Per Gerde

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Articles

Article: JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY. 2020;33(2):116-126

Adapting the Aerogen Mesh Nebulizer for Dried Aerosol Exposures Using the PreciseInhale Platform.

Gerde P; Nowenwik M; Sjöberg C-O; Selg E
Article: NANOTOXICOLOGY. 2019;13(10):1362-1379

Exposure of normal and chronic bronchitis-like mucosa models to aerosolized carbon nanoparticles: comparison of pro-inflammatory oxidative stress and tissue injury/repair responses.

Ji J; Ganguly K; Mihai X; Sun J; Malmlöf M; Gerde P; Upadhyay S; Palmberg L
Article: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 2019;139:213-223

Effect of particle deposition density of dry powders on the results produced by an in vitro test system simulating dissolution- and absorption rates in the lungs.

Malmlöf M; Nowenwik M; Meelich K; Rådberg I; Selg E; Burns J; Mascher H; Gerde P
Article: MOLECULAR PHARMACEUTICS. 2019;16(3):1245-1254

Use of PBPK Modeling To Evaluate the Performance of Dissolv It, a Biorelevant Dissolution Assay for Orally Inhaled Drug Products.

Hassoun M; Malmlöf M; Scheibelhofer O; Kumar A; Bansal S; Selg E; Nowenwik M; Gerde P; Radivojev S; Paudel A; Arora S; Forbes B
Article: CHEMOSPHERE. 2018;208:40-49

Daily intake of phthalates, MEHP, and DINCH by ingestion and inhalation.

Weiss JM; Gustafsson Å; Gerde P; Bergman Å; Lindh CH; Krais AM
Article: PARTICLE AND FIBRE TOXICOLOGY. 2018;15(1):19

Multi-cellular human bronchial models exposed to diesel exhaust particles: assessment of inflammation, oxidative stress and macrophage polarization.

Ji J; Upadhyay S; Xiong X; Malmlöf M; Sandström T; Gerde P; Palmberg L
Article: ENVIRONMENTAL RESEARCH. 2018;161:284-290

Isolation and characterization of a respirable particle fraction from residential house-dust.

Gustafsson Å; Krais AM; Gorzsás A; Lundh T; Gerde P
Article: JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY. 2018;31(1):61-70

Investigation of Lung Pharmacokinetic of the Novel PDE4 Inhibitor CHF6001 in Preclinical Models: Evaluation of the PreciseInhale Technology.

Fioni A; Selg E; Cenacchi V; Acevedo F; Brogin G; Gerde P; Puccini P
Article: PULMONARY PHARMACOLOGY & THERAPEUTICS. 2018;48:203-210

Effects of tiotropium bromide on airway hyperresponsiveness and inflammation in mice exposed to organic dust.

Gregory JA; Kemi C; Ji J; Karén J; Delin I; Gerde P; Pieper MP; Adner M; Larsson K
Article: ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES. 2017;15(2):77-88

DissolvIt: An In Vitro Method for Simulating the Dissolution and Absorption of Inhaled Dry Powder Drugs in the Lungs.

Gerde P; Malmlöf M; Havsborn L; Sjöberg C-O; Ewing P; Eirefelt S; Ekelund K
Article: PLOS ONE. 2017;12(1):e0170428

Development of Combining of Human Bronchial Mucosa Models with XposeALI® for Exposure of Air Pollution Nanoparticles.

Ji J; Hedelin A; Malmlöf M; Kessler V; Seisenbaeva G; Gerde P; Palmberg L
Article: PROCESS SAFETY AND ENVIRONMENTAL PROTECTION. 2015;93:163-173

Counter-current spray drying with stream separation: Computational modeling of a novel dryer design

Soltani S; Gerde P; Acevedo F; Rasmuson A
Article: JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY. 2013;26(4):181-189

Dry powder inhalation exposures of the endotracheally intubated rat lung, ex vivo and in vivo: the pulmonary pharmacokinetics of fluticasone furoate.

Selg E; Ewing P; Acevedo F; Sjöberg C-O; Ryrfeldt A; Gerde P
Article: ACS NANO. 2011;5(7):5312-5324

Solution-engineered palladium nanoparticles: model for health effect studies of automotive particulate pollution.

Wilkinson KE; Palmberg L; Witasp E; Kupczyk M; Feliu N; Gerde P; Seisenbaeva GA; Fadeel B; Dahlén S-E; Kessler VG
Article: JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY. 2010;23(5):273-284

Delivering horseradish peroxidase as a respirable powder to the isolated, perfused, and ventilated lung of the rat: the pulmonary disposition of an inhaled model biopharmaceutical.

Selg E; Acevedo F; Nybom R; Blomgren B; Ryrfeldt A; Gerde P
Article: PULMONARY PHARMACOLOGY & THERAPEUTICS. 2010;23(1):9-14

Vasoconstriction after inhalation of budesonide: a study in the isolated and perfused rat lung.

Ewing P; Ryrfeldt A; Sjöberg C-O; Andersson P; Edsbäcker S; Gerde P
Article: JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY. 2008;21(2):169-180

Short inhalation exposures of the isolated and perfused rat lung to respirable dry particle aerosols; the detailed pharmacokinetics of budesonide, formoterol, and terbutaline.

Ewing P; Eirefelt SJ; Andersson P; Blomgren A; Ryrfeldt A; Gerde P
Article: ENVIRONMENTAL RESEARCH. 2007;104(2):250-257

Aggregates of ultrafine particles modulate lipid peroxidation and bacterial killing by alveolar macrophages.

Lundborg M; Bouhafs R; Gerde P; Ewing P; Camner P; Dahlén S-E; Jarstrand C
Article: TOXICOLOGICAL SCIENCES. 2006;91(2):332-340

Increasing exposure levels cause an abrupt change in the absorption and metabolism of acutely inhaled benzo(a)pyrene in the isolated, ventilated, and perfused lung of the rat.

Ewing P; Blomgren B; Ryrfeldt A; Gerde P
Article: ENVIRONMENTAL RESEARCH. 2006;100(2):197-204

Aggregates of ultrafine particles impair phagocytosis of microorganisms by human alveolar macrophages.

Lundborg M; Dahlén S-E; Johard U; Gerde P; Jarstrand C; Camner P; Låstbom L
Article: INHALATION TOXICOLOGY. 2004;16(1):45-52

A novel method to aerosolize powder for short inhalation exposures at high concentrations: isolated rat lungs exposed to respirable diesel soot.

Gerde P; Ewing P; Låstbom L; Ryrfeldt A; Waher J; Lidén G
Article: JOURNAL OF APPLIED PHYSIOLOGY. 2002;92(6):2608-2616

Experimental and calculated parameters on particle phagocytosis by alveolar macrophages.

Camner P; Lundborg M; Låstbom L; Gerde P; Gross N; Jarstrand C
Article: INHALATION TOXICOLOGY. 2001;13(10):903-929

A model for absorption of low-volatile toxicants by the airway mucosa.

Gerde P; Scott BR
Article: ENVIRONMENTAL RESEARCH. 2001;86(3):244-253

Human alveolar macrophage phagocytic function is impaired by aggregates of ultrafine carbon particles.

Lundborg M; Johard U; Låstbom L; Gerde P; Camner P
Article: CARCINOGENESIS. 2001;22(5):741-749

The rapid alveolar absorption of diesel soot-adsorbed benzo[a]pyrene: bioavailability, metabolism and dosimetry of an inhaled particle-borne carcinogen.

Gerde P; Muggenburg BA; Lundborg M; Dahl AR
Article: RESEARCH REPORT (HEALTH EFFECTS INSTITUTE). 2001;(101):5-25

Respiratory epithelial penetration and clearance of particle-borne benzo[a]pyrene.

Gerde P; Muggenburg BA; Lundborg M; Tesfaigzi Y; Dahl AR
Article: CANCER RESEARCH. 1998;58(7):1417-1422

A relevant dose of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is extensively metabolized and rapidly absorbed in the canine tracheal mucosa.

Gerde P; Muggenburg BA; Stephens T; Lewis JL; Pyon KH; Dahl AR
Article: CARCINOGENESIS. 1998;19(3):493-500

Local metabolism in lung airways increases the uncertainty of pyrene as a biomarker of polycyclic aromatic hydrocarbon exposure.

Gerde P; Muggenburg BA; Scott GG; Lewis JL; Pyon KH; Dahl AR
Article: TOXICOLOGY MECHANISMS AND METHODS. 1998;8(1):37-44

A rapid combustion method for the accurate determination of low levels of tritium in biological samples

Gerde P; Stephens T; Dahl AR
Article: TOXICOLOGY MECHANISMS AND METHODS. 1998;8(1):17-25

HPLC determination of tritiated polycyclic aromatic hydrocarbon metabolites in the subfemtomole range

Scott GG; Stephens JA; Rohrbacher KD; Thornton-Manning JR; Gerde P; Dahl AR
Article: CARCINOGENESIS. 1997;18(9):1825-1832

Benzo[a]pyrene at an environmentally relevant dose is slowly absorbed by, and extensively metabolized in, tracheal epithelium.

Gerde P; Muggenburg BA; Thornton-Manning JR; Lewis JL; Pyon KH; Dahl AR
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All other publications

Published conference paper: PLANETARY AND SPACE SCIENCE. 2012;74(1):57-71

Toxicity of lunar dust

Linnarsson D; Carpenter J; Fubini B; Gerde P; Karlsson LL; Loftus DJ; Prisk GK; Staufer U; Tranfield EM; van Westrenen W
Review: ADVANCED DRUG DELIVERY REVIEWS. 2011;63(1-2):69-87

Challenges in inhaled product development and opportunities for open innovation.

Forbes B; Asgharian B; Dailey LA; Ferguson D; Gerde P; Gumbleton M; Gustavsson L; Hardy C; Hassall D; Jones R; Lock R; Maas J; McGovern T; Pitcairn GR; Somers G; Wolff RK
Published conference paper: EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY. 2008;60(2-3):181-184

How do we compare dose to cells in vitro with dose to live animals and humans? Some experiences with inhaled substances.

Gerde P
Published conference paper: EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY. 2005;57 Suppl 1:143-146

Animal models and their limitations: on the problem of high-to-low dose extrapolations following inhalation exposures.

Gerde P
Review: ENVIRONMENTAL HEALTH PERSPECTIVES. 2002;110 Suppl 3(Suppl 3):451-488

Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air.

Boström C-E; Gerde P; Hanberg A; Jernström B; Johansson C; Kyrklund T; Rannug A; Törnqvist M; Victorin K; Westerholm R

Employments

Affiliated to Research, Institute of Environmental Medicine, Karolinska Institutet, 2021-2024

Degrees and Education

Docent, Karolinska institutet, 2000

Articles

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Degrees and Education

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