Pontus Plaven Sigray

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Articles

Article: BMC NEUROLOGY. 2024;24(1):111

Evaluating the effect of rapamycin treatment in Alzheimer's disease and aging using in vivo imaging: the ERAP phase IIa clinical study protocol.

Svensson JE; Bolin M; Thor D; Williams PA; Brautaset R; Carlsson M; Sörensson P; Marlevi D; Spin-Neto R; Probst M; Hagman G; Morén AF; Kivipelto M; Plavén-Sigray P
Article: JAMA PSYCHIATRY. 2024

Cognitive Function and Variability in Antipsychotic Drug-Naive Patients With First-Episode Psychosis: A Systematic Review and Meta-Analysis.

Lee M; Cernvall M; Borg J; Plavén-Sigray P; Larsson C; Erhardt S; Sellgren CM; Fatouros-Bergman H; Cervenka S
Journal article: HUMAN BRAIN MAPPING. 2023;44(17):6139-6148

Prediction of brain age using structural magnetic resonance imaging: A comparison of accuracy and test-retest reliability of publicly available software packages.

Dörfel RP; Arenas-Gomez JM; Fisher PM; Ganz M; Knudsen GM; Svensson JE; Plavén-Sigray P
Article: ADDICTION. 2023;118(6):1053-1061

Striatal dopamine D2 receptor availability as a predictor of subsequent alcohol use in social drinkers.

Jangard S; Jayaram-Lindström N; Isacsson NH; Matheson GJ; Plavén-Sigray P; Franck J; Borg J; Farde L; Cervenka S
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2023;26(4):241-248

Associations Between Cognition and Serotonin 1B Receptor Availability in Healthy Volunteers: A [11C]AZ10419369 Positron Emission Tomography Study.

Tangen Ä; Veldman ER; Svensson J; Tiger M; Nord M; Sorjonen K; Andersson M; Plavén-Sigray P; Varrone A; Halldin C; Varnäs K; Borg J; Lundberg J
Article: NEUROPSYCHOPHARMACOLOGY. 2022;47(10):1863-1868

In vivo correlation of serotonin transporter and 1B receptor availability in the human brain: a PET study.

Svensson JE; Tiger M; Plavén-Sigray P; Halldin C; Schain M; Lundberg J
Article: MOLECULAR PSYCHIATRY. 2022;27(2):1233-1240

Thalamic dopamine D2-receptor availability in schizophrenia: a study on antipsychotic-naive patients with first-episode psychosis and a meta-analysis.

Plavén-Sigray P; Ikonen Victorsson P; Santillo A; Matheson GJ; Lee M; Collste K; Fatouros-Bergman H; Sellgren CM; Erhardt S; Agartz I; Halldin C; Farde L; Cervenka S
Article: NPJ SCHIZOPHRENIA. 2021;7(1):46

No association between cortical dopamine D2 receptor availability and cognition in antipsychotic-naive first-episode psychosis.

Lee M; Fatouros-Bergman H; Plavén-Sigray P; Ikonen Victorsson P; Sellgren CM; Erhardt S; Flyckt L; Farde L; Cervenka S
Article: TRANSLATIONAL PSYCHIATRY. 2021;11(1):264

Serotonin transporter availability increases in patients recovering from a depressive episode.

Svensson JE; Svanborg C; Plavén-Sigray P; Kaldo V; Halldin C; Schain M; Lundberg J
Article: JOURNAL OF NUCLEAR MEDICINE. 2021;62(3):412-417

Nondisplaceable Binding Is a Potential Confounding Factor in 11C-PBR28 Translocator Protein PET Studies.

Laurell GL; Plavén-Sigray P; Jucaite A; Varrone A; Cosgrove KP; Svarer C; Knudsen GM; Karolinska Schizophrenia Project Consortium; Ogden RT; Zanderigo F; Cervenka S; Hillmer AT; Schain M
Article: NEUROIMAGE. 2021;226:117523

Low convergent validity of [11C]raclopride binding in extrastriatal brain regions: A PET study of within-subject correlations with [11C]FLB 457.

Freiburghaus T; Svensson JE; Matheson GJ; Plavén-Sigray P; Lundberg J; Farde L; Cervenka S
Article: SCHIZOPHRENIA RESEARCH. 2020;222:175-184

Dopamine D1 receptor availability is not associated with delusional ideation measures of psychosis proneness.

Matheson GJ; Plavén-Sigray P; Louzolo A; Borg J; Farde L; Petrovic P; Cervenka S
Article: NEUROIMAGE. 2019;202:116143

Validity and reliability of extrastriatal [11C]raclopride binding quantification in the living human brain.

Svensson JE; Schain M; Plavén-Sigray P; Cervenka S; Tiger M; Nord M; Halldin C; Farde L; Lundberg J
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2019;46(11):2329-2338

Effects of age, BMI and sex on the glial cell marker TSPO - a multicentre [11C]PBR28 HRRT PET study.

Tuisku J; Plavén-Sigray P; Gaiser EC; Airas L; Al-Abdulrasul H; Brück A; Carson RE; Chen M-K; Cosgrove KP; Ekblad L; Esterlis I; Farde L; Forsberg A; Halldin C; Helin S; Kosek E; Lekander M; Lindgren N; Marjamäki P; Rissanen E; Sucksdorff M; Varrone A; HRRT [11C ]PBR28 study group; Collste K; Gallezot J-D; Hillmer A; Huang Y; Höglund CO; Johansson J; Jucaite A; Lampa J; Nabulsi N; Pittman B; Sandiego CM; Stenkrona P; Rinne J; Matuskey D; Cervenka S
Article: NEUROIMAGE. 2019;188:102-110

Accuracy and reliability of [11C]PBR28 specific binding estimated without the use of a reference region.

Plavén-Sigray P; Schain M; Zanderigo F; Karolinska [(11)C]PBR28 study group; Rabiner EA; Gunn RN; Ogden RT; Cervenka S
Article: EJNMMI RESEARCH. 2018;8(1):102

Test-retest reliability and convergent validity of (R)-[11C]PK11195 outcome measures without arterial input function.

Plavén-Sigray P; Matheson GJ; Cselényi Z; Jucaite A; Farde L; Cervenka S
Article: BIOLOGICAL PSYCHIATRY. 2018;84(6):433-442

Positron Emission Tomography Studies of the Glial Cell Marker Translocator Protein in Patients With Psychosis: A Meta-analysis Using Individual Participant Data.

Plavén-Sigray P; Matheson GJ; Collste K; Ashok AH; Coughlin JM; Howes OD; Mizrahi R; Pomper MG; Rusjan P; Veronese M; Wang Y; Cervenka S
Article: PLOS COMPUTATIONAL BIOLOGY. 2018;14(5):e1006196

Simulations to benchmark time-varying connectivity methods for fMRI.

Thompson WH; Richter CG; Plavén-Sigray P; Fransson P
Article: PLOS ONE. 2018;13(12):e0209584

Trait impulsivity is not related to post-commissural putamen volumes: A replication study in healthy men.

Caravaggio F; Plavén-Sigray P; Matheson GJ; Plitman E; Chakravarty MM; Borg J; Graff-Guerrero A; Cervenka S
Article: PLOS ONE. 2018;13(3):e0193770

Is dopamine D1 receptor availability related to social behavior? A positron emission tomography replication study.

Plavén-Sigray P; Matheson GJ; Gustavsson P; Stenkrona P; Halldin C; Farde L; Cervenka S
Article: EJNMMI RESEARCH. 2017;7(1):58

Assessment of simplified ratio-based approaches for quantification of PET [11C]PBR28 data.

Matheson GJ; Plavén-Sigray P; Forsberg A; Varrone A; Farde L; Cervenka S
Article: ELIFE. 2017;6:e27725

The readability of scientific texts is decreasing over time.

Plavén-Sigray P; Matheson GJ; Schiffler BC; Thompson WH
Article: NEUROIMAGE. 2017;155:344-353

Reliability of volumetric and surface-based normalisation and smoothing techniques for PET analysis of the cortex: A test-retest analysis using [11C]SCH-23390.

Matheson GJ; Stenkrona P; Cselényi Z; Plavén-Sigray P; Halldin C; Farde L; Cervenka S
Article: MOLECULAR PSYCHIATRY. 2017;22(6):850-856

Lower levels of the glial cell marker TSPO in drug-naive first-episode psychosis patients as measured using PET and [11C]PBR28.

Collste K; Plavén-Sigray P; Fatouros-Bergman H; Victorsson P; Schain M; Forsberg A; Amini N; Aeinehband S; Karolinska Schizophrenia Project (KaSP) consortium; Erhardt S; Halldin C; Flyckt L; Farde L; Cervenka S
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2017;27(5):462-469

Extrastriatal dopamine D2-receptor availability in social anxiety disorder.

Plavén-Sigray P; Hedman E; Victorsson P; Matheson GJ; Forsberg A; Djurfeldt DR; Rück C; Halldin C; Lindefors N; Cervenka S
Article: NEUROIMAGE. 2014;102 Pt 2:590-595

Dopamine D1 receptor availability is related to social behavior: a positron emission tomography study.

Plavén-Sigray P; Gustavsson P; Farde L; Borg J; Stenkrona P; Nyberg L; Bäckman L; Cervenka S
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Review: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2021;41(11):2805-2819

Early stopping in clinical PET studies: How to reduce expense and exposure.

Svensson JE; Schain M; Knudsen GM; Ogden RT; Plavén-Sigray P
Letter: BIOLOGICAL PSYCHIATRY. 2021;89(3):e5-e8

Meta-analysis of the Glial Marker TSPO in Psychosis Revisited: Reconciling Inconclusive Findings of Patient-Control Differences.

Plavén-Sigray P; Matheson GJ; Coughlin JM; Hafizi S; Laurikainen H; Ottoy J; De Picker L; Rusjan P; Hietala J; Howes OD; Mizrahi R; Morrens M; Pomper MG; Cervenka S
Conference publication: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2021;41(1_SUPPL):228-229

Meta-analysis of the glial marker TSPO in psychosis revisited: Reconciling inconclusive findings of patient-control differences

Plaven-Sigray P; Matheson GJ; Coughlin JM; Hafizi S; Laurikainen H; Ottoy J; de'Picker L; Rusjan PM; Hietala J; Howes OD; Mizrahi R; Morrens M; Pomper MG; Cervenka S
Letter: NEUROIMAGE. 2020;207:116371

In response to the letter "[11C]raclopride and extrastriatal binding to D2/3 receptors".

Svensson JE; Schain M; Plavén-Sigray P; Cervenka S; Tiger M; Nord M; Halldin C; Farde L; Lundberg J
Letter: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2020;47(2):502-504

Clinical brain PET research must embrace multi-centre collaboration and data sharing or risk its demise.

Matheson GJ; Plavén-Sigray P; Tuisku J; Rinne J; Matuskey D; Cervenka S
Editorial comment: PSYCHOLOGICAL MEDICINE. 2019;49(10):1624-1628

Meta-analytic studies of the glial cell marker TSPO in psychosis - a question of apples and pears?

Plavén-Sigray P; Cervenka S
Thesis / dissertation: 2018

Positron emission tomography : development, evaluation and application of quantification methods

Plavén-Sigray, Pontus
Review: PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES. 2018;373(1744):20170156

Brain neuroreceptor density and personality traits: towards dimensional biomarkers for psychiatric disorders.

Farde L; Plavén-Sigray P; Borg J; Cervenka S

Employments

Postdoctoral Researcher, Department of Clinical Neuroscience, Karolinska Institutet, 2022-2025
Postdoc, Neurobiology Research Unit, Copenhagen University Hospital, 2019-2025
Postdoctoral Researcher, Department of Clinical Neuroscience, Karolinska Institutet, 2019-2019
Phd Student, Department of Clinical Neuroscience, Karolinska Institutet, 2014-2014
R&D Trainee, Department of Clinical Neuroscience, Karolinska Institutet, 2013-2013
Research Assistant, Department of Clinical Neuroscience, Karolinska Institutet, 2009-2010

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Clinical Neuroscience, Karolinska Institutet, 2019
Degree Of Master Of Science In Psychology, Karolinska Institutet, 2013

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