Rudolf Ladenstein

Publications
Public outreach and news

Articles

Article: EMBO JOURNAL. 2009;28(16):2479-2489

Structure and function of a novel endonuclease acting on branched DNA substrates.

Ren B; Kühn J; Meslet-Cladiere L; Briffotaux J; Norais C; Lavigne R; Flament D; Ladenstein R; Myllykallio H
Article: NUCLEIC ACIDS RESEARCH. 2008;36(10):3235-3243

Structural analysis of the Sulfolobus solfataricus MCM protein N-terminal domain.

Liu W; Pucci B; Rossi M; Pisani FM; Ladenstein R
Article: JOURNAL OF ORGANIC CHEMISTRY. 2008;73(7):2715-2724

A new series of N-[2,4-dioxo-6-d-ribitylamino-1,2,3,4-tetrahydropyrimidin-5-yl]oxalamic acid derivatives as inhibitors of lumazine synthase and riboflavin synthase: design, synthesis, biochemical evaluation, crystallography, and mechanistic implications.

Zhang Y; Illarionov B; Morgunova E; Jin G; Bacher A; Fischer M; Ladenstein R; Cushman M
Article: JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY. 2007;12(8):1163-1171

Ultrahigh-resolution study on Pyrococcus abyssi rubredoxin: II. Introduction of an O-H...Sgamma-Fe hydrogen bond increased the reduction potential by 65 mV.

Bönisch H; Schmidt CL; Bianco P; Ladenstein R
Article: BIOCHEMISTRY. 2007;46(29):8537-8549

Dynamic arrangement of ion pairs and individual contributions to the thermal stability of the cofactor-binding domain of glutamate dehydrogenase from Thermotoga maritima.

Danciulescu C; Ladenstein R; Nilsson L
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2007;282(23):17231-17241

Lumazine synthase from Candida albicans as an anti-fungal target enzyme: structural and biochemical basis for drug design.

Morgunova E; Saller S; Haase I; Cushman M; Bacher A; Fischer M; Ladenstein R
Article: JOURNAL OF MOLECULAR BIOLOGY. 2007;369(2):474-488

Crystal structure of the archaeal heat shock regulator from Pyrococcus furiosus: a molecular chimera representing eukaryal and bacterial features.

Liu W; Vierke G; Wenke A-K; Thomm M; Ladenstein R
Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2007;63(Pt 5):406-408

Crystallization and preliminary X-ray analysis of a RecB-family nuclease from the archaeon Pyrococcus abyssi.

Ren B; Kuhn J; Meslet-Cladiere L; Myllykallio H; Ladenstein R
Article: EXTREMOPHILES. 2007;11(3):481-493

Thermal stability of isocitrate dehydrogenase from Archaeoglobus fulgidus studied by crystal structure analysis and engineering of chimers.

Stokke R; Karlström M; Yang N; Leiros I; Ladenstein R; Birkeland NK; Steen IH
Article: EXTREMOPHILES. 2007;11(1):105-114

The phosphofructokinase-B (MJ0406) from Methanocaldococcus jannaschii represents a nucleoside kinase with a broad substrate specificity.

Hansen T; Arnfors L; Ladenstein R; Schönheit P
Article: FEBS JOURNAL. 2006;273(20):4790-4804

Structural and thermodynamic insights into the binding mode of five novel inhibitors of lumazine synthase from Mycobacterium tuberculosis.

Morgunova E; Illarionov B; Sambaiah T; Haase I; Bacher A; Cushman M; Fischer M; Ladenstein R
Article: JOURNAL OF MOLECULAR BIOLOGY. 2006;362(4):753-770

Multiple assembly states of lumazine synthase: a model relating catalytic function and molecular assembly.

Zhang X; Konarev PV; Petoukhov MV; Svergun DI; Xing L; Cheng RH; Haase I; Fischer M; Bacher A; Ladenstein R; Meining W
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2006;62(Pt 9):1085-1097

Structure of Methanocaldococcus jannaschii nucleoside kinase: an archaeal member of the ribokinase family.

Arnfors L; Hansen T; Schönheit P; Ladenstein R; Meining W
Article: FEBS JOURNAL. 2006;273(13):2851-2868

The crystal structure of a hyperthermostable subfamily II isocitrate dehydrogenase from Thermotoga maritima.

Karlström M; Steen IH; Madern D; Fedöy A-E; Birkeland N-K; Ladenstein R
Article: JOURNAL OF ORGANIC CHEMISTRY. 2005;70(20):8162-8170

Design, synthesis, and biochemical evaluation of 1,5,6,7-tetrahydro-6,7-dioxo-9-D-ribitylaminolumazines bearing alkyl phosphate substituents as inhibitors of lumazine synthase and riboflavin synthase.

Cushman M; Jin G; Sambaiah T; Illarionov B; Fischer M; Ladenstein R; Bacher A
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2005;61(Pt 7):990-1004

Ultrahigh-resolution study on Pyrococcus abyssi rubredoxin. I. 0.69 A X-ray structure of mutant W4L/R5S.

Bönisch H; Schmidt CL; Bianco P; Ladenstein R
Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2005;61(Pt 6):591-594

Expression, purification, crystallization and preliminary X-ray analysis of a nucleoside kinase from the hyperthermophile Methanocaldococcus jannaschii.

Arnfors L; Hansen T; Meining W; Schönheit P; Ladenstein R
Article: BIOCHEMISTRY. 2005;44(8):2746-2758

Crystal structure of lumazine synthase from Mycobacterium tuberculosis as a target for rational drug design: binding mode of a new class of purinetrione inhibitors.

Morgunova E; Meining W; Illarionov B; Haase I; Jin G; Bacher A; Cushman M; Fischer M; Ladenstein R
Article: JOURNAL OF MOLECULAR BIOLOGY. 2005;345(3):579-598

Drosophila alcohol dehydrogenase: acetate-enzyme interactions and novel insights into the effects of electrostatics on catalysis.

Benach J; Winberg J-O; Svendsen J-S; Atrian S; Gonzàlez-Duarte R; Ladenstein R
Article: JOURNAL OF MOLECULAR BIOLOGY. 2005;345(3):559-577

Isocitrate dehydrogenase from the hyperthermophile Aeropyrum pernix: X-ray structure analysis of a ternary enzyme-substrate complex and thermal stability.

Karlström M; Stokke R; Steen IH; Birkeland N-K; Ladenstein R
Article: FEBS JOURNAL. 2004;271(16):3437-3448

Functional properties of the protein disulfide oxidoreductase from the archaeon Pyrococcus furiosus: a member of a novel protein family related to protein disulfide-isomerase.

Pedone E; Ren B; Ladenstein R; Rossi M; Bartolucci S
Article: BIOCHEMICAL JOURNAL. 2004;381(Pt 2):489-494

Human hereditary glutathione synthetase deficiency: kinetic properties of mutant enzymes.

Njålsson R; Carlsson K; Bhansali V; Luo J-L; Nilsson L; Ladenstein R; Anderson M; Larsson A; Norgren S
Article: JOURNAL OF MOLECULAR BIOLOGY. 2004;335(1):343-356

The 2.9A resolution crystal structure of malate dehydrogenase from Archaeoglobus fulgidus: mechanisms of oligomerisation and thermal stabilisation.

Irimia A; Vellieux FMD; Madern D; Zaccaï G; Karshikoff A; Tibbelin G; Ladenstein R; Lien T; Birkeland NK
Article: JOURNAL OF MOLECULAR BIOLOGY. 2003;331(5):1053-1063

The structure of the N-terminal domain of riboflavin synthase in complex with riboflavin at 2.6A resolution.

Meining W; Eberhardt S; Bacher A; Ladenstein R
Article: CHEMBIOCHEM. 2003;4(8):734-741

Protein stabilisation by compatible solutes: effect of mannosylglycerate on unfolding thermodynamics and activity of ribonuclease A.

Faria TQ; Knapp S; Ladenstein R; Maçanita AL; Santos H
Article: JOURNAL OF MOLECULAR BIOLOGY. 2003;329(3):467-477

The multi-layered structure of Dps with a novel di-nuclear ferroxidase center.

Ren B; Tibbelin G; Kajino T; Asami O; Ladenstein R
Article: PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2003;51(2):289-298

The catalytic mechanism of Drosophila alcohol dehydrogenase: evidence for a proton relay modulated by the coupled ionization of the active site Lysine/Tyrosine pair and a NAD+ ribose OH switch.

Koumanov A; Benach J; Atrian S; Gonzàlez-Duarte R; Karshikoff A; Ladenstein R
Article: JOURNAL OF MOLECULAR BIOLOGY. 2003;328(1):167-182

A structure-based model of the reaction catalyzed by lumazine synthase from Aquifex aeolicus.

Zhang X; Meining W; Cushman M; Haase I; Fischer M; Bacher A; Ladenstein R
Article: JOURNAL OF MOLECULAR BIOLOGY. 2003;326(3):783-793

Enzyme catalysis via control of activation entropy: site-directed mutagenesis of 6,7-dimethyl-8-ribityllumazine synthase.

Fischer M; Haase I; Kis K; Meining W; Ladenstein R; Cushman M; Schramek N; Huber R; Bacher A
Article: BIOCHEMISTRY. 2002;41(52):15524-15535

Structural and thermodynamic studies on a salt-bridge triad in the NADP-binding domain of glutamate dehydrogenase from Thermotoga maritima: cooperativity and electrostatic contribution to stability.

Lebbink JHG; Consalvi V; Chiaraluce R; Berndt KD; Ladenstein R
Article: BIOCHEMISTRY. 2002;41(50):14659-14668

Structure of bacterial 3beta/17beta-hydroxysteroid dehydrogenase at 1.2 A resolution: a model for multiple steroid recognition.

Benach J; Filling C; Oppermann UCT; Roversi P; Bricogne G; Berndt KD; Jörnvall H; Ladenstein R
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2002;58(Pt 12):2162-2164

Crystallization and preliminary X-ray structure analysis of isocitrate dehydrogenase from two hyperthermophiles, Aeropyrum pernix and Thermotoga maritima.

Karlström M; Steen IH; Tibbelin G; Lien T; Birkeland N-K; Ladenstein R
Article: FEBS LETTERS. 2002;530(1-3):79-84

Human spermatid-specific thioredoxin-1 (Sptrx-1) is a two-domain protein with oxidizing activity.

Jiménez A; Johansson C; Ljung J; Sagemark J; Berndt KD; Ren B; Tibbelin G; Ladenstein R; Kieselbach T; Holmgren A; Gustafsson JA; Miranda-Vizuete A
Article: JOURNAL OF MOLECULAR BIOLOGY. 2002;321(2):341-353

Formation of metal nanoclusters on specific surface sites of protein molecules.

Braun N; Meining W; Hars U; Fischer M; Ladenstein R; Huber R; Bacher A; Weinkauf S; Bachmann L
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(28):25677-25684

Critical residues for structure and catalysis in short-chain dehydrogenases/reductases.

Filling C; Berndt KD; Benach J; Knapp S; Prozorovski T; Nordling E; Ladenstein R; Jörnvall H; Oppermann U
Article: JOURNAL OF MOLECULAR BIOLOGY. 2002;319(3):791-805

The structure of the soluble domain of an archaeal Rieske iron-sulfur protein at 1.1 A resolution.

Bönisch H; Schmidt CL; Schäfer G; Ladenstein R
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2001;289(3):712-717

Structural role of conserved Asn179 in the short-chain dehydrogenase/reductase scaffold.

Filling C; Nordling E; Benach J; Berndt KD; Ladenstein R; Jörnvall H; Oppermann U
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(47):43924-43931

Comparison of isocitrate dehydrogenase from three hyperthermophiles reveals differences in thermostability, cofactor specificity, oligomeric state, and phylogenetic affiliation.

Steen IH; Madern D; Karlström M; Lien T; Ladenstein R; Birkeland NK
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(40):37215-37222

DNA topoisomerase VI generates ATP-dependent double-strand breaks with two-nucleotide overhangs.

Buhler C; Lebbink JH; Bocs C; Ladenstein R; Forterre P
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2001;57(Pt 9):1296-1299

Crystallization and preliminary crystallographic analysis of the recombinant N-terminal domain of riboflavin synthase.

Meining W; Eberhardt S; Bacher A; Ladenstein R
Article: JOURNAL OF MOLECULAR BIOLOGY. 2001;306(5):1099-1114

X-ray structure analysis and crystallographic refinement of lumazine synthase from the hyperthermophile Aquifex aeolicus at 1.6 A resolution: determinants of thermostability revealed from structural comparisons.

Zhang X; Meining W; Fischer M; Bacher A; Ladenstein R
Article: INTERNATIONAL DAIRY JOURNAL. 2001;11(1-2):71-81

The effect of storage and heat treatment on glutathione peroxidase in bovine milk and whey

Lindmark-Månsson H; Chen J; Paulsson M; Aldén G; Ren B; Ladenstein R; Åkesson B
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2000;56(Pt 11):1470-1472

Crystallization and preliminary X-ray crystallographic studies of the thermoactive pullulanase type I, hydrolyzing alpha-1,6 glycosidic linkages, from Fervidobacterium pennivorans Ven5.

Lebbink JH; Bertoldo C; Tibbelin G; Andersen JT; Duffner F; Antranikian G; Ladenstein R
Article: PROTEIN ENGINEERING DESIGN & SELECTION. 2000;13(7):501-507

Thermal unfolding and conformational stability of the recombinant domain II of glutamate dehydrogenase from the hyperthermophile Thermotoga maritima.

Consalvi V; Chiaraluce R; Giangiacomo L; Scandurra R; Christova P; Karshikoff A; Knapp S; Ladenstein R
Article: FEBS JOURNAL. 2000;267(12):3613-3622

Structure-function relationships in Drosophila melanogaster alcohol dehydrogenase allozymes ADH(S), ADH(F) and ADH(UF), and distantly related forms.

Benach J; Atrian S; Fibla J; Gonzàlez-Duarte R; Ladenstein R
Article: JOURNAL OF MOLECULAR BIOLOGY. 2000;299(1):181-197

The atomic structure of pentameric lumazine synthase from Saccharomyces cerevisiae at 1.85 A resolution reveals the binding mode of a phosphonate intermediate analogue.

Meining W; Mörtl S; Fischer M; Cushman M; Bacher A; Ladenstein R
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2000;56(Pt 5):643-644

Crystallization and preliminary crystallographic analysis of Rieske iron-sulfur protein II (soxF) from sulfolobus acidocaldarius.

Bönisch H; Schmidt CL; Schäfer G; Ladenstein R
Article: EXTREMOPHILES. 1999;3(3):191-198

Extrinsic protein stabilization by the naturally occurring osmolytes beta-hydroxyectoine and betaine.

Knapp S; Ladenstein R; Galinski EA
Article: JOURNAL OF MOLECULAR BIOLOGY. 1999;289(2):357-369

Engineering activity and stability of Thermotoga maritima glutamate dehydrogenase. II: construction of a 16-residue ion-pair network at the subunit interface.

Lebbink JH; Knapp S; van der Oost J; Rice D; Ladenstein R; de Vos WM
Article: JOURNAL OF MOLECULAR BIOLOGY. 1999;289(2):335-355

The catalytic reaction and inhibition mechanism of Drosophila alcohol dehydrogenase: observation of an enzyme-bound NAD-ketone adduct at 1.4 A resolution by X-ray crystallography.

Benach J; Atrian S; Gonzàlez-Duarte R; Ladenstein R
Article: JOURNAL OF MOLECULAR BIOLOGY. 1999;285(2):689-702

Refined crystal structure of a superoxide dismutase from the hyperthermophilic archaeon Sulfolobus acidocaldarius at 2.2 A resolution.

Knapp S; Kardinahl S; Hellgren N; Tibbelin G; Schäfer G; Ladenstein R
Article: PROTEIN ENGINEERING DESIGN & SELECTION. 1998;11(10):867-872

Proteins from thermophilic and mesophilic organisms essentially do not differ in packing.

Karshikoff A; Ladenstein R
Article: JOURNAL OF MOLECULAR BIOLOGY. 1998;282(2):383-399

The refined crystal structure of Drosophila lebanonensis alcohol dehydrogenase at 1.9 A resolution.

Benach J; Atrian S; Gonzàlez-Duarte R; Ladenstein R
Article: JOURNAL OF STRUCTURAL BIOLOGY. 1998;123(1):30-36

Two-dimensional crystallization of the chaperonin TF55 from the hyperthermophilic archaeon Sulfolobus solfataricus.

Ellis MJ; Knapp S; Koeck PJ; Fakoor-Biniaz Z; Ladenstein R; Hebert H
Article: FEBS LETTERS. 1998;432(3):141-144

Isolation and structure of repressor-like proteins from the archaeon Sulfolobus solfataricus. Co-purification of RNase A with Sso7c.

Oppermann UC; Knapp S; Bonetto V; Ladenstein R; Jörnvall H
Article: JOURNAL OF MOLECULAR BIOLOGY. 1998;280(2):287-296

Engineering activity and stability of Thermotoga maritima glutamate dehydrogenase. I. Introduction of a six-residue ion-pair network in the hinge region.

Lebbink JH; Knapp S; van der Oost J; Rice D; Ladenstein R; de Vos WM
Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 1998;5(7):602-611

A protein disulfide oxidoreductase from the archaeon Pyrococcus furiosus contains two thioredoxin fold units.

Ren B; Tibbelin G; de Pascale D; Rossi M; Bartolucci S; Ladenstein R
Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 1998;5(7):579-584

Architecture of nonspecific protein-DNA interactions in the Sso7d-DNA complex.

Agback P; Baumann H; Knapp S; Ladenstein R; Härd T
Article: PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 1998;31(3):309-319

Thermal unfolding of small proteins with SH3 domain folding pattern.

Knapp S; Mattson PT; Christova P; Berndt KD; Karshikoff A; Vihinen M; Smith CI; Ladenstein R
Article: NUCLEIC ACIDS RESEARCH. 1998;26(10):2322-2328

In vitro DNA binding of the archaeal protein Sso7d induces negative supercoiling at temperatures typical for thermophilic growth.

López-García P; Knapp S; Ladenstein R; Forterre P
Article: JOURNAL OF MOLECULAR BIOLOGY. 1998;276(4):775-786

Thermodynamic characterization of non-sequence-specific DNA-binding by the Sso7d protein from Sulfolobus solfataricus.

Lundbäck T; Hansson H; Knapp S; Ladenstein R; Härd T
Article: JOURNAL OF STRUCTURAL BIOLOGY. 1998;121(1):53-60

Evidence for local 32 symmetry in homotrimeric riboflavin synthase of Escherichia coli.

Meining W; Tibbelin G; Ladenstein R; Eberhardt S; Fischer M; Bacher A
Article: FEBS LETTERS. 1997;413(2):191-193

Drosophila alcohol dehydrogenase: evaluation of Ser139 site-directed mutants.

Cols N; Atrian S; Benach J; Ladenstein R; Gonzàlez-Duarte R
Article: PROTEIN SCIENCE. 1997;6(6):1190-1196

Optimization of the electrostatic interactions between ionized groups and peptide dipoles in proteins.

Spassov VZ; Ladenstein R; Karshikoff AD
Article: JOURNAL OF STRUCTURAL BIOLOGY. 1997;119(1):1-5

Crystallization and preliminary X-ray structure analysis of a hyperthermostable thioltransferase from the archaeon Pyrococcus furiosus

Ren B; Tibbelin G; dePascale D; Rossi M; Bartolucci S; Ladenstein R
Article: JOURNAL OF MOLECULAR BIOLOGY. 1997;268(5):869-885

The crystal structure of seleno-glutathione peroxidase from human plasma at 2.9 A resolution.

Ren B; Huang W; Akesson B; Ladenstein R
Article: JOURNAL OF MOLECULAR BIOLOGY. 1997;267(4):916-932

Crystal structure of glutamate dehydrogenase from the hyperthermophilic eubacterium Thermotoga maritima at 3.0 A resolution.

Knapp S; de Vos WM; Rice D; Ladenstein R
Article: BIOCHEMISTRY. 1997;36(1):34-40

Active site directed mutagenesis of 3 beta/17 beta-hydroxysteroid dehydrogenase establishes differential effects on short-chain dehydrogenase/reductase reactions.

Oppermann UC; Filling C; Berndt KD; Persson B; Benach J; Ladenstein R; Jörnvall H
Article: JOURNAL OF MOLECULAR BIOLOGY. 1996;264(5):1132-1144

Thermal unfolding of the DNA-binding protein Sso7d from the hyperthermophile Sulfolobus solfataricus.

Knapp S; Karshikoff A; Berndt KD; Christova P; Atanasov B; Ladenstein R
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 1996;52(Pt 3):447-452

Locating a local symmetry axis from patterson map cross vectors: application to crystal data from GroEl, GTP cyclohydrolase I and the proteosome.

Stubbs MT; Nar H; Löwe J; Huber R; Ladenstein R; Spangfort MD; Svensson LA
Article: FEBS JOURNAL. 1996;236(1):144-148

Crystallization and crystal packing of recombinant 3 (or 17) beta-hydroxysteroid dehydrogenase from Comamonas testosteroni ATTC 11996.

Benach J; Knapp S; Oppermann UC; Hägglund O; Jörnvall H; Ladenstein R
Article: PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 1995;23(4):595-597

Crystallization and preliminary crystallographic analysis of an amylopullulanase from the hyperthermophilic archaeon Pyrococcus woesei.

Knapp S; Rüdiger A; Antranikian G; Jorgensen PL; Ladenstein R
Article: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 1995;117(51):12883-12884

Flexibility of an arginine side chain at a DNA-protein interface

Berglund H; Baumann H; Knapp S; Ladenstein R; Hard T
Article: PROTEIN SCIENCE. 1995;4(8):1516-1527

The optimization of protein-solvent interactions: thermostability and the role of hydrophobic and electrostatic interactions.

Spassov VZ; Karshikoff AD; Ladenstein R
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 1995;51(Pt 1):69-72

Well ordered crystals of a short-chain alcohol dehydrogenase from Drosophila lebanonensis: re-evaluation of the crystallographic data and rotation-function analysis.

Ladenstein R; Tibbelin G; Karshikoff A; Atrian S; González-Duarte R
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Review: BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT. 2009;23(2):1153-1161

METAMORPHOSIS OF AN ENZYME

Ladenstein R; Meining W; Zhang X; Fischer M; Bacher A
Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 2008;65(24):3918-3935

Medium- and short-chain dehydrogenase/reductase gene and protein families : Structure-function relationships in short-chain alcohol dehydrogenases.

Ladenstein R; Winberg J-O; Benach J
Letter: JOURNAL OF APPLIED CRYSTALLOGRAPHY. 2008;41:659

Of crystals, structure factors and diffraction images

Jovine L; Morgunova E; Ladenstein R
Review: EXTREMOPHILES. 2008;12(1):29-38

Reconsideration of an early dogma, saying "there is no evidence for disulfide bonds in proteins from archaea".

Ladenstein R; Ren B
Published conference paper: BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT. 2008;22(1):612-619

Heat capacity, configurational entropy, and the role of ionic interactions in protein thermostability

Ladenstein R
Review: FEBS JOURNAL. 2006;273(18):4170-4185

Protein disulfides and protein disulfide oxidoreductases in hyperthermophiles.

Ladenstein R; Ren B
Review: TRENDS IN BIOCHEMICAL SCIENCES. 2001;26(9):550-556

Ion pairs and the thermotolerance of proteins from hyperthermophiles: a "traffic rule" for hot roads.

Karshikoff A; Ladenstein R
Published conference paper: CHEMICO-BIOLOGICAL INTERACTIONS. 2001;130-132(1-3):405-415

Genesis of Drosophila ADH: the shaping of the enzymatic activity from a SDR ancestor.

Benach J; Atrian S; Ladenstein R; Gonzàlez-Duarte R
Review: RECOMBINANT PROTEIN EXPRESSION: PROKARYOTIC HOSTS AND CELL-FREE SYSTEMS. 2001;334:74-88

Protein disulfide oxidoreductase from Pyrococcus furiosus: structural properties.

Ren B; Ladenstein R
Published conference paper: BIOCHEMICAL SOCIETY TRANSACTIONS. 1996;24(1):89-94

Biosynthesis of riboflavin: structure and mechanism of lumazine synthase.

Bacher A; Fischer M; Kis K; Kugelbrey K; Mörtl S; Scheuring J; Weinkauf S; Eberhardt S; Schmidt-Bäse K; Huber R; Ritsert K; Cushman M; Ladenstein R
Published conference paper: BIOCHEMICAL SOCIETY TRANSACTIONS. 1996;24(1):34S

Structural investigation on recombinant riboflavin synthase from E. coli.

Tibbelin G; Eberhardt S; Richter G; Bacher A; Ladenstein R
Other: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 1995;51(Pt 5):824-826

Crystallization and preliminary X-ray diffraction analysis of glutathione peroxidase from human plasma.

Ren B; Huang W; Akesson B; Ladenstien R
Other: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 1995;51(Pt 3):395-398

Preliminary crystallographic analysis of an extremely thermostable glutamate dehydrogenase from the archaeon Pyrococcus woesei.

Knapp S; Karshikoff A; Waldkötter K; Rüdiger A; Antranikian G; Ladenstein R
Other: JOURNAL OF MOLECULAR BIOLOGY. 1995;247(5):840-846

DNA-binding surface of the Sso7d protein from Sulfolobus solfataricus.

Baumann H; Knapp S; Karshikoff A; Ladenstein R; Härd T

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