(8):1563-70

Expression and role of FLT3 in regulation of the earliest stage of normal granulocyte-monocyte progenitor development
Boiers C, Buza-vidas N, Jensen Ct, Pronk Cjh, Kharazi S, Wittmann L, et al
BLOOD 2010;115(24):5061-8

Identification of an NK/T cell-restricted progenitor in adult bone marrow contributing to bone marrow- and thymic-dependent NK cells
Charoudeh Hn, Tang Yj, Cheng M, Cilio Cm, Jacobsen Sew, Sitnicka E
BLOOD 2010;116(2):183-92

Maintenance treatment with azacytidine for patients with high-risk myelodysplastic syndromes (MDS) or acute myeloid leukaemia following MDS in complete remission after induction chemotherapy
Grovdal M, Karimi M, Khan R, Aggerholm A, Antunovic P, Astermark J, et al
BRITISH JOURNAL OF HAEMATOLOGY 2010;150(3):293-302

Persistent Malignant Stem Cells in del(5q) Myelodysplasia in Remission
Tehranchi R, Woll Ps, Anderson K, Buza-vidas N, Mizukami T, Mead Aj, et al
NEW ENGLAND JOURNAL OF MEDICINE 2010;363(11):1025-37

Characterization of bone marrow-derived mesenchymal stromal cells (MSC) based on gene expression profiling of functionally defined MSC subsets
Tormin A, Brune Jc, Olsson E, Valcich J, Neuman U, Olofsson T, et al
CYTOTHERAPY 2009;11(2):114-28

Cited2 Is an Essential Regulator of Adult Hematopoietic Stem Cells
Kranc Kr, Schepers H, Rodrigues Np, Bamforth S, Villadsen E, Ferry H, et al
CELL STEM CELL 2009;5(6):659-65

DEVELOPMENTAL BIOLOGY Instructions writ in blood
Enver T, Jacobsen Sew
NATURE 2009;461(7261):183-4

Distinct and Overlapping Patterns of Cytokine Regulation of Thymic and Bone Marrow-Derived NK Cell Development
Cheng M, Charoudeh Hn, Brodin P, Tang Yj, Lakshmikanth T, Hoglund P, et al
JOURNAL OF IMMUNOLOGY 2009;182(3):1460-8

DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction
Broske Am, Vockentanz L, Kharazi S, Huska Mr, Mancini E, Scheller M, et al
NATURE GENETICS 2009;41(11):1207-15

FLT3 receptor and ligand are dispensable for maintenance and posttransplantation expansion of mouse hematopoietic stem cells
Buza-vidas N, Cheng M, Duarte S, Charoudeh Hn, Jacobsen Sew, Sitnicka E
BLOOD 2009;113(15):3453-60

Hematopoietic Stem Cell Expansion Precedes the Generation of Committed Myeloid Leukemia-initiating Cells in C/EBP alpha Mutant AML
Bereshchenko O, Mancini E, Moore S, Bilbao D, Mansson R, Luc S, et al
CANCER CELL 2009;16(5):390-400

High GATA-2 expression inhibits human hematopoietic stem and progenitor cell function by effects on cell cycle
Tipping Aj, Pina C, Castor A, Hong Dl, Rodrigues Np, Lazzari L, et al
BLOOD 2009;113(12):2661-72

Long-Term Accumulation of Microglia with Proneurogenic Phenotype Concomitant with Persistent Neurogenesis in Adult Subventricular Zone After Stroke
Thored P, Heldmann U, Gomes-leal W, Gisler R, Darsalia V, Taneera J, et al
GLIA 2009;57(8):835-49

Polyclonal T-cell reconstitution of X-SCID recipients after in utero transplantation of lymphoid-primed multipotent progenitors
Liuba K, Pronk Cjh, Stott Srw, Jacobsen Sew
BLOOD 2009;113(19):4790-8

B-lineage commitment prior to surface expression of B220 and CD19 on hematopoietic progenitor cells
Mansson R, Zandi S, Anderson K, Martensson Il, Jacobsen Sew, Bryder D, et al
BLOOD 2008;112(4):1048-55

Delineating the cellular pathways of hematopoietic lineage commitment
Luc S, Buza-vidas N, Jacobsen Sew
SEMINARS IN IMMUNOLOGY 2008;20(4):213-20

Down-regulation of Mpl marks the transition to lymphoid-primed multipotent progenitors with gradual loss of granulocyte-monocyte potential
Luc S, Anderson K, Kharazi S, Buza-vidas N, Boiers C, Jensen Ct, et al
BLOOD 2008;111(7):3424-34

Exit of pediatric pre-B acute lymphoblastic leukaemia cells from the bone marrow to the peripheral blood is not associated with cell maturation or alterations in gene expression
Hansson F, Toporski J, Mansson R, Johansson B, Noren-nystrom U, Jacobsen Sew, et al
MOLECULAR CANCER 2008;:67-

FLT3 ligand and not TSLP is the key regulator of IL-7-independent B-1 and B-2 B lymphopoiesis
Jensen Ct, Kharazi S, Boiers C, Cheng M, Lubking A, Sitnicka E, et al
BLOOD 2008;112(6):2297-304

Involvement of CCR9 at multiple stages of adult T lymphopoiesis
Svensson M, Marsal J, Uronen-hansson H, Cheng M, Jenkinson W, Cilio C, et al
JOURNAL OF LEUKOCYTE BIOLOGY 2008;83(1):156-64

Kit regulates maintenance of quiescent hematopoietic stem cells
Thoren La, Liuba K, Bryder D, Nygren Jm, Jensen Ct, Qian H, et al
JOURNAL OF IMMUNOLOGY 2008;180(4):2045-53

Modeling of C/EBP alpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells
Kirstetter P, Schuster Mb, Bereshchenko O, Moore S, Dvinge H, Kurz E, et al
CANCER CELL 2008;13(4):299-310

Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion
Nygren Jm, Liuba K, Breitbach M, Stott S, Thoren L, Roell W, et al
NATURE CELL BIOLOGY 2008;10(5):584-92

NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements
Weischenfeldt J, Damgaard I, Bryder D, Theilgaard-monch K, Thoren La, Nielsen Fc, et al
GENES & DEVELOPMENT 2008;22(10):1381-96

Permissive roles of hematopoietin and cytokine tyrosine kinase receptors in early T-cell development
Jensen Ct, Boiers C, Kharazi S, Lubking A, Ryden T, Sigvardsson M, et al
BLOOD 2008;111(4):2083-90

Protein kinase B (c-akt) regulates hematopoietic lineage choice decisions during myelopoiesis
Buitenhuis M, Verhagen Lp, Van Deutekom Hwm, Castor A, Verploegen S, Koenderman L, et al
BLOOD 2008;111(1):112-21

Biological and molecular evidence for existence of lymphoid-primed multipotent progenitors
Luc S, Buza-vidas N, Jacobsen Sew
HEMATOPOIETIC STEM CELLS VI 2007;:89-94

CD133 is not present on neurogenic astrocytes in the adult subventricular zone, but on embryonic neural stem cells, ependymal cells, and glioblastoma cells
Pfenninger Cv, Roschupkina T, Hertwig F, Kottwitz D, Englund E, Bengzon J, et al
CANCER RESEARCH 2007;67(12):5727-36

Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBP alpha interaction
Fujimoto T, Anderson K, Jacobsen Sew, Nishikawa S, Nerlov C
EMBO JOURNAL 2007;26(9):2361-70

Critical role of FLT3 ligand in IL-7 receptor-independent T lymphopoiesis and regulation of lymphoid-primed multipotent progenitors
Sitnicka E, Buza-vidas N, Ahlenius H, Cilio Cm, Gekas C, Nygren Jm, et al
BLOOD 2007;110(8):2955-64

Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells
Qian H, Buza-vidas N, Hyland Cd, Jensen Ct, Antonchuk J, Mansson R, et al
CELL STEM CELL 2007;1(6):671-84

Crucial role of FLT3 ligand in immune reconstitution after bone marrow transplantation and high-dose chemotherapy
Buza-vidas N, Cheng M, Duarte S, Nozad H, Jacobsen Sew, Sitnicka E
BLOOD 2007;110(1):424-32

Delineation of the earliest lineage commitment steps of haematopoietic stem cells: new developments, controversies and major challenges
Buza-vidas N, Luc S, Jacobsen Sew
CURRENT OPINION IN HEMATOLOGY 2007;14(4):315-21

Distinct roles of integrins alpha 6 and alpha 4 in homing of fetal liver hematopoietic stem and progenitor cells
Qian H, Georges-labouesse E, Nystrom A, Domogatskaya A, Tryggvason K, Jacobsen Sew, et al
BLOOD 2007;110(7):2399-407

Ectopic expression of PAX5 promotes maintenance of biphenotypic myeloid progenitors coexpressing myeloid and B-cell lineage-associated genes
Anderson K, Rusterholz C, Mansson R, Jensen Ct, Bacos K, Zandi S, et al
BLOOD 2007;109(9):3697-705

FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia
Lee Bh, Tothova Z, Levine Rl, Anderson K, Buza-vidas N, Cullen De, et al
CANCER CELL 2007;12(4):367-80

Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors
Mansson R, Hultquist A, Luc S, Yang L, Anderson K, Kharazi S, et al
IMMUNITY 2007;26(4):407-19

Negative effect of DNA hypermethylation on the outcome of intensive chemotherapy in older patients with high-risk myelodysplastic syndromes and acute myeloid leukemia following Myelodysplastic syndrome
Grovdal M, Khan R, Aggerholm A, Antunovic P, Astermark J, Bernell P, et al
CLINICAL CANCER RESEARCH 2007;13(23):7107-12

Potential risks of bone marrow cell transplantation into infarcted hearts
Breitbach M, Bostani T, Roell W, Xia Y, Dewald O, Nygren Jm, et al
BLOOD 2007;110(4):1362-9

The molecular signature of MDS stem cells supports a stem-cell origin of 5q - myelodysplastic syndromes
Nilsson L, Eden P, Olsson E, Mansson R, Astrand-grundstrom I, Strombeck B, et al
BLOOD 2007;110(8):3005-14

TSLP-mediated fetal B lymphopoiesis?
Jensen Ct, Kharazi S, Boiers C, Liuba K, Jacobsen Sew
NATURE IMMUNOLOGY 2007;8(9):897-author

Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block
Kirstetter P, Anderson K, Porse Bt, Jacobsen Sew, Nerlov C
NATURE IMMUNOLOGY 2006;7(10):1048-56

Contribution of alpha 6 integrins to hematopoietic stem and progenitor cell homing to bone marrow and collaboration with alpha 4 integrins
Qian H, Tryggvason K, Jacobsen Se, Ekblom M
BLOOD 2006;107(9):3503-10

Cytokines regulate postnatal hematopoietic stem cell expansion: opposing roles of thrombopoietin and LNK
Buza-vidas N, Antonchuk J, Qian H, Mansson R, Luc S, Zandi S, et al
GENES & DEVELOPMENT 2006;20(15):2018-23

Engraftment of engineered ES cell-derived cardiomyocytes but not BM cells restores contractile function to the infarcted myocardium
Kolossov E, Bostani T, Roell W, Breitbach M, Pillekamp F, Nygren Jm, et al
JOURNAL OF EXPERIMENTAL MEDICINE 2006;203(10):2315-27

Failure of transdifferentiation of adult hematopoietic stem cells into neurons
Roybon L, Ma Z, Asztely F, Fosum A, Jacobsen Sew, Brundin P, et al
STEM CELLS 2006;24(6):1594-604

Failure of transplanted bone marrow cells to adopt a pancreatic beta-cell fate
Taneera J, Rosengren A, Renstrom E, Nygren Jm, Serup P, Rorsman P, et al
DIABETES 2006;55(2):290-6

Prolonged cell cycle transit is a defining and developmentally conserved hemopoietic stem cell property
Nygren Jm, Bryder D, Jacobsen Sew
JOURNAL OF IMMUNOLOGY 2006;177(1):201-8

Tumor necrosis factor receptor 1 is a negative regulator of progenitor proliferation in adult hippocampal neurogenesis
Iosif Re, Ekdahl Ct, Ahlenius H, Pronk Cjh, Bonde S, Kokaia Z, et al
JOURNAL OF NEUROSCIENCE 2006;26(38):9703-12

Biosynthetic profiles of neutrophil serine proteases in a human bone marrow-derived cellular myeloid differentiation model
Garwicz D, Lennartsson A, Jacobsen Sew, Gullberg U, Lindmark A
HAEMATOLOGICA 2005;90(1):38-44

Deficiency of oncoretrovirally transduced hematopoietic stem cells and correction through ex vivo expansion
Bryder D, Bjorgvinsdottir H, Sasaki Y, Jacobsen Sew
JOURNAL OF GENE MEDICINE 2005;7(2):137-44

Defining 'stemness': Notch and Wnt join forces?
Jacobsen Sew
NATURE IMMUNOLOGY 2005;6(3):234-6

Differential regulation of granulopoiesis by the basic helix-loop-helix transcriptional inhibitors Id1 and Id2
Buitenhuis M, Van Deutekom Hwm, Verhagen Lp, Castor A, Jacobsen Sew, Lammers Jwj, et al
BLOOD 2005;105(11):4272-81

Distinct patterns of hematopoietic stem cell involvement in acute lymphoblastic leukemia
Castor A, Nilsson L, Astrand-grundstrom I, Buitenhuis M, Ramirez C, Anderson K, et al
NATURE MEDICINE 2005;11(6):630-7

Identification of Flt3(+) lympho-myeloid stem cells lacking erythro-megakaryocytic potential: A revised road map for adult blood lineage commitment
Adolfsson J, Mansson R, Buza-vidas N, Hultquist A, Liuba K, Jensen Ct, et al
CELL 2005;121(2):295-306

Identification of Lin(-)Sca1(+)kit(+)CD34(+)Flt(3-) short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients
Yang Lp, Bryder D, Adolfsson J, Nygren J, Mansson R, Sigvardsson M, et al
BLOOD 2005;105(7):2717-23

IFN-gamma negatively modulates self-renewal of repopulating human hemopoietic stem cells
Yang Lp, Dybedal I, Bryder D, Nilsson L, Sitnicka E, Sasaki Y, et al
JOURNAL OF IMMUNOLOGY 2005;174(2):752-7

Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage
Porse Bt, Bryder D, Theilgaard-monch K, Hasemann Ms, Anderson K, Damgaard I, et al
JOURNAL OF EXPERIMENTAL MEDICINE 2005;202(1):85-96

Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation
Nygren Jm, Jovinge S, Breitbach M, Sawen P, Roll W, Hescheler J, et al
NATURE MEDICINE 2004;10(5):494-501

Deceptive multilineage reconstitution analysis of mice transplanted with hemopoietic stem cells, and implications for assessment of stem cell numbers and lineage potentials
Bryder D, Sasaki Y, Borge Oj, Jacobsen Sew
JOURNAL OF IMMUNOLOGY 2004;172(3):1548-52

Enforced expression of cyclin D2 enhances the proliferative potential of myeloid progenitors, accelerates in vivo myeloid reconstitution, and promotes rescue of mice from lethal myeloablation
Sasaki Y, Jensen Ct, Karlsson S, Jacobsen Sew
BLOOD 2004;104(4):986-92

MDS/AML-associated cytogenetic abnormalities in multiple myeloma and monoclonal gammopathy of undetermined significance: Evidence for frequent de novo occurrence and multipotent stem cell involvement of del(20q)
Nilsson T, Nilsson L, Lenhoff S, Rylander L, Astrand-grundstrom I, Strombeck B, et al
GENES CHROMOSOMES & CANCER 2004;41(3):223-31

P2 receptor mRNA expression profiles in human lymphocytes, monocytes and CD34+ stem and progenitor cells
Wang L, Jacobsen Se, Bengtsson A, Erlinge D
BMC immunology 2004;5():16-

Complementary signaling through flt3 and interleukin-7 receptor alpha is indispensable for fetal and adult B cell genesis
Sitnicka E, Brakebusch C, Martensson Il, Svensson M, Agace Ww, Sigvardsson M, et al
JOURNAL OF EXPERIMENTAL MEDICINE 2003;198(10):1495-506

Human CD34(+) hematopoietic stem cells capable of multilineage engrafting NOD/SCID mice express flt3: distinct flt3 and c-kit expression and response patterns on mouse and candidate human hematopoietic stem cells
Sitnicka E, Buza-vidas N, Larsson S, Nygren Jm, Liuba K, Jacobsen Sew
BLOOD 2003;102(3):881-6

Human reconstituting hematopoietic stem cells up-regulate Fas expression upon active cell cycling but remain resistant to Fas-induced suppression
Dybedal I, Yang Lp, Bryder D, Aastrand-grundstrom I, Leandersson K, Jacobsen Sew
BLOOD 2003;102(1):118-26

Laminin isoform-specific promotion of adhesion and migration of human bone marrow progenitor cells
Gu Yc, Kortesmaa J, Tryggvason K, Persson J, Ekblom P, Jacobsen Se, et al
BLOOD 2003;101(3):877-85

Efficient oncoretroviral transduction of extended long-term culture-initiating cells and NOD/SCID repopulating cells: Enhanced reconstitution with gene-marked cells through an ex vivo expansion approach
Bjorgvinsdottir H, Bryder D, Sitnicka E, Ramsfjell V, De Jong I, Olsson K, et al
HUMAN GENE THERAPY 2002;13(9):1061-73

Involvement and functional impairment of the CD34(+)CD38(-)Thy-1(+) hematopoietic stem cell pool in myelodysplastic syndromes with trisomy 8
Nilsson L, Astrand-grundstrom I, Anderson K, Arvidsson I, Hokland P, Bryder D, et al
BLOOD 2002;100(1):259-67

Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool
Sitnicka E, Bryder D, Theilgaard-monch K, Buza-vidas N, Adolfsson J, Jacobsen Sew
IMMUNITY 2002;17(4):463-72

Transient disruption of autocrine TGF-beta signaling leads to enhanced survival and proliferation potential in single primitive human hemopoietic progenitor cells
Fan Xl, Valdimarsdottir G, Larsson J, Brun A, Magnusson M, Jacobsen Se, et al
JOURNAL OF IMMUNOLOGY 2002;168(2):755-62

Self-renewal of multipotent long-term repopulating hematopoietic stem cells is negatively regulated by Fas and tumor necrosis factor receptor activation
Bryder D, Ramsfjell V, Dybedal I, Theilgaard-monch K, Hogerkorp Cm, Adolfsson J, et al
JOURNAL OF EXPERIMENTAL MEDICINE 2001;194(7):941-52

Tumor necrosis factor (TNF)-mediated activation of the p55 TNF receptor negatively regulates maintenance of cycling reconstituting human hematopoietic stem cells
Dybedal I, Bryder D, Fossum A, Rusten Ls, Jacobsen Sew
BLOOD 2001;98(6):1782-91

Upregulation of flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity
Adolfsson J, Borge Oj, Bryder D, Theilgaard-monch K, Astrand-grundstrom I, Sitnicka E, et al
IMMUNITY 2001;15(4):659-69

Cloning of human early B-cell factor and identification of target genes suggest a conserved role in B-cell development in man and mouse
Gisler R, Jacobsen Sew, Sigvardsson M
BLOOD 2000;96(4):1457-64

Efficient adenoviral vector transduction of human hematopoietic SCID-repopulating and long-term culture-initiating cells
Fan Xl, Brun A, Segren S, Jacobsen Sew, Karlsson S
HUMAN GENE THERAPY 2000;11(9):1313-27

Interleukin-3 supports expansion of long-term multilineage repopulating activity after multiple stem cell divisions in vitro
Bryder D, Jacobsen Sew
BLOOD 2000;96(5):1748-55

Isolation and characterization of hematopoietic progenitor/stem cells in 5q-deleted myelodysplastic syndromes: evidence for involvement at the hematopoietic stem cell level
Nilsson L, Astrand-grundstrom I, Arvidsson I, Jacobsson B, Hellstrom-lindberg E, Hast R, et al
BLOOD 2000;96(6):2012-21

Lentiviral gene transfer into primary and secondary NOD/SCID repopulating cells
Woods Nb, Fahlman C, Mikkola H, Hamaguchi S, Olsson K, Zufferey R, et al
BLOOD 2000;96(12):3725-33

Lentivirus gene transfer in murine hematopoietic progenitor cells is compromised by a delay in proviral integration and results in transduction mosaicism and heterogeneous gene expression in progeny cells
Mikkola H, Woods Nb, Sjogren M, Helgadottir H, Hamaguchi I, Jacobsen Se, et al
JOURNAL OF VIROLOGY 2000;74(24):11911-8

Distinct requirements for optimal growth and in vitro expansion of human CD34(+)CD38(-) bone marrow long-term culture-initiating cells (LTC-IC), extended LTC-IC, and murine in vivo long-term reconstituting stem cells
Ramsfjell V, Bryder D, Bjorgvinsdottir H, Kornfalt S, Nilsson L, Borge Oj, et al
BLOOD 1999;94(12):4093-102

Involvement of the retinoblastoma protein in monocytic and neutrophilic lineage commitment of human bone marrow progenitor cells
Bergh G, Ehinger M, Olsson I, Jacobsen Sew, Gullberg U
BLOOD 1999;94(6):1971-8

Lymphoid-restricted development from multipotent candidate murine stem cells: Distinct and complimentary functions of the c-kit and flt3-ligands
Borge Oj, Adolfsson J, Martensson A, Martensson Il, Jacobsen Sew
BLOOD 1999;94(11):3781-90

c-kit ligand and flt3 ligand: Stem/progenitor cell factors with overlapping yet distinct activities
Lyman Sd, Jacobsen Sew
BLOOD 1998;91(4):1101-34

Ability of early acting cytokines to directly promote survival and suppress apoptosis of human primitive CD34(+)CD38(-) bone marrow cells with multilineage potential at the single-cell level: Key role of thrombopoietin
Borge Oj, Ramsfjell V, Cui L, Jacobsen Sew
BLOOD 1997;90(6):2282-92

Bidirectional effect of interleukin-10 on early murine B-cell development: Stimulation of flt3-ligand plus interleukin-7-dependent generation of CD19(-) ProB cells from uncommitted bone marrow progenitor cells and growth inhibition of CD19(+) ProB cells
Veiby Op, Borge Oj, Martensson A, Beck Ex, Schade Ae, Grzegorzewski K, et al
BLOOD 1997;90(11):4321-31

Interleukin-13 in combination with CD40 ligand potently inhibits apoptosis in human B lymphocytes: Upregulation of Bcl-xL and Mcl-1
Lomo J, Blomhoff Hk, Jacobsen Se, Krajewski S, Reed Jc, Smeland Eb
BLOOD 1997;89(12):4415-24

Thrombopoietin directly and potently stimulates multilineage growth and progenitor cell expansion from primitive (CD34(+)CD38(-)) human bone marrow progenitor cells - Distinct and key interactions with the ligands for c-kit and flt3, and inhibitory EfFects of TGF-beta and TNF-alpha
Ramsfjell V, Borge Oj, Cui L, Jacobsen Sew
JOURNAL OF IMMUNOLOGY 1997;158(11):5169-77

Thrombopoietin promotes adhesion of primitive human hemopoietic cells to fibronectin and vascular cell adhesion molecule-1 - Role of activation of very late antigen (VLA)-4 and VLA-5
Cui L, Ramsfjell V, Borge Oj, Veiby Op, Lok S, Jacobsen Sew
JOURNAL OF IMMUNOLOGY 1997;159(4):1961-9

Transforming growth factor-beta(1) abrogates Fas-induced growth suppression and apoptosis of murine bone marrow progenitor cells
Dybedal I, Guan Fg, Borge Oj, Veiby Op, Ramsfjell V, Nagata S, et al
BLOOD 1997;90(9):3395-403

Ability of flt3 ligand to stimulate the in vitro growth of primitive murine hematopoietic progenitors is potently and directly inhibited by transforming growth factor-beta and tumor necrosis factor-alpha
Jacobsen Sew, Veiby Op, Myklebust J, Okkenhaug C, Lyman Sd
BLOOD 1996;87(12):5016-26

Combined signaling through interleukin-7 receptors and flt3 but not c-kit potently and selectively promotes B-cell commitment and differentiation from uncommitted murine bone marrow progenitor cells
Veiby Op, Lyman Sd, Jacobsen Sew
BLOOD 1996;88(4):1256-65

Megakaryocytopoiesis in vitro: from the stem cells' perspective
Cardier Je, Foster Dc, Lok S, Jacobsen Se, Murphy Mj
Stem cells (Dayton, Ohio) 1996;14 Suppl 1():163-72

The FLT3 ligand is a direct and potent stimulator of the growth of primitive and committed human CD34(+) bone marrow progenitor cells in vitro
Rusten Ls, Lyman Sd, Veiby Op, Jacobsen Sew
BLOOD 1996;87(4):1317-25

The flt3 ligand promotes the survival of primitive hemopoietic progenitor cells with myeloid as well as B lymphoid potential - Suppression of apoptosis and counteraction by TNF-alpha and TGF-beta
Veiby Op, Jacobsen Fw, Cui L, Lyman Sd, Jacobsen Sew
JOURNAL OF IMMUNOLOGY 1996;157(7):2953-60

The RAR-RXR as well as the RXR-RXR pathway is involved in signaling growth inhibition of human CD34(+) erythroid progenitor cells
Rusten Ls, Dybedal I, Blomhoff Hk, Blomhoff R, Smeland Eb, Jacobsen Sew
BLOOD 1996;87(5):1728-36

Thrombopoietin, a direct stimulator of viability and multilineage growth of primitive bone marrow progenitor cells
Jacobsen Se, Borge Oj, Ramsfjell V, Cui L, Cardier Je, Veiby Op, et al
Stem cells (Dayton, Ohio) 1996;14 Suppl 1():173-80

Thrombopoietin, but not erythropoietin, directly stimulates multilineage growth of primitive murine bone marrow progenitor cells in synergy with early acting cytokines: Distinct interactions with the ligands for c-kit and FLT3
Ramsfjell V, Borge Oj, Veiby Op, Cardier J, Murphy Mj, Lyman Sd, et al
BLOOD 1996;88(12):4481-92

Thrombopoietin, but not erythropoietin promotes viability and inhibits apoptosis of multipotent murine hematopoietic progenitor cells in vitro
Borge Oj, Ramsfjell V, Veiby Op, Murphy Mj, Lok S, Jacobsen Sew
BLOOD 1996;88(8):2859-70

TNF-alpha bidirectionally modulates the viability of primitive murine hematopoietic progenitor cells in vitro
Jacobsen Fw, Veiby Op, Stokke T, Jacobsen Sew
JOURNAL OF IMMUNOLOGY 1996;157(3):1193-9

ALL-TRANS-RETINOIC AND 9-CIS-RETINOIC ACID INHIBIT GROWTH OF NORMAL HUMAN AND MURINE B-CELL PRECURSORS
Fahlman C, Jacobsen Se, Smeland Eb, Lomo J, Naess Ce, Funderud S, et al
JOURNAL OF IMMUNOLOGY 1995;155(1):58-65

DIRECT SYNERGISTIC EFFECTS OF IL-4 AND IL-11 ON PROLIFERATION OF PRIMITIVE HEMATOPOIETIC PROGENITOR CELLS
Jacobsen Fw, Keller Jr, Ruscetti Fw, Veiby Op, Jacobsen Sew
EXPERIMENTAL HEMATOLOGY 1995;23(9):990-5

IL12, a direct stimulator and indirect inhibitor of haematopoiesis
Jacobsen Sew
RESEARCH IN IMMUNOLOGY 1995;146(7-8):506-14

IL-12 DIRECTLY ENHANCES IN-VITRO MURINE ERYTHROPOIESIS IN COMBINATION WITH IL-4 AND STEM-CELL FACTOR
Dybedal I, Larsen S, Jacobsen Sew
JOURNAL OF IMMUNOLOGY 1995;154(10):4950-5

INHIBITION OF STEM-CELL FACTOR-INDUCED PROLIFERATION OF PRIMITIVE MURINE HEMATOPOIETIC PROGENITOR CELLS SIGNALED THROUGH THE 75-KILODALTON TUMOR-NECROSIS-FACTOR RECEPTOR - REGULATION OF C-KIT AND P53 EXPRESSION
Jacobsen Fw, Dubois Cm, Rusten Ls, Veiby Op, Jacobsen Sew
JOURNAL OF IMMUNOLOGY 1995;154(8):3732-41

MOBILIZATION OF LONG-TERM RECONSTITUTING HEMATOPOIETIC STEM-CELLS IN MICE BY RECOMBINANT HUMAN INTERLEUKIN-7
Grzegorzewski Kj, Komschlies Kl, Jacobsen Sew, Ruscetti Fw, Keller Jr, Wiltrout Rh
JOURNAL OF EXPERIMENTAL MEDICINE 1995;181(1):369-74

RETINOIC ACID POTENTLY STIMULATES THE PRODUCTION OF GRANULOCYTE-COLONY-STIMULATING FACTOR IN THE HUMAN MONOCYTIC THP-1 CELL-LINE
Wang Y, Garg M, Guan F, Dai W, Jacobsen Sew, Murphy Mj
INTERNATIONAL JOURNAL OF ONCOLOGY 1995;7(1):45-50

THE FLT3 LIGAND POTENTLY AND DIRECTLY STIMULATES THE GROWTH AND EXPANSION OF PRIMITIVE MURINE BONE-MARROW PROGENITOR CELLS IN-VITRO - SYNERGISTIC INTERACTIONS WITH INTERLEUKIN (IL)-11, IL-12, AND OTHER HEMATOPOIETIC GROWTH-FACTORS
Jacobsen Sew, Okkenhaug C, Myklebust J, Veiby Op, Lyman Sd
JOURNAL OF EXPERIMENTAL MEDICINE 1995;181(4):1357-63

TRANSFORMING GROWTH-FACTOR-BETA POTENTLY INHIBITS THE VIABILITY-PROMOTING ACTIVITY OF STEM-CELL FACTOR AND OTHER CYTOKINES AND INDUCES APOPTOSIS OF PRIMITIVE MURINE HEMATOPOIETIC PROGENITOR CELLS
Jacobsen Fw, Stokke T, Jacobsen Sew
BLOOD 1995;86(8):2957-66

TRANSFORMING GROWTH-FACTOR-BETA (TGF-BETA), A POTENT INHIBITOR OF ERYTHROPOIESIS - NEUTRALIZING TGF-BETA ANTIBODIES SHOW ERYTHROPOIETIN AS A POTENT STIMULATOR OF MURINE BURST-FORMING UNIT ERYTHROID COLONY FORMATION IN THE ABSENCE OF A BURST-PROMOTING ACTIVITY
Dybedal I, Jacobsen Sew
BLOOD 1995;86(3):949-57

TUMOR-NECROSIS-FACTOR (TNF)-ALPHA DIRECTLY INHIBITS HUMAN ERYTHROPOIESIS IN-VITRO - ROLE OF P55 AND P75 TNF RECEPTORS
Rusten Ls, Jacobsen Sew
BLOOD 1995;85(4):989-96

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