Denna sida på svenska

Petter Brodin

Assistant professor

Visiting address : Science For Life Laboratory, Tomtebodavägen 23a 171 65 Solna, Sweden
Postal address : Department of Medicine, Solna (MedS), K2, Research Group P Brodin, Science For Life Laboratory, Box 1031 171 21 Solna, Sweden
Delivery address : Science For Life Laboratory, Tomtebodavägen 23b 171 65 Solna, Sweden


M.D, 2010, Karolinska Institutet

Ph.D, Immunology, 2011, Karolinska Institutet

Postdoc, 2012-2013, Stanford University School of Medicine

Research description

Our group is seeking to understand how human immune systems vary between individuals, what factors determine this variation and when during development or adult life this occurs. We are also interested in understanding how this relates to the risk of immunological health and disease.

To understand systems-level behaviors in the immune system we develop and apply novel experimental tools for comprehensive analyses of human blood. By simultaneously analyzing all cell populations, their frequencies and functional states and combining this with serum protein measurements, we are acquiring systems-level snapshots over time that can be used to better understand systems-level regulation.

To analyze the generated data we develop novel computational tools to identify cell populations in a data driven manner from single-cell data.

More information on our lab website:


Academic honors, awards and prizes

ERC starting grant 2015

VR young researcher grant 2015

SSMF young researcher grant 2014

Wenner-Gren Fellow 2012

Prins Bertil's award, Sweden-America Foundation 2012

Mary Bevé award 2009


Immune Adaptation to Environmental Influence: The Case of NK Cells and HCMV
Rölle A, Brodin P
Trends in immunology 2016;37(3):233-43

Powerful Populations Respond to Viruses and Vaccines
Brodin P
Immunity 2015;43(6):1035-7

Risks and benefits of sex-mismatched hematopoietic cell transplantation differ according to conditioning strategy
Nakasone H, Remberger M, Tian L, Brodin P, Sahaf B, Wu F, et al
Haematologica 2015;100(11):1477-85

Variation in the human immune system is largely driven by non-heritable influences
Brodin P, Jojic V, Gao T, Bhattacharya S, Angel Cj, Furman D, et al
Cell 2015;160(1-2):37-47

Automatic Classification of Cellular Expression by Nonlinear Stochastic Embedding (ACCENSE)
Shekhar K, Brodin P, Davis Mm, Chakraborty Ak
Proceedings of the National Academy of Sciences of the United States of America 2014;111(1):202-7

Natural killer cell inhibitory receptor expression in humans and mice: a closer look
Sternberg-simon M, Brodin P, Pickman Y, Onfelt B, Kärre K, Malmberg Kj, et al
Frontiers in immunology 2013;4():65-

Systems level immune response analysis and personalized medicine
Brodin P, Valentini D, Uhlin M, Mattsson J, Zumla A, Maeurer Mj
Expert review of clinical immunology 2013;9(4):307-17

Major surgery in a neutropenic patient undergoing allogeneic stem cell transplantation for high risk myelofibrosis
Brodin P, Gilg S, Lundell L, Mattsson J
International journal of hematology 2012;96(6):798-800

MicroRNA-203 functions as a tumor suppressor in basal cell carcinoma
Sonkoly E, Lovén J, Xu N, Meisgen F, Wei T, Brodin P, et al
Oncogenesis 2012;1():e3-

Skewing of the NK Cell Repertoire by MHC Class I via Quantitatively Controlled Enrichment and Contraction of Specific Ly49 Subsets
Brodin P, Lakshmikanth T, Karre K, Hoglund P
JOURNAL OF IMMUNOLOGY 2012;188(5):2218-26

MiR-125b, a MicroRNA Downregulated in Psoriasis, Modulates Keratinocyte Proliferation by Targeting FGFR2
Xu N, Brodin P, Wei Tl, Meisgen F, Eidsmo L, Nagy N, et al

Current perspectives of natural killer cell education by MHC class I molecules
Hoglund P, Brodin P

MYCN-regulated microRNAs repress estrogen receptor-alpha (ESR1) expression and neuronal differentiation in human neuroblastoma
Loven J, Zinin N, Wahlstrom T, Muller I, Brodin P, Fredlund E, et al

Natural Killer Cell Tolerance Persists Despite Significant Reduction of Self MHC Class I on Normal Target Cells in Mice
Brodin P, Lakshmikanth T, Mehr R, Johansson Mh, Duru Ad, Achour A, et al
PLOS ONE 2010;5(10):-

The role of human microRNA-125b in psoriasis
Xu N, Brodin P, Wei Tl, Meisgen F, Eidsmo L, Stahle M, et al

A Role for cis Interaction between the Inhibitory Ly49A Receptor and MHIC Class I for Natural Killer Cell Education
Chalifour A, Scarpellino L, Back J, Brodin P, Devevre E, Gros F, et al
IMMUNITY 2009;30(3):337-47

Classical Major Histocompatibility Complex Class I Molecules in Motoneurons: New Actors at the Neuromuscular Junction
Thams S, Brodin P, Plantman S, Saxelin R, Karre K, Cullheim S
JOURNAL OF NEUROSCIENCE 2009;29(43):13503-15

Distinct and Overlapping Patterns of Cytokine Regulation of Thymic and Bone Marrow-Derived NK Cell Development
Cheng M, Charoudeh Hn, Brodin P, Tang Yj, Lakshmikanth T, Hoglund P, et al
JOURNAL OF IMMUNOLOGY 2009;182(3):1460-8

NK cell education: not an on-off switch but a tunable rheostat
Brodin P, Karre K, Hoglund P
TRENDS IN IMMUNOLOGY 2009;30(4):143-9

Probing Natural Killer Cell Education by Ly49 Receptor Expression Analysis and Computational Modelling in Single MHC Class I Mice
Johansson S, Salmon-divon M, Johansson Mh, Pickman Y, Brodin P, Karre K, et al
PLOS ONE 2009;4(6):e6046-

The strength of inhibitory input during education quantitatively tunes the functional responsiveness of individual natural killer cells
Brodin P, Lakshmikanth T, Johansson S, Karre K, Hoglund P
BLOOD 2009;113(11):2434-41

Beyond licensing and disarming: a quantitative view on NK-cell education
Brodin P, Höglund P
European journal of immunology 2008;38(11):2934-7

Critical role of Qa1(b) in the protection of mature dendritic cells from NK cell-mediated killing
Persson Cm, Assarsson E, Vahlne G, Brodin P, Chambers Bj

IFN-gamma production and degranulation are differentially regulated in response to stimulation in murine natural killer cells
Vahlne G, Becker S, Brodin P, Johansson Mh

Show all publications