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Simon Cervenka

Senior lecturer, Chief physician

Organisational affiliation



Department of Clinical Neuroscience (CNS), K8

Visiting address : Centrum För Psykiatriforskning, Norra Stationsgatan 69 113 64 Stockholm, Sweden
Postal address : Department of Clinical Neuroscience (CNS), K8, CPF GU KS, Centrum För Psykiatriforskning, Norra Stationsgatan 69 113 64 Stockholm, Sweden
Delivery address : Centrum För Psykiatriforskning, Norra Stationsgatan 69 113 64 Stockholm, Sweden

About me

Associate professor and senior clinical lecturer. Head of the psychosis research area in the PET group. Consultant in Psychiatry at Psykiatri Nordväst. Visiting researcher affiliation at deparment of Psychiatry, University of Cambridge.


Medical degree, Uppsala University, 1999

Licence to practice medicine, 2002

PhD, Department of Clinical Neuroscience, Karolinska Institutet, 2008

Specialist in General Psychiatry, 2009

Research description

The main objective of my research is to use Positron Emission Tomography (PET) to find brain biomarkers for psychiatric disorders. Currently, the main focus is the assessment of neuroinflammation and brain neurotransmission in patients with early stage schizophrenia. This work also includes preclinical studies using small animal PET as well as collaborative clinical studies combining PET and fMRI. Another line of research is to identify biochemical correlates to personality and social behaviour, aiming to disentangle the relationship between trait and state in related anxiety disorders. Ongoing projects also include methodological developments in PET data quantification.

Teaching portfolio

Responsible for psychiatry course at Solna for medical students. 


Contribution of non-genetic factors to dopamine and serotonin receptor availability in the adult human brain
Borg J, Cervenka S, Kuja-halkola R, Matheson Gj, Jönsson Eg, Lichtenstein P, et al
Molecular psychiatry 2016;21(8):1077-84

In vivo evidence of a functional association between immune cells in blood and brain in healthy human subjects
Kanegawa N, Collste K, Forsberg A, Schain M, Arakawa R, Jucaite A, et al
Brain, behavior, and immunity 2016;54():149-57

Test-retest reproducibility of [(11)C]PBR28 binding to TSPO in healthy control subjects
Collste K, Forsberg A, Varrone A, Amini N, Aeinehband S, Yakushev I, et al
European journal of nuclear medicine and molecular imaging 2016;43(1):173-83

D-Cycloserine vs Placebo as Adjunct to Cognitive Behavioral Therapy for Obsessive-Compulsive Disorder and Interaction With Antidepressants: A Randomized Clinical Trial
Andersson E, Hedman E, Enander J, Radu Djurfeldt D, Ljótsson B, Cervenka S, et al
JAMA psychiatry 2015;72(7):659-67

Diurnal and seasonal variation of the brain serotonin system in healthy male subjects
Matheson Gj, Schain M, Almeida R, Lundberg J, Cselényi Z, Borg J, et al
NeuroImage 2015;112():225-31

[New findings about schizophrenia can provide new diagnostics and treatment]
Schalling M, Engberg G, Andreassen O, Erhardt S, Cunningham J, Agartz I, et al
Lakartidningen 2015;112():-

Dopamine D1 receptor availability is related to social behavior: a positron emission tomography study
Plavén-sigray P, Gustavsson P, Farde L, Borg J, Stenkrona P, Nyberg L, et al
NeuroImage 2014;102 Pt 2():590-5

Meta-analysis of cognitive performance in drug-naïve patients with schizophrenia
Fatouros-bergman H, Cervenka S, Flyckt L, Edman G, Farde L
Schizophrenia research 2014;158(1-3):156-62

Effects of amphetamine on the human brain opioid system--a positron emission tomography study
Guterstam J, Jayaram-lindström N, Cervenka S, Frost Jj, Farde L, Halldin C, et al
The international journal of neuropsychopharmacology 2013;16(4):763-9

[Greater clarity on scientific competence is needed]
Cervenka S, Runeson B, Lönnqvist P, Hedlund A, Grönvall Ke, Flyckt L
Lakartidningen 2013;110(32-33):1416-7

Individual differences in the proneness to have flow experiences are linked to dopamine D2-receptor availability in the dorsal striatum
De Manzano Ö, Cervenka S, Jucaite A, Hellenäs O, Farde L, Ullén F
NeuroImage 2013;67():1-6

A Comparison of Gray Matter Density in Restless Legs Syndrome Patients and Matched Controls Using Voxel-Based Morphometry
Comley Ra, Cervenka S, Palhagen Se, Panagiotidis G, Matthews Jc, Lai Ry, et al

Changes in dopamine D2-receptor binding are associated to symptom reduction after psychotherapy in social anxiety disorder
Cervenka S, Hedman E, Ikoma Y, Djurfeldt Dr, Rück C, Halldin C, et al
Translational psychiatry 2012;2():e120-

Association between striatal and extrastriatal dopamine D2-receptor binding and social desirability
Cervenka S, Gustavsson Jp, Halldin C, Farde L
NEUROIMAGE 2010;50(1):323-8

Dopamine D2 receptor density in the limbic striatum is related to implicit but not explicit movement sequence learning
Karabanov A, Cervenka S, De Manzano O, Forssberg H, Farde L, Ullen F

PET Studies of D2-Receptor Binding in Striatal and Extrastriatal Brain Regions: Biochemical Support In Vivo for Separate Dopaminergic Systems in Humans
Cervenka S, Varrone A, Fransen E, Halldin C, Farde L
SYNAPSE 2010;64(6):478-85

Thinking Outside a Less Intact Box: Thalamic Dopamine D2 Receptor Densities Are Negatively Related to Psychometric Creativity in Healthy Individuals
De Manzano O, Cervenka S, Karabanov A, Farde L, Ullen F
PLOS ONE 2010;5(5):e10670-

Extrastriatal dopamine D2 receptor binding modulates intraindividual variability in episodic recognition and executive functioning
Macdonald Sws, Cervenka S, Farde L, Nyberg L, Backman L
NEUROPSYCHOLOGIA 2009;47(11):2299-304

Age-related diurnal effect on D-2 receptor binding: a preliminary PET study
Cervenka S, Halldin C, Farde L

Associations between dopamine D2-receptor binding and cognitive performance indicate functional compartmentalization of the human striatum
Cervenka S, Backman L, Cselenyi Z, Halldin C, Farde L
NEUROIMAGE 2008;40(3):1287-95

[Coming generation of researchers--a question of fate for psychiatry]
Cervenka S, Reutfors J, Lundberg J, Papadopoulos F, Lundén E, Sjöström C, et al
Lakartidningen 2007;104(26-27):2002-3

Support for dopaminergic hypoactivity in restless legs syndrome: a PET study on D2-receptor binding
Cervenka S, Palhagen Se, Comley Ra, Panagiotidis G, Cselenyi Z, Matthews Jc, et al
BRAIN 2006;:2017-28

A cross-validation study on the relationship between central D-2 receptor occupancy and serum perphenazine concentration
Talvik M, Nordstrom Al, Larsen Ne, Jucaite A, Cervenka S, Halldin C, et al
PSYCHOPHARMACOLOGY 2004;175(2):148-53

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