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About me

I am an assistant professor working in Unit of Dermatology, Karolinska Institutet. I received my Ph.D. degree in medical virology from Uppsala University, Sweden (2008) and did postdoc research at Molecular Dermatology research group led by Prof. Mona Ståhle in Karolinska Institutet (2009-2013). 

Research description

Research profile:

Project  1. The role of non-coding RNAs in human skin wound healing

The goal of our research is to develop novel RNA-based treatments to improve healing of human skin wounds. The immense economic and social impact of deficient wound healing e.g. chronic ulcers post-surgical wounds care and skin scarring, calls for attention and allocation of resources to understand biological mechanisms underlying wound complications. Due to the complex nature of wounds, efficient targeted approach to enhance healing are essentially lacking today.

The recent discovery of non-coding RNAs (ncRNAs) as powerful gene regulators provides hope to develop novel RNA-based treatments for a wide variety of diseases. Compared to traditional drugs targeting single proteins, modulating ncRNAs may be more effective strategies, since a single ncRNA may modulate an entire functional network. The role of ncRNAs in human skin wound healing remains largely unexplored.

The objective of our study is to reveal the role(s) of ncRNAs in skin wound healing and to explore the potential of RNA-based therapy for chronic wounds. We primarily focus on small ncRNAs, i.e. microRNAs (miRNAs) and long-non-coding RNAs (lncRNAs) and study:

  • The expression profiles of miRNA/lncRNA in injured human skin;
  • The biological function of differentially expressed miRNAs/lncRNAs in wounds;
  • The molecular mechanisms mediating the biological functions of wound related miRNAs/lncRNAs;
  • The therapeutic potentials of targeting wound related miRNAs.

Our research network is composed of both clinicians and scientists, which allows us to perform ‘Bench-to-Bedside’ research. At present, we are investigating the novel roles of miRNAs and lncRNAs in skin wounds using our unique collection of human wound tissues. In the next step, we aim to translate our basic scientific findings into therapeutic interventions for wound patients.


Project  2. Investigation of the mechanistic links between psoriasis and co-morbidities

Psoriasis is an immune-mediated inflammatory disease of the skin. It is a lifelong disease with spontaneous remissions and exacerbations, affecting the patients’ life quality substantially, and there is no cure for it today. Epidemiological studies show that psoriasis patients have increased risks of developing systemic co-morbidities, e.g. obesity, overt diabetes and cardiovascular disease; however, the molecular mechanisms behind these co-morbidities remain unexplored. We have previously demonstrated that miRNAs play important roles in skin inflammation of psoriasis. Here, we study whether miRNA could also be a key mechanistic link between psoriasis and its co-morbidities, using materials from a large biobank of psoriasis patients in Stockholm. This study will further increase our understanding about pathogenesis of psoriasis. It is essential for the effective management of psoriasis and prevention of its related co-morbidities.


Previous and Current Research Funding:


Team members:



  • Xi Liu, Master
  • Aoxue Wang, MD, PhD
  • Benedicta Ugochi Iwuagwu, Master


Key publications:

MicroRNA-132 enhances transition from inflammation to proliferation during wound healing.
Li D, Wang A, Liu X, Meisgen F, Grünler J, Botusan I, et al
J. Clin. Invest. 2015 Aug;125(8):3008-26

MicroRNA-31 Promotes Skin Wound Healing by Enhancing Keratinocyte Proliferation and Migration.
Li D, Li X, Wang A, Meisgen F, Pivarcsi A, Sonkoly E, et al
J. Invest. Dermatol. 2015 Jun;135(6):1676-85

MicroRNA-31 is overexpressed in cutaneous squamous cell carcinoma and regulates cell motility and colony formation ability of tumor cells.
Wang A, Landén N, Meisgen F, Lohcharoenkal W, Ståhle M, Sonkoly E, et al
PLoS ONE 2014 ;9(7):e103206 

MiR-146a negatively regulates TLR2-induced inflammatory responses in keratinocytes.
Meisgen F, Xu Landén N, Wang A, Réthi B, Bouez C, Zuccolo M, et al
J. Invest. Dermatol. 2014 Jul;134(7):1931-40

Activation of toll-like receptors alters the microRNA expression profile of keratinocytes.
Meisgen F, Xu Landén N, Bouez C, Zuccolo M, Gueniche A, Ståhle M, et al
Exp. Dermatol. 2014 Apr;23(4):281-3

MicroRNA-31 is overexpressed in psoriasis and modulates inflammatory cytokine and chemokine production in keratinocytes via targeting serine/threonine kinase 40.
Xu N, Meisgen F, Butler L, Han G, Wang X, Söderberg-Nauclér C, et al
J. Immunol. 2013 Jan;190(2):678-88

MicroRNA-125b down-regulates matrix metallopeptidase 13 and inhibits cutaneous squamous cell carcinoma cell proliferation, migration, and invasion.
Xu N, Zhang L, Meisgen F, Harada M, Heilborn J, Homey B, et al
J. Biol. Chem. 2012 Aug;287(35):29899-908

MiR-125b, a microRNA downregulated in psoriasis, modulates keratinocyte proliferation by targeting FGFR2.
Xu N, Brodin P, Wei T, Meisgen F, Eidsmo L, Nagy N, et al
J. Invest. Dermatol. 2011 Jul;131(7):1521-9


Full publication list (PubMed)


Vacant positions:

We always want to get in touch with talented potential co-workers. If you are interested in doing research within our group, as a degree project or as a researcher, please contact me. I would also be happy to help with applications for external support for PhD study or postdoctoral fellowships.

Academic honors, awards and prizes

2015 Ragnar Söderberg Fellowship in Medicine

2013 European Dermatology Research prize awarded by La Roche-Posay Foundation

2013 Academy for Future Leaders in Dermatology, European Society for Dermatological Research

2012 New investigator prize awarded by European Skin Research Foundation


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