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Paolo Parini

Professor/senior physician

Visiting address : C1 62 Karolinska Universitetssjukhuset Huddinge 14186 Stockholm, Sweden
Postal address : Department of Laboratory Medicine (LABMED), H5, Division of clinical chemistry, C1 74 Karolinska Universitetssjukhuset Huddinge 14186 Stockholm, Sweden
Delivery address : C1 62 Karolinska Universitetssjukhuset Huddinge 14186 Stockholm, Sweden

Publications

Culturing of HepG2 cells with human serum improve their functionality and suitability in studies of lipid metabolism
Pramfalk C, Larsson L, Härdfeldt J, Eriksson M, Parini P
Biochimica et biophysica acta 2016;1861(1):51-9

Impaired Cholesterol Efflux Capacity of High-Density Lipoprotein Isolated From Interstitial Fluid in Type 2 Diabetes Mellitus-Brief Report
Apro J, Tietge Uj, Dikkers A, Parini P, Angelin B, Rudling M
Arteriosclerosis, thrombosis, and vascular biology 2016;36(5):787-91

Levels of atherogenic lipoproteins are unexpectedly reduced in interstitial fluid from type 2 diabetes patients
Apro J, Parini P, Broijersén A, Angelin B, Rudling M
Journal of lipid research 2015;56(8):1633-9

Lipids around the Clock: Focus on Circadian Rhythms and Lipid Metabolism
Gnocchi D, Pedrelli M, Hurt-camejo E, Parini P
Biology 2015;4(1):104-32

Prevention of Spontaneous Hepatocarcinogenesis in Farnesoid X Receptor-Null Mice by Intestinal-Specific Farnesoid X Receptor Reactivation
Degirolamo C, Modica S, Vacca M, Di Tullio G, Morgano A, D'orazio A, et al
HEPATOLOGY 2015;61(1):161-70

RNA therapeutics inactivate PCSK9 by inducing a unique intracellular retention form
Rocha Cs, Wiklander Op, Larsson L, Moreno Pm, Parini P, Lundin Ke, et al
Journal of molecular and cellular cardiology 2015;82():186-93

Role of TG-interacting factor (Tgif) in lipid metabolism
Pramfalk C, Eriksson M, Parini P
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 2015;1851(1):9-12

The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance
Warrier M, Shih Dm, Burrows Ac, Ferguson D, Gromovsky Ad, Brown Al, et al
CELL REPORTS 2015;10(3):326-338

Cholesterol, oxysterol, triglyceride, and coenzyme Q homeostasis in ALS. Evidence against the hypothesis that elevated 27-hydroxycholesterol is a pathogenic factor
Wuolikainen A, Acimovic J, Lövgren-sandblom A, Parini P, Andersen Pm, Björkhem I
PloS one 2014;9(11):e113619-

Estrogen Receptor Ligands Ameliorate Fatty Liver Through a Nonclassical Estrogen Receptor/Liver X Receptor Pathway in Mice
Han Si, Komatsu Y, Murayama A, Steffensen Kr, Nakagawa Y, Nakajima Y, et al
HEPATOLOGY 2014;59(5):1791-802

Hepatic ACAT2 knock down increases ABCA1 and modifies HDL metabolism in mice
Pedrelli M, Davoodpour P, Degirolamo C, Gomaraschi M, Graham M, Ossoli A, et al
PloS one 2014;9(4):e93552-

Skeletal muscle as a target of LXR agonist after long-term treatment: focus on lipid homeostasis
Archer A, Laurencikiene J, Ahmed O, Steffensen Kr, Parini P, Gustafsson JÅ, et al
American journal of physiology. Endocrinology and metabolism 2014;306(5):E494-502

TG-interacting factor 1 acts as a transcriptional repressor of sterol O-acyltransferase 2
Pramfalk C, Melhuish Ta, Wotton D, Jiang Zy, Eriksson M, Parini P
Journal of lipid research 2014;55(4):709-17

The thyroid receptor β modulator GC-1 reduces atherosclerosis in ApoE deficient mice
Kannisto K, Rehnmark S, Slätis K, Webb P, Larsson L, Gåfvels M, et al
Atherosclerosis 2014;237(2):544-54

Atorvastatin treatment induces uptake and efflux transporters in human liver
Björkhem-bergman L, Bergström H, Johansson M, Parini P, Eriksson M, Rane A, et al
Drug metabolism and disposition: the biological fate of chemicals 2013;41(9):1610-5

Is it possible to improve memory function by upregulation of the cholesterol 24S-hydroxylase (CYP46A1) in the brain?
Maioli S, Båvner A, Ali Z, Heverin M, Ismail Ma, Puerta E, et al
PloS one 2013;8(7):e68534-

Mice with chimeric livers are an improved model for human lipoprotein metabolism
Ellis Ec, Naugler We, Parini P, Mörk Lm, Jorns C, Zemack H, et al
PloS one 2013;8(11):e78550-

Serum apolipoprotein E as a marker to monitor graft function after hepatocyte transplantation in a clinically relevant mouse model
Jorns C, Takahashi T, Callaghan E, Zemack H, Larsson L, Nowak G, et al
Transplantation proceedings 2013;45(5):1780-6

The thyroid receptor modulator KB3495 reduces atherosclerosis independently of total cholesterol in the circulation in ApoE deficient mice
Mörk Lm, Rehnmark S, Davoodpour P, Norata Gd, Larsson L, Witt Mr, et al
PloS one 2013;8(12):e78534-

Cholesteryl esters and ACAT
Pramfalk C, Eriksson M, Parini P
EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY 2012;114(6):624-633

Fasting-induced FGF21 is repressed by LXR activation via recruitment of an HDAC3 corepressor complex in mice
Archer A, Venteclef N, Mode A, Pedrelli M, Gabbi C, Clément K, et al
Molecular endocrinology (Baltimore, Md.) 2012;26(12):1980-90

Increased expression of the very low-density lipoprotein receptor mediates lipid accumulation in clear-cell renal cell carcinoma
Sundelin Jp, Ståhlman M, Lundqvist A, Levin M, Parini P, Johansson Me, et al
PloS one 2012;7(11):e48694-

Influence of Neonatal Hypothyroidism on Hepatic Gene Expression and Lipid Metabolism in Adulthood
Santana-farre R, Mirecki-garrido M, Bocos C, Henriquez-hernandez La, Kahlon N, Herrera E, et al
PLOS ONE 2012;7(5):e37386-

LXR beta activation increases intestinal cholesterol absorption, leading to an atherogenic lipoprotein profile
Hu X, Steffensen Kr, Jiang Zy, Parini P, Gustafsson Ja, Gafvels M, et al
JOURNAL OF INTERNAL MEDICINE 2012;272(5):452-64

Physical training increases osteoprotegerin in postmenopausal women
Bergstrom I, Parini P, Gustafsson Sa, Andersson G, Brinck J
JOURNAL OF BONE AND MINERAL METABOLISM 2012;30(2):202-7

SOCS2 deletion protects against hepatic steatosis but worsens insulin resistance in high-fat-diet-fed mice
Zadjali F, Santana-farre R, Vesterlund M, Carow B, Mirecki-garrido M, Hernandez-hernandez I, et al
FASEB JOURNAL 2012;26(8):3282-91

Statins inhibit expression of Thioredoxin reductase 1 in rat and human liver and reduce tumour development
Skogastierna C, Johansson M, Parini P, Eriksson M, Eriksson Lc, Ekstrom L, et al
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2012;417(3):1046-51

Both liver-X receptor (LXR) isoforms control energy expenditure by regulating Brown Adipose Tissue activity
Korach-andre M, Archer A, Barros Rp, Parini P, Gustafsson Ja
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2011;108(1):403-8

Effects of high-dose statin on the human hepatic expression of genes involved in carbohydrate and triglyceride metabolism
Pramfalk C, Parini P, Gustafsson U, Sahlin S, Eriksson M
JOURNAL OF INTERNAL MEDICINE 2011;269(3):333-9

Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo
Shafaati M, Olin M, Bavner A, Pettersson H, Rozell B, Meaney S, et al
JOURNAL OF INTERNAL MEDICINE 2011;270(4):377-87

Hepatic Niemann-Pick C1-like 1
Pramfalk C, Jiang Zy, Parini P
CURRENT OPINION IN LIPIDOLOGY 2011;22(3):225-30

Late Cardiac Tamponade by Chylous Pericardial Effusion after Coronary Artery Bypass Surgery: Case Report
Albage A, Eggertsen G, Parini P
HEART SURGERY FORUM 2011;14(3):E195-7

Liver X receptors regulate de novo lipogenesis in a tissue-specific manner in C57BL/6 female mice
Korach-andre M, Archer A, Gabbi C, Barros Rp, Pedrelli M, Steffensen Kr, et al
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2011;301(1):E210-22

Prevalence and clinical implications of testosterone deficiency in men with end-stage renal disease
Carrero Jj, Qureshi Ar, Nakashima A, Arver S, Parini P, Lindholm B, et al
NEPHROLOGY DIALYSIS TRANSPLANTATION 2011;26(1):184-90

Report of the 33rd Annual Conference of the European Lipoprotein Club, Tutzing, 6-9 September 2010
Bernini F, Fisher R, Freeman D, Groen A, Kalopissis A, Malle E, et al
ATHEROSCLEROSIS 2011;215(1):249-55

Role of thyroid receptor beta in lipid metabolism
Pramfalk C, Pedrelli M, Parini P
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2011;1812(8):929-37

UTILIZATION OF LIPID ELECTROPHORESIS IMPROVED THE DIAGNOSIS IN A CASE WITH CHYLOPERICARDIUM
Albage A, Eggertsen G, Parini P
CLINICAL CHEMISTRY AND LABORATORY MEDICINE 2011;:S756-S756

Abolished synthesis of cholic acid reduces atherosclerotic development in apolipoprotein E knockout mice
Slatis K, Gafvels M, Kannisto K, Ovchinnikova O, Paulsson-berne G, Parini P, et al
JOURNAL OF LIPID RESEARCH 2010;51(11):3289-98

An Increased Cholesterol Synthesis to Cholesterol Absorption Ratio Is Associated with Coronary Artery Calcification in Treatment-Naive Patients
Joshi Ph, Marvasty I, Lestrange R, Vazquez G, Silas S, Flockhart N, et al
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2010;30(11):E248-E248

Decreased Fat Storage by Lactobacillus Paracasei Is Associated with Increased Levels of Angiopoietin-Like 4 Protein (ANGPTL4)
Aronsson L, Huang Y, Parini P, Korach-andre M, Hakansson J, Gustafsson Ja, et al
PLOS ONE 2010;5(9):-

Down-Regulation of the LXR Transcriptome Provides the Requisite Cholesterol Levels to Proliferating Hepatocytes
Lo Sasso G, Celli N, Caboni M, Murzilli S, Salvatore L, Morgano A, et al
HEPATOLOGY 2010;51(4):1334-44

EFFECTS OF HIGH DOSE STATIN ON THE HUMAN HEPATIC EXPRESSION OF GENES INVOLVED IN CARBOHYDRATE AND TRIGLYCERIDE METABOLISM
Pramfalk C, Parini P, Gustafsson U, Sahlin S, Eriksson M
ATHEROSCLEROSIS SUPPLEMENTS 2010;11(2):64-64

First Demonstration of the Relationship Between Endogenous Cholesterol Synthesis, Intestinal Cholesterol Absorption, and Serum Lipoprotein Levels
Joshi Ph, Marvasty I, Lestrange R, Vazquez G, Silas S, Flockhart N, et al
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2010;30(11):E212-E212

GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXR beta in the hepatic acute phase response
Venteclef N, Jakobsson T, Ehrlund A, Damdimopoulos A, Mikkonen L, Ellis E, et al
GENES & DEVELOPMENT 2010;24(4):381-95

HDL Metabolism and Hepatic Acyl Coenzyme A: Cholesterol Acyltransferase (ACAT) 2 Inhibition in Mice
Pedrelli M, Davoodpour P, Degirolamo C, Gomaraschi M, Larsson L, Rudel Ll, et al
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2010;30(11):E191-E191

HNF1 alpha and SREBP2 are important regulators of NPC1L1 in human liver
Pramfalk C, Jiang Zy, Cai Q, Hu H, Zhang Sd, Han Tq, et al
JOURNAL OF LIPID RESEARCH 2010;51(6):1354-62

Intestinal Specific LXR Activation Stimulates Reverse Cholesterol Transport and Protects from Atherosclerosis
Lo Sasso G, Murzilli S, Salvatore L, D'ernco I, Petruzzelli M, Conca P, et al
CELL METABOLISM 2010;12(2):187-93

Liver X Receptor Beta: A Nuclear Receptor Promoting Intestinal Cholesterol Absorption and Influencing Bile Acid Composition in Mice
Hu Xl, Steffensen K, Jiang Zy, Parini P, Gustafsson Ja, Gafvels M, et al
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2010;30(11):E281-E282

Lovastatin Prevents Carcinogenesis in a Rat Model for Liver Cancer. Effects of Ubiquinone Supplementation
Bjorkhem-bergman L, Acimovic J, Torndal Ub, Parini P, Eriksson Lc
ANTICANCER RESEARCH 2010;30(4):1105-12

Separate and overlapping metabolic functions of LXR alpha and LXR beta in C57Bl/6 female mice
Korach-andre M, Parini P, Larsson L, Arner A, Steffensen Kr, Gustafsson Ja
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2010;298(2):E167-78

Thyroid hormones and thyroid hormone receptors: Effects of thyromimetics on reverse cholesterol transport
Pedrelli M, Pramfalk C, Parini P
WORLD JOURNAL OF GASTROENTEROLOGY 2010;16(47):5958-64

ACAT2 and human hepatic cholesterol metabolism: Identification of important gender-related differences in normolipidemic, non-obese Chinese patients
Parini P, Jiang Zy, Einarsson C, Eggertsen G, Zhang Sd, Rudel Ll, et al
ATHEROSCLEROSIS 2009;207(1):266-71

Carotid Atherosclerosis Progression and ACAT Inhibition
Parini P, Eriksson M, Rudel Ll
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 2009;302(3):255-author

Cocoa Butter and Safflower Oil Elicit Different Effects on Hepatic Gene Expression and Lipid Metabolism in Rats
Gustavsson C, Parini P, Ostojic J, Cheung L, Hu J, Zadjali F, et al
LIPIDS 2009;44(11):1011-27

Control of ACAT2 Liver Expression by HNF4 alpha Lesson From MODY1 Patients
Pramfalk C, Karlsson E, Groop L, Rudel Ll, Angelin B, Eriksson M, et al
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2009;29(8):1235-41

Hypercholesterolemia leads to elevated TGF-beta 1 activity and T helper 3-dependent autoimmune responses in atherosclerotic mice
Zhou Xh, Johnston Tp, Johansson D, Parini P, Funa K, Svensson J, et al
ATHEROSCLEROSIS 2009;204(2):381-7

Increased NPC1L1 and ACAT2 expression in the jejunal mucosa from Chinese gallstone patients
Jiang Zy, Jiang Cy, Wang L, Wang Jc, Zhang Sd, Einarsson C, et al
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2009;379(1):49-54

Low Serum Testosterone Increases Mortality Risk among Male Dialysis Patients
Carrero Jj, Qureshi Ar, Parini P, Arver S, Lindholm B, Barany P, et al
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 2009;20(3):613-20

T Cell-Mediated Inflammation in Adipose Tissue Does Not Cause Insulin Resistance in Hyperlipidemic Mice
Sultan A, Strodthoff D, Robertson Ak, Paulsson-berne G, Fauconnier J, Parini P, et al
CIRCULATION RESEARCH 2009;104(8):961-8

The Gender-Related Difference of Hepatic Microsomal ACAT2 Activity in Mice and Its Relation with Estrogen Receptors
Jiang Zy, Inzunza J, Gustafsson Ja, Eriksson M, Parini P
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2009;29(7):E72-E72

The oxysterol receptor LXR inhibits proliferation of human breast cancer cells
Vedin Ll, Lewandowski Sa, Parini P, Gustafsson Ja, Steffensen Kr
CARCINOGENESIS 2009;30(4):575-9

Thyroid Hormone Receptor Modulation Reduces the Atherosclerotic Process Through Increased Reverse Cholesterol Transport
Nilsson Lm, Rehnmark S, Davoodpour P, Larsson L, Parini P
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2009;29(7):E71-E71

Cholesterol synthesis inhibition elicits an integrated molecular response in human livers including decreased ACAT2
Parini P, Gustafsson U, Davis Ma, Larsson L, Einarsson C, Wilson M, et al
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2008;28(6):1200-6

Hypocholesterolemic effects of fatty acid bile acid conjugates (FABACs) in mice
Leikin-frenkel A, Parini P, Konikoff Fm, Benthin L, Lelkin-gobbi D, Goldiner I, et al
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 2008;471(1):63-71

Increased expression of LXR alpha, ABCG5, ABCG8, and SR-BI in the liver from normolipidemic, nonobese Chinese gallstone patients
Jiang Zy, Parini P, Eggertsen G, Davis Ma, Hu H, Suo Gj, et al
JOURNAL OF LIPID RESEARCH 2008;49(2):464-72

Liver X receptor beta (LXR beta): A link between beta-sitosterol and amyotrophic lateral sclerosis-Parkinson's dementia
Kim Hj, Fan Xt, Gabbi C, Yakimchuk K, Parini P, Warner M, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2008;105(6):2094-9

Monomeric Tartrate Resistant Acid Phosphatase Induces Insulin Sensitive Obesity
Lang P, Van Harmelen V, Ryden M, Kaaman M, Parini P, Carneheim C, et al
PLOS ONE 2008;3(3):e1713-

ACAT2 and human hepatic cholesterol mkiabolism: Identification of important gender-related differences
Jiang Zy, Parini P, Einarsson C, Eggertsen G, Davis Ma, Wang L, et al
ATHEROSCLEROSIS SUPPLEMENTS 2007;8(1):24-24

Age-induced hypercholesterolemia in the rat relates to reduced elimination but not increased intestinal absorption of cholesterol
Galman C, Matasconi M, Persson L, Parini P, Angelin B, Rudling M
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2007;293(3):E737-42

Bile acids and lipoprotein metabolism: Effects of cholestyramine and chenodeoxycholic acid on human hepatic mRNA expression
Nilsson Lm, Abrahamsson A, Sahlin S, Gustafsson U, Angelin B, Parini P, et al
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2007;357(3):707-11

Cholesterol regulates ACAT2 gene expression and enzyme activity in human hepatoma cells
Pramfalk C, Angelin B, Eriksson M, Parini P
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2007;364(2):402-9

Physiological differences between human and rat primary hepatocytes in response to liver X receptor activation by 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2diphenylethyl)amino]propyloxy] phenylacetic acid hydrochloride (GW3965)
Kotokorpi P, Ellis E, Parini P, Nilsson Lm, Strom S, Steffensen Kr, et al
MOLECULAR PHARMACOLOGY 2007;72(4):947-55

Studies on the cholesterol-free mouse - Strong activation of LXR-regulated hepatic genes when replacing cholesterol with desmosterol
Heverin M, Meaney S, Brafman A, Shafir M, Olin M, Shafaati M, et al
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2007;27(10):2191-7

Targeting liver X receptor beta: a new therapeutic approach to prevent atherosclerosis?
Parini P, Gustafsson Ja
FUTURE LIPIDOLOGY 2007;2(6):603-607

Improved metabolic control by depletion of Liver X Receptors in mice
Schuster Gu, Johansson L, Kietz S, Stulnig Tm, Parini P, Gustafsson Ja
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2006;348(1):176-82

Lipoprotein profiles in plasma and interstitial fluid analyzed with an automated gel-filtration system
Parini P, Johansson L, Broijersen A, Angelin B, Rudling M
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 2006;36(2):98-104

Obesity and disturbed lipoprotein profile in estrogen receptor-alpha-deficient male mice (vol 278, pg 640, 2000)
Ohlsson C, Hellberg N, Parini P, Vidal O, Bohlooly-y M, Rudling M, et al
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2006;348(1):326-326

Studies on LXR- and FXR-mediated effects on cholesterol homeostasis in normal and cholic acid-depleted mice
Wang J, Einarsson C, Murphy C, Parini P, Bjorkhem I, Gafvels M, et al
JOURNAL OF LIPID RESEARCH 2006;47(2):421-30

ACAT2 is a target for treatment of coronary heart disease associated with hypercholesterolemia
Rudel Ll, Lee Rg, Parini P
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2005;25(6):1112-8

Cholic acid as key regulator of cholesterol synthesis, intestinal absorption and hepatic storage in mice
Murphy C, Parini P, Wang J, Bjorkhem I, Eggertsen G, Gafvels M
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 2005;1735(3):167-75

Control of ACAT2 liver expression by HNF1
Pramfalk C, Davis Ma, Eriksson M, Rudel Ll, Parini P
JOURNAL OF LIPID RESEARCH 2005;46(9):1868-76

Lesion development and response to immunization reveal a complex role for CD4 in atherosclerosis
Zhou Xh, Robertson Akl, Rudling M, Parini P, Hansson Gk
CIRCULATION RESEARCH 2005;96(4):427-34

LXR deficiency and cholesterol feeding affect the expression and phenobarbital-mediated induction of cytochromes P450 in mouse liver
Gnerre C, Schuster Gu, Roth A, Handschin C, Johansson L, Looser R, et al
JOURNAL OF LIPID RESEARCH 2005;46(8):1633-42

Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice
Johansson L, Rudling M, Scanlan Ts, Lundasen T, Webb P, Baxter J, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2005;102(29):10297-302

ACAT2 is localized to Hepatocytes and is the major cholesterol-esterifying enzyme in human liver
Parini P, Davis M, Lada At, Erickson Sk, Wright Tl, Gustafsson U, et al
CIRCULATION 2004;110(14):2017-23

Angiogenesis inhibitor, TNP-470, prevents diet-induced and genetic obesity in mice
Brakenhielm E, Cao Rh, Gao Bh, Angelin B, Cannon B, Parini P, et al
CIRCULATION RESEARCH 2004;94(12):1579-88

Growth hormone-mediated alteration of fuel metabolism in the aged rat as determined from transcript profiles
Tollet-egnell P, Parini P, Stahlberg N, Lonnstedt I, Lee Nh, Rudling M, et al
PHYSIOLOGICAL GENOMICS 2004;16(2):261-7

Is there a need for cholesteryl ester transfer protein inhibition?
Parini P, Rudel Ll
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2003;23(3):374-5

Accumulation of foam cells in liver X receptor-deficient mice
Schuster Gu, Parini P, Wang L, Alberti S, Steffensen Kr, Hansson Gk, et al
CIRCULATION 2002;106(9):1147-53

Different regulation of the LXR alpha promoter activity by isoforms of CCAAT/enhancer-binding proteins
Steffensen Kr, Schuster Gu, Parini P, Holter E, Sadek Cm, Cassel T, et al
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2002;293(5):1333-40

Reverse cholesterol transport in man: promotion of fecal steroid excretion by infusion of reconstituted HDL
Angelin B, Parini P, Eriksson M
ATHEROSCLEROSIS SUPPLEMENTS 2002;3(4):23-30

Estrogenic influence on the regulation of hepatic estrogen receptor-alpha and serum level of angiotensinogen in female rats
Stavreus-evers A, Parini P, Freyschuss B, Elger W, Reddersen G, Sahlin L, et al
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 2001;78(1):83-8

Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXR beta-deficient mice
Alberti S, Schuster G, Parini P, Feltkamp D, Diczfalusy U, Rudling M, et al
JOURNAL OF CLINICAL INVESTIGATION 2001;107(5):565-73

Biphasic effects of the natural estrogen 17 beta-estradiol on hepatic cholesterol metabolism in intact female rats
Parini P, Angelin B, Stavreus-evers A, Freyschuss B, Eriksson H, Rudling M
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2000;20(7):1817-23

Obesity and disturbed lipoprotein profile in estrogen receptor-alpha-deficient male mice
Ohlsson C, Hellberg N, Parini P, Vidal O, Bohlooly M, Rudling M, et al
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2000;278(3):640-5

Cholesterol and lipoprotein metabolism in aging - Reversal of hypercholesterolemia by growth hormone treatment in old rats
Parini P, Angelin B, Rudling M
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 1999;19(4):832-9

Effects of growth hormone on hepatic cholesterol metabolism. Lessons from studies in rats and humans
Rudling M, Parini P, Angelin B
GROWTH HORMONE & IGF RESEARCH 1999;:1-7

Lipoprotein receptors in acute myelogenous leukemia - Failure to defect increased low-density lipoprotein (LDL) receptor numbers in cell membranes despite increased cellular LDL degradation
Rudling M, Gafvels M, Parini P, Gahrton G, Angelin B
AMERICAN JOURNAL OF PATHOLOGY 1998;153(6):1923-35

Growth hormone and bile acid synthesis - Key role for the activity of hepatic microsomal cholesterol 7 alpha-hydroxylase in the rat
Rudling M, Parini P, Angelin B
JOURNAL OF CLINICAL INVESTIGATION 1997;99(9):2239-45

Importance of estrogen receptors in hepatic LDL receptor regulation
Parini P, Angelin B, Rudling M
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 1997;17(9):1800-5

GROWTH-HORMONE SPECIFICALLY STIMULATES THE EXPRESSION OF LOW-DENSITY-LIPOPROTEIN RECEPTORS IN HUMAN HEPATOMA-CELLS
Parini P, Angelin B, Lobie Pe, Norstedt G, Rudling M
ENDOCRINOLOGY 1995;136(9):3767-73

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