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Simon Cervenka

Senior lecturer, Chief physician

Organisational affiliation

CPF GU KS

Department

Department of Clinical Neuroscience (CNS), K8

Visiting address : Centrum För Psykiatriforskning, Norra Stationsgatan 69 113 64 Stockholm, Sweden
Postal address : Department of Clinical Neuroscience (CNS), K8, CPF GU KS, Centrum För Psykiatriforskning, Norra Stationsgatan 69 113 64 Stockholm, Sweden
Delivery address : Centrum För Psykiatriforskning, Norra Stationsgatan 69 113 64 Stockholm, Sweden

About me

Associate professor and senior clinical lecturer. Head of the psychosis research area in the PET group. Consultant in Psychiatry at Psykiatri Nordväst.

Education

Medical degree, Uppsala University, 1999

Licence to practice medicine, 2002

PhD, Department of Clinical Neuroscience, Karolinska Institutet, 2008

Specialist in General Psychiatry, 2009

Research description

The main objective of my research is to find brain biomarkers for psychiatric disorders, to enable new diagnostic tools and treatment approaches. Currently, the main focus is the assessment of neuroinflammation and brain neurotransmission in patients with early stage schizophrenia using Positron Emission Tomography (PET), as part of Karolinska Schizophrenia Project. Ongoing projects also include methodological developments in PET data quantification to improve reliability and sensitivity in clinical studies. 

Teaching portfolio

Responsible for psychiatry course at Solna for medical students. 

Publications

Assessment of simplified ratio-based approaches for quantification of PET [C]PBR28 data
Matheson Gj, Plavén-sigray P, Forsberg A, Varrone A, Farde L, Cervenka S
EJNMMI research 2017;7(1):58-

CSF GABA is reduced in first-episode psychosis and associates to symptom severity
Orhan F, Fatouros-bergman H, Goiny M, Malmqvist A, Piehl F, Karolinska Schizophrenia Project (kasp) Consortium, et al
Molecular psychiatry 2017;():-

Extrastriatal dopamine D2-receptor availability in social anxiety disorder
Plavén-sigray P, Hedman E, Victorsson P, Matheson Gj, Forsberg A, Djurfeldt Dr, et al
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2017;27(5):462-469

In vivo tau PET imaging in dementia: Pathophysiology, radiotracer quantification, and a systematic review of clinical findings
Hall B, Mak E, Cervenka S, Aigbirhio Fi, Rowe Jb, O'brien Jt
Ageing research reviews 2017;36():50-63

Lower levels of the glial cell marker TSPO in drug-naive first-episode psychosis patients as measured using PET and [C]PBR28
Collste K, Plavén-sigray P, Fatouros-bergman H, Victorsson P, Schain M, Forsberg A, et al
Molecular psychiatry 2017;22(6):850-856

Naltrexone modulates dopamine release following chronic, but not acute amphetamine administration: a translational study
Jayaram-lindström N, Guterstam J, Häggkvist J, Ericson M, Malmlöf T, Schilström B, et al
Translational psychiatry 2017;7(4):e1104-

Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium
Walton E, Hibar Dp, Van Erp Tg, Potkin Sg, Roiz-santiañez R, Crespo-facorro B, et al
Acta psychiatrica Scandinavica 2017;135(5):439-447

Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium
Walton E, Hibar Dp, Van Erp Tgm, Potkin Sg, Roiz-santiañez R, Crespo-facorro B, et al
Psychological medicine 2017;():1-13

Reliability of volumetric and surface-based normalisation and smoothing techniques for PET analysis of the cortex: A test-retest analysis using [C]SCH-23390
Matheson Gj, Stenkrona P, Cselényi Z, Plavén-sigray P, Halldin C, Farde L, et al
NeuroImage 2017;155():344-353

The immune response of the human brain to abdominal surgery
Forsberg A, Cervenka S, Jonsson Fagerlund M, Rasmussen Ls, Zetterberg H, Erlandsson Harris H, et al
Annals of neurology 2017;81(4):572-582

Contribution of non-genetic factors to dopamine and serotonin receptor availability in the adult human brain
Borg J, Cervenka S, Kuja-halkola R, Matheson Gj, Jönsson Eg, Lichtenstein P, et al
Molecular psychiatry 2016;21(8):1077-84

In vivo evidence of a functional association between immune cells in blood and brain in healthy human subjects
Kanegawa N, Collste K, Forsberg A, Schain M, Arakawa R, Jucaite A, et al
Brain, behavior, and immunity 2016;54():149-157

Test-retest reproducibility of [(11)C]PBR28 binding to TSPO in healthy control subjects
Collste K, Forsberg A, Varrone A, Amini N, Aeinehband S, Yakushev I, et al
European journal of nuclear medicine and molecular imaging 2016;43(1):173-83

Tryptophan Metabolism Along the Kynurenine Pathway Downstream of Toll-like Receptor Stimulation in Peripheral Monocytes
Orhan F, Bhat M, Sandberg K, Ståhl S, Piehl F, Karolinska Schizophrenia Project (kasp) Consortium, et al
Scandinavian journal of immunology 2016;84(5):262-271

D-Cycloserine vs Placebo as Adjunct to Cognitive Behavioral Therapy for Obsessive-Compulsive Disorder and Interaction With Antidepressants: A Randomized Clinical Trial
Andersson E, Hedman E, Enander J, Radu Djurfeldt D, Ljótsson B, Cervenka S, et al
JAMA psychiatry 2015;72(7):659-67

Diurnal and seasonal variation of the brain serotonin system in healthy male subjects
Matheson Gj, Schain M, Almeida R, Lundberg J, Cselényi Z, Borg J, et al
NeuroImage 2015;112():225-31

[New findings about schizophrenia can provide new diagnostics and treatment]
Schalling M, Engberg G, Andreassen O, Erhardt S, Cunningham J, Agartz I, et al
Lakartidningen 2015;112():-

Dopamine D1 receptor availability is related to social behavior: a positron emission tomography study
Plavén-sigray P, Gustavsson P, Farde L, Borg J, Stenkrona P, Nyberg L, et al
NeuroImage 2014;102 Pt 2():590-5

Meta-analysis of cognitive performance in drug-naïve patients with schizophrenia
Fatouros-bergman H, Cervenka S, Flyckt L, Edman G, Farde L
Schizophrenia research 2014;158(1-3):156-62

Effects of amphetamine on the human brain opioid system--a positron emission tomography study
Guterstam J, Jayaram-lindström N, Cervenka S, Frost Jj, Farde L, Halldin C, et al
The international journal of neuropsychopharmacology 2013;16(4):763-9

[Greater clarity on scientific competence is needed]
Cervenka S, Runeson B, Lönnqvist P, Hedlund A, Grönvall Ke, Flyckt L
Lakartidningen 2013;110(32-33):1416-7

Individual differences in the proneness to have flow experiences are linked to dopamine D2-receptor availability in the dorsal striatum
De Manzano Ö, Cervenka S, Jucaite A, Hellenäs O, Farde L, Ullén F
NeuroImage 2013;67():1-6

A Comparison of Gray Matter Density in Restless Legs Syndrome Patients and Matched Controls Using Voxel-Based Morphometry
Comley Ra, Cervenka S, Palhagen Se, Panagiotidis G, Matthews Jc, Lai Ry, et al
JOURNAL OF NEUROIMAGING 2012;22(1):28-32

Changes in dopamine D2-receptor binding are associated to symptom reduction after psychotherapy in social anxiety disorder
Cervenka S, Hedman E, Ikoma Y, Djurfeldt Dr, Rück C, Halldin C, et al
Translational psychiatry 2012;2():e120-

Association between striatal and extrastriatal dopamine D2-receptor binding and social desirability
Cervenka S, Gustavsson Jp, Halldin C, Farde L
NEUROIMAGE 2010;50(1):323-8

Dopamine D2 receptor density in the limbic striatum is related to implicit but not explicit movement sequence learning
Karabanov A, Cervenka S, De Manzano O, Forssberg H, Farde L, Ullen F
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2010;107(16):7574-9

PET Studies of D2-Receptor Binding in Striatal and Extrastriatal Brain Regions: Biochemical Support In Vivo for Separate Dopaminergic Systems in Humans
Cervenka S, Varrone A, Fransen E, Halldin C, Farde L
SYNAPSE 2010;64(6):478-85

Thinking Outside a Less Intact Box: Thalamic Dopamine D2 Receptor Densities Are Negatively Related to Psychometric Creativity in Healthy Individuals
De Manzano O, Cervenka S, Karabanov A, Farde L, Ullen F
PLOS ONE 2010;5(5):e10670-

Extrastriatal dopamine D2 receptor binding modulates intraindividual variability in episodic recognition and executive functioning
Macdonald Sws, Cervenka S, Farde L, Nyberg L, Backman L
NEUROPSYCHOLOGIA 2009;47(11):2299-304

Age-related diurnal effect on D-2 receptor binding: a preliminary PET study
Cervenka S, Halldin C, Farde L
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY 2008;11(5):671-8

Associations between dopamine D2-receptor binding and cognitive performance indicate functional compartmentalization of the human striatum
Cervenka S, Backman L, Cselenyi Z, Halldin C, Farde L
NEUROIMAGE 2008;40(3):1287-95

[Coming generation of researchers--a question of fate for psychiatry]
Cervenka S, Reutfors J, Lundberg J, Papadopoulos F, Lundén E, Sjöström C, et al
Lakartidningen 2007;104(26-27):2002-3

Support for dopaminergic hypoactivity in restless legs syndrome: a PET study on D2-receptor binding
Cervenka S, Palhagen Se, Comley Ra, Panagiotidis G, Cselenyi Z, Matthews Jc, et al
BRAIN 2006;:2017-28

A cross-validation study on the relationship between central D-2 receptor occupancy and serum perphenazine concentration
Talvik M, Nordstrom Al, Larsen Ne, Jucaite A, Cervenka S, Halldin C, et al
PSYCHOPHARMACOLOGY 2004;175(2):148-53

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