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Nuno Leal

Graduate Student

About me

I started my studies at Karolinska Institutet as a master student in 2013. Currently, I am on my third year of my PhD studies at the Department of Neurobiology, Care Science and Society (NVS) at the Center for Alzheimer Research.

Currently I am also a member of the Student Council at NVS as a Deputy Chairman ( 


- Master of Science from Stockholm University (Sweden).

- Bachelor of Science from Univeristy of Porto (Portugal).

Research description

My main project is focused on mitochondria-ER associated membranes (MAM/MERCS). In our group we try to understand the role between this subcellular region and Alzheimer's disease (AD) - with special interest in Aβ production. We are interested as well in the relationship between MAM, Aβ production and autophagosome formation.

I am also involved in side projects with colleagues including:

- Identify new proteins and their respective functions at MAM;

- Characterization of mitochondria in differentiated neuronal cells;

- Characterization of MAM in synapses.


Mitofusin-2 knockdown increases ER-mitochondria contact and decreases amyloid β-peptide production
Leal Ns, Schreiner B, Pinho Cm, Filadi R, Wiehager B, Karlström H, et al
Journal of cellular and molecular medicine 2016;20(9):1686-95