Sebastian Thams

Publications
CV
Public outreach and news

Articles

Article: JOURNAL OF INFLAMMATION-LONDON. 2023;20(1):22

Stem cell-derived brainstem mouse astrocytes obtain a neurotoxic phenotype in vitro upon neuroinflammation.

Lindblad C; Neumann S; Kolbeinsdóttir S; Zachariadis V; Thelin EP; Enge M; Thams S; Brundin L; Svensson M
Article: AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION. 2023;24(3-4):237-245

Dying from ALS in Sweden: clinical status, setting, and symptoms.

Sennfält S; Kläppe U; Thams S; Samuelsson K; Press R; Fang F; Ingre C
Article: AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION. 2023;24(1-2):45-53

The path to diagnosis in ALS: delay, referrals, alternate diagnoses, and clinical progression.

Sennfält S; Kläppe U; Thams S; Samuelsson K; Press R; Fang F; Ingre C
Article: NEUROLOGY-GENETICS. 2020;6(6):e526

Heterozygous variants in DCC: Beyond congenital mirror movements.

Thams S; Islam M; Lindefeldt M; Nordgren A; Granberg T; Tesi B; Barbany G; Nilsson D; Paucar M
Article: CELL CHEMICAL BIOLOGY. 2019;26(12):1703-1715.e37

Development of MAP4 Kinase Inhibitors as Motor Neuron-Protecting Agents.

Bos PH; Lowry ER; Costa J; Thams S; Garcia-Diaz A; Zask A; Wichterle H; Stockwell BR
Article: CELL STEM CELL. 2019;25(2):193-209.e7

Mir-17∼92 Confers Motor Neuron Subtype Differential Resistance to ALS-Associated Degeneration.

Tung Y-T; Peng K-C; Chen Y-C; Yen Y-P; Chang M; Thams S; Chen J-A
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2019;597(12):3133-3146

Intact single muscle fibres from SOD1G93A amyotrophic lateral sclerosis mice display preserved specific force, fatigue resistance and training-like adaptations.

Cheng AJ; Allodi I; Chaillou T; Schlittler M; Ivarsson N; Lanner JT; Thams S; Hedlund E; Andersson DC
Article: SCIENTIFIC REPORTS. 2019;9(1):4965

Transgenic substitution with Greater Amberjack Seriola dumerili fish insulin 2 in NOD mice reduces beta cell immunogenicity.

Foo KS; Skowronski AA; Baum D; Firdessa-Fite R; Thams S; Shang L; Creusot RJ; LeDuc CA; Egli D; Leibel RL
Article: MOLECULAR THERAPY. 2019;27(1):87-101

A Stem Cell-Based Screening Platform Identifies Compounds that Desensitize Motor Neurons to Endoplasmic Reticulum Stress.

Thams S; Lowry ER; Larraufie M-H; Spiller KJ; Li H; Williams DJ; Hoang P; Jiang E; Williams LA; Sandoe J; Eggan K; Lieberam I; Kanning KC; Stockwell BR; Henderson CE; Wichterle H
Article: MOLECULAR THERAPY. 2018;26(7):1644-1659

Human ISL1+ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction.

Foo KS; Lehtinen ML; Leung CY; Lian X; Xu J; Keung W; Geng L; Kolstad TRS; Thams S; Wong AO-T; Wong N; Bylund K; Zhou C; He X; Jin S-B; Clarke J; Lendahl U; Li RA; Louch WE; Chien KR
Article: CELL REPORTS. 2015;11(8):1305-1318

Mir-17∼92 Governs Motor Neuron Subtype Survival by Mediating Nuclear PTEN.

Tung Y-T; Lu Y-L; Peng K-C; Yen Y-P; Chang M; Li J; Jung H; Thams S; Huang Y-P; Hung J-H; Chen J-A
Article: CELL STEM CELL. 2014;14(6):781-795

Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1.

Kiskinis E; Sandoe J; Williams LA; Boulting GL; Moccia R; Wainger BJ; Han S; Peng T; Thams S; Mikkilineni S; Mellin C; Merkle FT; Davis-Dusenbery BN; Ziller M; Oakley D; Ichida J; Di Costanzo S; Atwater N; Maeder ML; Goodwin MJ; Nemesh J; Handsaker RE; Paull D; Noggle S; McCarroll SA; Joung JK; Woolf CJ; Brown RH; Eggan K
Article: PLOS ONE. 2013;8(3):e59647

The extent of synaptic stripping of motoneurons after axotomy is not correlated to activation of surrounding glia or downregulation of postsynaptic adhesion molecules.

Berg A; Zelano J; Thams S; Cullheim S
Article: EXPERIMENTAL NEUROLOGY. 2012;237(1):8-17

Reduced removal of synaptic terminals from axotomized spinal motoneurons in the absence of complement C3.

Berg A; Zelano J; Stephan A; Thams S; Barres BA; Pekny M; Pekna M; Cullheim S
Article: RESTORATIVE NEUROLOGY AND NEUROSCIENCE. 2012;30(2):91-102

FGF1 containing biodegradable device with peripheral nerve grafts induces corticospinal tract regeneration and motor evoked potentials after spinal cord resection.

Nordblom J; Persson JKE; Aberg J; Blom H; Engqvist H; Brismar H; Sjödahl J; Josephson A; Frostell A; Thams S; Brundin L; Svensson M; Mattsson P
Article: GLIA. 2011;59(1):45-57

Evidence of hypothalamic degeneration in the anorectic anx/anx mouse.

Nilsson IAK; Thams S; Lindfors C; Bergstrand A; Cullheim S; Hökfelt T; Johansen JE
Article: NEUROSCIENTIST. 2010;16(6):600-607

Classic major histocompatibility complex class I molecules: new actors at the neuromuscular junction.

Cullheim S; Thams S
Article: AMERICAN JOURNAL OF PATHOLOGY. 2010;177(1):493-500

Distinct infiltration of neutrophils in lesion shoulders in ApoE-/- mice.

Rotzius P; Thams S; Soehnlein O; Kenne E; Tseng C-N; Björkström NK; Malmberg K-J; Lindbom L; Eriksson EE
Article: JOURNAL OF COMPARATIVE NEUROLOGY. 2009;517(5):670-682

SynCAM1 expression correlates with restoration of central synapses on spinal motoneurons after two different models of peripheral nerve injury.

Zelano J; Berg A; Thams S; Hailer NP; Cullheim S
Article: JOURNAL OF NEUROSCIENCE. 2009;29(43):13503-13515

Classical major histocompatibility complex class I molecules in motoneurons: new actors at the neuromuscular junction.

Thams S; Brodin P; Plantman S; Saxelin R; Kärre K; Cullheim S
Article: ATHEROSCLEROSIS. 2009;202(1):111-118

ApoE(-/-)/lysozyme M(EGFP/EGFP) mice as a versatile model to study monocyte and neutrophil trafficking in atherosclerosis.

Rotzius P; Soehnlein O; Kenne E; Lindbom L; Nystrom K; Thams S; Eriksson EE
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(4):1325-1330

Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons.

Ekstrand MI; Terzioglu M; Galter D; Zhu S; Hofstetter C; Lindqvist E; Thams S; Bergstrand A; Hansson FS; Trifunovic A; Hoffer B; Cullheim S; Mohammed AH; Olson L; Larsson N-G
Article: JOURNAL OF NEUROSCIENCE. 2005;25(14):3692-3700

Impeded interaction between Schwann cells and axons in the absence of laminin alpha4.

Wallquist W; Plantman S; Thams S; Thyboll J; Kortesmaa J; Lännergren J; Domogatskaya A; Ogren SO; Risling M; Hammarberg H; Tryggvason K; Cullheim S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(51):17843-17848

A role for MHC class I molecules in synaptic plasticity and regeneration of neurons after axotomy.

Oliveira ALR; Thams S; Lidman O; Piehl F; Hökfelt T; Kärre K; Lindå H; Cullheim S
Article: JOURNAL OF COMPARATIVE NEUROLOGY. 2002;454(3):284-293

Laminin chains in rat and human peripheral nerve: distribution and regulation during development and after axonal injury.

Wallquist W; Patarroyo M; Thams S; Carlstedt T; Stark B; Cullheim S; Hammarberg H
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All other publications

Editorial comment: NEUROLOGY-GENETICS. 2021;7(6):e636

Predominant Spastic Paraparesis Associated With the D178N Mutation in PRNP.

Thams S; Paucar M; Wingård L; Thonberg H; Smith C; Nennesmo I; Svenningsson P
Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(7):3582

The Role of BDNF in Experimental and Clinical Traumatic Brain Injury.

Gustafsson D; Klang A; Thams S; Rostami E
Published conference paper: BRAIN RESEARCH REVIEWS. 2008;57(1):265-269

MHC class I expression and synaptic plasticity after nerve lesion.

Thams S; Oliveira A; Cullheim S
Published conference paper: BRAIN RESEARCH REVIEWS. 2007;55(1):89-96

The microglial networks of the brain and their role in neuronal network plasticity after lesion.

Cullheim S; Thams S

Employments

Senior Research Specialist, Department of Neuroscience, Karolinska Institutet, 2024-
Adjunct Lecturer, Department of Neuroscience, Karolinska Institutet, 2022-2024

Degrees and Education

Degree Of Doctor Of Philosophy, Department of neuroscience, Karolinska Institutet, 2009
University Medical Degree, Karolinska Institutet, 2006

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