I am an assistant professor working in Unit of Dermatology, Karolinska Institutet. I received my Ph.D. degree in medical virology from Uppsala University, Sweden (2008) and did postdoc research at Molecular Dermatology research group led by Prof. Mona Ståhle in Karolinska Institutet (2009-2013).
Project 1. The role of non-coding RNAs in human skin wound healing
The goal of our research is to develop novel RNA-based treatments to improve healing of human skin wounds. The immense economic and social impact of deficient wound healing e.g. chronic ulcers post-surgical wounds care and skin scarring, calls for attention and allocation of resources to understand biological mechanisms underlying wound complications. Due to the complex nature of wounds, efficient targeted approach to enhance healing are essentially lacking today.
The recent discovery of non-coding RNAs (ncRNAs) as powerful gene regulators provides hope to develop novel RNA-based treatments for a wide variety of diseases. Compared to traditional drugs targeting single proteins, modulating ncRNAs may be more effective strategies, since a single ncRNA may modulate an entire functional network. The role of ncRNAs in human skin wound healing remains largely unexplored.
The objective of our study is to reveal the role(s) of ncRNAs in skin wound healing and to explore the potential of RNA-based therapy for chronic wounds. We primarily focus on small ncRNAs, i.e. microRNAs (miRNAs) and long-non-coding RNAs (lncRNAs) and study:
- The expression profiles of miRNA/lncRNA in injured human skin;
- The biological function of differentially expressed miRNAs/lncRNAs in wounds;
- The molecular mechanisms mediating the biological functions of wound related miRNAs/lncRNAs;
- The therapeutic potentials of targeting wound related miRNAs.
Our research network is composed of both clinicians and scientists, which allows us to perform ‘Bench-to-Bedside’ research. At present, we are investigating the novel roles of miRNAs and lncRNAs in skin wounds using our unique collection of human wound tissues. In the next step, we aim to translate our basic scientific findings into therapeutic interventions for wound patients.
Project 2. Investigation of the mechanistic links between psoriasis and co-morbidities
Psoriasis is an immune-mediated inflammatory disease of the skin. It is a lifelong disease with spontaneous remissions and exacerbations, affecting the patients’ life quality substantially, and there is no cure for it today. Epidemiological studies show that psoriasis patients have increased risks of developing systemic co-morbidities, e.g. obesity, overt diabetes and cardiovascular disease; however, the molecular mechanisms behind these co-morbidities remain unexplored. We have previously demonstrated that miRNAs play important roles in skin inflammation of psoriasis. Here, we study whether miRNA could also be a key mechanistic link between psoriasis and its co-morbidities, using materials from a large biobank of psoriasis patients in Stockholm. This study will further increase our understanding about pathogenesis of psoriasis. It is essential for the effective management of psoriasis and prevention of its related co-morbidities.
Previous and Current Research Funding:
- 2016-2020 Ragnar Söderberg Fellowship in Medicine
- 2016 Åke Wibergs Foundation
- 2016-2017 Jeanssons Foundation
- 2014-2016 Swedish Research Council (Vetenskapsrådet)
- 2010-2016 Swedish Dermatology Foundation (HudFonden)
- 2010-2016 Karolinska Institutet
- 2014 LA-ROCHE POSAY Foundation
- 2014 Hedlunds Foundation
- 2012 European Skin Research Foundation
- 2012 Swedish Medical Doctor Society (SLS)
- 2011 Pfizer AB Investigator Initiated Research Fund
- 2011-2013 Swedish Society for Medical Research (SSMF)
- 2010-2013 Swedish Psoriasis Foundation
- 2010-2012 Tore Nilssons Foundation for Medical Research
- 2010-2012 Lars Hiertas Memorial Foundation
- 2010-2012, 2014 Sigurt and Elsa Goljes Memorial Foundation
- Ning Xu Landén, MD, PhD, Team Leader
- Dongqing Li, PhD, Postdoc
- Eva Herter, PhD, Postdoc
- Xi Li, MD, PhD student
- Eleni Liapi, Master
- Xi Liu, Master
- Aoxue Wang, MD, PhD
- Benedicta Ugochi Iwuagwu, Master
MicroRNA-132 enhances transition from inflammation to proliferation during wound healing.
J. Clin. Invest. 2015 Aug;125(8):3008-26
MicroRNA-31 Promotes Skin Wound Healing by Enhancing Keratinocyte Proliferation and Migration.
J. Invest. Dermatol. 2015 Jun;135(6):1676-85
MiR-146a negatively regulates TLR2-induced inflammatory responses in keratinocytes.
J. Invest. Dermatol. 2014 Jul;134(7):1931-40
Activation of toll-like receptors alters the microRNA expression profile of keratinocytes.
Exp. Dermatol. 2014 Apr;23(4):281-3
MicroRNA-125b down-regulates matrix metallopeptidase 13 and inhibits cutaneous squamous cell carcinoma cell proliferation, migration, and invasion.
J. Biol. Chem. 2012 Aug;287(35):29899-908
MiR-125b, a microRNA downregulated in psoriasis, modulates keratinocyte proliferation by targeting FGFR2.
J. Invest. Dermatol. 2011 Jul;131(7):1521-9
We always want to get in touch with talented potential co-workers. If you are interested in doing research within our group, as a degree project or as a researcher, please contact me. I would also be happy to help with applications for external support for PhD study or postdoctoral fellowships.
Academic honors, awards and prizes
2012 New investigator prize awarded by European Skin Research Foundation